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The map label for this gene is irlR [H]

Identifier: 83590975

GI number: 83590975

Start: 2254640

End: 2255461

Strand: Reverse

Name: irlR [H]

Synonym: Moth_2152

Alternate gene names: 83590975

Gene position: 2255461-2254640 (Counterclockwise)

Preceding gene: 83590978

Following gene: 83590974

Centisome position: 85.8

GC content: 59.12

Gene sequence:

>822_bases
GTGAAAACCTTGCTAGCCTTGCCGGAAAAGAGCGTCCTGCTGGTGGAAGACTCGACCCTCACCAGGTTTTCCTCCAGGAG
AACACTGGAGGAGAAGGGCTACCTGGTGGACGAAGCCGCCAGCGGCCAGGAGGCGCTGGTTAAGGCCAGGGGAAAAGGAG
AACCGTACGACTTGGTGATCCTCGACATCCACCTCCCGGGAATGGACGGCCTGGGAGTGCTAGAGAAACTTAAACGCCTG
CCGGAGTATCGCTACGTCCCGGTCATGGTGGTAACGGTCGAGAGCAACGCCGCCGTGGTCAAGAAGGCGATAGATCTGGG
GGCGGTGGAATACCTCTGCAAGCCCTACTCGGTAGAGGAGCTGGTGCGCCGCGTAGAGAAACTGATAGGTCCTGGCGCCA
GAGGAGAGGTTGCCCCCGCGGAGCTGCTGCACAAAGTACTCAGGAATGAGATCAACCGGGCGAACAGGGGCGGGCTAAAG
GTAGCCCTTGTTCTGGCCCGGTATGAAAGGTTGGGCAAGGGAAAGATTGGTGAATGCGCCAGGCAGGCGCGACGGCGCCT
GCGCGAGATAGACACCGTCATAGAGCTCAGTAAGAGCACGCTGGCGTTGATTCTCCCTCATACGGGGAAAGAAGGCGCGC
AGGTGGTGACAACGAAACTGGAAAGCTTCCTGCCCGGTACGTGGAGCTACGGGATTGCGGTATATCCCGACAACGGGAAG
GACGGGGAAGAGCTTTTCGCCTACGCCGAAGTTGCCCTTAAAGAGAGCTGGGAGAAAAAAGAGCCGGGTGCGCCAGCACA
GCAGCAGACCTCTGACACTTAG

Upstream 100 bases:

>100_bases
ATATTTCGGTCCGGCCTTTGTCCTTGGTTAAACAAAGGGAGAAAACTCTTTGATAAATTCGGAATAGATTCCGGAACCGA
AAACAGTCTCAAAGGGAGAG

Downstream 100 bases:

>100_bases
CACCCCAGGACTTATTTCGCAGTCCAGGCTCTCAGCCCCCGGTCAACGGCGCAGTGTTACAATTAAAGAGAGTTATGGAG
ATAGATACTTAAAAGCTGTA

Product: response regulator receiver modulated diguanylate cyclase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 273; Mature: 273

Protein sequence:

>273_residues
MKTLLALPEKSVLLVEDSTLTRFSSRRTLEEKGYLVDEAASGQEALVKARGKGEPYDLVILDIHLPGMDGLGVLEKLKRL
PEYRYVPVMVVTVESNAAVVKKAIDLGAVEYLCKPYSVEELVRRVEKLIGPGARGEVAPAELLHKVLRNEINRANRGGLK
VALVLARYERLGKGKIGECARQARRRLREIDTVIELSKSTLALILPHTGKEGAQVVTTKLESFLPGTWSYGIAVYPDNGK
DGEELFAYAEVALKESWEKKEPGAPAQQQTSDT

Sequences:

>Translated_273_residues
MKTLLALPEKSVLLVEDSTLTRFSSRRTLEEKGYLVDEAASGQEALVKARGKGEPYDLVILDIHLPGMDGLGVLEKLKRL
PEYRYVPVMVVTVESNAAVVKKAIDLGAVEYLCKPYSVEELVRRVEKLIGPGARGEVAPAELLHKVLRNEINRANRGGLK
VALVLARYERLGKGKIGECARQARRRLREIDTVIELSKSTLALILPHTGKEGAQVVTTKLESFLPGTWSYGIAVYPDNGK
DGEELFAYAEVALKESWEKKEPGAPAQQQTSDT
>Mature_273_residues
MKTLLALPEKSVLLVEDSTLTRFSSRRTLEEKGYLVDEAASGQEALVKARGKGEPYDLVILDIHLPGMDGLGVLEKLKRL
PEYRYVPVMVVTVESNAAVVKKAIDLGAVEYLCKPYSVEELVRRVEKLIGPGARGEVAPAELLHKVLRNEINRANRGGLK
VALVLARYERLGKGKIGECARQARRRLREIDTVIELSKSTLALILPHTGKEGAQVVTTKLESFLPGTWSYGIAVYPDNGK
DGEELFAYAEVALKESWEKKEPGAPAQQQTSDT

Specific function: Member of the two-component regulatory system irlR/irlS. May be involved in invasion of eukaryotic cells and heavy-metal resistance [H]

COG id: COG0784

COG function: function code T; FOG: CheY-like receiver

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI87082012, Length=114, Percent_Identity=36.8421052631579, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1789402, Length=121, Percent_Identity=36.3636363636364, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1790299, Length=118, Percent_Identity=33.0508474576271, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1786911, Length=115, Percent_Identity=38.2608695652174, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI48994928, Length=128, Percent_Identity=39.0625, Blast_Score=61, Evalue=8e-11,
Organism=Escherichia coli, GI1788191, Length=126, Percent_Identity=32.5396825396825, Blast_Score=61, Evalue=9e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 30078; Mature: 30078

Theoretical pI: Translated: 8.59; Mature: 8.59

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLLALPEKSVLLVEDSTLTRFSSRRTLEEKGYLVDEAASGQEALVKARGKGEPYDLVI
CCCCCCCCCCCEEEEECCHHHHHHHHCCHHHCCCEEECCCCCHHHHHHHCCCCCCEEEEE
LDIHLPGMDGLGVLEKLKRLPEYRYVPVMVVTVESNAAVVKKAIDLGAVEYLCKPYSVEE
EEEECCCCCCHHHHHHHHHCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCHHH
LVRRVEKLIGPGARGEVAPAELLHKVLRNEINRANRGGLKVALVLARYERLGKGKIGECA
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHH
RQARRRLREIDTVIELSKSTLALILPHTGKEGAQVVTTKLESFLPGTWSYGIAVYPDNGK
HHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCC
DGEELFAYAEVALKESWEKKEPGAPAQQQTSDT
CHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKTLLALPEKSVLLVEDSTLTRFSSRRTLEEKGYLVDEAASGQEALVKARGKGEPYDLVI
CCCCCCCCCCCEEEEECCHHHHHHHHCCHHHCCCEEECCCCCHHHHHHHCCCCCCEEEEE
LDIHLPGMDGLGVLEKLKRLPEYRYVPVMVVTVESNAAVVKKAIDLGAVEYLCKPYSVEE
EEEECCCCCCHHHHHHHHHCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCHHH
LVRRVEKLIGPGARGEVAPAELLHKVLRNEINRANRGGLKVALVLARYERLGKGKIGECA
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHH
RQARRRLREIDTVIELSKSTLALILPHTGKEGAQVVTTKLESFLPGTWSYGIAVYPDNGK
HHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCC
DGEELFAYAEVALKESWEKKEPGAPAQQQTSDT
CHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9393784 [H]