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The map label for this gene is pyrG

Identifier: 83591225

GI number: 83591225

Start: 2528723

End: 2530336

Strand: Reverse

Name: pyrG

Synonym: Moth_2409

Alternate gene names: 83591225

Gene position: 2530336-2528723 (Counterclockwise)

Preceding gene: 83591226

Following gene: 83591224

Centisome position: 96.25

GC content: 57.62

Gene sequence:

>1614_bases
ATGCCTGCCAAATTTATTTTTGTTACCGGCGGTGTCACTTCTTCCCTGGGGAAGGGGATAACCGCCGCTTCTTTAGGTAG
ACTTCTAAAAAGCCGAGGCCTCAAAGTAGCCATCCAGAAGTTCGACCCCTATATCAATATCGACCCCGGCACCATGAGCC
CGTACCAGCATGGCGAGGTCTTCGTCACCGATGACGGCGCCGAAACTGATCTGGACCTGGGCCATTACGAGCGCTTTATC
GACATTAGCCTTACCAAGGCCAGCAACGTCACCGCCGGCAAGGTATACTGGTCCGTCATCACGAAAGAACGGCGCGGCGA
TTTCCTCGGCGGTACAGTCCAGGTCATACCCCACATCACCAATGAGATCAAGGCCCGCCTCCTCCGGGTGGCCGAGGAGA
GCGACCCGGACGTTGTCATTACCGAGATTGGCGGTACTGTGGGGGATATCGAATCTCTGCCTTTCCTGGAAGCCATCCGC
CAGATGAAGAGCGATATCGGCCGCGATCGTGTCCTCTATATCCATGTCACCCTGGTTCCCTACCTGCGGGCTGCCGGCGA
AGCCAAAACCAAACCTACCCAGCACAGCGTCAAAGAGTTACGCAGCATTGGCATCCAGCCGGATATCATCGTCTGCCGGA
CTGAACGTCCCTTCTCCCGGGAAATGGAAGAAAAAATAGCTCTCTTTTGCGATATTGACCCCGATGCCGTCATCCAGGCC
TGGGATGCCGATTCCATCTATGAGGTCCCCCTGATGATGCAAGAGGAAGGCCTGGACAGCATCGTCGTCGAGCGGCTGAA
GTTAAACTGCGGTCCTGCTCAAATGGACGATTGGCGGGCCATGGTAGCAAAGTTAAAGAATATCACCAGGCACCTGGAGA
TCGCCCTGGTGGGCAAATACGTCACCCTGCCGGACGCCTATTTAAGCGTAGTAGAATCCCTGCGCCATGCCGGCATGTAT
CACAACGTCCAGGTGGATATTCGCTGGATTTATTCGGCTGACCTGGAGCGGGGGGGCCTTGAACAACTCCAGGATGTGGC
CGGCATCCTGGTACCCGGGGGCTTTGGCGACCGGGGGGTTGAAGGGAAGATCATAGCCGCCCGGTATGCCCGGGAGCATG
GTATACCCTTCCTGGGTATTTGCCTGGGGATGCAGCTGGCAGTGGTTGAGTTTGCCCGTCACGTCTGCGGACTGGAAGCG
GCCAACAGCTCGGAATTCAACCCGGAAACGCCCCACCCAGTCATCGACCTTTTGCCGGAGCAAAAGGAGATTGAAGATAA
GGGTGGTACCATGCGCCTGGGCCTCTATCCCTGCCGCTTACAGCCCGGTACCCGGGCCCACCAGGCCTATGGCGAAGAAA
TTATCTATGAACGCCATCGCCATCGCTATGAATTTAATAACAACTACCGGGCCGAACTGACGGCCAGGGGTATGGTTATC
AGCGGCACCTCCCCGGACGACCGCCTGGTTGAGATTATTGAGCTGGCGGATCACCCGTGGTTTGTGGCCTGCCAGTTCCA
TCCGGAATTCAAATCCCGGCCTAACCGGCCGCATCCCCTTTTCCGGGACTTCATCGGCGCCGCCTGCCGGCGGGCCGGGG
GGGGTGCAGGCTGA

Upstream 100 bases:

>100_bases
GGAGTCACCGCCCCGGAGAGGATGTAGCATAAAGCCCAATCAGGGCCCGGAGGGAACCTTCCCTTCCGGGATGCCAGTGA
AAGTAACACGGAGGATCACT

Downstream 100 bases:

>100_bases
TGGCCAGGGAGGCCAGACTTATCGGGCCCGAGGAAGAAAAGCGCTTCGATGCCTTTGTAGCCGGCCACCCCAAGGGGCAC
TTCCTGCAGTCCTATGGCTG

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase

Number of amino acids: Translated: 537; Mature: 536

Protein sequence:

>537_residues
MPAKFIFVTGGVTSSLGKGITAASLGRLLKSRGLKVAIQKFDPYINIDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFI
DISLTKASNVTAGKVYWSVITKERRGDFLGGTVQVIPHITNEIKARLLRVAEESDPDVVITEIGGTVGDIESLPFLEAIR
QMKSDIGRDRVLYIHVTLVPYLRAAGEAKTKPTQHSVKELRSIGIQPDIIVCRTERPFSREMEEKIALFCDIDPDAVIQA
WDADSIYEVPLMMQEEGLDSIVVERLKLNCGPAQMDDWRAMVAKLKNITRHLEIALVGKYVTLPDAYLSVVESLRHAGMY
HNVQVDIRWIYSADLERGGLEQLQDVAGILVPGGFGDRGVEGKIIAARYAREHGIPFLGICLGMQLAVVEFARHVCGLEA
ANSSEFNPETPHPVIDLLPEQKEIEDKGGTMRLGLYPCRLQPGTRAHQAYGEEIIYERHRHRYEFNNNYRAELTARGMVI
SGTSPDDRLVEIIELADHPWFVACQFHPEFKSRPNRPHPLFRDFIGAACRRAGGGAG

Sequences:

>Translated_537_residues
MPAKFIFVTGGVTSSLGKGITAASLGRLLKSRGLKVAIQKFDPYINIDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFI
DISLTKASNVTAGKVYWSVITKERRGDFLGGTVQVIPHITNEIKARLLRVAEESDPDVVITEIGGTVGDIESLPFLEAIR
QMKSDIGRDRVLYIHVTLVPYLRAAGEAKTKPTQHSVKELRSIGIQPDIIVCRTERPFSREMEEKIALFCDIDPDAVIQA
WDADSIYEVPLMMQEEGLDSIVVERLKLNCGPAQMDDWRAMVAKLKNITRHLEIALVGKYVTLPDAYLSVVESLRHAGMY
HNVQVDIRWIYSADLERGGLEQLQDVAGILVPGGFGDRGVEGKIIAARYAREHGIPFLGICLGMQLAVVEFARHVCGLEA
ANSSEFNPETPHPVIDLLPEQKEIEDKGGTMRLGLYPCRLQPGTRAHQAYGEEIIYERHRHRYEFNNNYRAELTARGMVI
SGTSPDDRLVEIIELADHPWFVACQFHPEFKSRPNRPHPLFRDFIGAACRRAGGGAG
>Mature_536_residues
PAKFIFVTGGVTSSLGKGITAASLGRLLKSRGLKVAIQKFDPYINIDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFID
ISLTKASNVTAGKVYWSVITKERRGDFLGGTVQVIPHITNEIKARLLRVAEESDPDVVITEIGGTVGDIESLPFLEAIRQ
MKSDIGRDRVLYIHVTLVPYLRAAGEAKTKPTQHSVKELRSIGIQPDIIVCRTERPFSREMEEKIALFCDIDPDAVIQAW
DADSIYEVPLMMQEEGLDSIVVERLKLNCGPAQMDDWRAMVAKLKNITRHLEIALVGKYVTLPDAYLSVVESLRHAGMYH
NVQVDIRWIYSADLERGGLEQLQDVAGILVPGGFGDRGVEGKIIAARYAREHGIPFLGICLGMQLAVVEFARHVCGLEAA
NSSEFNPETPHPVIDLLPEQKEIEDKGGTMRLGLYPCRLQPGTRAHQAYGEEIIYERHRHRYEFNNNYRAELTARGMVIS
GTSPDDRLVEIIELADHPWFVACQFHPEFKSRPNRPHPLFRDFIGAACRRAGGGAG

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI148491070, Length=550, Percent_Identity=47.8181818181818, Blast_Score=503, Evalue=1e-142,
Organism=Homo sapiens, GI28559085, Length=547, Percent_Identity=46.4351005484461, Blast_Score=493, Evalue=1e-139,
Organism=Homo sapiens, GI28559083, Length=547, Percent_Identity=46.4351005484461, Blast_Score=493, Evalue=1e-139,
Organism=Homo sapiens, GI221316689, Length=547, Percent_Identity=46.4351005484461, Blast_Score=493, Evalue=1e-139,
Organism=Escherichia coli, GI1789142, Length=538, Percent_Identity=56.3197026022305, Blast_Score=609, Evalue=1e-175,
Organism=Caenorhabditis elegans, GI25148299, Length=603, Percent_Identity=39.1376451077944, Blast_Score=429, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6322563, Length=560, Percent_Identity=45.3571428571429, Blast_Score=485, Evalue=1e-138,
Organism=Saccharomyces cerevisiae, GI6319432, Length=567, Percent_Identity=44.4444444444444, Blast_Score=478, Evalue=1e-135,
Organism=Drosophila melanogaster, GI24664469, Length=550, Percent_Identity=48.7272727272727, Blast_Score=507, Evalue=1e-144,
Organism=Drosophila melanogaster, GI21357815, Length=496, Percent_Identity=46.7741935483871, Blast_Score=435, Evalue=1e-122,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PYRG_MOOTA (Q2RFU8)

