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The map label for this gene is cpx [H]

Identifier: 83590944

GI number: 83590944

Start: 2214131

End: 2215447

Strand: Reverse

Name: cpx [H]

Synonym: Moth_2118

Alternate gene names: 83590944

Gene position: 2215447-2214131 (Counterclockwise)

Preceding gene: 83590945

Following gene: 83590943

Centisome position: 84.28

GC content: 44.34

Gene sequence:

>1317_bases
ATGAAGAGGGGGAAAACGGTGAGTAGTCGTTTTATTGGTGTGGACGAAAAACCTGCCCTCCCATACTTAATTATGTATGG
GATCCAGCATGTCCTGGCTATGTTTGCCGGTATCGTAGCTGTACCCCTAATGGTTGGCACTGCATTAAAATTACCCGGCG
AACAGATTACTATTCTCGTTCAAGGTTCGCTTTTAACCAGTGGGATTGGGACATTAGTCCAATCCCTTGGTATTGGTAGG
CTGGGTGCTCGCCTCCCTATATGTATGGGTACAGCATTTGTCTTTATATCGCCATTTATAAGCGTAGGTTCTCAATTGGG
TATCCAGGCTATTCTTGGAGCAGTTATTGTTGGTGGTATCGTTGAATTTGTTTTTAGCTTTTTCGTTTGGCGTATTCAGA
AATATGTACCTCCAGTTGTTACAGGGACCGTTGTTGTCTTGATTGGTATGGGATTGATGCCCCTAGGTTTTACTTGGCTA
GCAGGTGGGGAAAGCTCGCTGTTTGGTCAGCCAATAAGTTTTGCTATCGGTGGTTTAGTTTTAGTTATACTGATTTTGAT
TAACCAATTTACAAAAGGATTTTGGCCTTCTATATCTGTTGCTCTGGCCATTGTTGTAGGTTACCTGGCTGCTGGTATCG
CTGGTGTTTTGAATCTTGGGTTGGTCAAGGAGGCAACATGGTTTGCTATACCAAAAGTTTTTTCCTTTGGACTGCCAAAG
TTTTCGTTTCCTGCTATTTTAGCGGTTCTGGTAGCACAATTTGCCTCTATGCTGGAGACTATAGGGGATACTTATGCAAC
AGGCTTAGTAGCTCATAAGGAAATAGGTCGGCGCGAGTTATCCGGAGCAATCAGTGTTGACGGTTTGCTGTCATCAATTG
CAGTTTTATTCAATGGGTTATCAATCACTTCCTTTAGCCAGAACATTGGGGTCATAAGTATTACAGGAGTGGCCAGTCGC
TTTGCTGTAGCTGTCAGTGGCATTATATTATTGCTTATGGGCCTCGTACCAAAATTTGCGGCTCTGATTGCAAGTATGCC
CGCGCCAGTACTTGGTGGTGCTGCCCTGGTAATGTTTGGCGCAATTGCAGGATCAGGTATTTTACAGTTCCGCGAAGCAA
AAGTTTTTGGGGAACGGGAGATTTTCATTTTTGCTATCTCAGTTGCCCTGGGGATGGGTTTTGGGTTGCATCCAGAAGGT
GCACTAGAGCATTTACCATCTTACCTTACAGTTATCCTGGGATCCGGTGTTGCGGTAGGGGGGATAACGGCCATTATACT
TAATCAGCTATTGCCACTCAGACAGAAAGAAGAATAA

Upstream 100 bases:

>100_bases
ATTTACAAGTAGACACTCCTGCCGTTCAAATATCGTCAACGAAAGACTATACCATGTATACTCGCATTGCCATAATTACT
TGAATTAAGGTAATGAAATT

Downstream 100 bases:

>100_bases
AGAGATCCTCGCTATTTCGTGTGGGTAAACACTTGATTTTATAACTCTAATTGCGGCCTTTAATCGGAGCAAAGCGCAGA
ACCTTGACATGAAGAATGCC

Product: uracil-xanthine permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MKRGKTVSSRFIGVDEKPALPYLIMYGIQHVLAMFAGIVAVPLMVGTALKLPGEQITILVQGSLLTSGIGTLVQSLGIGR
LGARLPICMGTAFVFISPFISVGSQLGIQAILGAVIVGGIVEFVFSFFVWRIQKYVPPVVTGTVVVLIGMGLMPLGFTWL
AGGESSLFGQPISFAIGGLVLVILILINQFTKGFWPSISVALAIVVGYLAAGIAGVLNLGLVKEATWFAIPKVFSFGLPK
FSFPAILAVLVAQFASMLETIGDTYATGLVAHKEIGRRELSGAISVDGLLSSIAVLFNGLSITSFSQNIGVISITGVASR
FAVAVSGIILLLMGLVPKFAALIASMPAPVLGGAALVMFGAIAGSGILQFREAKVFGEREIFIFAISVALGMGFGLHPEG
ALEHLPSYLTVILGSGVAVGGITAIILNQLLPLRQKEE

Sequences:

>Translated_438_residues
MKRGKTVSSRFIGVDEKPALPYLIMYGIQHVLAMFAGIVAVPLMVGTALKLPGEQITILVQGSLLTSGIGTLVQSLGIGR
LGARLPICMGTAFVFISPFISVGSQLGIQAILGAVIVGGIVEFVFSFFVWRIQKYVPPVVTGTVVVLIGMGLMPLGFTWL
AGGESSLFGQPISFAIGGLVLVILILINQFTKGFWPSISVALAIVVGYLAAGIAGVLNLGLVKEATWFAIPKVFSFGLPK
FSFPAILAVLVAQFASMLETIGDTYATGLVAHKEIGRRELSGAISVDGLLSSIAVLFNGLSITSFSQNIGVISITGVASR
FAVAVSGIILLLMGLVPKFAALIASMPAPVLGGAALVMFGAIAGSGILQFREAKVFGEREIFIFAISVALGMGFGLHPEG
ALEHLPSYLTVILGSGVAVGGITAIILNQLLPLRQKEE
>Mature_438_residues
MKRGKTVSSRFIGVDEKPALPYLIMYGIQHVLAMFAGIVAVPLMVGTALKLPGEQITILVQGSLLTSGIGTLVQSLGIGR
LGARLPICMGTAFVFISPFISVGSQLGIQAILGAVIVGGIVEFVFSFFVWRIQKYVPPVVTGTVVVLIGMGLMPLGFTWL
AGGESSLFGQPISFAIGGLVLVILILINQFTKGFWPSISVALAIVVGYLAAGIAGVLNLGLVKEATWFAIPKVFSFGLPK
FSFPAILAVLVAQFASMLETIGDTYATGLVAHKEIGRRELSGAISVDGLLSSIAVLFNGLSITSFSQNIGVISITGVASR
FAVAVSGIILLLMGLVPKFAALIASMPAPVLGGAALVMFGAIAGSGILQFREAKVFGEREIFIFAISVALGMGFGLHPEG
ALEHLPSYLTVILGSGVAVGGITAIILNQLLPLRQKEE

Specific function: Unknown

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680148, Length=505, Percent_Identity=26.7326732673267, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI40316845, Length=505, Percent_Identity=26.7326732673267, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI44680145, Length=507, Percent_Identity=25.8382642998028, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI44680143, Length=227, Percent_Identity=33.4801762114537, Blast_Score=96, Evalue=7e-20,
Organism=Escherichia coli, GI87082181, Length=411, Percent_Identity=38.1995133819951, Blast_Score=257, Evalue=1e-69,
Organism=Escherichia coli, GI1790087, Length=454, Percent_Identity=31.9383259911894, Blast_Score=206, Evalue=2e-54,
Organism=Escherichia coli, GI87082178, Length=442, Percent_Identity=31.447963800905, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI1788843, Length=403, Percent_Identity=29.5285359801489, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI87081818, Length=417, Percent_Identity=29.4964028776978, Blast_Score=122, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17542262, Length=442, Percent_Identity=22.3981900452489, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17541904, Length=489, Percent_Identity=22.0858895705521, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17558856, Length=230, Percent_Identity=29.1304347826087, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71993493, Length=473, Percent_Identity=23.0443974630021, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17542260, Length=218, Percent_Identity=27.0642201834862, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI193206893, Length=298, Percent_Identity=23.8255033557047, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI21356175, Length=494, Percent_Identity=23.8866396761134, Blast_Score=96, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017588
- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 45600; Mature: 45600

Theoretical pI: Translated: 9.94; Mature: 9.94

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRGKTVSSRFIGVDEKPALPYLIMYGIQHVLAMFAGIVAVPLMVGTALKLPGEQITILV
CCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
QGSLLTSGIGTLVQSLGIGRLGARLPICMGTAFVFISPFISVGSQLGIQAILGAVIVGGI
ECCHHHHHHHHHHHHCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VEFVFSFFVWRIQKYVPPVVTGTVVVLIGMGLMPLGFTWLAGGESSLFGQPISFAIGGLV
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCHHHHCCEEECCCCCCCCCCCHHHHHHHHH
LVILILINQFTKGFWPSISVALAIVVGYLAAGIAGVLNLGLVKEATWFAIPKVFSFGLPK
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
FSFPAILAVLVAQFASMLETIGDTYATGLVAHKEIGRRELSGAISVDGLLSSIAVLFNGL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCC
SITSFSQNIGVISITGVASRFAVAVSGIILLLMGLVPKFAALIASMPAPVLGGAALVMFG
CEEECCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
AIAGSGILQFREAKVFGEREIFIFAISVALGMGFGLHPEGALEHLPSYLTVILGSGVAVG
HHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHH
GITAIILNQLLPLRQKEE
HHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKRGKTVSSRFIGVDEKPALPYLIMYGIQHVLAMFAGIVAVPLMVGTALKLPGEQITILV
CCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
QGSLLTSGIGTLVQSLGIGRLGARLPICMGTAFVFISPFISVGSQLGIQAILGAVIVGGI
ECCHHHHHHHHHHHHCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VEFVFSFFVWRIQKYVPPVVTGTVVVLIGMGLMPLGFTWLAGGESSLFGQPISFAIGGLV
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCHHHHCCEEECCCCCCCCCCCHHHHHHHHH
LVILILINQFTKGFWPSISVALAIVVGYLAAGIAGVLNLGLVKEATWFAIPKVFSFGLPK
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
FSFPAILAVLVAQFASMLETIGDTYATGLVAHKEIGRRELSGAISVDGLLSSIAVLFNGL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCC
SITSFSQNIGVISITGVASRFAVAVSGIILLLMGLVPKFAALIASMPAPVLGGAALVMFG
CEEECCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
AIAGSGILQFREAKVFGEREIFIFAISVALGMGFGLHPEGALEHLPSYLTVILGSGVAVG
HHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHH
GITAIILNQLLPLRQKEE
HHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11792842; 8162194 [H]