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The map label for this gene is sdhA [H]

Identifier: 83592540

GI number: 83592540

Start: 1420795

End: 1422579

Strand: Direct

Name: sdhA [H]

Synonym: Rru_A1204

Alternate gene names: 83592540

Gene position: 1420795-1422579 (Clockwise)

Preceding gene: 83592539

Following gene: 83592541

Centisome position: 32.64

GC content: 65.38

Gene sequence:

>1785_bases
ATGGCATCCTACGAGATTGTCGACCACGAATATGATGCTTTGGTCGTTGGCGCCGGTGGCGCCGGCCTGCGCGCCACCTT
CGGTCTGGTCGAACAGGGCCTCAAGACCGCCTGCATCACCAAGGTCTTCCCCACCCGCTCCCATACCGTGGCCGCCCAGG
GCGGCATCGGCGCCGCCCTTGGCAATATGGCCGAGGACAATTGGAAGTGGCATATGTACGATACCGTCAAGGGCGCCGAC
TGGCTCGGCGACCAGGACGCCATCGAATATATGTGCCGCGAGGCGATTCCGGCGGTTTACGAGCTTGAGCACTACGGCGT
GCCCTTCTCGCGCACCGAAGACGGCCGCATCTATCAGCGGCCTTTCGGCGGCCATATGCGCAACTTCGGCGAGGCACCGG
TTCAGCGCGCCTGCGCCGCCGCCGACCGCACCGGCCACGCCATTTTGCAGACCCTCTATCAACAGTCTCTGCGCTTCAAC
GCCGAGTTCTTCGTTGAATACTTCGCCCTTGATCTGATCATCGAGGACGGGGTCTGTCGTGGCGTGATCGCTTGGTGCAT
GGAAGACGGCACCATCCACCGCTTCAAGTCCCATACCACGGTGCTGGCCACCGGCGGCTATGGCCGCGCCTATTTCTCGT
GTACCTCGGCCCATACCTGTACGGGCGATGGCAACGGCATGGTCGCCCGCGCCGGTCTGCCGCTCCAGGACATGGAATTC
GTGCAGTTCCACCCCACCGGCATCTATGGGGCGGGCTGCCTGATCACCGAGGGCGCGCGCGGCGAGGGTGGTTACCTGAC
CAATTCGGAAGGCGAGCGCTTCATGGAGCGCTATGCCCCCACCGCCAAGGATCTGGCCAGCCGCGACGTGGTCAGCCGGG
CGATGACGGTGGAAATCCGCGAGGGCCGGGGCGTCGGTCCGAAGAAGGACCACATCAACCTGCACCTCGAACACCTGGGC
CCCGAGGTTCTGCATTCCCGGCTGCCCGGCATCACCGAGACCGCCAAGGTCTTCTCGGGTGTCGACGCCACCCGCGATCC
GATCCCGGTGCTGCCCACCGTCCACTACAACATGGGCGGCATTCCGACCAATTATCACGGCGAGGTGCTGAACCCGACCA
AGGCCGATCCCGAGGCGATCTTCCCCGGGCTGATGGCCGTTGGCGAATGCGCCTGCGTGTCGGTGCATGGCGCCAACCGC
CTGGGCACCAACTCGCTGCTCGACATCGTGGTCTTCGGCCGCGCCGCCGCGCTGCGCGCCGCCGAGGTGGTCAAGCCCGG
CATCGCCCACAAGCCGCTCAAGGCCGATGCCGCCGATCTGGCGCTGTCGCGTCTTGATCGTCTGCGCAGCGCCAAGGGCG
CGAAGCTGACCGCCGAGATCCGCGACGACCTGCAGCAGGCCATGCAGCGCGACGCCGCGGTGTTCCGCACCACCAAGTCG
TTGGCCGAGGGCGTCGCCCGCGTCGATCAGGTCGCCGCCAGCCTCGCCGATATCAAGCTTGTCGACACCTCGATGATCTT
CAATACGGATCTCGCCGAGGCGCTCGAACTCGAAAATCTGATGGCCTGCGCTCAGACCACCATCCATGGGGCGGCGGCGC
GCCAGGAAAGCCGGGGCGCCCACGCCCATGAGGATTTCCCCGATCGCGACGACAAGACCTGGATGAAGCACACCCTCGCC
TGGCTCGACCCCAAGGGCAAGGTCACGCTGGACTACCGTCCGGTTCACACCTTCACCCTGACCGACGAGATCGACTACAT
CGAACCCAAGGCGCGCGTGTACTGA

Upstream 100 bases:

>100_bases
TCAAGAACGCTTTGGTCTTCGGAACCAAGCTCTACGCCTTGTTCGGTGCCGTTCTGGCCGCCGTCTCCATCCTCAAGCTG
ACTTTCGGGGGCTAAGTCCG

Downstream 100 bases:

>100_bases
CGAGCCAAGCAGGCTGGAGGCATCACAGATGGTTGAATTCGCTCTGCCCCCCAACAGCCGGGTCAAGGAAGGCAAGACCT
TCCCCGCGCCGGATGGGGCG

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 594; Mature: 593

Protein sequence:

>594_residues
MASYEIVDHEYDALVVGAGGAGLRATFGLVEQGLKTACITKVFPTRSHTVAAQGGIGAALGNMAEDNWKWHMYDTVKGAD
WLGDQDAIEYMCREAIPAVYELEHYGVPFSRTEDGRIYQRPFGGHMRNFGEAPVQRACAAADRTGHAILQTLYQQSLRFN
AEFFVEYFALDLIIEDGVCRGVIAWCMEDGTIHRFKSHTTVLATGGYGRAYFSCTSAHTCTGDGNGMVARAGLPLQDMEF
VQFHPTGIYGAGCLITEGARGEGGYLTNSEGERFMERYAPTAKDLASRDVVSRAMTVEIREGRGVGPKKDHINLHLEHLG
PEVLHSRLPGITETAKVFSGVDATRDPIPVLPTVHYNMGGIPTNYHGEVLNPTKADPEAIFPGLMAVGECACVSVHGANR
LGTNSLLDIVVFGRAAALRAAEVVKPGIAHKPLKADAADLALSRLDRLRSAKGAKLTAEIRDDLQQAMQRDAAVFRTTKS
LAEGVARVDQVAASLADIKLVDTSMIFNTDLAEALELENLMACAQTTIHGAAARQESRGAHAHEDFPDRDDKTWMKHTLA
WLDPKGKVTLDYRPVHTFTLTDEIDYIEPKARVY

Sequences:

>Translated_594_residues
MASYEIVDHEYDALVVGAGGAGLRATFGLVEQGLKTACITKVFPTRSHTVAAQGGIGAALGNMAEDNWKWHMYDTVKGAD
WLGDQDAIEYMCREAIPAVYELEHYGVPFSRTEDGRIYQRPFGGHMRNFGEAPVQRACAAADRTGHAILQTLYQQSLRFN
AEFFVEYFALDLIIEDGVCRGVIAWCMEDGTIHRFKSHTTVLATGGYGRAYFSCTSAHTCTGDGNGMVARAGLPLQDMEF
VQFHPTGIYGAGCLITEGARGEGGYLTNSEGERFMERYAPTAKDLASRDVVSRAMTVEIREGRGVGPKKDHINLHLEHLG
PEVLHSRLPGITETAKVFSGVDATRDPIPVLPTVHYNMGGIPTNYHGEVLNPTKADPEAIFPGLMAVGECACVSVHGANR
LGTNSLLDIVVFGRAAALRAAEVVKPGIAHKPLKADAADLALSRLDRLRSAKGAKLTAEIRDDLQQAMQRDAAVFRTTKS
LAEGVARVDQVAASLADIKLVDTSMIFNTDLAEALELENLMACAQTTIHGAAARQESRGAHAHEDFPDRDDKTWMKHTLA
WLDPKGKVTLDYRPVHTFTLTDEIDYIEPKARVY
>Mature_593_residues
ASYEIVDHEYDALVVGAGGAGLRATFGLVEQGLKTACITKVFPTRSHTVAAQGGIGAALGNMAEDNWKWHMYDTVKGADW
LGDQDAIEYMCREAIPAVYELEHYGVPFSRTEDGRIYQRPFGGHMRNFGEAPVQRACAAADRTGHAILQTLYQQSLRFNA
EFFVEYFALDLIIEDGVCRGVIAWCMEDGTIHRFKSHTTVLATGGYGRAYFSCTSAHTCTGDGNGMVARAGLPLQDMEFV
QFHPTGIYGAGCLITEGARGEGGYLTNSEGERFMERYAPTAKDLASRDVVSRAMTVEIREGRGVGPKKDHINLHLEHLGP
EVLHSRLPGITETAKVFSGVDATRDPIPVLPTVHYNMGGIPTNYHGEVLNPTKADPEAIFPGLMAVGECACVSVHGANRL
GTNSLLDIVVFGRAAALRAAEVVKPGIAHKPLKADAADLALSRLDRLRSAKGAKLTAEIRDDLQQAMQRDAAVFRTTKSL
AEGVARVDQVAASLADIKLVDTSMIFNTDLAEALELENLMACAQTTIHGAAARQESRGAHAHEDFPDRDDKTWMKHTLAW
LDPKGKVTLDYRPVHTFTLTDEIDYIEPKARVY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=613, Percent_Identity=62.4796084828711, Blast_Score=751, Evalue=0.0,
Organism=Escherichia coli, GI1786942, Length=552, Percent_Identity=56.3405797101449, Blast_Score=580, Evalue=1e-166,
Organism=Escherichia coli, GI1790597, Length=577, Percent_Identity=41.0745233968804, Blast_Score=407, Evalue=1e-114,
Organism=Escherichia coli, GI1788928, Length=555, Percent_Identity=29.7297297297297, Blast_Score=201, Evalue=9e-53,
Organism=Caenorhabditis elegans, GI17550100, Length=614, Percent_Identity=61.400651465798, Blast_Score=733, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505833, Length=613, Percent_Identity=58.7275693311582, Blast_Score=696, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322701, Length=595, Percent_Identity=66.0504201680672, Blast_Score=804, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322416, Length=599, Percent_Identity=64.6076794657763, Blast_Score=774, Evalue=0.0,
Organism=Drosophila melanogaster, GI17137288, Length=610, Percent_Identity=63.2786885245902, Blast_Score=767, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655642, Length=610, Percent_Identity=63.2786885245902, Blast_Score=767, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655647, Length=610, Percent_Identity=63.2786885245902, Blast_Score=767, Evalue=0.0,
Organism=Drosophila melanogaster, GI24663005, Length=612, Percent_Identity=54.5751633986928, Blast_Score=660, Evalue=0.0,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 64736; Mature: 64605

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASYEIVDHEYDALVVGAGGAGLRATFGLVEQGLKTACITKVFPTRSHTVAAQGGIGAAL
CCCCEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHH
GNMAEDNWKWHMYDTVKGADWLGDQDAIEYMCREAIPAVYELEHYGVPFSRTEDGRIYQR
CCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCHHEEHHHCCCCCCCCCCCEEEEC
PFGGHMRNFGEAPVQRACAAADRTGHAILQTLYQQSLRFNAEFFVEYFALDLIIEDGVCR
CCCCHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHH
GVIAWCMEDGTIHRFKSHTTVLATGGYGRAYFSCTSAHTCTGDGNGMVARAGLPLQDMEF
HHHHHHHCCCCEEEECCCEEEEEECCCCCEEEEECCCCEECCCCCCEEEECCCCCCCCCE
VQFHPTGIYGAGCLITEGARGEGGYLTNSEGERFMERYAPTAKDLASRDVVSRAMTVEIR
EEECCCCEEECCEEEECCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHEEEEEEE
EGRGVGPKKDHINLHLEHLGPEVLHSRLPGITETAKVFSGVDATRDPIPVLPTVHYNMGG
CCCCCCCCCCCEEEEHHHCCHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCEEECCCCC
IPTNYHGEVLNPTKADPEAIFPGLMAVGECACVSVHGANRLGTNSLLDIVVFGRAAALRA
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHH
AEVVKPGIAHKPLKADAADLALSRLDRLRSAKGAKLTAEIRDDLQQAMQRDAAVFRTTKS
HHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHH
LAEGVARVDQVAASLADIKLVDTSMIFNTDLAEALELENLMACAQTTIHGAAARQESRGA
HHHHHHHHHHHHHHHHHEEEEEHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
HAHEDFPDRDDKTWMKHTLAWLDPKGKVTLDYRPVHTFTLTDEIDYIEPKARVY
CCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECEEEEEEECCCCCCCCCCCCC
>Mature Secondary Structure 
ASYEIVDHEYDALVVGAGGAGLRATFGLVEQGLKTACITKVFPTRSHTVAAQGGIGAAL
CCCEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHH
GNMAEDNWKWHMYDTVKGADWLGDQDAIEYMCREAIPAVYELEHYGVPFSRTEDGRIYQR
CCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCHHEEHHHCCCCCCCCCCCEEEEC
PFGGHMRNFGEAPVQRACAAADRTGHAILQTLYQQSLRFNAEFFVEYFALDLIIEDGVCR
CCCCHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHH
GVIAWCMEDGTIHRFKSHTTVLATGGYGRAYFSCTSAHTCTGDGNGMVARAGLPLQDMEF
HHHHHHHCCCCEEEECCCEEEEEECCCCCEEEEECCCCEECCCCCCEEEECCCCCCCCCE
VQFHPTGIYGAGCLITEGARGEGGYLTNSEGERFMERYAPTAKDLASRDVVSRAMTVEIR
EEECCCCEEECCEEEECCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHEEEEEEE
EGRGVGPKKDHINLHLEHLGPEVLHSRLPGITETAKVFSGVDATRDPIPVLPTVHYNMGG
CCCCCCCCCCCEEEEHHHCCHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCEEECCCCC
IPTNYHGEVLNPTKADPEAIFPGLMAVGECACVSVHGANRLGTNSLLDIVVFGRAAALRA
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHH
AEVVKPGIAHKPLKADAADLALSRLDRLRSAKGAKLTAEIRDDLQQAMQRDAAVFRTTKS
HHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHH
LAEGVARVDQVAASLADIKLVDTSMIFNTDLAEALELENLMACAQTTIHGAAARQESRGA
HHHHHHHHHHHHHHHHHEEEEEHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
HAHEDFPDRDDKTWMKHTLAWLDPKGKVTLDYRPVHTFTLTDEIDYIEPKARVY
CCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECEEEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA