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The map label for this gene is phoR [H]

Identifier: 83591310

GI number: 83591310

Start: 2599308

End: 2600777

Strand: Reverse

Name: phoR [H]

Synonym: Moth_2494

Alternate gene names: 83591310

Gene position: 2600777-2599308 (Counterclockwise)

Preceding gene: 83591311

Following gene: 83591309

Centisome position: 98.93

GC content: 55.31

Gene sequence:

>1470_bases
ATGCATTCACTACGCTGGAAGATTACCCTAAACTTTTTGACCCTCCTTTTCTTCACTCTGTTGGGGGCCTATCTCTACTT
ACACCAGGCTATCTTGAAGGCCATGGGATTACCATGGTTACCCCCCTTCCGGGCCGGGTTCCTGGCTGCCAGGTTAGAGG
GACAACTGCTGGCCGTCATGATCCTAGTTTTGATTATAATGGGCATTGGCACCTTTATCCTGGCCCGGGGGATTATAACC
CCCCTGACGGCCCTCCTGCCCCTGACCCGCAGGATTGCCGCCGGTGACCTGGAACAGCGGGTAGAGATCCAGAGTGACGA
TGAGGTGGGTTTATTAAGCCATCATCTAAATATCATGGTGGAAACTCTACGCAATAATTTCCGGGAAATAGCAGACGAGC
GCAATAAAATGAAGGCTATCCTGGCCAGTATAACCGACGGCCTGGTAGCTGTTGACCAGGTGGGCCGGGTTATAATGCTC
AATCCGGCGGCAGAGAAGATGTTCGGTAAAAAGGGGGCAGAGGTCGAGCACAAGTATCTCCTCAAGGTTGTCCGTAACCA
TGAAATCGATGCCATGGTAAAGGAGATCCTGGCCAGTGGCCTGCCCCTGGAGAATGAGGTCCGGCTCTTCCCGACTACCA
GTCAGTTATTCAGAATCTATGGTACGCCCATCACCAGCGAACAGGGACGAATAATCGGGGCCGTGCTCACCATCCGGGAT
ATTACCGACATCCGCCGCCTGGAGCAGATGCGGACGGAGTTTGTGGCCAACGTCTCCCATGAATTACGTACCCCCCTGAC
CTCAATCCGGGGCTTTGTTGAGACTCTGCTGGAGGGGGCCCTTGAAGACCCGGAGGTCAGCCGGCGCTTCCTGGGAATTA
TCAACCATGAAGCCCAGCGATTGCAGCAATTAATCGAAGACCTTCTCTCCCTGTCACGACTGGAGAGCCAACCAAAGCGA
CAGGATGCTGGGCGTGCGGACCTGGCGGCCACCTTGGACCGGGTCCTCACTACTGTTAACCAGTTAGCAAGGGAGAAAGG
AGTCGCCCTGGAGAAGGAGATACCGGCGGAGATACCGGAGTTGGCCATCAGTGAGAGCTATCTGAACCAAGTGCTCCTTA
ATCTGATTGATAATGGCATTAAGTATACCCCCGCCGGTGGCAGGGTAACTATACGTGCTGCCCGGTTAGGGGAATTAGTT
CAGGTAGAGGTGGCAGATACCGGCATAGGCATCCCCCCCGAGAGCCTTCCCCGCGTATTTGAACGATTCTACCGGGTAGA
TAAGGCGCGTTCCCGGGAGATGGGAGGCACCGGTCTGGGCCTGGCTATCGTCAAGCATATAGTCGAGTCCCATGGTGGCA
GTATCAGTGTGACCAGCAGGCCGGGCCAGGGCAGCCATTTCTTCTTTACCCTCCCCATTGCCGCTGAGGAAGGGGGGCGA
AGCAATTACCAGGAAGAACCGGGCACCTGA

Upstream 100 bases:

>100_bases
GAGGCTTTAAAAATCCTGGCAGGGGGGGCCGGCACTCAGTTTGACCCGGAGGTGACAGCAGTTGCCTCCTGCCTGCTAGC
CTGACAGGGGGGACGGGATT

Downstream 100 bases:

>100_bases
CCGTAAAACTCCTGGTGGCAACAGACGCATAGTTGATTGCAAAGGGCGGGTAACTCTACCTGCTAAATTAAGGCAGCAAC
TGGATCTATACCCTGGCGCA

Product: multi-sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 489; Mature: 489

Protein sequence:

>489_residues
MHSLRWKITLNFLTLLFFTLLGAYLYLHQAILKAMGLPWLPPFRAGFLAARLEGQLLAVMILVLIIMGIGTFILARGIIT
PLTALLPLTRRIAAGDLEQRVEIQSDDEVGLLSHHLNIMVETLRNNFREIADERNKMKAILASITDGLVAVDQVGRVIML
NPAAEKMFGKKGAEVEHKYLLKVVRNHEIDAMVKEILASGLPLENEVRLFPTTSQLFRIYGTPITSEQGRIIGAVLTIRD
ITDIRRLEQMRTEFVANVSHELRTPLTSIRGFVETLLEGALEDPEVSRRFLGIINHEAQRLQQLIEDLLSLSRLESQPKR
QDAGRADLAATLDRVLTTVNQLAREKGVALEKEIPAEIPELAISESYLNQVLLNLIDNGIKYTPAGGRVTIRAARLGELV
QVEVADTGIGIPPESLPRVFERFYRVDKARSREMGGTGLGLAIVKHIVESHGGSISVTSRPGQGSHFFFTLPIAAEEGGR
SNYQEEPGT

Sequences:

>Translated_489_residues
MHSLRWKITLNFLTLLFFTLLGAYLYLHQAILKAMGLPWLPPFRAGFLAARLEGQLLAVMILVLIIMGIGTFILARGIIT
PLTALLPLTRRIAAGDLEQRVEIQSDDEVGLLSHHLNIMVETLRNNFREIADERNKMKAILASITDGLVAVDQVGRVIML
NPAAEKMFGKKGAEVEHKYLLKVVRNHEIDAMVKEILASGLPLENEVRLFPTTSQLFRIYGTPITSEQGRIIGAVLTIRD
ITDIRRLEQMRTEFVANVSHELRTPLTSIRGFVETLLEGALEDPEVSRRFLGIINHEAQRLQQLIEDLLSLSRLESQPKR
QDAGRADLAATLDRVLTTVNQLAREKGVALEKEIPAEIPELAISESYLNQVLLNLIDNGIKYTPAGGRVTIRAARLGELV
QVEVADTGIGIPPESLPRVFERFYRVDKARSREMGGTGLGLAIVKHIVESHGGSISVTSRPGQGSHFFFTLPIAAEEGGR
SNYQEEPGT
>Mature_489_residues
MHSLRWKITLNFLTLLFFTLLGAYLYLHQAILKAMGLPWLPPFRAGFLAARLEGQLLAVMILVLIIMGIGTFILARGIIT
PLTALLPLTRRIAAGDLEQRVEIQSDDEVGLLSHHLNIMVETLRNNFREIADERNKMKAILASITDGLVAVDQVGRVIML
NPAAEKMFGKKGAEVEHKYLLKVVRNHEIDAMVKEILASGLPLENEVRLFPTTSQLFRIYGTPITSEQGRIIGAVLTIRD
ITDIRRLEQMRTEFVANVSHELRTPLTSIRGFVETLLEGALEDPEVSRRFLGIINHEAQRLQQLIEDLLSLSRLESQPKR
QDAGRADLAATLDRVLTTVNQLAREKGVALEKEIPAEIPELAISESYLNQVLLNLIDNGIKYTPAGGRVTIRAARLGELV
QVEVADTGIGIPPESLPRVFERFYRVDKARSREMGGTGLGLAIVKHIVESHGGSISVTSRPGQGSHFFFTLPIAAEEGGR
SNYQEEPGT

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=345, Percent_Identity=33.0434782608696, Blast_Score=181, Evalue=7e-47,
Organism=Escherichia coli, GI1789149, Length=226, Percent_Identity=37.1681415929204, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1788549, Length=386, Percent_Identity=28.7564766839378, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI1786783, Length=270, Percent_Identity=33.3333333333333, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI48994928, Length=274, Percent_Identity=32.1167883211679, Blast_Score=128, Evalue=8e-31,
Organism=Escherichia coli, GI1788393, Length=227, Percent_Identity=33.0396475770925, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI145693157, Length=227, Percent_Identity=33.920704845815, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1790436, Length=233, Percent_Identity=32.1888412017167, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1790861, Length=207, Percent_Identity=37.6811594202899, Blast_Score=112, Evalue=7e-26,
Organism=Escherichia coli, GI1786912, Length=231, Percent_Identity=33.7662337662338, Blast_Score=105, Evalue=7e-24,
Organism=Escherichia coli, GI1788713, Length=366, Percent_Identity=26.2295081967213, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1790346, Length=234, Percent_Identity=32.4786324786325, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1790567, Length=364, Percent_Identity=28.8461538461538, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1787894, Length=231, Percent_Identity=28.5714285714286, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI87081816, Length=231, Percent_Identity=29.8701298701299, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI87082128, Length=234, Percent_Identity=30.3418803418803, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1790300, Length=356, Percent_Identity=26.123595505618, Blast_Score=89, Evalue=9e-19,
Organism=Escherichia coli, GI1789808, Length=237, Percent_Identity=29.535864978903, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788279, Length=234, Percent_Identity=30.3418803418803, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1789403, Length=202, Percent_Identity=29.2079207920792, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1786837, Length=358, Percent_Identity=25.1396648044693, Blast_Score=69, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6322044, Length=75, Percent_Identity=42.6666666666667, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 54257; Mature: 54257

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS50885 HAMP ; PS50112 PAS ; PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHSLRWKITLNFLTLLFFTLLGAYLYLHQAILKAMGLPWLPPFRAGFLAARLEGQLLAVM
CCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHH
ILVLIIMGIGTFILARGIITPLTALLPLTRRIAAGDLEQRVEIQSDDEVGLLSHHLNIMV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHHH
ETLRNNFREIADERNKMKAILASITDGLVAVDQVGRVIMLNPAAEKMFGKKGAEVEHKYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHCCCCCCHHHHHH
LKVVRNHEIDAMVKEILASGLPLENEVRLFPTTSQLFRIYGTPITSEQGRIIGAVLTIRD
HHHHHCCCHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHCCCCCCCCCCEEEHHHHHHH
ITDIRRLEQMRTEFVANVSHELRTPLTSIRGFVETLLEGALEDPEVSRRFLGIINHEAQR
HHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
LQQLIEDLLSLSRLESQPKRQDAGRADLAATLDRVLTTVNQLAREKGVALEKEIPAEIPE
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCHHHH
LAISESYLNQVLLNLIDNGIKYTPAGGRVTIRAARLGELVQVEVADTGIGIPPESLPRVF
HHHHHHHHHHHHHHHHHCCCEECCCCCEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHH
ERFYRVDKARSREMGGTGLGLAIVKHIVESHGGSISVTSRPGQGSHFFFTLPIAAEEGGR
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEEEEEECCCCC
SNYQEEPGT
CCCCCCCCC
>Mature Secondary Structure
MHSLRWKITLNFLTLLFFTLLGAYLYLHQAILKAMGLPWLPPFRAGFLAARLEGQLLAVM
CCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHH
ILVLIIMGIGTFILARGIITPLTALLPLTRRIAAGDLEQRVEIQSDDEVGLLSHHLNIMV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHHH
ETLRNNFREIADERNKMKAILASITDGLVAVDQVGRVIMLNPAAEKMFGKKGAEVEHKYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHCCCCCCHHHHHH
LKVVRNHEIDAMVKEILASGLPLENEVRLFPTTSQLFRIYGTPITSEQGRIIGAVLTIRD
HHHHHCCCHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHCCCCCCCCCCEEEHHHHHHH
ITDIRRLEQMRTEFVANVSHELRTPLTSIRGFVETLLEGALEDPEVSRRFLGIINHEAQR
HHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
LQQLIEDLLSLSRLESQPKRQDAGRADLAATLDRVLTTVNQLAREKGVALEKEIPAEIPE
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCHHHH
LAISESYLNQVLLNLIDNGIKYTPAGGRVTIRAARLGELVQVEVADTGIGIPPESLPRVF
HHHHHHHHHHHHHHHHHCCCEECCCCCEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHH
ERFYRVDKARSREMGGTGLGLAIVKHIVESHGGSISVTSRPGQGSHFFFTLPIAAEEGGR
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEEEEEECCCCC
SNYQEEPGT
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]