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The map label for this gene is pepA [H]

Identifier: 83591794

GI number: 83591794

Start: 534503

End: 536005

Strand: Direct

Name: pepA [H]

Synonym: Rru_A0454

Alternate gene names: 83591794

Gene position: 534503-536005 (Clockwise)

Preceding gene: 83591792

Following gene: 83591795

Centisome position: 12.28

GC content: 66.47

Gene sequence:

>1503_bases
ATGAAAGTCTCGTTCGCCAAGCCGGAAATTCCCGCTCAGGGCGCGCTCGTTCTCGGTGTTCTTGAAGGGGCGCAGCTTTC
GCCGCTCGGACGCGAGGTCGACACGCAGACCGACGGTGCGCTTACCCGGGCGATCGCCGCCTATCCCCGCTTCAAGGGCG
AGGCCGGGCAGTCGCTGTCGCTGGCCGCGCCCCATGGCCTGACCGCCTCGCGCGTGCTGCTGATCGGTCTGGGCAAGGCC
GATGGCCTGAGCGCCAGCGGGCTTGAAACCTTTGGCGCCAGCGTTCAATCCACGCTCAACCATACGGGCGACAGTGAAGG
CGTGGTGGTGATCGAAGCCGCGCTGCTGGGCGGTTTCGACCTTGGCGAGGCCGCCGCCCGGGTCGCCCTGGGGGCGCGGT
TGCGCAGCTATCGCTTCGACAAATACCACACCACCCAAAAGGACGACGAGAAGCCCCAGCTTGCCACCTTGACCGTGGCG
GTCGAGGATCCGGCGGCGGCCGAGGCCGCCTATGCGCCGCTGCGCGCCCTGGCCAAGGGCGTGTTCCTGACCCGCGATCT
GGTCAGCGAGCCGGCCAATGTCCTTTATCCCGAAAGCTTCGCCGCCCAGTGCGAGGATCTGAAGAAGCTGGGTATCGAGG
TCGAGGTTCTGGGCGAAAAGGAGATGCGCAAGCTGGGCATGGGCGCCCTGCTGGGCGTGGCCCAGGGCAGCGCCCGCGAG
CCCAAGCTGGTGGTGCTCAGCTATCACGGCGGCAAGAAGGGCGACCAGCCGGTGGCCTTCATCGGCAAGGGCGTGTGCTT
TGATTCCGGCGGCATTTCGATCAAGCCGGCGGCCAATATGGAAGACATGAAGTGGGACATGGGCGGCGCCGGCGTGGTGG
CCGGGCTGTTCAAGGCCCTGGCCGGGCGCAAGGCCAAGGTCAACGCCGTTGGCCTGATGGGCTTGGTCGAGAACATGCCG
AGCGGCACCGCCCAGCGTCCGGGTGACGTGGTGACCTCGATGAGCGGTCAGACGATCGAGGTGATCAACACCGATGCCGA
GGGCCGCTTGGTTCTGGCCGACGTGCTGCATTACTGCAACGACCGCTTCAAGCCGCGCCAGATGATCGACCTCGCCACCC
TGACCGGCGCCATCATCATCGCCCTGGGCACCGAACACGCCGGGGTGTTCAGCAATGACGACGCCCTGGCCGAGGGTCTG
GCCAAGGCCGGCAAGGCCACCGGCGAGAAGGTGTGGCGCCTGCCCCTGGGCGACGCCTATGACAAGCAGATCAACTCCGA
CATCGCCGATATGCGCAATTCCACCGGGCGCGAGGGCGGATCGATCACCGCCGCCCAGTTCCTCAAGCGCTTCGTCGGCG
AGACCCCCTGGGCCCATATCGATATCGCCGGGGTGACCTGGTCGAAGAAGGATGCGGGCATCGTTCCCAAGGGCGGCACC
GGTTTTGGCGTGCGCCTGCTTGACGCCTATGTCGCCGAGACCTTTGAGGAGGCGGGCAAGTAA

Upstream 100 bases:

>100_bases
ACAGGCGGCGGCGCGGGTGCGCCGTTGGGTTCGCCGGGTCCGTCACCGGGCTCGCGCCCTTGCTCCTGCCCGCGCATCAT
CCATAGAGGATTCCTCGTCC

Downstream 100 bases:

>100_bases
GCGCGCCCGCGCAACCCGATAAGACCGGGGTCATCGCATGATTTCCCAACCCGCCGGGCCGGCCGCCTCACGTATCGGCC
CGGCGATCCGCTCGCGCTTC

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 500; Mature: 500

Protein sequence:

>500_residues
MKVSFAKPEIPAQGALVLGVLEGAQLSPLGREVDTQTDGALTRAIAAYPRFKGEAGQSLSLAAPHGLTASRVLLIGLGKA
DGLSASGLETFGASVQSTLNHTGDSEGVVVIEAALLGGFDLGEAAARVALGARLRSYRFDKYHTTQKDDEKPQLATLTVA
VEDPAAAEAAYAPLRALAKGVFLTRDLVSEPANVLYPESFAAQCEDLKKLGIEVEVLGEKEMRKLGMGALLGVAQGSARE
PKLVVLSYHGGKKGDQPVAFIGKGVCFDSGGISIKPAANMEDMKWDMGGAGVVAGLFKALAGRKAKVNAVGLMGLVENMP
SGTAQRPGDVVTSMSGQTIEVINTDAEGRLVLADVLHYCNDRFKPRQMIDLATLTGAIIIALGTEHAGVFSNDDALAEGL
AKAGKATGEKVWRLPLGDAYDKQINSDIADMRNSTGREGGSITAAQFLKRFVGETPWAHIDIAGVTWSKKDAGIVPKGGT
GFGVRLLDAYVAETFEEAGK

Sequences:

>Translated_500_residues
MKVSFAKPEIPAQGALVLGVLEGAQLSPLGREVDTQTDGALTRAIAAYPRFKGEAGQSLSLAAPHGLTASRVLLIGLGKA
DGLSASGLETFGASVQSTLNHTGDSEGVVVIEAALLGGFDLGEAAARVALGARLRSYRFDKYHTTQKDDEKPQLATLTVA
VEDPAAAEAAYAPLRALAKGVFLTRDLVSEPANVLYPESFAAQCEDLKKLGIEVEVLGEKEMRKLGMGALLGVAQGSARE
PKLVVLSYHGGKKGDQPVAFIGKGVCFDSGGISIKPAANMEDMKWDMGGAGVVAGLFKALAGRKAKVNAVGLMGLVENMP
SGTAQRPGDVVTSMSGQTIEVINTDAEGRLVLADVLHYCNDRFKPRQMIDLATLTGAIIIALGTEHAGVFSNDDALAEGL
AKAGKATGEKVWRLPLGDAYDKQINSDIADMRNSTGREGGSITAAQFLKRFVGETPWAHIDIAGVTWSKKDAGIVPKGGT
GFGVRLLDAYVAETFEEAGK
>Mature_500_residues
MKVSFAKPEIPAQGALVLGVLEGAQLSPLGREVDTQTDGALTRAIAAYPRFKGEAGQSLSLAAPHGLTASRVLLIGLGKA
DGLSASGLETFGASVQSTLNHTGDSEGVVVIEAALLGGFDLGEAAARVALGARLRSYRFDKYHTTQKDDEKPQLATLTVA
VEDPAAAEAAYAPLRALAKGVFLTRDLVSEPANVLYPESFAAQCEDLKKLGIEVEVLGEKEMRKLGMGALLGVAQGSARE
PKLVVLSYHGGKKGDQPVAFIGKGVCFDSGGISIKPAANMEDMKWDMGGAGVVAGLFKALAGRKAKVNAVGLMGLVENMP
SGTAQRPGDVVTSMSGQTIEVINTDAEGRLVLADVLHYCNDRFKPRQMIDLATLTGAIIIALGTEHAGVFSNDDALAEGL
AKAGKATGEKVWRLPLGDAYDKQINSDIADMRNSTGREGGSITAAQFLKRFVGETPWAHIDIAGVTWSKKDAGIVPKGGT
GFGVRLLDAYVAETFEEAGK

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=321, Percent_Identity=42.9906542056075, Blast_Score=244, Evalue=2e-64,
Organism=Homo sapiens, GI47155554, Length=334, Percent_Identity=35.3293413173653, Blast_Score=165, Evalue=1e-40,
Organism=Escherichia coli, GI1790710, Length=499, Percent_Identity=39.2785571142285, Blast_Score=327, Evalue=9e-91,
Organism=Escherichia coli, GI87082123, Length=313, Percent_Identity=38.3386581469649, Blast_Score=179, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17556903, Length=298, Percent_Identity=34.8993288590604, Blast_Score=155, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI17565172, Length=253, Percent_Identity=30.0395256916996, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21355725, Length=317, Percent_Identity=37.5394321766561, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI20129969, Length=483, Percent_Identity=30.0207039337474, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24661038, Length=317, Percent_Identity=37.8548895899054, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24662227, Length=389, Percent_Identity=32.133676092545, Blast_Score=192, Evalue=5e-49,
Organism=Drosophila melanogaster, GI161077148, Length=354, Percent_Identity=32.2033898305085, Blast_Score=178, Evalue=7e-45,
Organism=Drosophila melanogaster, GI20130057, Length=354, Percent_Identity=32.2033898305085, Blast_Score=178, Evalue=7e-45,
Organism=Drosophila melanogaster, GI20129963, Length=354, Percent_Identity=31.9209039548023, Blast_Score=169, Evalue=5e-42,
Organism=Drosophila melanogaster, GI21355645, Length=473, Percent_Identity=26.4270613107822, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24662223, Length=473, Percent_Identity=26.4270613107822, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI221379063, Length=323, Percent_Identity=34.3653250773994, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI221379062, Length=323, Percent_Identity=34.3653250773994, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI21357381, Length=323, Percent_Identity=34.3653250773994, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI19922386, Length=297, Percent_Identity=32.3232323232323, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24646701, Length=346, Percent_Identity=26.878612716763, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24646703, Length=346, Percent_Identity=26.878612716763, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21358201, Length=346, Percent_Identity=26.878612716763, Blast_Score=84, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 52218; Mature: 52218

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVSFAKPEIPAQGALVLGVLEGAQLSPLGREVDTQTDGALTRAIAAYPRFKGEAGQSLS
CCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCEEE
LAAPHGLTASRVLLIGLGKADGLSASGLETFGASVQSTLNHTGDSEGVVVIEAALLGGFD
EECCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEEHHCCCC
LGEAAARVALGARLRSYRFDKYHTTQKDDEKPQLATLTVAVEDPAAAEAAYAPLRALAKG
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHH
VFLTRDLVSEPANVLYPESFAAQCEDLKKLGIEVEVLGEKEMRKLGMGALLGVAQGSARE
HHHHHHHHHCCCCEECCCHHHHHHHHHHHCCCEEEEECHHHHHHHCCHHHHHHCCCCCCC
PKLVVLSYHGGKKGDQPVAFIGKGVCFDSGGISIKPAANMEDMKWDMGGAGVVAGLFKAL
CEEEEEEECCCCCCCCCEEEEECCEEECCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHH
AGRKAKVNAVGLMGLVENMPSGTAQRPGDVVTSMSGQTIEVINTDAEGRLVLADVLHYCN
CCCCCEEHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCEEEEEECCCCCCEEHHHHHHHHC
DRFKPRQMIDLATLTGAIIIALGTEHAGVFSNDDALAEGLAKAGKATGEKVWRLPLGDAY
CCCCCHHHHHHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCHH
DKQINSDIADMRNSTGREGGSITAAQFLKRFVGETPWAHIDIAGVTWSKKDAGIVPKGGT
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCCCCC
GFGVRLLDAYVAETFEEAGK
CCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKVSFAKPEIPAQGALVLGVLEGAQLSPLGREVDTQTDGALTRAIAAYPRFKGEAGQSLS
CCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCEEE
LAAPHGLTASRVLLIGLGKADGLSASGLETFGASVQSTLNHTGDSEGVVVIEAALLGGFD
EECCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEEHHCCCC
LGEAAARVALGARLRSYRFDKYHTTQKDDEKPQLATLTVAVEDPAAAEAAYAPLRALAKG
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHH
VFLTRDLVSEPANVLYPESFAAQCEDLKKLGIEVEVLGEKEMRKLGMGALLGVAQGSARE
HHHHHHHHHCCCCEECCCHHHHHHHHHHHCCCEEEEECHHHHHHHCCHHHHHHCCCCCCC
PKLVVLSYHGGKKGDQPVAFIGKGVCFDSGGISIKPAANMEDMKWDMGGAGVVAGLFKAL
CEEEEEEECCCCCCCCCEEEEECCEEECCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHH
AGRKAKVNAVGLMGLVENMPSGTAQRPGDVVTSMSGQTIEVINTDAEGRLVLADVLHYCN
CCCCCEEHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCEEEEEECCCCCCEEHHHHHHHHC
DRFKPRQMIDLATLTGAIIIALGTEHAGVFSNDDALAEGLAKAGKATGEKVWRLPLGDAY
CCCCCHHHHHHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCHH
DKQINSDIADMRNSTGREGGSITAAQFLKRFVGETPWAHIDIAGVTWSKKDAGIVPKGGT
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCCCCC
GFGVRLLDAYVAETFEEAGK
CCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]