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The map label for this gene is ywrD [H]

Identifier: 83592685

GI number: 83592685

Start: 1589219

End: 1590805

Strand: Direct

Name: ywrD [H]

Synonym: Rru_A1349

Alternate gene names: 83592685

Gene position: 1589219-1590805 (Clockwise)

Preceding gene: 83592684

Following gene: 83592686

Centisome position: 36.51

GC content: 68.37

Gene sequence:

>1587_bases
ATGAGAGATTTCTTTCGCGTTGGGCGGGACCCCGTGTTGGCCCGCGAGGCGATGATCGCCACCTCCCATCCGCTCTCGAC
GGCGGCCGGGCTGGAAATTCTGAGCGCCGGCGGCACGGCGGTGGACGCGGCCCTGGCTGCCGTCGCCGTGCAAAGCGTCG
TCGATCCGCTGATGACCGGCATCGGCGGCGATTGCTTCGCCCTTTACGCCCCGGCCAAGGGCGATGTGGTCGCCCTGAAC
GGCAGCGGCCGGGCGCCTTTGGCGGCCAGCGTGTCGCGCCTGAAGGCCCTGGGGGTGGGCGAGATCACCCAGACCAGCCC
CCATGCCATTACCGTGCCCGGCGCGGTCGGCGCCTGGACCAAGCTGCATGGCGATTACGGACGGCTGCCGCTCGCCACCT
TGTTCGCCCGCGCCATCGCCTATGCCGAGGGCGGCTATCCGGTGACGCCAAGGGTGGCCCATGATTGGGCGCGCGAAGCC
GCCCTGGTCGCCGGCGACTCCGGGGCGGCGGCGGTTTTCCTGCCCGATGGCCGGGCGCCGGTGGCCGGGGCGCGTCACGC
CCAACCCAAGCTTGGCGACCAATTGCGCGCCATCGCCAGGGACGGGGCGGCTGCCTTTTATCTGGGGCCGACCGCCGAGG
CGCTGGTCGCCTATCTTCAGGGGTTGGGCGGGCTGCATACCCTTGACGACTTCGCCTGCGGTCTGGAGGACGCCGAGTAT
GTGACGCCGATTTCGACGATTTATCGTGGTCACGAGGTCTTTGAATGTCCGCCCAATGGCCAGGGGCTGGCGGCCTTGAT
GATCCTCAATATCCTGTCGGGCTTCGATCTGTCCGATGATCTCGCGCTCGCCGACCGCCTGCATCTGCAGGCCGAGGCGA
CCAAGCTCGCCTATTATCACCGCGACGCCCTGATCGCCGATCCGGCCCATCTGCCCTATCCGCCCGACGCGCTGCTCGCC
CCCGAAGTCGCCGAGACCCTGCGTCGGCGCATCCGCATGGACCGGGTTCTGGCCCCGGCCCTGTGGACCGAACCCGAGCA
CAAGGACACGGTTTACCTTTGTGTCGTCGATGGTCAGGGCAATGCCGTGTCCTTGATCAATTCGATCTTCCATGGCTTCG
GCTCCACCCATCTCGATCCGGCGACGGGGATCTTGCTGCACAGCCGTGGGGCGTCGTTCCGGGTGATCGAGGGACATCCC
AACGCCATCGGTCCGCGCAAGCGCCCGATGCACACCATCATTCCCGGCATGGTCCGCAAGGACGGCAAGACCGTGATGCC
CTTTGGCGTCATGGGCGGCCAGTATCAGGCCGCCGGTCACGCCGCCTTCCTGTCGGGGGTGCTCGATCGCCGTCTCGATG
TGCAGCAAGCCATCGACGCCCCGCGCGCCTTTGGCTTTGGCGGCACGCTGGAGGTCGAACCGACCGTCGAGGCCGGGGTG
CTGGCCGCCCTGGCGGCGCGCGGCCACCGGGTGACGACGGCGGCCAATCCCATCGGCGGCGCCCAGGCGATCTGGATCGA
TCCGCAAAGCGGCCTGCTGGCCGGCGGCTCCGATCAGCGCAAGGACGGCTGCGCTTTGGGGTTCTAA

Upstream 100 bases:

>100_bases
TTCTGGCGATCACCGCCCTGCGCATGCTGTGGACCGTGTTCAGCGCCTGAAGACGCCTTGCCGTCGTGGAGTCATCAATC
TGGGTTAGGATAAGCCGATC

Downstream 100 bases:

>100_bases
GAACCATTATCGATCAAACGCGCAACCGGCCTTGACCAGCCCCCGTTGGGGGAGAGGCGAACGCCCCCGGCGGGGCGGTT
CCGGGTCATGGGATGGGTTG

Product: gamma-glutamyltransferase 2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 528; Mature: 528

Protein sequence:

>528_residues
MRDFFRVGRDPVLAREAMIATSHPLSTAAGLEILSAGGTAVDAALAAVAVQSVVDPLMTGIGGDCFALYAPAKGDVVALN
GSGRAPLAASVSRLKALGVGEITQTSPHAITVPGAVGAWTKLHGDYGRLPLATLFARAIAYAEGGYPVTPRVAHDWAREA
ALVAGDSGAAAVFLPDGRAPVAGARHAQPKLGDQLRAIARDGAAAFYLGPTAEALVAYLQGLGGLHTLDDFACGLEDAEY
VTPISTIYRGHEVFECPPNGQGLAALMILNILSGFDLSDDLALADRLHLQAEATKLAYYHRDALIADPAHLPYPPDALLA
PEVAETLRRRIRMDRVLAPALWTEPEHKDTVYLCVVDGQGNAVSLINSIFHGFGSTHLDPATGILLHSRGASFRVIEGHP
NAIGPRKRPMHTIIPGMVRKDGKTVMPFGVMGGQYQAAGHAAFLSGVLDRRLDVQQAIDAPRAFGFGGTLEVEPTVEAGV
LAALAARGHRVTTAANPIGGAQAIWIDPQSGLLAGGSDQRKDGCALGF

Sequences:

>Translated_528_residues
MRDFFRVGRDPVLAREAMIATSHPLSTAAGLEILSAGGTAVDAALAAVAVQSVVDPLMTGIGGDCFALYAPAKGDVVALN
GSGRAPLAASVSRLKALGVGEITQTSPHAITVPGAVGAWTKLHGDYGRLPLATLFARAIAYAEGGYPVTPRVAHDWAREA
ALVAGDSGAAAVFLPDGRAPVAGARHAQPKLGDQLRAIARDGAAAFYLGPTAEALVAYLQGLGGLHTLDDFACGLEDAEY
VTPISTIYRGHEVFECPPNGQGLAALMILNILSGFDLSDDLALADRLHLQAEATKLAYYHRDALIADPAHLPYPPDALLA
PEVAETLRRRIRMDRVLAPALWTEPEHKDTVYLCVVDGQGNAVSLINSIFHGFGSTHLDPATGILLHSRGASFRVIEGHP
NAIGPRKRPMHTIIPGMVRKDGKTVMPFGVMGGQYQAAGHAAFLSGVLDRRLDVQQAIDAPRAFGFGGTLEVEPTVEAGV
LAALAARGHRVTTAANPIGGAQAIWIDPQSGLLAGGSDQRKDGCALGF
>Mature_528_residues
MRDFFRVGRDPVLAREAMIATSHPLSTAAGLEILSAGGTAVDAALAAVAVQSVVDPLMTGIGGDCFALYAPAKGDVVALN
GSGRAPLAASVSRLKALGVGEITQTSPHAITVPGAVGAWTKLHGDYGRLPLATLFARAIAYAEGGYPVTPRVAHDWAREA
ALVAGDSGAAAVFLPDGRAPVAGARHAQPKLGDQLRAIARDGAAAFYLGPTAEALVAYLQGLGGLHTLDDFACGLEDAEY
VTPISTIYRGHEVFECPPNGQGLAALMILNILSGFDLSDDLALADRLHLQAEATKLAYYHRDALIADPAHLPYPPDALLA
PEVAETLRRRIRMDRVLAPALWTEPEHKDTVYLCVVDGQGNAVSLINSIFHGFGSTHLDPATGILLHSRGASFRVIEGHP
NAIGPRKRPMHTIIPGMVRKDGKTVMPFGVMGGQYQAAGHAAFLSGVLDRRLDVQQAIDAPRAFGFGGTLEVEPTVEAGV
LAALAARGHRVTTAANPIGGAQAIWIDPQSGLLAGGSDQRKDGCALGF

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=540, Percent_Identity=28.8888888888889, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI73915090, Length=540, Percent_Identity=28.8888888888889, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI73915096, Length=540, Percent_Identity=28.8888888888889, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI73915094, Length=540, Percent_Identity=28.8888888888889, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI113429324, Length=545, Percent_Identity=29.3577981651376, Blast_Score=143, Evalue=5e-34,
Organism=Homo sapiens, GI113429326, Length=532, Percent_Identity=28.9473684210526, Blast_Score=135, Evalue=9e-32,
Organism=Homo sapiens, GI109148539, Length=508, Percent_Identity=29.7244094488189, Blast_Score=117, Evalue=4e-26,
Organism=Homo sapiens, GI153266885, Length=538, Percent_Identity=27.3234200743494, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI153266901, Length=539, Percent_Identity=27.2727272727273, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI153266907, Length=538, Percent_Identity=26.2081784386617, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1789856, Length=533, Percent_Identity=30.5816135084428, Blast_Score=200, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17506189, Length=519, Percent_Identity=25.4335260115607, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI193208245, Length=489, Percent_Identity=25.1533742331288, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI193208247, Length=489, Percent_Identity=25.1533742331288, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI18859893, Length=506, Percent_Identity=29.4466403162055, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI161077878, Length=527, Percent_Identity=27.8937381404175, Blast_Score=123, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24642670, Length=527, Percent_Identity=27.8937381404175, Blast_Score=123, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24642666, Length=527, Percent_Identity=27.8937381404175, Blast_Score=123, Evalue=4e-28,
Organism=Drosophila melanogaster, GI161077880, Length=527, Percent_Identity=27.8937381404175, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI45551474, Length=527, Percent_Identity=27.8937381404175, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI18859741, Length=552, Percent_Identity=25.5434782608696, Blast_Score=112, Evalue=7e-25,
Organism=Drosophila melanogaster, GI161077496, Length=490, Percent_Identity=25.3061224489796, Blast_Score=101, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 55072; Mature: 55072

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDFFRVGRDPVLAREAMIATSHPLSTAAGLEILSAGGTAVDAALAAVAVQSVVDPLMTG
CCCHHHCCCCCHHHHHHHHHCCCCCCHHHCHHHEECCCHHHHHHHHHHHHHHHHHHHHHC
IGGDCFALYAPAKGDVVALNGSGRAPLAASVSRLKALGVGEITQTSPHAITVPGAVGAWT
CCCCEEEEEECCCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCHH
KLHGDYGRLPLATLFARAIAYAEGGYPVTPRVAHDWAREAALVAGDSGAAAVFLPDGRAP
HCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCEEEEECCCCCEEEEECCCCCC
VAGARHAQPKLGDQLRAIARDGAAAFYLGPTAEALVAYLQGLGGLHTLDDFACGLEDAEY
CCCCCCCCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCCCHHHHHHCCCCCCHH
VTPISTIYRGHEVFECPPNGQGLAALMILNILSGFDLSDDLALADRLHLQAEATKLAYYH
HCHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHEEE
RDALIADPAHLPYPPDALLAPEVAETLRRRIRMDRVLAPALWTEPEHKDTVYLCVVDGQG
CCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCC
NAVSLINSIFHGFGSTHLDPATGILLHSRGASFRVIEGHPNAIGPRKRPMHTIIPGMVRK
CHHHHHHHHHHHCCCCCCCCCCEEEEECCCCEEEEECCCCCCCCCCCCCHHHHCCHHHHC
DGKTVMPFGVMGGQYQAAGHAAFLSGVLDRRLDVQQAIDAPRAFGFGGTLEVEPTVEAGV
CCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCEEEECCCHHHHH
LAALAARGHRVTTAANPIGGAQAIWIDPQSGLLAGGSDQRKDGCALGF
HHHHHHCCCEEEECCCCCCCCEEEEECCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MRDFFRVGRDPVLAREAMIATSHPLSTAAGLEILSAGGTAVDAALAAVAVQSVVDPLMTG
CCCHHHCCCCCHHHHHHHHHCCCCCCHHHCHHHEECCCHHHHHHHHHHHHHHHHHHHHHC
IGGDCFALYAPAKGDVVALNGSGRAPLAASVSRLKALGVGEITQTSPHAITVPGAVGAWT
CCCCEEEEEECCCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCHH
KLHGDYGRLPLATLFARAIAYAEGGYPVTPRVAHDWAREAALVAGDSGAAAVFLPDGRAP
HCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCEEEEECCCCCEEEEECCCCCC
VAGARHAQPKLGDQLRAIARDGAAAFYLGPTAEALVAYLQGLGGLHTLDDFACGLEDAEY
CCCCCCCCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCCCHHHHHHCCCCCCHH
VTPISTIYRGHEVFECPPNGQGLAALMILNILSGFDLSDDLALADRLHLQAEATKLAYYH
HCHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHEEE
RDALIADPAHLPYPPDALLAPEVAETLRRRIRMDRVLAPALWTEPEHKDTVYLCVVDGQG
CCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCC
NAVSLINSIFHGFGSTHLDPATGILLHSRGASFRVIEGHPNAIGPRKRPMHTIIPGMVRK
CHHHHHHHHHHHCCCCCCCCCCEEEEECCCCEEEEECCCCCCCCCCCCCHHHHCCHHHHC
DGKTVMPFGVMGGQYQAAGHAAFLSGVLDRRLDVQQAIDAPRAFGFGGTLEVEPTVEAGV
CCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCEEEECCCHHHHH
LAALAARGHRVTTAANPIGGAQAIWIDPQSGLLAGGSDQRKDGCALGF
HHHHHHCCCEEEECCCCCCCCEEEEECCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]