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The map label for this gene is lpxD [H]

Identifier: 83591383

GI number: 83591383

Start: 45342

End: 46511

Strand: Direct

Name: lpxD [H]

Synonym: Rru_A0043

Alternate gene names: 83591383

Gene position: 45342-46511 (Clockwise)

Preceding gene: 83591382

Following gene: 83591384

Centisome position: 1.04

GC content: 67.52

Gene sequence:

>1170_bases
ATGCCCGCGGTTTGCCCCGTCCTGTGGAGGGAAGCCGTCTGCAGGAGTTCATCTATTCAAATGACACAGCCCCTTCCGAT
GACCCTGACGCAGGTGGCCGAGGCCCTTGGCGGCACGCTGCATGGCCAGGGTGATTTGATTATCCGCCGTCCCGTCCATC
CGGCCCGGGCCGAAGCCGGCGAGGGCGTGACCGATCTGGCCGTCGCCATGGAGCCGGCCTTGTTGGCCGCCCTGGAGGGC
TCGGCCGCCCGCGCCGCCCTGGTGGCCGGCGGCGCCGTTCCGCCCGCCGGCTCGGTCGATGGCTGGATCGAGGTGGGGCG
TCCGCGCTTTGCCATGCATGTCATCACCGGGCGTTTCGAACAGCCCGCCCGTCTGGCCCCGGGCATCCATCCCAGCGCCG
TGGTCGAAGAGGGCGCCGAGATTGGCGAGGGCGCGGCGCTTGGCCCCTTCGTCCATGTCGGCTTCGGTGCCCGCGTCGGG
GCGGGAAGCCGGGTGCATAGCGGCGTCAGCATCGGCGCCGGGGCGGTGGTCGGGGCCGACTGCCTGCTCCATCCCGGGGT
GCGCATCGGCGAGCGCGTGCGCGTGGGTGATCGCGTCATCCTTCACGCCAACGCCGTGATCGGCGCCGATGGCTTCAGCT
TCGTCACCCCCGAACCGGGATCGGTGGAAAGCGCCAAGGCCACCGGCCGGGTTGACGCCATCAACAGCCGGTTGGCGCGC
ATCGCCTCGCTGGGCGCGGTGGTGCTGGGCGATGACGTGGAAATCGGCGCCAATACCTGTATCGATCGCGGCACCCTGGA
TGATACCCGGATCGGCGACGGCACCAAGATCGACGATATGGTGATGATCGGCCATAACGTGCGGGTTGGTCGCCTGTGCA
TGCTCTGCGCCCAGGTCGGCATCGCCGGCAGCGCGGTGATCGGCGATGGCGTGGTTCTGGCCGGCCGGGTTGGCGTCGCC
GACCACATCACCATTGGCGACAACGCCGTGGTTGGCGCCGGATCGGGGGTTGGCAGCAATATCCCGCCGCGCTCCGTCTG
GATGGGGTATCCCGCCCTGCCAAAAGACCAGGCGACGGAACACTATCTTTTCTCGCGCCGTCTTAAACATCTGTTCAAGG
ATGTTTCAGAGCTGAAAAAGCGGATAAGATCCCTTACTGTCCCGTCCTGA

Upstream 100 bases:

>100_bases
CGGTATGGTCGCCGCGCGGGATGGGGACGGTTCTCCGGCTTAGGCGGGCCGTTCCTTCCTGGCGTCGCCGACCGCGCGAC
CGGCTTTCCGAGAGACCGCG

Downstream 100 bases:

>100_bases
AATCTTTGTATCAACAACCAATTGGTTCGATCATCAATGAGCGACGTCGAAAGCAAGATCTACGATATCATCGTCGAAAA
GACCAACATCGATCGCGCCA

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MPAVCPVLWREAVCRSSSIQMTQPLPMTLTQVAEALGGTLHGQGDLIIRRPVHPARAEAGEGVTDLAVAMEPALLAALEG
SAARAALVAGGAVPPAGSVDGWIEVGRPRFAMHVITGRFEQPARLAPGIHPSAVVEEGAEIGEGAALGPFVHVGFGARVG
AGSRVHSGVSIGAGAVVGADCLLHPGVRIGERVRVGDRVILHANAVIGADGFSFVTPEPGSVESAKATGRVDAINSRLAR
IASLGAVVLGDDVEIGANTCIDRGTLDDTRIGDGTKIDDMVMIGHNVRVGRLCMLCAQVGIAGSAVIGDGVVLAGRVGVA
DHITIGDNAVVGAGSGVGSNIPPRSVWMGYPALPKDQATEHYLFSRRLKHLFKDVSELKKRIRSLTVPS

Sequences:

>Translated_389_residues
MPAVCPVLWREAVCRSSSIQMTQPLPMTLTQVAEALGGTLHGQGDLIIRRPVHPARAEAGEGVTDLAVAMEPALLAALEG
SAARAALVAGGAVPPAGSVDGWIEVGRPRFAMHVITGRFEQPARLAPGIHPSAVVEEGAEIGEGAALGPFVHVGFGARVG
AGSRVHSGVSIGAGAVVGADCLLHPGVRIGERVRVGDRVILHANAVIGADGFSFVTPEPGSVESAKATGRVDAINSRLAR
IASLGAVVLGDDVEIGANTCIDRGTLDDTRIGDGTKIDDMVMIGHNVRVGRLCMLCAQVGIAGSAVIGDGVVLAGRVGVA
DHITIGDNAVVGAGSGVGSNIPPRSVWMGYPALPKDQATEHYLFSRRLKHLFKDVSELKKRIRSLTVPS
>Mature_388_residues
PAVCPVLWREAVCRSSSIQMTQPLPMTLTQVAEALGGTLHGQGDLIIRRPVHPARAEAGEGVTDLAVAMEPALLAALEGS
AARAALVAGGAVPPAGSVDGWIEVGRPRFAMHVITGRFEQPARLAPGIHPSAVVEEGAEIGEGAALGPFVHVGFGARVGA
GSRVHSGVSIGAGAVVGADCLLHPGVRIGERVRVGDRVILHANAVIGADGFSFVTPEPGSVESAKATGRVDAINSRLARI
ASLGAVVLGDDVEIGANTCIDRGTLDDTRIGDGTKIDDMVMIGHNVRVGRLCMLCAQVGIAGSAVIGDGVVLAGRVGVAD
HITIGDNAVVGAGSGVGSNIPPRSVWMGYPALPKDQATEHYLFSRRLKHLFKDVSELKKRIRSLTVPS

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=358, Percent_Identity=27.3743016759777, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1786378, Length=233, Percent_Identity=27.0386266094421, Blast_Score=69, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691 [H]

Pfam domain/function: PF00132 Hexapep [H]

EC number: 2.3.1.-

Molecular weight: Translated: 39964; Mature: 39832

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAVCPVLWREAVCRSSSIQMTQPLPMTLTQVAEALGGTLHGQGDLIIRRPVHPARAEAG
CCCCCHHHHHHHHHCCCCCEECCCCCHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHCC
EGVTDLAVAMEPALLAALEGSAARAALVAGGAVPPAGSVDGWIEVGRPRFAMHVITGRFE
CCHHHHHHHHHHHHHHHHCCCCHHEEEEECCCCCCCCCCCCCEECCCCEEEEEEECCCCC
QPARLAPGIHPSAVVEEGAEIGEGAALGPFVHVGFGARVGAGSRVHSGVSIGAGAVVGAD
CCHHHCCCCCHHHHHHCCHHHCCCCCCCCEEEECCCCCCCCCCHHCCCCCCCCCHHHCCH
CLLHPGVRIGERVRVGDRVILHANAVIGADGFSFVTPEPGSVESAKATGRVDAINSRLAR
HHCCCCCCCCCEEECCCEEEEEECEEEECCCCEEECCCCCCCCCCCCCCCHHHHHHHHHH
IASLGAVVLGDDVEIGANTCIDRGTLDDTRIGDGTKIDDMVMIGHNVRVGRLCMLCAQVG
HHHCCEEEECCCCEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHC
IAGSAVIGDGVVLAGRVGVADHITIGDNAVVGAGSGVGSNIPPRSVWMGYPALPKDQATE
CCCCEEECCCEEEEECCCCCEEEEECCCEEEECCCCCCCCCCCCCEECCCCCCCCCCCHH
HYLFSRRLKHLFKDVSELKKRIRSLTVPS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PAVCPVLWREAVCRSSSIQMTQPLPMTLTQVAEALGGTLHGQGDLIIRRPVHPARAEAG
CCCCHHHHHHHHHCCCCCEECCCCCHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHCC
EGVTDLAVAMEPALLAALEGSAARAALVAGGAVPPAGSVDGWIEVGRPRFAMHVITGRFE
CCHHHHHHHHHHHHHHHHCCCCHHEEEEECCCCCCCCCCCCCEECCCCEEEEEEECCCCC
QPARLAPGIHPSAVVEEGAEIGEGAALGPFVHVGFGARVGAGSRVHSGVSIGAGAVVGAD
CCHHHCCCCCHHHHHHCCHHHCCCCCCCCEEEECCCCCCCCCCHHCCCCCCCCCHHHCCH
CLLHPGVRIGERVRVGDRVILHANAVIGADGFSFVTPEPGSVESAKATGRVDAINSRLAR
HHCCCCCCCCCEEECCCEEEEEECEEEECCCCEEECCCCCCCCCCCCCCCHHHHHHHHHH
IASLGAVVLGDDVEIGANTCIDRGTLDDTRIGDGTKIDDMVMIGHNVRVGRLCMLCAQVG
HHHCCEEEECCCCEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHC
IAGSAVIGDGVVLAGRVGVADHITIGDNAVVGAGSGVGSNIPPRSVWMGYPALPKDQATE
CCCCEEECCCEEEEECCCCCEEEEECCCEEEECCCCCCCCCCCCCEECCCCCCCCCCCHH
HYLFSRRLKHLFKDVSELKKRIRSLTVPS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA