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The map label for this gene is ubiB [H]

Identifier: 83591231

GI number: 83591231

Start: 2537446

End: 2539083

Strand: Reverse

Name: ubiB [H]

Synonym: Moth_2415

Alternate gene names: 83591231

Gene position: 2539083-2537446 (Counterclockwise)

Preceding gene: 83591232

Following gene: 83591230

Centisome position: 96.59

GC content: 61.78

Gene sequence:

>1638_bases
TTGACGAGGCACTACCGTTACCTGCAGCGCTATACTGAAGTGGCTACCGTACTTCTCCGCCACGGCTGGCAGGCTTACTG
CGAAACCCGCCCCCGCCGCGCTCCGGCCCGGCGCCCCCTGGTTACAGGTCGGGAGCCAGGCGATCCGGTTTACCGGCACC
TGCGCCTGGCCTTTGAGGAACTGGGACCGGTTTTTATCAAGCTGGGCCAGCTCCTGAGTACCAGGCCCGACCTGATACCG
ACGGAGATGGCTGCGGAATTCAGCTACCTCCAGGACCGGGTACGGCCCCTGGCCCCGGACGTCATCCGGCAGCAGGTCTT
CCGGGAACTGGGGACTGCTCCGGAAAAGGCCTTCAGTTACTTTGATTACCAGCCCCTCGCGGCGGCATCCATCGCCCAGG
TCCATAAAGCCCGGTTACCTGGTGGCCAGGAGGTGGCCGTCAAGGTGCAGCGCCCCCAGCTCGATGGGGTGGTCGTTACC
GACCTGGCCGTCCTGGAGAATCTCGGCCGGAGATTCAAGGGCACCGTCGTCGGCCGTATTTGTGCCTTGGAGGAGATCCT
GGCCACCTTTCGCCGCCAGATTGAACGGGAACTCGATTTTACCGTGGAAGCCCTGGCCATGGAGAATTTTCGCCGCCTGT
ACCGTGAGTTTCCGCAGATAGTGGTCCCCAGGGTTTACTGGGATTATACGACCAGGGGCCTCCTGACCATGGATTACCTG
GCCGGGAAAAGGCTCAGCGACTGGTACGGGAAGGGTACGGACTGTCAGCGGGCAGCCCTGCTTATCAAGGCGCTCCTGGC
GCCTTTTTTCCAGGAAGGCATCTTCCACGGCGACCCCCATCCGGGAAACATTCTCTTTCTTCCCGGCGGTCGCCTGGGCT
TAATTGATTTTGGCATCGTCGGTCGCCTGGATGAGGATTATCGTTACCAGGCTGCCAGGCTGATTCTAGGCCTCCAGGAA
CGCGATTTACAGGCCGTAATGGAAGTAACCCTGAAACTGGGTAAGCCCATGGCCGCAGTAGATTACCAGGCCCTCTATGA
AGACACGGCAGAACTGGTTGACCGGGTGACCGGCATGGGCAAAGGGGATGTCAATCTGGCCGGTCTCCTGCTGGGAATGG
TGGAACTGGCCCGCCGCCATAGCATCCGTATGCCCGGTACCTTCTTCGTCCTGGGGCGGACGATTATGGAAGGGGAGAGC
CTGGCCCGCCGCCTGGATCCTTCCCTGGATCTGGTGCAGGTAAGCGGGCCCCTGGCTGCCAGTTACCTGCGCAGCCGCCT
GCGTCCCAACCCCACGCCCGGGCGAACCTACCACCGGGCGGCCTCAACCCTGCAGGATTTGCTGGAACTGCCGCGGGATA
TCTCCCGCAGCCTGGATAAACTTGCCCGGGGGCAGTTAACTACCATTTTTGTCCACCGGGGCCTGGAAACCCTTTACCAC
AGACTGGATATGGTTTCCGCCCGGCTTTCTGCCGCTCTCATCGTGGCTGCCCTCATCGGCGCCGGGGCCCTAATCCTCCA
CGCGGGTGCCGGTCCTAAAACCGGTGGCCTTTCCCTCCTCGGTCTGGGAGTGCTGGGCGGCGCCCTTATCCTGGGTTGTC
TCTGGGCTCTGCTCCTCAAGGTAGGACAGAAGGAATAG

Upstream 100 bases:

>100_bases
CCAGCGGGGTGAAACTTACCACCGTTAAAACCGTACATGACGGTGATTTTTTTGGTCATAATACTTCCTGGATATGTTTA
CCAGGGAGGCCAGAATACTC

Downstream 100 bases:

>100_bases
CCCCCATGTCCTTTTCCTGGAGGTTGAACAGGGGTACCACCCCCTTGCCTTTTGCCGTCAGTCACAATAGAATTATAGAG
GTGATGCATTGGGGAGGCTG

Product: hypothetical protein

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 545; Mature: 544

Protein sequence:

>545_residues
MTRHYRYLQRYTEVATVLLRHGWQAYCETRPRRAPARRPLVTGREPGDPVYRHLRLAFEELGPVFIKLGQLLSTRPDLIP
TEMAAEFSYLQDRVRPLAPDVIRQQVFRELGTAPEKAFSYFDYQPLAAASIAQVHKARLPGGQEVAVKVQRPQLDGVVVT
DLAVLENLGRRFKGTVVGRICALEEILATFRRQIERELDFTVEALAMENFRRLYREFPQIVVPRVYWDYTTRGLLTMDYL
AGKRLSDWYGKGTDCQRAALLIKALLAPFFQEGIFHGDPHPGNILFLPGGRLGLIDFGIVGRLDEDYRYQAARLILGLQE
RDLQAVMEVTLKLGKPMAAVDYQALYEDTAELVDRVTGMGKGDVNLAGLLLGMVELARRHSIRMPGTFFVLGRTIMEGES
LARRLDPSLDLVQVSGPLAASYLRSRLRPNPTPGRTYHRAASTLQDLLELPRDISRSLDKLARGQLTTIFVHRGLETLYH
RLDMVSARLSAALIVAALIGAGALILHAGAGPKTGGLSLLGLGVLGGALILGCLWALLLKVGQKE

Sequences:

>Translated_545_residues
MTRHYRYLQRYTEVATVLLRHGWQAYCETRPRRAPARRPLVTGREPGDPVYRHLRLAFEELGPVFIKLGQLLSTRPDLIP
TEMAAEFSYLQDRVRPLAPDVIRQQVFRELGTAPEKAFSYFDYQPLAAASIAQVHKARLPGGQEVAVKVQRPQLDGVVVT
DLAVLENLGRRFKGTVVGRICALEEILATFRRQIERELDFTVEALAMENFRRLYREFPQIVVPRVYWDYTTRGLLTMDYL
AGKRLSDWYGKGTDCQRAALLIKALLAPFFQEGIFHGDPHPGNILFLPGGRLGLIDFGIVGRLDEDYRYQAARLILGLQE
RDLQAVMEVTLKLGKPMAAVDYQALYEDTAELVDRVTGMGKGDVNLAGLLLGMVELARRHSIRMPGTFFVLGRTIMEGES
LARRLDPSLDLVQVSGPLAASYLRSRLRPNPTPGRTYHRAASTLQDLLELPRDISRSLDKLARGQLTTIFVHRGLETLYH
RLDMVSARLSAALIVAALIGAGALILHAGAGPKTGGLSLLGLGVLGGALILGCLWALLLKVGQKE
>Mature_544_residues
TRHYRYLQRYTEVATVLLRHGWQAYCETRPRRAPARRPLVTGREPGDPVYRHLRLAFEELGPVFIKLGQLLSTRPDLIPT
EMAAEFSYLQDRVRPLAPDVIRQQVFRELGTAPEKAFSYFDYQPLAAASIAQVHKARLPGGQEVAVKVQRPQLDGVVVTD
LAVLENLGRRFKGTVVGRICALEEILATFRRQIERELDFTVEALAMENFRRLYREFPQIVVPRVYWDYTTRGLLTMDYLA
GKRLSDWYGKGTDCQRAALLIKALLAPFFQEGIFHGDPHPGNILFLPGGRLGLIDFGIVGRLDEDYRYQAARLILGLQER
DLQAVMEVTLKLGKPMAAVDYQALYEDTAELVDRVTGMGKGDVNLAGLLLGMVELARRHSIRMPGTFFVLGRTIMEGESL
ARRLDPSLDLVQVSGPLAASYLRSRLRPNPTPGRTYHRAASTLQDLLELPRDISRSLDKLARGQLTTIFVHRGLETLYHR
LDMVSARLSAALIVAALIGAGALILHAGAGPKTGGLSLLGLGVLGGALILGCLWALLLKVGQKE

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI41393593, Length=273, Percent_Identity=33.3333333333333, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI40254938, Length=289, Percent_Identity=30.4498269896194, Blast_Score=122, Evalue=9e-28,
Organism=Homo sapiens, GI217035081, Length=246, Percent_Identity=30.0813008130081, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI34147522, Length=280, Percent_Identity=27.1428571428571, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI27363457, Length=295, Percent_Identity=25.7627118644068, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI217416386, Length=445, Percent_Identity=25.3932584269663, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI2367309, Length=444, Percent_Identity=30.6306306306306, Blast_Score=184, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17559152, Length=285, Percent_Identity=30.1754385964912, Blast_Score=112, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI32565180, Length=282, Percent_Identity=27.3049645390071, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6321319, Length=317, Percent_Identity=28.391167192429, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6325148, Length=438, Percent_Identity=22.3744292237443, Blast_Score=100, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6323282, Length=273, Percent_Identity=30.4029304029304, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24662575, Length=263, Percent_Identity=34.6007604562738, Blast_Score=139, Evalue=5e-33,
Organism=Drosophila melanogaster, GI22024280, Length=287, Percent_Identity=32.0557491289199, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI18859849, Length=277, Percent_Identity=29.6028880866426, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 60751; Mature: 60620

Theoretical pI: Translated: 9.81; Mature: 9.81

Prosite motif: PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRHYRYLQRYTEVATVLLRHGWQAYCETRPRRAPARRPLVTGREPGDPVYRHLRLAFEE
CCCHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
LGPVFIKLGQLLSTRPDLIPTEMAAEFSYLQDRVRPLAPDVIRQQVFRELGTAPEKAFSY
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHH
FDYQPLAAASIAQVHKARLPGGQEVAVKVQRPQLDGVVVTDLAVLENLGRRFKGTVVGRI
CCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
CALEEILATFRRQIERELDFTVEALAMENFRRLYREFPQIVVPRVYWDYTTRGLLTMDYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHH
AGKRLSDWYGKGTDCQRAALLIKALLAPFFQEGIFHGDPHPGNILFLPGGRLGLIDFGIV
CCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCEEEEEHHHH
GRLDEDYRYQAARLILGLQERDLQAVMEVTLKLGKPMAAVDYQALYEDTAELVDRVTGMG
CCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCC
KGDVNLAGLLLGMVELARRHSIRMPGTFFVLGRTIMEGESLARRLDPSLDLVQVSGPLAA
CCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHH
SYLRSRLRPNPTPGRTYHRAASTLQDLLELPRDISRSLDKLARGQLTTIFVHRGLETLYH
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
RLDMVSARLSAALIVAALIGAGALILHAGAGPKTGGLSLLGLGVLGGALILGCLWALLLK
HHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VGQKE
HCCCC
>Mature Secondary Structure 
TRHYRYLQRYTEVATVLLRHGWQAYCETRPRRAPARRPLVTGREPGDPVYRHLRLAFEE
CCHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
LGPVFIKLGQLLSTRPDLIPTEMAAEFSYLQDRVRPLAPDVIRQQVFRELGTAPEKAFSY
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHH
FDYQPLAAASIAQVHKARLPGGQEVAVKVQRPQLDGVVVTDLAVLENLGRRFKGTVVGRI
CCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
CALEEILATFRRQIERELDFTVEALAMENFRRLYREFPQIVVPRVYWDYTTRGLLTMDYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHH
AGKRLSDWYGKGTDCQRAALLIKALLAPFFQEGIFHGDPHPGNILFLPGGRLGLIDFGIV
CCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCEEEEEHHHH
GRLDEDYRYQAARLILGLQERDLQAVMEVTLKLGKPMAAVDYQALYEDTAELVDRVTGMG
CCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCC
KGDVNLAGLLLGMVELARRHSIRMPGTFFVLGRTIMEGESLARRLDPSLDLVQVSGPLAA
CCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHH
SYLRSRLRPNPTPGRTYHRAASTLQDLLELPRDISRSLDKLARGQLTTIFVHRGLETLYH
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
RLDMVSARLSAALIVAALIGAGALILHAGAGPKTGGLSLLGLGVLGGALILGCLWALLLK
HHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VGQKE
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]