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The map label for this gene is opuE [H]

Identifier: 83591100

GI number: 83591100

Start: 2388442

End: 2389956

Strand: Reverse

Name: opuE [H]

Synonym: Moth_2279

Alternate gene names: 83591100

Gene position: 2389956-2388442 (Counterclockwise)

Preceding gene: 83591101

Following gene: 83591099

Centisome position: 90.91

GC content: 55.64

Gene sequence:

>1515_bases
GTGAAGTTTTTTATTTTGGGCCTGTATTTTGCCGTGCTTTTGGCAATCGGTTTTTATAGCTTGAAGAAATCGCGGGATGT
CGGCGGCTTTTTCCTGGGTAATCGTACCGTGGGCCCCTGGGTATCGGCCTTTGCTTACGGGACGACTTACTTTTCCGCCG
TTATTTTTATAGGTTATGCCGGTAAAGTGGGGTGGGGTTTCGGCCTGTCCGACCTGTGGATCGTCATCGGTAACGCCTTC
ATCGGCAGTTTCCTGGCCTGGAAGGTCCTGGCGCGGCCGACCAGGGAAATGACGGTTCGCTTGAAGGCCATGACCATGCC
CGAGTTCCTGGCCGCACGTTACGACAGCCCGGCTTTACGAACGTTGGGGGCGCTGGTAATCTTTATTTTCCTGGTACCGT
ATTCGGCTTCGGTTTATATGGGTTTGAGTTACCTCTTCGAGCAGGTTTTCCGCATTAACTTTACCACAGCCCTCATTGCC
ATGGCTGCCTTTACGGCCCTTTATCTGGTCCTGGGCGGCTACATTGCCGTTACCCTGACTGATTTCATCCAGGGTTTGAT
TATGATTGGCGGCGTTGTGGTCCTGATATATTATGTTATATCTGCGCCGCCTGTGGGCGGGCTGGCTGGCGGCATCAGCC
GCCTGGCGGCCATCGACCCGCGCCTGGTTAACCCGTTGGGCCCCAACTGGTTCGCCCTCCTTTCCCTGGTAGTGCTCACC
AGCCTGGGACCCTGGGGCCTGCCCCAGATGGTACAGAAGTTTTACGCTATTAAAGATGAAGGTTCCATCTGGCCGGCGAC
GGTGGTTTCGACCCTGTTCGCCCTGATTATAGCTACCGGTGCATATTTCACCGGCGCCTTTGGCCGTCTCTTCTTCAACA
ACCAGATGCCCTTGCTTAACGGCCAACCTAACCCGGATCTCATTATGCCCCAGATTATCAATCATTATCTGCCGCCCTGG
ATAGGCCTGCTCTTGTTGCTGCTGGTGCTGGCGGCCTCCATGTCTACCCTGGCTTCCCTGGTACTGGTATCGAGTTCCGC
GGTGGCTATTGACCTGGTCCAGGGCGGAGCTCCTGGGGTTTCCCGCCGTATAATCCTGGCCCTGCTGCGTTTCCTGTGTT
TCTTCTTTATTGGCCTTTCGGTCTATATTGCCCTGAAGCCCACTATTATCCTGGTCCTCATGTCCCTCTCCTGGGGCACG
GTGGCCGGAGCCTTCCTGGCCCCTTATATCTACGGCCTGTACTGGCCCCGGACCACTAAAGCCGGGGCCTGGGCGGGGCT
CCTGAGCGGGCTGGCTATATCCCTGGGCCTGTCCTTTTACTACCACCTGGATGGCAGCGTCATCCCGACGATAGGCTCCC
TGGCCATGGTTATCCCTCTGGGAGTGGTTCCCATGGTGAGCCTCGTCACGCCGGCCTTTTCCAGGGAACATCTAGCTAAA
GTTTTTGGTGCTGATAGGACAACTACTACGGCAACTAAAGGATTGGTGACTGATGATCTGGGATTCGGAAAATGA

Upstream 100 bases:

>100_bases
AAAACGATTAAAGAAACTTAACTGGCCCGGCAGGATTCTACCCTTTGATGTGGAATAAGAAAACCAATTAAACTTCAAGG
CAGGACGGGAGGATGGCAGG

Downstream 100 bases:

>100_bases
ATGCCGCCCCCGGGCGGAGATCGAGGCCCTGCAACTGGCGCGCCTCCAGGAGACGGTGGCCAGGGCCTACGAGAGGGTAC
CCTTTTATCGCCAGGCCATG

Product: SSS family solute/sodium (Na+) symporter

Products: NA

Alternate protein names: Sodium/proline symporter [H]

Number of amino acids: Translated: 504; Mature: 504

Protein sequence:

>504_residues
MKFFILGLYFAVLLAIGFYSLKKSRDVGGFFLGNRTVGPWVSAFAYGTTYFSAVIFIGYAGKVGWGFGLSDLWIVIGNAF
IGSFLAWKVLARPTREMTVRLKAMTMPEFLAARYDSPALRTLGALVIFIFLVPYSASVYMGLSYLFEQVFRINFTTALIA
MAAFTALYLVLGGYIAVTLTDFIQGLIMIGGVVVLIYYVISAPPVGGLAGGISRLAAIDPRLVNPLGPNWFALLSLVVLT
SLGPWGLPQMVQKFYAIKDEGSIWPATVVSTLFALIIATGAYFTGAFGRLFFNNQMPLLNGQPNPDLIMPQIINHYLPPW
IGLLLLLLVLAASMSTLASLVLVSSSAVAIDLVQGGAPGVSRRIILALLRFLCFFFIGLSVYIALKPTIILVLMSLSWGT
VAGAFLAPYIYGLYWPRTTKAGAWAGLLSGLAISLGLSFYYHLDGSVIPTIGSLAMVIPLGVVPMVSLVTPAFSREHLAK
VFGADRTTTTATKGLVTDDLGFGK

Sequences:

>Translated_504_residues
MKFFILGLYFAVLLAIGFYSLKKSRDVGGFFLGNRTVGPWVSAFAYGTTYFSAVIFIGYAGKVGWGFGLSDLWIVIGNAF
IGSFLAWKVLARPTREMTVRLKAMTMPEFLAARYDSPALRTLGALVIFIFLVPYSASVYMGLSYLFEQVFRINFTTALIA
MAAFTALYLVLGGYIAVTLTDFIQGLIMIGGVVVLIYYVISAPPVGGLAGGISRLAAIDPRLVNPLGPNWFALLSLVVLT
SLGPWGLPQMVQKFYAIKDEGSIWPATVVSTLFALIIATGAYFTGAFGRLFFNNQMPLLNGQPNPDLIMPQIINHYLPPW
IGLLLLLLVLAASMSTLASLVLVSSSAVAIDLVQGGAPGVSRRIILALLRFLCFFFIGLSVYIALKPTIILVLMSLSWGT
VAGAFLAPYIYGLYWPRTTKAGAWAGLLSGLAISLGLSFYYHLDGSVIPTIGSLAMVIPLGVVPMVSLVTPAFSREHLAK
VFGADRTTTTATKGLVTDDLGFGK
>Mature_504_residues
MKFFILGLYFAVLLAIGFYSLKKSRDVGGFFLGNRTVGPWVSAFAYGTTYFSAVIFIGYAGKVGWGFGLSDLWIVIGNAF
IGSFLAWKVLARPTREMTVRLKAMTMPEFLAARYDSPALRTLGALVIFIFLVPYSASVYMGLSYLFEQVFRINFTTALIA
MAAFTALYLVLGGYIAVTLTDFIQGLIMIGGVVVLIYYVISAPPVGGLAGGISRLAAIDPRLVNPLGPNWFALLSLVVLT
SLGPWGLPQMVQKFYAIKDEGSIWPATVVSTLFALIIATGAYFTGAFGRLFFNNQMPLLNGQPNPDLIMPQIINHYLPPW
IGLLLLLLVLAASMSTLASLVLVSSSAVAIDLVQGGAPGVSRRIILALLRFLCFFFIGLSVYIALKPTIILVLMSLSWGT
VAGAFLAPYIYGLYWPRTTKAGAWAGLLSGLAISLGLSFYYHLDGSVIPTIGSLAMVIPLGVVPMVSLVTPAFSREHLAK
VFGADRTTTTATKGLVTDDLGFGK

Specific function: Catalyzes the sodium-dependent uptake of extracellular proline [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=442, Percent_Identity=27.8280542986425, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI17941285, Length=470, Percent_Identity=26.1702127659574, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI110835708, Length=576, Percent_Identity=24.8263888888889, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI157671931, Length=463, Percent_Identity=23.7580993520518, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1787251, Length=426, Percent_Identity=31.2206572769953, Blast_Score=161, Evalue=9e-41,
Organism=Escherichia coli, GI87082237, Length=435, Percent_Identity=30.3448275862069, Blast_Score=140, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI115533094, Length=386, Percent_Identity=26.6839378238342, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011851
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 54288; Mature: 54288

Theoretical pI: Translated: 9.97; Mature: 9.97

Prosite motif: PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHCCCCCCCHHHCCCEECCCCCCC
>Mature Secondary Structure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HHCCCCCCCHHHCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969499; 9384377 [H]