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The map label for this gene is cobW [H]

Identifier: 83592010

GI number: 83592010

Start: 793740

End: 794792

Strand: Direct

Name: cobW [H]

Synonym: Rru_A0671

Alternate gene names: 83592010

Gene position: 793740-794792 (Clockwise)

Preceding gene: 83592009

Following gene: 83592012

Centisome position: 18.24

GC content: 69.04

Gene sequence:

>1053_bases
ATGAGCGTTTCCGCCCGCCATGCCCCCCGCCGCATTCCCGCCACCGTGATCACCGGCTTTCTGGGGGCGGGCAAGACCAC
CCTGGTGCGTCATTTGATGGAACATGCCGGCGGCCGACGCATCGCCCTGATCATCAATGAATTCGGCGATGTCGGCATGG
ACCGCGAGATCCTGGCGGCCTGCGGCGTCGCCGGCTGCGCCGAGGATGACATCGTCGAACTGGCCAATGGCTGCATCTGC
TGCACGGTGGCCGATGAATTCCTGCCGACGATGGAGGCGCTGCTCGCCCGGCCGCAGCCGCCCGAGCATATCATCATCGA
AACCTCGGGCCTCGCCCTGCCCAAGCCGCTGGTCCGCGCCTTTGATTGGCCCGACGTGCGGGCGCGGGTAACGGTGGACG
GGGTGGTGGCGGTGGTCGACGCCCGCTCGGTCCACGATGGCCGCTTCACCGAGGATCCGGCCGGTCTGGCGGCGCGCCGG
GCCGCCGATCCGGCGCTTGATCACGACAATCCGCTGGAAGAGGTTTTCGAGGATCAGTTGCTGTGCGCCGATATGGTCGT
GCTCAACAAGGTCGATCTGCTGAGCGAGGCCGAGACGGCGGCGCTGATCGCCGAGCTGGGCGGCCGCCTGCGCCCGGGCA
CCCGGCTGGTGCCCGTGGTCGAGGGCCGGGTCGATCCCGCCGTGGCCCTTGGCCTGATGGCCGGGGTGGAGGACGACCTT
GAGGGCCGCCCCAGCCACCACGATACGGCGACCGATCACGACCACGACGATTTCCACAGCTTCGTCGTTGGCCTGGGCGC
CGTGGCCGATCCGGCCGAGGCCCGCCAGCGCCTGGGCGCGGTGATCGCCGATCACGACATCTTGCGCATCAAGGGATTTT
TGGCGGTGCCGGGCAAGCCGATGCGCCATCTGATCCAGGCGGTCGGCCCGCGGGTTTCGGGCTATTACGACCGGCCGTGG
CGGGACGACGAGGCCCGCGAATCGCGATTGGTGGTGATCGGCCTGCGCGGATTGGACGAGGCGGCGATTCGCGGCGCCCT
GGTCGGCCTGTAA

Upstream 100 bases:

>100_bases
GGTGCTCAATCAGCGCATGGCCACGCTCTGCGGCCGGGTGGTATTATGCGCCGCAGGACTACCCTTGGTTCTTAAAGATC
TGCCTGATTTGGAGTGACCG

Downstream 100 bases:

>100_bases
GCGGCCGGGCCCGTCCCTCCGGGCTTGGTTCGGCCAGTGGTCGGCCAAGCCCGGGGGCGGGAGCCTTTTACGAGACGGGA
GTTTTTACGAGACGAAGGTG

Product: cobalamin synthesis CobW protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 350; Mature: 349

Protein sequence:

>350_residues
MSVSARHAPRRIPATVITGFLGAGKTTLVRHLMEHAGGRRIALIINEFGDVGMDREILAACGVAGCAEDDIVELANGCIC
CTVADEFLPTMEALLARPQPPEHIIIETSGLALPKPLVRAFDWPDVRARVTVDGVVAVVDARSVHDGRFTEDPAGLAARR
AADPALDHDNPLEEVFEDQLLCADMVVLNKVDLLSEAETAALIAELGGRLRPGTRLVPVVEGRVDPAVALGLMAGVEDDL
EGRPSHHDTATDHDHDDFHSFVVGLGAVADPAEARQRLGAVIADHDILRIKGFLAVPGKPMRHLIQAVGPRVSGYYDRPW
RDDEARESRLVVIGLRGLDEAAIRGALVGL

Sequences:

>Translated_350_residues
MSVSARHAPRRIPATVITGFLGAGKTTLVRHLMEHAGGRRIALIINEFGDVGMDREILAACGVAGCAEDDIVELANGCIC
CTVADEFLPTMEALLARPQPPEHIIIETSGLALPKPLVRAFDWPDVRARVTVDGVVAVVDARSVHDGRFTEDPAGLAARR
AADPALDHDNPLEEVFEDQLLCADMVVLNKVDLLSEAETAALIAELGGRLRPGTRLVPVVEGRVDPAVALGLMAGVEDDL
EGRPSHHDTATDHDHDDFHSFVVGLGAVADPAEARQRLGAVIADHDILRIKGFLAVPGKPMRHLIQAVGPRVSGYYDRPW
RDDEARESRLVVIGLRGLDEAAIRGALVGL
>Mature_349_residues
SVSARHAPRRIPATVITGFLGAGKTTLVRHLMEHAGGRRIALIINEFGDVGMDREILAACGVAGCAEDDIVELANGCICC
TVADEFLPTMEALLARPQPPEHIIIETSGLALPKPLVRAFDWPDVRARVTVDGVVAVVDARSVHDGRFTEDPAGLAARRA
ADPALDHDNPLEEVFEDQLLCADMVVLNKVDLLSEAETAALIAELGGRLRPGTRLVPVVEGRVDPAVALGLMAGVEDDLE
GRPSHHDTATDHDHDDFHSFVVGLGAVADPAEARQRLGAVIADHDILRIKGFLAVPGKPMRHLIQAVGPRVSGYYDRPWR
DDEARESRLVVIGLRGLDEAAIRGALVGL

Specific function: Might be involved in cobalt reduction leading to cobalt(I) corrinoids [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI33469141, Length=364, Percent_Identity=28.8461538461538, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI126722884, Length=367, Percent_Identity=28.8828337874659, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI146231952, Length=360, Percent_Identity=26.9444444444444, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI148727351, Length=367, Percent_Identity=28.8828337874659, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI223941779, Length=348, Percent_Identity=27.0114942528736, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI223941776, Length=372, Percent_Identity=27.4193548387097, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI119120938, Length=171, Percent_Identity=34.5029239766082, Blast_Score=101, Evalue=1e-21,
Organism=Escherichia coli, GI87082430, Length=352, Percent_Identity=32.3863636363636, Blast_Score=134, Evalue=6e-33,
Organism=Escherichia coli, GI1788499, Length=190, Percent_Identity=30, Blast_Score=84, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324356, Length=226, Percent_Identity=28.3185840707965, Blast_Score=105, Evalue=9e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012824
- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 37491; Mature: 37360

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVSARHAPRRIPATVITGFLGAGKTTLVRHLMEHAGGRRIALIINEFGDVGMDREILAA
CCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHH
CGVAGCAEDDIVELANGCICCTVADEFLPTMEALLARPQPPEHIIIETSGLALPKPLVRA
CCCCCCCCHHHHHHHCCEEEEEEHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHH
FDWPDVRARVTVDGVVAVVDARSVHDGRFTEDPAGLAARRAADPALDHDNPLEEVFEDQL
CCCCCCEEEEEECCEEEEEECCCCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHH
LCADMVVLNKVDLLSEAETAALIAELGGRLRPGTRLVPVVEGRVDPAVALGLMAGVEDDL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCC
EGRPSHHDTATDHDHDDFHSFVVGLGAVADPAEARQRLGAVIADHDILRIKGFLAVPGKP
CCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEEEEECCCHH
MRHLIQAVGPRVSGYYDRPWRDDEARESRLVVIGLRGLDEAAIRGALVGL
HHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHCCC
>Mature Secondary Structure 
SVSARHAPRRIPATVITGFLGAGKTTLVRHLMEHAGGRRIALIINEFGDVGMDREILAA
CCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHH
CGVAGCAEDDIVELANGCICCTVADEFLPTMEALLARPQPPEHIIIETSGLALPKPLVRA
CCCCCCCCHHHHHHHCCEEEEEEHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHH
FDWPDVRARVTVDGVVAVVDARSVHDGRFTEDPAGLAARRAADPALDHDNPLEEVFEDQL
CCCCCCEEEEEECCEEEEEECCCCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHH
LCADMVVLNKVDLLSEAETAALIAELGGRLRPGTRLVPVVEGRVDPAVALGLMAGVEDDL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCC
EGRPSHHDTATDHDHDDFHSFVVGLGAVADPAEARQRLGAVIADHDILRIKGFLAVPGKP
CCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEEEEECCCHH
MRHLIQAVGPRVSGYYDRPWRDDEARESRLVVIGLRGLDEAAIRGALVGL
HHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1655697 [H]