Other databases:

- EMBL:   CP000232
- RefSeq:   YP_431234.1
- HSSP:   P17812
- ProteinModelPortal:   Q2RFU8
- SMR:   Q2RFU8
- STRING:   Q2RFU8
- GeneID:   3830776
- GenomeReviews:   CP000232_GR
- KEGG:   mta:Moth_2409
- eggNOG:   COG0504
- HOGENOM:   HBG597806
- OMA:   RVTMQKL
- PhylomeDB:   Q2RFU8
- ProtClustDB:   PRK05380
- BioCyc:   MTHE264732:MOTH_2409-MONOMER
- HAMAP:   MF_01227
- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991
- TIGRFAMs:   TIGR00337

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase

EC number: =6.3.4.2

Molecular weight: Translated: 59781; Mature: 59650

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 381-381 ACT_SITE 507-507 ACT_SITE 509-509

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAKFIFVTGGVTSSLGKGITAASLGRLLKSRGLKVAIQKFDPYINIDPGTMSPYQHGEV
CCCEEEEEECCCHHHHCCCCHHHHHHHHHHHCCCEEEEEECCCEEEECCCCCCCCCCCEE
FVTDDGAETDLDLGHYERFIDISLTKASNVTAGKVYWSVITKERRGDFLGGTVQVIPHIT
EEECCCCCCCCCHHHHHEEEEEEEECCCCCCCHHEEEEEHHHHHCCCCCCCHHEEHHHHH
NEIKARLLRVAEESDPDVVITEIGGTVGDIESLPFLEAIRQMKSDIGRDRVLYIHVTLVP
HHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEEHHH
YLRAAGEAKTKPTQHSVKELRSIGIQPDIIVCRTERPFSREMEEKIALFCDIDPDAVIQA
HHHHCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHCCEEEEEECCHHHHEEE
WDADSIYEVPLMMQEEGLDSIVVERLKLNCGPAQMDDWRAMVAKLKNITRHLEIALVGKY
CCCCCEEECCCHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHEEEEEEECE
VTLPDAYLSVVESLRHAGMYHNVQVDIRWIYSADLERGGLEQLQDVAGILVPGGFGDRGV
EECCHHHHHHHHHHHHCCCEEEEEEEEEEEEECCCCCCCHHHHHHHHCEEECCCCCCCCC
EGKIIAARYAREHGIPFLGICLGMQLAVVEFARHVCGLEAANSSEFNPETPHPVIDLLPE
CCCEEEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCC
QKEIEDKGGTMRLGLYPCRLQPGTRAHQAYGEEIIYERHRHRYEFNNNYRAELTARGMVI
HHHHHCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCEEE
SGTSPDDRLVEIIELADHPWFVACQFHPEFKSRPNRPHPLFRDFIGAACRRAGGGAG
ECCCCHHHHHHHHHHCCCCEEEEEEECCHHHCCCCCCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PAKFIFVTGGVTSSLGKGITAASLGRLLKSRGLKVAIQKFDPYINIDPGTMSPYQHGEV
CCEEEEEECCCHHHHCCCCHHHHHHHHHHHCCCEEEEEECCCEEEECCCCCCCCCCCEE
FVTDDGAETDLDLGHYERFIDISLTKASNVTAGKVYWSVITKERRGDFLGGTVQVIPHIT
EEECCCCCCCCCHHHHHEEEEEEEECCCCCCCHHEEEEEHHHHHCCCCCCCHHEEHHHHH
NEIKARLLRVAEESDPDVVITEIGGTVGDIESLPFLEAIRQMKSDIGRDRVLYIHVTLVP
HHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEEHHH
YLRAAGEAKTKPTQHSVKELRSIGIQPDIIVCRTERPFSREMEEKIALFCDIDPDAVIQA
HHHHCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHCCEEEEEECCHHHHEEE
WDADSIYEVPLMMQEEGLDSIVVERLKLNCGPAQMDDWRAMVAKLKNITRHLEIALVGKY
CCCCCEEECCCHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHEEEEEEECE
VTLPDAYLSVVESLRHAGMYHNVQVDIRWIYSADLERGGLEQLQDVAGILVPGGFGDRGV
EECCHHHHHHHHHHHHCCCEEEEEEEEEEEEECCCCCCCHHHHHHHHCEEECCCCCCCCC
EGKIIAARYAREHGIPFLGICLGMQLAVVEFARHVCGLEAANSSEFNPETPHPVIDLLPE
CCCEEEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCC
QKEIEDKGGTMRLGLYPCRLQPGTRAHQAYGEEIIYERHRHRYEFNNNYRAELTARGMVI
HHHHHCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCEEE
SGTSPDDRLVEIIELADHPWFVACQFHPEFKSRPNRPHPLFRDFIGAACRRAGGGAG
ECCCCHHHHHHHHHHCCCCEEEEEEECCHHHCCCCCCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA