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The map label for this gene is hutH

Identifier: 83592637

GI number: 83592637

Start: 1534495

End: 1536039

Strand: Reverse

Name: hutH

Synonym: Rru_A1301

Alternate gene names: 83592637

Gene position: 1536039-1534495 (Counterclockwise)

Preceding gene: 83592638

Following gene: 83592636

Centisome position: 35.29

GC content: 68.16

Gene sequence:

>1545_bases
ATGACCGAGCCGCTTTGCCTCACCCCCGGCGGACTCAGCCTGGATGTATTGCGCCGTATCCATCGCGAGGCGCCGCCGTT
GACGCTCGATCCGCGCTCTTACGCGGCGATGGCCGCCTCGCAGGCGGTGGTGGCGGCGATCGCCGGTGGCGAAAGCGCCG
TTTATGGCATCAACACCGGCTTTGGCAAGCTCGCCCACAAGCGCATCGCCCCGGCCGATCTTGAAGCCCTGCAGACCAAT
CTGATCTTGTCGCACGCCACCGGCATGGGGGCGCCGATCGCCGATGCCACGGTGCGGCTGATCCTGGCGATCAAAGCCGC
CAGTCTGGCGGTTGGCGCCTCGGGCATCCGCGCCGAGATCGTCGACGCCCTGCTCGCCCTGGCCAATGCCGATGTGCTAC
CGGTGATCCCGTCAAAGGGCTCGGTCGGCGCCTCGGGCGATCTGGCGCCGCTCGCCCATCTGTGCTGCGCCCTGCTTGGC
ATCGGCTCGGTTCGCCATAAGGGCGCGGTGCTGCCGGCCGGCGAAGGTCTGGCGATCGCCGGCCTGTCCCCGATCACCCT
GCGGGCCAAGGAAGGTCTAGCGCTGATCAACGGCACCCAGGTGTCAACCGCCCTGGCCTTGGCCGGCTTGTTCGAGATCG
AGCGCGCCTTCGCCGCCGCCATCCTGGCCGGGGCGCTGTCGGTCGAGGCGGTGATGGGCAGCCACCGCCCCTTCGACCCG
CGGATCAGCGCCCTGCGCGGCCAGTTCGGCCAGATTGATGTCGCCGCCCTTTTCCGCCTGCTGCTCGATGGCAGCCCGCT
GAACGCCGCCCATCAGGGACCGTCGTGCGAGCGGGTTCAAGACCCCTATTCCCTGCGCTGTCAGCCCCAGGTGATGGGGG
CGGTGCTTGATCAGATGCGCTTCGCCGCGCGCACCCTGACCATCGAAGCCAATGGCGTGACCGATAATCCGCTGGTGCTG
GTCGATACGGGCGAGGTGCTGTCGGGGGGCAACTTCCATGCCGAGCCGGTGGCGATGGCCGCCGATCAGTTGGCGATCGC
CGCCTCGGAGATCGGCGCCTTGTCGGAACGGCGCATCGCCATGCTGATCGACAGCACGATCAGCGGCCTGCCGCCCTTCC
TGGTCGCCGAACCGGGGTTGAATTCGGGCTTCATGATCGCCCATGTGACGGCCGCCGCCCTGGCCTCCGAGAACAAATCC
CTGGCCCATCCCGCCAGCGTCGACAGCTTGCCAACCTCGGCCAATCAGGAAGACCACGTCAGCATGGCGACCTTCGCCGC
CCGCCGCCTGGGCGACATCGCCGCCAATGTCACGGGCATCGTCGGCATCGAACTGCTCGCCGCCGCCCAGGGTCTGGAAT
TCCACCGCCCCTTGCGCTCGAGCCAAACCCTGGAAACGGCCATGGCGATGATCCGCGAGCGGGTGCCCTCCTATCGCGTC
GACCGCTATTTCGCCCCCGACCTGGAAGCCATCGCCCACCTGATCGGCGAAGGCCGCTTCGACGCCCTGGTCCCGGTCGA
TCTGTCGACCCTGGGATCGGTCTGA

Upstream 100 bases:

>100_bases
CGGTGGTGGTTGGCGGCGCCCTTGTCGTTGAAAATGGCCGCCATCGGGCCGAAGAGGCCGTGGCCCGGCGTTTCGCATCC
ACCCTTGGGAGACTTCTCGC

Downstream 100 bases:

>100_bases
AAAGGAACCTCCCCCCGTGACCGCCGTCTATGATCTGATCGAAGGCGAGAGCCCGCTGATCGTCAGCATTCCCCATTGCG
GCACCACCTTGCCGCCGGGG

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase

Number of amino acids: Translated: 514; Mature: 513

Protein sequence:

>514_residues
MTEPLCLTPGGLSLDVLRRIHREAPPLTLDPRSYAAMAASQAVVAAIAGGESAVYGINTGFGKLAHKRIAPADLEALQTN
LILSHATGMGAPIADATVRLILAIKAASLAVGASGIRAEIVDALLALANADVLPVIPSKGSVGASGDLAPLAHLCCALLG
IGSVRHKGAVLPAGEGLAIAGLSPITLRAKEGLALINGTQVSTALALAGLFEIERAFAAAILAGALSVEAVMGSHRPFDP
RISALRGQFGQIDVAALFRLLLDGSPLNAAHQGPSCERVQDPYSLRCQPQVMGAVLDQMRFAARTLTIEANGVTDNPLVL
VDTGEVLSGGNFHAEPVAMAADQLAIAASEIGALSERRIAMLIDSTISGLPPFLVAEPGLNSGFMIAHVTAAALASENKS
LAHPASVDSLPTSANQEDHVSMATFAARRLGDIAANVTGIVGIELLAAAQGLEFHRPLRSSQTLETAMAMIRERVPSYRV
DRYFAPDLEAIAHLIGEGRFDALVPVDLSTLGSV

Sequences:

>Translated_514_residues
MTEPLCLTPGGLSLDVLRRIHREAPPLTLDPRSYAAMAASQAVVAAIAGGESAVYGINTGFGKLAHKRIAPADLEALQTN
LILSHATGMGAPIADATVRLILAIKAASLAVGASGIRAEIVDALLALANADVLPVIPSKGSVGASGDLAPLAHLCCALLG
IGSVRHKGAVLPAGEGLAIAGLSPITLRAKEGLALINGTQVSTALALAGLFEIERAFAAAILAGALSVEAVMGSHRPFDP
RISALRGQFGQIDVAALFRLLLDGSPLNAAHQGPSCERVQDPYSLRCQPQVMGAVLDQMRFAARTLTIEANGVTDNPLVL
VDTGEVLSGGNFHAEPVAMAADQLAIAASEIGALSERRIAMLIDSTISGLPPFLVAEPGLNSGFMIAHVTAAALASENKS
LAHPASVDSLPTSANQEDHVSMATFAARRLGDIAANVTGIVGIELLAAAQGLEFHRPLRSSQTLETAMAMIRERVPSYRV
DRYFAPDLEAIAHLIGEGRFDALVPVDLSTLGSV
>Mature_513_residues
TEPLCLTPGGLSLDVLRRIHREAPPLTLDPRSYAAMAASQAVVAAIAGGESAVYGINTGFGKLAHKRIAPADLEALQTNL
ILSHATGMGAPIADATVRLILAIKAASLAVGASGIRAEIVDALLALANADVLPVIPSKGSVGASGDLAPLAHLCCALLGI
GSVRHKGAVLPAGEGLAIAGLSPITLRAKEGLALINGTQVSTALALAGLFEIERAFAAAILAGALSVEAVMGSHRPFDPR
ISALRGQFGQIDVAALFRLLLDGSPLNAAHQGPSCERVQDPYSLRCQPQVMGAVLDQMRFAARTLTIEANGVTDNPLVLV
DTGEVLSGGNFHAEPVAMAADQLAIAASEIGALSERRIAMLIDSTISGLPPFLVAEPGLNSGFMIAHVTAAALASENKSL
AHPASVDSLPTSANQEDHVSMATFAARRLGDIAANVTGIVGIELLAAAQGLEFHRPLRSSQTLETAMAMIRERVPSYRVD
RYFAPDLEAIAHLIGEGRFDALVPVDLSTLGSV

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family

Homologues:

Organism=Homo sapiens, GI4504333, Length=479, Percent_Identity=47.3903966597077, Blast_Score=406, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17567831, Length=486, Percent_Identity=44.238683127572, Blast_Score=359, Evalue=2e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTH_RHORT (Q2RUU3)

Other databases:

- EMBL:   CP000230
- RefSeq:   YP_426389.1
- HSSP:   P21310
- ProteinModelPortal:   Q2RUU3
- SMR:   Q2RUU3
- STRING:   Q2RUU3
- GeneID:   3833609
- GenomeReviews:   CP000230_GR
- KEGG:   rru:Rru_A1301
- NMPDR:   fig|1085.1.peg.3065
- eggNOG:   COG2986
- HOGENOM:   HBG510887
- OMA:   QKGQIDS
- ProtClustDB:   CLSK2773207
- BioCyc:   RRUB269796:RRU_A1301-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00229
- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- TIGRFAMs:   TIGR01225

Pfam domain/function: PF00221 PAL; SSF48557 L-Aspartase-like

EC number: =4.3.1.3

Molecular weight: Translated: 52974; Mature: 52843

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEPLCLTPGGLSLDVLRRIHREAPPLTLDPRSYAAMAASQAVVAAIAGGESAVYGINTG
CCCCCEECCCCCCHHHHHHHHHCCCCCEECCHHHHHHHHHHHHEEEEECCCEEEEECCCC
FGKLAHKRIAPADLEALQTNLILSHATGMGAPIADATVRLILAIKAASLAVGASGIRAEI
HHHHHHHHCCCHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHH
VDALLALANADVLPVIPSKGSVGASGDLAPLAHLCCALLGIGSVRHKGAVLPAGEGLAIA
HHHHHHHHCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEECCCCEEEE
GLSPITLRAKEGLALINGTQVSTALALAGLFEIERAFAAAILAGALSVEAVMGSHRPFDP
CCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
RISALRGQFGQIDVAALFRLLLDGSPLNAAHQGPSCERVQDPYSLRCQPQVMGAVLDQMR
HHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHH
FAARTLTIEANGVTDNPLVLVDTGEVLSGGNFHAEPVAMAADQLAIAASEIGALSERRIA
HHHEEEEEEECCCCCCCEEEEECCCEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEE
MLIDSTISGLPPFLVAEPGLNSGFMIAHVTAAALASENKSLAHPASVDSLPTSANQEDHV
EEEHHHHCCCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHH
SMATFAARRLGDIAANVTGIVGIELLAAAQGLEFHRPLRSSQTLETAMAMIRERVPSYRV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHHHCCCCCC
DRYFAPDLEAIAHLIGEGRFDALVPVDLSTLGSV
CCCCCCCHHHHHHHHCCCCCCEEECCCHHHHCCC
>Mature Secondary Structure 
TEPLCLTPGGLSLDVLRRIHREAPPLTLDPRSYAAMAASQAVVAAIAGGESAVYGINTG
CCCCEECCCCCCHHHHHHHHHCCCCCEECCHHHHHHHHHHHHEEEEECCCEEEEECCCC
FGKLAHKRIAPADLEALQTNLILSHATGMGAPIADATVRLILAIKAASLAVGASGIRAEI
HHHHHHHHCCCHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHH
VDALLALANADVLPVIPSKGSVGASGDLAPLAHLCCALLGIGSVRHKGAVLPAGEGLAIA
HHHHHHHHCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEECCCCEEEE
GLSPITLRAKEGLALINGTQVSTALALAGLFEIERAFAAAILAGALSVEAVMGSHRPFDP
CCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
RISALRGQFGQIDVAALFRLLLDGSPLNAAHQGPSCERVQDPYSLRCQPQVMGAVLDQMR
HHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHH
FAARTLTIEANGVTDNPLVLVDTGEVLSGGNFHAEPVAMAADQLAIAASEIGALSERRIA
HHHEEEEEEECCCCCCCEEEEECCCEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEE
MLIDSTISGLPPFLVAEPGLNSGFMIAHVTAAALASENKSLAHPASVDSLPTSANQEDHV
EEEHHHHCCCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHH
SMATFAARRLGDIAANVTGIVGIELLAAAQGLEFHRPLRSSQTLETAMAMIRERVPSYRV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHHHCCCCCC
DRYFAPDLEAIAHLIGEGRFDALVPVDLSTLGSV
CCCCCCCHHHHHHHHCCCCCCEEECCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA