Click here to switch to the map view.

The map label for this gene is groL2

Identifier: 83590955

GI number: 83590955

Start: 2227221

End: 2228831

Strand: Reverse

Name: groL2

Synonym: Moth_2129

Alternate gene names: 83590955

Gene position: 2228831-2227221 (Counterclockwise)

Preceding gene: 83590956

Following gene: 83590954

Centisome position: 84.79

GC content: 60.71

Gene sequence:

>1611_bases
ATGGCCAAACAAGTAGTTTTCGACCGCGAAGCCAGGGAGGCCCTGGAAAAAGGTATTACCAAACTCACCGAAGCCGTCCG
GGTCACCCTGGGACCCCGGGGACGCAACGTGGTCTTGGAAAAGAAATTCGGGGCCCCTACCATTACCAACGACGGCGTGA
CCATTGCCAAGGAGGTTGAGCTGGAAGACCCCCTTGAGAATGTGGGCGCGCTGCTGGTGCGGGAAGTAGCCTCCAAGACC
AACGATGTCGCCGGCGATGGGACTACTACCGCCTGTGTTCTGGCCCAGGCTATTGTCCGGGAGGGCATGAAAAACGTGGC
CGCCGGGGCCAATCCTATGTTCATGAAGCGGGGTATTGAAAAGGCGGTGGCGGCCGTGGTGGAGAACCTTAAGGCCCAGG
CCCGGCCGGTGGAAACCAAGGACTCCATCAGCCAGGTAGCCTCCATTTCTGCCAATGACCCCCAGATCGGCGCCCTGGTG
GCCGACGCCATGGAAAAGGTGGGGAAGGACGGCGTCATAACCGTGGAGGAATCCAAAGGTATGGAAACCGCCGTGGACGT
CGTGGAAGGCATGCAGTTCGATCGCGGCTATATCTCTCCGTATATGGTCACCGACAACGAGCGCATGGAAGCCGTCCTGG
AAGAGCCCTACATCCTCATCACCGATAAAAAGATTACCGCCGTGGCCGACCTGGTACCCGTCCTGGAACGGGTAGTACGG
ACGGGTAAACCCCTGCTTATAATCTGCGAGGATATGGAGGGTGAAGCTCTGGCCACCCTGGTGGTCAATAAGATCCGGGG
CACCTTTACCTGCGTGGCCGTCAAGGCGCCGGCCTTCGGCGATCGGCGCAAGGCCATGCTACAGGACATCGCCATCCTGA
CGGGTGGCCAGGTTATTACCGAAGAAGCCGGCTTGAAACTGGAGAACACCACCCTGGATATGCTGGGCCAGGCGCGCCAG
GTCCGGGTGGGTAAAGAGGAAACCACCATCGTCGAAGGTCGCGGCAAAGAAGAGGCCATTGAAGCCCGGATAGCCCAGAT
TCGCCGCGAGTACGAGGAGTCGACCTCGGACTACGACCGGGAGAAACTCCAGGAACGCCTGGCCAAACTGGCCGGCGGTG
TGGCGGTCATTAAAGTCGGGGCCGCTACCGAGACGGAAATGAAAGAAAAGAAAATGCGCATCGAAGACGCCCTCGCAGCC
ACCCGGGCGGCGGTGGAGGAGGGCATTGTCCCCGGCGGCGGCACCGCCCTGGTACGCGCCCAGACGGCCCTGGATGGTGT
CCAGGCCCAGGGTGACGAACTGACGGGGGTGCGTCTGGTCTACCGCGCCCTGGAAGAACCCATGCGCCAGATTGCGGCCA
ATGCCGGCGTTGATGGATCGGTGGTAGTGGAGAAGGTGCGCCAGAGCGGTGACAGCATGGGCTTTAACGCCGCTACCCGG
GAGTATGTCAACCTCTTTGAAGCGGGTATTGTCGATCCCTTGAAGGTGACCCGTTCCGCCCTGGAGAATGCTGCCAGCAT
TGCCTCCCTGGTCCTGACCACTGAGAGTCTAATAGCCGACATTCCGGAGGAAGAACCGCCCGTTCCCGGCGGCGGTATGC
CTCCCATGTAA

Upstream 100 bases:

>100_bases
CCGGTATGCCGGCACCGAACTAAAACAGGGCGACACCAAATACCTGGTCCTCAGCGAGCGCGATATCCTGGCGGTAGTTG
AATAGGGAGGGAGATACATA

Downstream 100 bases:

>100_bases
AGGCGAGAAAATCAACAAGCCCCGGCGTTTTTTAAACGCGGGGGCTTTTTCTTGCAGGAAAAGGGATTTTGGTGGCGAAT
ACAGAAAAGATTTTTGGTAA

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 2; Protein Cpn60 2

Number of amino acids: Translated: 536; Mature: 535

Protein sequence:

>536_residues
MAKQVVFDREAREALEKGITKLTEAVRVTLGPRGRNVVLEKKFGAPTITNDGVTIAKEVELEDPLENVGALLVREVASKT
NDVAGDGTTTACVLAQAIVREGMKNVAAGANPMFMKRGIEKAVAAVVENLKAQARPVETKDSISQVASISANDPQIGALV
ADAMEKVGKDGVITVEESKGMETAVDVVEGMQFDRGYISPYMVTDNERMEAVLEEPYILITDKKITAVADLVPVLERVVR
TGKPLLIICEDMEGEALATLVVNKIRGTFTCVAVKAPAFGDRRKAMLQDIAILTGGQVITEEAGLKLENTTLDMLGQARQ
VRVGKEETTIVEGRGKEEAIEARIAQIRREYEESTSDYDREKLQERLAKLAGGVAVIKVGAATETEMKEKKMRIEDALAA
TRAAVEEGIVPGGGTALVRAQTALDGVQAQGDELTGVRLVYRALEEPMRQIAANAGVDGSVVVEKVRQSGDSMGFNAATR
EYVNLFEAGIVDPLKVTRSALENAASIASLVLTTESLIADIPEEEPPVPGGGMPPM

Sequences:

>Translated_536_residues
MAKQVVFDREAREALEKGITKLTEAVRVTLGPRGRNVVLEKKFGAPTITNDGVTIAKEVELEDPLENVGALLVREVASKT
NDVAGDGTTTACVLAQAIVREGMKNVAAGANPMFMKRGIEKAVAAVVENLKAQARPVETKDSISQVASISANDPQIGALV
ADAMEKVGKDGVITVEESKGMETAVDVVEGMQFDRGYISPYMVTDNERMEAVLEEPYILITDKKITAVADLVPVLERVVR
TGKPLLIICEDMEGEALATLVVNKIRGTFTCVAVKAPAFGDRRKAMLQDIAILTGGQVITEEAGLKLENTTLDMLGQARQ
VRVGKEETTIVEGRGKEEAIEARIAQIRREYEESTSDYDREKLQERLAKLAGGVAVIKVGAATETEMKEKKMRIEDALAA
TRAAVEEGIVPGGGTALVRAQTALDGVQAQGDELTGVRLVYRALEEPMRQIAANAGVDGSVVVEKVRQSGDSMGFNAATR
EYVNLFEAGIVDPLKVTRSALENAASIASLVLTTESLIADIPEEEPPVPGGGMPPM
>Mature_535_residues
AKQVVFDREAREALEKGITKLTEAVRVTLGPRGRNVVLEKKFGAPTITNDGVTIAKEVELEDPLENVGALLVREVASKTN
DVAGDGTTTACVLAQAIVREGMKNVAAGANPMFMKRGIEKAVAAVVENLKAQARPVETKDSISQVASISANDPQIGALVA
DAMEKVGKDGVITVEESKGMETAVDVVEGMQFDRGYISPYMVTDNERMEAVLEEPYILITDKKITAVADLVPVLERVVRT
GKPLLIICEDMEGEALATLVVNKIRGTFTCVAVKAPAFGDRRKAMLQDIAILTGGQVITEEAGLKLENTTLDMLGQARQV
RVGKEETTIVEGRGKEEAIEARIAQIRREYEESTSDYDREKLQERLAKLAGGVAVIKVGAATETEMKEKKMRIEDALAAT
RAAVEEGIVPGGGTALVRAQTALDGVQAQGDELTGVRLVYRALEEPMRQIAANAGVDGSVVVEKVRQSGDSMGFNAATRE
YVNLFEAGIVDPLKVTRSALENAASIASLVLTTESLIADIPEEEPPVPGGGMPPM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=527, Percent_Identity=48.1973434535104, Blast_Score=493, Evalue=1e-139,
Organism=Homo sapiens, GI31542947, Length=527, Percent_Identity=48.1973434535104, Blast_Score=493, Evalue=1e-139,
Organism=Homo sapiens, GI38455427, Length=543, Percent_Identity=23.9410681399632, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1790586, Length=526, Percent_Identity=60.4562737642585, Blast_Score=625, Evalue=1e-180,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=47.8260869565217, Blast_Score=491, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI193210679, Length=210, Percent_Identity=50, Blast_Score=203, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6323288, Length=524, Percent_Identity=51.7175572519084, Blast_Score=513, Evalue=1e-146,
Organism=Saccharomyces cerevisiae, GI6322524, Length=523, Percent_Identity=23.1357552581262, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=49.5256166982922, Blast_Score=507, Evalue=1e-144,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=49.5256166982922, Blast_Score=507, Evalue=1e-144,
Organism=Drosophila melanogaster, GI45550936, Length=527, Percent_Identity=46.8690702087287, Blast_Score=476, Evalue=1e-134,
Organism=Drosophila melanogaster, GI45550132, Length=527, Percent_Identity=46.8690702087287, Blast_Score=476, Evalue=1e-134,
Organism=Drosophila melanogaster, GI45550935, Length=527, Percent_Identity=46.8690702087287, Blast_Score=476, Evalue=1e-134,
Organism=Drosophila melanogaster, GI17864606, Length=523, Percent_Identity=42.6386233269598, Blast_Score=412, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24584129, Length=534, Percent_Identity=35.5805243445693, Blast_Score=294, Evalue=1e-79,
Organism=Drosophila melanogaster, GI19921262, Length=534, Percent_Identity=35.5805243445693, Blast_Score=294, Evalue=1e-79,
Organism=Drosophila melanogaster, GI24583944, Length=168, Percent_Identity=29.7619047619048, Blast_Score=70, Evalue=5e-12,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH602_MOOTA (Q2RGL8)

Other databases:

- EMBL:   CP000232
- RefSeq:   YP_430964.1
- HSSP:   P0A6F5
- ProteinModelPortal:   Q2RGL8
- SMR:   Q2RGL8
- STRING:   Q2RGL8
- GeneID:   3833280
- GenomeReviews:   CP000232_GR
- KEGG:   mta:Moth_2129
- NMPDR:   fig|264732.9.peg.2151
- eggNOG:   COG0459
- HOGENOM:   HBG625289
- OMA:   KPFNDGF
- BioCyc:   MTHE264732:MOTH_2129-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 57295; Mature: 57164

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKQVVFDREAREALEKGITKLTEAVRVTLGPRGRNVVLEKKFGAPTITNDGVTIAKEVE
CCCCHHCCHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEEECCCCCCCCCCCCEEEEECC
LEDPLENVGALLVREVASKTNDVAGDGTTTACVLAQAIVREGMKNVAAGANPMFMKRGIE
CCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
KAVAAVVENLKAQARPVETKDSISQVASISANDPQIGALVADAMEKVGKDGVITVEESKG
HHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCC
METAVDVVEGMQFDRGYISPYMVTDNERMEAVLEEPYILITDKKITAVADLVPVLERVVR
HHHHHHHHHCCCCCCCCCCCEEECCCHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHH
TGKPLLIICEDMEGEALATLVVNKIRGTFTCVAVKAPAFGDRRKAMLQDIAILTGGQVIT
CCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCEEEE
EEAGLKLENTTLDMLGQARQVRVGKEETTIVEGRGKEEAIEARIAQIRREYEESTSDYDR
CCCCCEECCCHHHHHCCHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHCCCHHHH
EKLQERLAKLAGGVAVIKVGAATETEMKEKKMRIEDALAATRAAVEEGIVPGGGTALVRA
HHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEH
QTALDGVQAQGDELTGVRLVYRALEEPMRQIAANAGVDGSVVVEKVRQSGDSMGFNAATR
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHH
EYVNLFEAGIVDPLKVTRSALENAASIASLVLTTESLIADIPEEEPPVPGGGMPPM
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AKQVVFDREAREALEKGITKLTEAVRVTLGPRGRNVVLEKKFGAPTITNDGVTIAKEVE
CCCHHCCHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEEECCCCCCCCCCCCEEEEECC
LEDPLENVGALLVREVASKTNDVAGDGTTTACVLAQAIVREGMKNVAAGANPMFMKRGIE
CCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
KAVAAVVENLKAQARPVETKDSISQVASISANDPQIGALVADAMEKVGKDGVITVEESKG
HHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCC
METAVDVVEGMQFDRGYISPYMVTDNERMEAVLEEPYILITDKKITAVADLVPVLERVVR
HHHHHHHHHCCCCCCCCCCCEEECCCHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHH
TGKPLLIICEDMEGEALATLVVNKIRGTFTCVAVKAPAFGDRRKAMLQDIAILTGGQVIT
CCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCEEEE
EEAGLKLENTTLDMLGQARQVRVGKEETTIVEGRGKEEAIEARIAQIRREYEESTSDYDR
CCCCCEECCCHHHHHCCHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHCCCHHHH
EKLQERLAKLAGGVAVIKVGAATETEMKEKKMRIEDALAATRAAVEEGIVPGGGTALVRA
HHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEH
QTALDGVQAQGDELTGVRLVYRALEEPMRQIAANAGVDGSVVVEKVRQSGDSMGFNAATR
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHH
EYVNLFEAGIVDPLKVTRSALENAASIASLVLTTESLIADIPEEEPPVPGGGMPPM
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA