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The map label for this gene is gmk

Identifier: 83591769

GI number: 83591769

Start: 501508

End: 502164

Strand: Direct

Name: gmk

Synonym: Rru_A0429

Alternate gene names: 83591769

Gene position: 501508-502164 (Clockwise)

Preceding gene: 83591768

Following gene: 83591770

Centisome position: 11.52

GC content: 64.69

Gene sequence:

>657_bases
ATGTCGGCCCCTTCCTCCGCCCCCGCCCTCATCCCCCGGCGCGGTATGATGCTGGTTCTCTCCTCGCCTTCCGGGGCGGG
GAAGACCACTATTTCCCGCGCTCTTCTGGCCGAAGAGGACGGATTGGAGATGTCGGTGAGCGTCACCACCCGGGCGCCGC
GGCCCGGTGAACGCGACGGCGAGCATTACCATTTCATCGACGTCGCCCGTTATATGGCCTTGACCAAGGACGACGGCCTA
CTTGAACACGCCCGGGTTTTCGAAAACTATTACGGTACCCCCCGGGCGCCGGTCGAGGCGGCCCTGGCCAGGGGCTGTGA
CGTCTTGTTCGATATCGATTGGCAGGGCACCCAGCAGGTGGCCGAAAAGGCGCGGACCGATCTGGTCAGCATCTTCATCC
TGCCGCCCTCGGTGGGGGAACTCGAACGCCGGCTGAAGGGCAGGGCCCAGGATAGCGATGCCGTGGTGGCGGCGCGCATG
GCCAAGGCGATGGACGAGATCAGCCACTACTTCGAATACGATTACATCATCGTCAATGATGATCTCGACCGCTCGATCGC
CGATGTGCGGGCCATCTTGCGGGCCGAGCGCCTGAAGCGCGCCCGCCGGATCGGTCTGGCCGAATTCGTCAACCGCATGC
GCGGCGCCGGGGAATAG

Upstream 100 bases:

>100_bases
ATCCTCCGACGTCGCCTTGACCCGCATCGGGTTGGACATGAAGGCGGTGATCGACCAATTCCGCGAACAAATCCTCAATA
TCGAATAGGACGGTTTTCCC

Downstream 100 bases:

>100_bases
GCGCCGCGCCTAGCGATCGCGTGGCAACAAGGCTGGGGCGAAAGCGTTGACGGGGCAGAGGCAACCGAGGGAAGCCGACC
GTGAACGCAAAATCCCGGCC

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 218; Mature: 217

Protein sequence:

>218_residues
MSAPSSAPALIPRRGMMLVLSSPSGAGKTTISRALLAEEDGLEMSVSVTTRAPRPGERDGEHYHFIDVARYMALTKDDGL
LEHARVFENYYGTPRAPVEAALARGCDVLFDIDWQGTQQVAEKARTDLVSIFILPPSVGELERRLKGRAQDSDAVVAARM
AKAMDEISHYFEYDYIIVNDDLDRSIADVRAILRAERLKRARRIGLAEFVNRMRGAGE

Sequences:

>Translated_218_residues
MSAPSSAPALIPRRGMMLVLSSPSGAGKTTISRALLAEEDGLEMSVSVTTRAPRPGERDGEHYHFIDVARYMALTKDDGL
LEHARVFENYYGTPRAPVEAALARGCDVLFDIDWQGTQQVAEKARTDLVSIFILPPSVGELERRLKGRAQDSDAVVAARM
AKAMDEISHYFEYDYIIVNDDLDRSIADVRAILRAERLKRARRIGLAEFVNRMRGAGE
>Mature_217_residues
SAPSSAPALIPRRGMMLVLSSPSGAGKTTISRALLAEEDGLEMSVSVTTRAPRPGERDGEHYHFIDVARYMALTKDDGLL
EHARVFENYYGTPRAPVEAALARGCDVLFDIDWQGTQQVAEKARTDLVSIFILPPSVGELERRLKGRAQDSDAVVAARMA
KAMDEISHYFEYDYIIVNDDLDRSIADVRAILRAERLKRARRIGLAEFVNRMRGAGE

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874833, Length=194, Percent_Identity=38.1443298969072, Blast_Score=116, Evalue=1e-26,
Organism=Homo sapiens, GI4504221, Length=194, Percent_Identity=38.1443298969072, Blast_Score=116, Evalue=1e-26,
Organism=Homo sapiens, GI226874831, Length=194, Percent_Identity=38.1443298969072, Blast_Score=116, Evalue=1e-26,
Organism=Escherichia coli, GI1790080, Length=195, Percent_Identity=52.8205128205128, Blast_Score=208, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI193203132, Length=191, Percent_Identity=32.9842931937173, Blast_Score=106, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI17508835, Length=191, Percent_Identity=32.9842931937173, Blast_Score=106, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6320662, Length=184, Percent_Identity=36.9565217391304, Blast_Score=129, Evalue=5e-31,
Organism=Drosophila melanogaster, GI21356141, Length=217, Percent_Identity=34.5622119815668, Blast_Score=112, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_RHORT (Q2RXB1)

Other databases:

- EMBL:   CP000230
- RefSeq:   YP_425521.1
- HSSP:   P0A5I4
- ProteinModelPortal:   Q2RXB1
- STRING:   Q2RXB1
- GeneID:   3833995
- GenomeReviews:   CP000230_GR
- KEGG:   rru:Rru_A0429
- NMPDR:   fig|1085.1.peg.1323
- eggNOG:   COG0194
- HOGENOM:   HBG671982
- OMA:   DIDWQGT
- PhylomeDB:   Q2RXB1
- ProtClustDB:   PRK00300
- BioCyc:   RRUB269796:RRU_A0429-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 24166; Mature: 24035

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPSSAPALIPRRGMMLVLSSPSGAGKTTISRALLAEEDGLEMSVSVTTRAPRPGERDG
CCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCC
EHYHFIDVARYMALTKDDGLLEHARVFENYYGTPRAPVEAALARGCDVLFDIDWQGTQQV
CEEHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHCCCEEEEECCCCCHHHH
AEKARTDLVSIFILPPSVGELERRLKGRAQDSDAVVAARMAKAMDEISHYFEYDYIIVND
HHHHHHCEEEEEEECCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEECC
DLDRSIADVRAILRAERLKRARRIGLAEFVNRMRGAGE
CCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCC
>Mature Secondary Structure 
SAPSSAPALIPRRGMMLVLSSPSGAGKTTISRALLAEEDGLEMSVSVTTRAPRPGERDG
CCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCC
EHYHFIDVARYMALTKDDGLLEHARVFENYYGTPRAPVEAALARGCDVLFDIDWQGTQQV
CEEHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHCCCEEEEECCCCCHHHH
AEKARTDLVSIFILPPSVGELERRLKGRAQDSDAVVAARMAKAMDEISHYFEYDYIIVND
HHHHHHCEEEEEEECCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEECC
DLDRSIADVRAILRAERLKRARRIGLAEFVNRMRGAGE
CCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA