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The map label for this gene is arcA [H]

Identifier: 83592618

GI number: 83592618

Start: 1509710

End: 1510459

Strand: Reverse

Name: arcA [H]

Synonym: Rru_A1282

Alternate gene names: 83592618

Gene position: 1510459-1509710 (Counterclockwise)

Preceding gene: 83592629

Following gene: 83592616

Centisome position: 34.7

GC content: 62.27

Gene sequence:

>750_bases
ATGGCAAACCATCATATTCTCGTGGTAGAGGACGATCCCGTCGGCCGCGAAACCCTCGCCGCCTATTTGCGTAAAGAGGG
ATACAAGGTAAGCGACGTTGAAGACGGCGATAGCATGCGCAAAGTGTTTTCGCAGCAGACCGTTGATCTGATCTTGCTCG
ACATCCGCCTGCCCGGCGTCGACGGACTACAGCTTTTAAGGGAAATTCGTCATCAGTCCGAGGTTGGGGTGATCATGGTC
ACCGGCAAGGACGACGAGGTCGATCGCATCGTCGCCCTGGAAATGGGCGCCGATGATTATGTGACGAAACCCTTCAACGT
CCGCGAGCTGCTCGCCCGCGCCAAGAACCTGTTGCGCCGGACGTTAAGCGCCCGCGAAGCCTCCGAGGACGAGAACCAGA
AATCCTTCGCCGGCTGGACGCTTGATATTCCCAGGCGCTGCCTGTTCGCCCCCGATGGCAGCGACGTGCGGCTGACGCGC
GGGGAATTCGAGCTGTTGTGCTGCTTCGCCAGCCGCCCGGGCCGGGTGATGACCCGCGACAACCTGCTTGATTACGTCAG
CCACCGCGACTGGGCGCCCAGTGACCGCACGGTCGACGTTCTGGTCGGCCGCCTGCGCCGCAAGATCGAAGCCGATCCCA
AGGCGCCGCGCCATATCATCACCGTCCACGGCATCGGCTATGTGTTCGCCGACAGCCGCCATATCGAACCGGGATCGCCC
GAGAAATCGGCCGCGCGCCAGGGCGGCTGA

Upstream 100 bases:

>100_bases
CCCGCTGTAAACCCGCTTCCGCGCAAAAATGAATACGCTGTAGAATGATGTGAACCGTGCGTAAACAAAAACGGACCAGC
AAGGGGGAATGCTCTTAATG

Downstream 100 bases:

>100_bases
TCCTCGCCCGCCCCGGCTGCTTGATGTCGTCTTCGCTGAATGGCCGGGTCATCCGTGAGCGGATGGCAGCGGCCGGATAT
CAGGAAACGTGTATCAATCC

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MANHHILVVEDDPVGRETLAAYLRKEGYKVSDVEDGDSMRKVFSQQTVDLILLDIRLPGVDGLQLLREIRHQSEVGVIMV
TGKDDEVDRIVALEMGADDYVTKPFNVRELLARAKNLLRRTLSAREASEDENQKSFAGWTLDIPRRCLFAPDGSDVRLTR
GEFELLCCFASRPGRVMTRDNLLDYVSHRDWAPSDRTVDVLVGRLRRKIEADPKAPRHIITVHGIGYVFADSRHIEPGSP
EKSAARQGG

Sequences:

>Translated_249_residues
MANHHILVVEDDPVGRETLAAYLRKEGYKVSDVEDGDSMRKVFSQQTVDLILLDIRLPGVDGLQLLREIRHQSEVGVIMV
TGKDDEVDRIVALEMGADDYVTKPFNVRELLARAKNLLRRTLSAREASEDENQKSFAGWTLDIPRRCLFAPDGSDVRLTR
GEFELLCCFASRPGRVMTRDNLLDYVSHRDWAPSDRTVDVLVGRLRRKIEADPKAPRHIITVHGIGYVFADSRHIEPGSP
EKSAARQGG
>Mature_248_residues
ANHHILVVEDDPVGRETLAAYLRKEGYKVSDVEDGDSMRKVFSQQTVDLILLDIRLPGVDGLQLLREIRHQSEVGVIMVT
GKDDEVDRIVALEMGADDYVTKPFNVRELLARAKNLLRRTLSAREASEDENQKSFAGWTLDIPRRCLFAPDGSDVRLTRG
EFELLCCFASRPGRVMTRDNLLDYVSHRDWAPSDRTVDVLVGRLRRKIEADPKAPRHIITVHGIGYVFADSRHIEPGSPE
KSAARQGG

Specific function: Member of the two-component regulatory system ArcB/ArcA. Represses a wide variety of aerobic enzymes under anaerobic conditions. It also may be involved in the osmoregulation of envelope proteins. When activated by ArcB, it negatively regulates the expres

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790863, Length=233, Percent_Identity=45.0643776824034, Blast_Score=217, Evalue=6e-58,
Organism=Escherichia coli, GI1787229, Length=230, Percent_Identity=48.2608695652174, Blast_Score=205, Evalue=3e-54,
Organism=Escherichia coli, GI1789809, Length=230, Percent_Identity=42.6086956521739, Blast_Score=182, Evalue=2e-47,
Organism=Escherichia coli, GI1788394, Length=230, Percent_Identity=37.8260869565217, Blast_Score=151, Evalue=3e-38,
Organism=Escherichia coli, GI1786599, Length=230, Percent_Identity=36.9565217391304, Blast_Score=130, Evalue=8e-32,
Organism=Escherichia coli, GI1786911, Length=229, Percent_Identity=36.6812227074236, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI87082012, Length=224, Percent_Identity=34.375, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1787375, Length=226, Percent_Identity=33.1858407079646, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1790860, Length=228, Percent_Identity=34.6491228070175, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI145693140, Length=238, Percent_Identity=32.7731092436975, Blast_Score=110, Evalue=6e-26,
Organism=Escherichia coli, GI2367329, Length=233, Percent_Identity=33.0472103004292, Blast_Score=110, Evalue=7e-26,
Organism=Escherichia coli, GI1786784, Length=225, Percent_Identity=34.2222222222222, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1789402, Length=228, Percent_Identity=32.0175438596491, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1790552, Length=225, Percent_Identity=32, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1790299, Length=190, Percent_Identity=30.5263157894737, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788550, Length=110, Percent_Identity=33.6363636363636, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1788905, Length=101, Percent_Identity=35.6435643564356, Blast_Score=63, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322000, Length=102, Percent_Identity=36.2745098039216, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 28029; Mature: 27898

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANHHILVVEDDPVGRETLAAYLRKEGYKVSDVEDGDSMRKVFSQQTVDLILLDIRLPGV
CCCCEEEEEECCCCCHHHHHHHHHHCCCEECCCCCCHHHHHHHHHCCEEEEEEEEECCCC
DGLQLLREIRHQSEVGVIMVTGKDDEVDRIVALEMGADDYVTKPFNVRELLARAKNLLRR
CHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHH
TLSAREASEDENQKSFAGWTLDIPRRCLFAPDGSDVRLTRGEFELLCCFASRPGRVMTRD
HHHHHHCCCCCCCHHHCCEEEECCCEEEECCCCCCEEEECCCEEEEEEECCCCCCEEEHH
NLLDYVSHRDWAPSDRTVDVLVGRLRRKIEADPKAPRHIITVHGIGYVFADSRHIEPGSP
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCEEEEECCCCCCCCCC
EKSAARQGG
HHHHHCCCC
>Mature Secondary Structure 
ANHHILVVEDDPVGRETLAAYLRKEGYKVSDVEDGDSMRKVFSQQTVDLILLDIRLPGV
CCCEEEEEECCCCCHHHHHHHHHHCCCEECCCCCCHHHHHHHHHCCEEEEEEEEECCCC
DGLQLLREIRHQSEVGVIMVTGKDDEVDRIVALEMGADDYVTKPFNVRELLARAKNLLRR
CHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHH
TLSAREASEDENQKSFAGWTLDIPRRCLFAPDGSDVRLTRGEFELLCCFASRPGRVMTRD
HHHHHHCCCCCCCHHHCCEEEECCCEEEECCCCCCEEEECCCEEEEEEECCCCCCEEEHH
NLLDYVSHRDWAPSDRTVDVLVGRLRRKIEADPKAPRHIITVHGIGYVFADSRHIEPGSP
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCEEEEECCCCCCCCCC
EKSAARQGG
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]