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The map label for this gene is add

Identifier: 83592105

GI number: 83592105

Start: 903144

End: 904148

Strand: Reverse

Name: add

Synonym: Rru_A0766

Alternate gene names: 83592105

Gene position: 904148-903144 (Counterclockwise)

Preceding gene: 83592106

Following gene: 83592081

Centisome position: 20.77

GC content: 66.37

Gene sequence:

>1005_bases
ATGGCCGTCGATCCCGCTTTCCTCCACGCCCTGCCCAAGGTGGAGCTTCACCTGCATATCGAAGGCAGCCTGGAACCCGA
GATGATGGTCGCCCTGGCCGAACGCAACGGCCTCCGCCTGCCCTACGCCTCGGTCGAGGCGGTGCGCGCGGCCTATGATT
TCCAGAACCTGCAGGATTTCCTTGATCTGTATTACCAGGGTATGGCGGTGCTGCGGACCGAGCGGGATTTCGAGGATCTG
GCGATGGCCTATTTCCAGCGCGCCGCCGCCCAGAATGTTCTGCATGCCGAGATTTTCTTCGATCCCCAGGGCCATACGGC
GCGCGGCGTCGCCCTGGAGGCGGTGATCGCCGGGCTGACCAGCGCCCGCAAGCGCGCCGAGGCCGAATTGGGGGTGAGTT
CGGAACTGATCTTGTCGTTCCTACGCCATCTGAGCGAGGAGGAGGCCTTCGCCACCCTTGAAGAAGCCTTGCCCCACCGC
GATCAGTTCATCGGCGTCGGCCTTGATAGCTCGGAAGTCGGCCATCCGCCGGCCAAATTCGCCCGGGTCTTCGCCCGGGC
GCGGGCCGAGGGCCTGCGGCTGGTCGCCCATGCCGGCGAGGAAGGCCCGCCCGATTACGTGCGCGAGGCCCTGGACCTGC
TGGCCATCGACCGCCTGGACCACGGCAACCGGGCGCTGGAGGACGAGGCGCTGATCGAGCGTCTGATCGCCGAGGGCATG
GCCCTGACGGTTTGCCCCTTGAGCAACCTCAAGCTCCGCGTCGTCGATGATCTCGGCGCCCATCCGCTCAAGGCCATGCT
CGAGCGCGGGCTGAAGGCCACGATCAATTCCGACGATCCGTCGTATTTCGGCGGCTATATGCTTGAGAACATGGCCGCCG
TCGCCGAGGCCCTGGCCCTGGAAACCCACCACCTGCGCACCCTGACCGCCAACGCCATCGACGCCTCCTTCGCCTCCCCC
GCCCGCAAGGCCGAGATGCACGCGCGCTTGGCCGCGGTAAACTGA

Upstream 100 bases:

>100_bases
GAGACGGGGACGATCCCGGGGCGGCTCCGGGGCGGCAAGGGTTGCCGGGGCCGGGATCCCGCCCTATTTATGCCCCTCCC
CCTCTCCCGGAGCATCCCCG

Downstream 100 bases:

>100_bases
GCGGCCAAACGCGCGCCCCCAAGCCTGCGCCTCCTCACCAAGTTTCGCCCTCACGGGAGCATGGATTGAAACAAACTGGC
GGGCCATGCGGGATAGCGAT

Product: adenosine deaminase

Products: NA

Alternate protein names: Adenosine aminohydrolase

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MAVDPAFLHALPKVELHLHIEGSLEPEMMVALAERNGLRLPYASVEAVRAAYDFQNLQDFLDLYYQGMAVLRTERDFEDL
AMAYFQRAAAQNVLHAEIFFDPQGHTARGVALEAVIAGLTSARKRAEAELGVSSELILSFLRHLSEEEAFATLEEALPHR
DQFIGVGLDSSEVGHPPAKFARVFARARAEGLRLVAHAGEEGPPDYVREALDLLAIDRLDHGNRALEDEALIERLIAEGM
ALTVCPLSNLKLRVVDDLGAHPLKAMLERGLKATINSDDPSYFGGYMLENMAAVAEALALETHHLRTLTANAIDASFASP
ARKAEMHARLAAVN

Sequences:

>Translated_334_residues
MAVDPAFLHALPKVELHLHIEGSLEPEMMVALAERNGLRLPYASVEAVRAAYDFQNLQDFLDLYYQGMAVLRTERDFEDL
AMAYFQRAAAQNVLHAEIFFDPQGHTARGVALEAVIAGLTSARKRAEAELGVSSELILSFLRHLSEEEAFATLEEALPHR
DQFIGVGLDSSEVGHPPAKFARVFARARAEGLRLVAHAGEEGPPDYVREALDLLAIDRLDHGNRALEDEALIERLIAEGM
ALTVCPLSNLKLRVVDDLGAHPLKAMLERGLKATINSDDPSYFGGYMLENMAAVAEALALETHHLRTLTANAIDASFASP
ARKAEMHARLAAVN
>Mature_333_residues
AVDPAFLHALPKVELHLHIEGSLEPEMMVALAERNGLRLPYASVEAVRAAYDFQNLQDFLDLYYQGMAVLRTERDFEDLA
MAYFQRAAAQNVLHAEIFFDPQGHTARGVALEAVIAGLTSARKRAEAELGVSSELILSFLRHLSEEEAFATLEEALPHRD
QFIGVGLDSSEVGHPPAKFARVFARARAEGLRLVAHAGEEGPPDYVREALDLLAIDRLDHGNRALEDEALIERLIAEGMA
LTVCPLSNLKLRVVDDLGAHPLKAMLERGLKATINSDDPSYFGGYMLENMAAVAEALALETHHLRTLTANAIDASFASPA
RKAEMHARLAAVN

Specific function: Unknown

COG id: COG1816

COG function: function code F; Adenosine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosine and AMP deaminases family

Homologues:

Organism=Homo sapiens, GI47078295, Length=353, Percent_Identity=26.0623229461756, Blast_Score=111, Evalue=1e-24,
Organism=Escherichia coli, GI1787910, Length=334, Percent_Identity=30.5389221556886, Blast_Score=149, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI32565969, Length=338, Percent_Identity=24.2603550295858, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17538512, Length=338, Percent_Identity=24.2603550295858, Blast_Score=92, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6324188, Length=336, Percent_Identity=44.3452380952381, Blast_Score=290, Evalue=3e-79,
Organism=Drosophila melanogaster, GI24645260, Length=338, Percent_Identity=26.9230769230769, Blast_Score=89, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ADD_RHORT (Q2RWC5)

Other databases:

- EMBL:   CP000230
- RefSeq:   YP_425857.1
- ProteinModelPortal:   Q2RWC5
- SMR:   Q2RWC5
- STRING:   Q2RWC5
- GeneID:   3834175
- GenomeReviews:   CP000230_GR
- KEGG:   rru:Rru_A0766
- NMPDR:   fig|1085.1.peg.1580
- eggNOG:   COG1816
- HOGENOM:   HBG630382
- OMA:   KLIMCLL
- PhylomeDB:   Q2RWC5
- ProtClustDB:   PRK09358
- BioCyc:   RRUB269796:RRU_A0766-MONOMER
- HAMAP:   MF_00540
- InterPro:   IPR001365
- InterPro:   IPR006330
- PANTHER:   PTHR11409
- TIGRFAMs:   TIGR01430

Pfam domain/function: PF00962 A_deaminase

EC number: =3.5.4.4

Molecular weight: Translated: 36593; Mature: 36462

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00485 A_DEAMINASE

Important sites: ACT_SITE 200-200 BINDING 19-19 BINDING 21-21 BINDING 279-279

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVDPAFLHALPKVELHLHIEGSLEPEMMVALAERNGLRLPYASVEAVRAAYDFQNLQDF
CCCCHHHHHHCCCEEEEEEECCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
LDLYYQGMAVLRTERDFEDLAMAYFQRAAAQNVLHAEIFFDPQGHTARGVALEAVIAGLT
HHHHHHCHHHHHCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHHH
SARKRAEAELGVSSELILSFLRHLSEEEAFATLEEALPHRDQFIGVGLDSSEVGHPPAKF
HHHHHHHHHCCCCHHHHHHHHHHHCHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCHHHH
ARVFARARAEGLRLVAHAGEEGPPDYVREALDLLAIDRLDHGNRALEDEALIERLIAEGM
HHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCC
ALTVCPLSNLKLRVVDDLGAHPLKAMLERGLKATINSDDPSYFGGYMLENMAAVAEALAL
EEEEECCCCCEEEEECCCCCCHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHH
ETHHLRTLTANAIDASFASPARKAEMHARLAAVN
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AVDPAFLHALPKVELHLHIEGSLEPEMMVALAERNGLRLPYASVEAVRAAYDFQNLQDF
CCCHHHHHHCCCEEEEEEECCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
LDLYYQGMAVLRTERDFEDLAMAYFQRAAAQNVLHAEIFFDPQGHTARGVALEAVIAGLT
HHHHHHCHHHHHCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHHH
SARKRAEAELGVSSELILSFLRHLSEEEAFATLEEALPHRDQFIGVGLDSSEVGHPPAKF
HHHHHHHHHCCCCHHHHHHHHHHHCHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCHHHH
ARVFARARAEGLRLVAHAGEEGPPDYVREALDLLAIDRLDHGNRALEDEALIERLIAEGM
HHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCC
ALTVCPLSNLKLRVVDDLGAHPLKAMLERGLKATINSDDPSYFGGYMLENMAAVAEALAL
EEEEECCCCCEEEEECCCCCCHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHH
ETHHLRTLTANAIDASFASPARKAEMHARLAAVN
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA