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The map label for this gene is fadH [C]

Identifier: 83590886

GI number: 83590886

Start: 2147795

End: 2149801

Strand: Reverse

Name: fadH [C]

Synonym: Moth_2056

Alternate gene names: 83590886

Gene position: 2149801-2147795 (Counterclockwise)

Preceding gene: 83590891

Following gene: 83590884

Centisome position: 81.78

GC content: 59.59

Gene sequence:

>2007_bases
GTGGTGGTAGCCTATACCAGACTTTTTGAGCCGATAAAGATCGGCAAGGTGGAGATTAAGAACAAGATTGCCATGGCCCC
CATGGGTGTCCTGGGCCTGGCCACCCAGGACGGCTGTTTCTCCAAGCGAGTGGTTGACTACTACGTGGAGAGGGCTAAAG
GCGGCACCGGGCTGATCATCACCAGCGTCACCAAAGTCGATAACGAAATCGAGAGGTTCAAAGCCGGTGCGGTGCCGGTG
GCCACGGCGAACCCCCTGCACTTTATCGCCACGGCGGGTGAATTGACGGAGCGGGTTCATGCCTATGGTACTAAGATTTT
TTTACAGTTAGGTATGGGCTTCGGCCGGGTGGCAGCGCCCATTCTCCTAGAAAGCCATCCTGTGGCGCCGTCAGCCCTCC
CTAACTTCTGGGATCCATCCATAACCTGCCGGGAGTTGACCACGGCGGAGGTCGAGACCCTGGTCCAGCGGGCAAGTGAA
GCGGCGGAGATCGCTGTGGAAGCCGGCTTTGACGGGGTGGAGATCCATGCCATGCACGAAGGCTACCTCCTCGACCAGTT
CACTATCGCCCTGTTTAACAGGAGGGGGGATAAATACGGCGGCGCTTTAGAGGACAGGCTGACCTTTCCCATTGAAATCG
TCCGCGCTATTAAAGACAGAGTGGGCAAAGATTTTCCCGTGGTGTTGCGTTTCAGTATCAAGAACTACATCAAGGACTGG
CGCCAGGGCGGTTTGCCCGGTGAGAACTTCCAGGAAAAGGGCCGGGACGTGGAAGAAGCCCTGGCGGCAGCAAAGATCCT
TGAAGGAGCGGGTTATGACGGCTTTGATGCCGATGCCGGCTCCTACGATGCCTGGTACTGGGCCCACCCGCCGGTTTACC
AGAAGCATGGCTGCTACTTGCCCCTCACTCAGAGGTTAAAGGAAGTGGTGAAGGTACCGGTGATCGTGGCCGGCAGGCTG
GAGATACCGGAGCTGGCAGAAGAGGCCCTGGTCAAGGGCCAGGCCGATATGATCGCCATCGGCCGCGGCCTTCTCACGGA
CCCTTATTGGGTTAACAAGGTCATGACCGGGAGGAGCAAGAATATCCGGCCCTGCATCGGTTGCCACGACGGTTGCCTGG
GACGGGGCTTCCTGGGCCGGCCCCTTTCCTGTACGGTGAACCCGGCCTGCGGCCGGGAAGAGGAGTACGCCATCGACCGG
GCGCCGGAAGCCAAACAGGTCATGGTTATCGGCGGCGGAGTGGCCGGTATGGAGGCGGCCCGGGTGGCCGCCTTGCGGGG
GCACAGGGTAAGCCTTTACGAGAAAAGCGACCGCCTGGGGGGCCATGTCGTCGAGGCTGCGGTACCGGATTTCAAGGCTG
ATGACGGACGCCTGCTGGAGTGGTACAAGACTGAACTCGGCGAGCTACAGGTGGAGATCCACCTGAACCAGGAGGTAACG
CCGGAGTTCGTAGAGGAGAAAAACCCTGATGTAGTCGTCGTGGCCACCGGTTCCACGCCGGCCATTCCCGATATACCGGG
CGTGAATAAAGATAAGGTGACAACGGTTTCCGACCTCCTCCTGGGTAAAAAGCAGGCCGGGGACAGGGTTGTTATTATCG
GCGGCGGGCTGGCCGGGTGTGAAACGGCCCTCTGGCTCGCCCAGCAGGGCAAGGACGTCACCATCATTGAGATCCTGGAT
GACCTGATGCGGGCCGGCATCCCCGTTCCCTATATGAACCGGATGATGCTCCTGGATTTGCTAAAAATGAACGGCGTCAA
ATGGCTGACTGAGACCAGCGTCCTGGAGGTAACCGACGACGGGGTGACCCTCATCGGTAAAACCTACCAGCGCAGCCCCC
TGCCGGCCGATACCGTTATCCTGGCTGTGGGCTTTGCCGCCGATCAGCGGCTCTATAACGCCTTGCGGGATAAAATCCCC
AACCTGTACCTCATCGGCGACTCCCGGGAGCCCCGGAATATCCTGGCGGCCATCTGGGAGGGTTATGAGGTAGGGCGAGG
GATTTAG

Upstream 100 bases:

>100_bases
AGCTGCGGGAATAAAAATATAAGGGTACTAATAATTGGCTGGTATTGGTGCACAATAAATTTAGTAAATACCTAATACCA
GGAAAAACGGGAGGTTAACT

Downstream 100 bases:

>100_bases
ATGGCGGAGAGCCCCGATTTCACCCTGCTAACCCCAGTCGCCGGCGCTAATAAAGGCATGGCGCCGCTATAGGTGTTTAA
CTGGAAAGAGGCCCCTGGCG

Product: NADH:flavin oxidoreductase/NADH oxidase

Products: trans-transtetradehydroacyl-CoA; NADPH [C]

Alternate protein names: NA

Number of amino acids: Translated: 668; Mature: 668

Protein sequence:

>668_residues
MVVAYTRLFEPIKIGKVEIKNKIAMAPMGVLGLATQDGCFSKRVVDYYVERAKGGTGLIITSVTKVDNEIERFKAGAVPV
ATANPLHFIATAGELTERVHAYGTKIFLQLGMGFGRVAAPILLESHPVAPSALPNFWDPSITCRELTTAEVETLVQRASE
AAEIAVEAGFDGVEIHAMHEGYLLDQFTIALFNRRGDKYGGALEDRLTFPIEIVRAIKDRVGKDFPVVLRFSIKNYIKDW
RQGGLPGENFQEKGRDVEEALAAAKILEGAGYDGFDADAGSYDAWYWAHPPVYQKHGCYLPLTQRLKEVVKVPVIVAGRL
EIPELAEEALVKGQADMIAIGRGLLTDPYWVNKVMTGRSKNIRPCIGCHDGCLGRGFLGRPLSCTVNPACGREEEYAIDR
APEAKQVMVIGGGVAGMEAARVAALRGHRVSLYEKSDRLGGHVVEAAVPDFKADDGRLLEWYKTELGELQVEIHLNQEVT
PEFVEEKNPDVVVVATGSTPAIPDIPGVNKDKVTTVSDLLLGKKQAGDRVVIIGGGLAGCETALWLAQQGKDVTIIEILD
DLMRAGIPVPYMNRMMLLDLLKMNGVKWLTETSVLEVTDDGVTLIGKTYQRSPLPADTVILAVGFAADQRLYNALRDKIP
NLYLIGDSREPRNILAAIWEGYEVGRGI

Sequences:

>Translated_668_residues
MVVAYTRLFEPIKIGKVEIKNKIAMAPMGVLGLATQDGCFSKRVVDYYVERAKGGTGLIITSVTKVDNEIERFKAGAVPV
ATANPLHFIATAGELTERVHAYGTKIFLQLGMGFGRVAAPILLESHPVAPSALPNFWDPSITCRELTTAEVETLVQRASE
AAEIAVEAGFDGVEIHAMHEGYLLDQFTIALFNRRGDKYGGALEDRLTFPIEIVRAIKDRVGKDFPVVLRFSIKNYIKDW
RQGGLPGENFQEKGRDVEEALAAAKILEGAGYDGFDADAGSYDAWYWAHPPVYQKHGCYLPLTQRLKEVVKVPVIVAGRL
EIPELAEEALVKGQADMIAIGRGLLTDPYWVNKVMTGRSKNIRPCIGCHDGCLGRGFLGRPLSCTVNPACGREEEYAIDR
APEAKQVMVIGGGVAGMEAARVAALRGHRVSLYEKSDRLGGHVVEAAVPDFKADDGRLLEWYKTELGELQVEIHLNQEVT
PEFVEEKNPDVVVVATGSTPAIPDIPGVNKDKVTTVSDLLLGKKQAGDRVVIIGGGLAGCETALWLAQQGKDVTIIEILD
DLMRAGIPVPYMNRMMLLDLLKMNGVKWLTETSVLEVTDDGVTLIGKTYQRSPLPADTVILAVGFAADQRLYNALRDKIP
NLYLIGDSREPRNILAAIWEGYEVGRGI
>Mature_668_residues
MVVAYTRLFEPIKIGKVEIKNKIAMAPMGVLGLATQDGCFSKRVVDYYVERAKGGTGLIITSVTKVDNEIERFKAGAVPV
ATANPLHFIATAGELTERVHAYGTKIFLQLGMGFGRVAAPILLESHPVAPSALPNFWDPSITCRELTTAEVETLVQRASE
AAEIAVEAGFDGVEIHAMHEGYLLDQFTIALFNRRGDKYGGALEDRLTFPIEIVRAIKDRVGKDFPVVLRFSIKNYIKDW
RQGGLPGENFQEKGRDVEEALAAAKILEGAGYDGFDADAGSYDAWYWAHPPVYQKHGCYLPLTQRLKEVVKVPVIVAGRL
EIPELAEEALVKGQADMIAIGRGLLTDPYWVNKVMTGRSKNIRPCIGCHDGCLGRGFLGRPLSCTVNPACGREEEYAIDR
APEAKQVMVIGGGVAGMEAARVAALRGHRVSLYEKSDRLGGHVVEAAVPDFKADDGRLLEWYKTELGELQVEIHLNQEVT
PEFVEEKNPDVVVVATGSTPAIPDIPGVNKDKVTTVSDLLLGKKQAGDRVVIIGGGLAGCETALWLAQQGKDVTIIEILD
DLMRAGIPVPYMNRMMLLDLLKMNGVKWLTETSVLEVTDDGVTLIGKTYQRSPLPADTVILAVGFAADQRLYNALRDKIP
NLYLIGDSREPRNILAAIWEGYEVGRGI

Specific function: Reduces a range of alternative electron acceptors [H]

COG id: COG1902

COG function: function code C; NADH:flavin oxidoreductases, Old Yellow Enzyme family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family [H]

Homologues:

Organism=Escherichia coli, GI1789463, Length=687, Percent_Identity=29.2576419213974, Blast_Score=267, Evalue=2e-72,
Organism=Escherichia coli, GI1787939, Length=377, Percent_Identity=29.4429708222812, Blast_Score=100, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17564188, Length=334, Percent_Identity=26.9461077844311, Blast_Score=97, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17559802, Length=258, Percent_Identity=27.906976744186, Blast_Score=95, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17565138, Length=343, Percent_Identity=26.530612244898, Blast_Score=90, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17540738, Length=330, Percent_Identity=26.3636363636364, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17559804, Length=351, Percent_Identity=25.3561253561254, Blast_Score=85, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17566914, Length=349, Percent_Identity=23.4957020057307, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI72001454, Length=343, Percent_Identity=24.4897959183673, Blast_Score=80, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6321973, Length=240, Percent_Identity=29.5833333333333, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6325086, Length=375, Percent_Identity=25.6, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013027
- InterPro:   IPR016040
- InterPro:   IPR001155
- InterPro:   IPR001327
- InterPro:   IPR000103 [H]

Pfam domain/function: PF00724 Oxidored_FMN; PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: 1.3.1.34 [C]

Molecular weight: Translated: 72960; Mature: 72960

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVAYTRLFEPIKIGKVEIKNKIAMAPMGVLGLATQDGCFSKRVVDYYVERAKGGTGLII
CEEEEHHHCCCHHCCEEEECCEEEECCCCCEEECCCCCCHHHHHHHHHHHHCCCCCEEEE
TSVTKVDNEIERFKAGAVPVATANPLHFIATAGELTERVHAYGTKIFLQLGMGFGRVAAP
EEHHHHHHHHHHHHCCCCCEECCCCEEEEEEHHHHHHHHHHHHHHEEEECCCCCCHHHHH
ILLESHPVAPSALPNFWDPSITCRELTTAEVETLVQRASEAAEIAVEAGFDGVEIHAMHE
HEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEEEC
GYLLDQFTIALFNRRGDKYGGALEDRLTFPIEIVRAIKDRVGKDFPVVLRFSIKNYIKDW
CEEHHHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHH
RQGGLPGENFQEKGRDVEEALAAAKILEGAGYDGFDADAGSYDAWYWAHPPVYQKHGCYL
HHCCCCCCCHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCC
PLTQRLKEVVKVPVIVAGRLEIPELAEEALVKGQADMIAIGRGLLTDPYWVNKVMTGRSK
HHHHHHHHHHHCCEEEECCCCCHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHCCCCC
NIRPCIGCHDGCLGRGFLGRPLSCTVNPACGREEEYAIDRAPEAKQVMVIGGGVAGMEAA
CCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHH
RVAALRGHRVSLYEKSDRLGGHVVEAAVPDFKADDGRLLEWYKTELGELQVEIHLNQEVT
HHHHHCCCEEEEEECCCCCCCEEEECCCCCCCCCCCCHHHHHHHCCCEEEEEEEECCCCC
PEFVEEKNPDVVVVATGSTPAIPDIPGVNKDKVTTVSDLLLGKKQAGDRVVIIGGGLAGC
HHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCHHH
ETALWLAQQGKDVTIIEILDDLMRAGIPVPYMNRMMLLDLLKMNGVKWLTETSVLEVTDD
HHHHHHHHCCCCEEHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEEECCEEEEEECC
GVTLIGKTYQRSPLPADTVILAVGFAADQRLYNALRDKIPNLYLIGDSREPRNILAAIWE
CEEEEECCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHC
GYEVGRGI
CHHHCCCC
>Mature Secondary Structure
MVVAYTRLFEPIKIGKVEIKNKIAMAPMGVLGLATQDGCFSKRVVDYYVERAKGGTGLII
CEEEEHHHCCCHHCCEEEECCEEEECCCCCEEECCCCCCHHHHHHHHHHHHCCCCCEEEE
TSVTKVDNEIERFKAGAVPVATANPLHFIATAGELTERVHAYGTKIFLQLGMGFGRVAAP
EEHHHHHHHHHHHHCCCCCEECCCCEEEEEEHHHHHHHHHHHHHHEEEECCCCCCHHHHH
ILLESHPVAPSALPNFWDPSITCRELTTAEVETLVQRASEAAEIAVEAGFDGVEIHAMHE
HEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEEEC
GYLLDQFTIALFNRRGDKYGGALEDRLTFPIEIVRAIKDRVGKDFPVVLRFSIKNYIKDW
CEEHHHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHH
RQGGLPGENFQEKGRDVEEALAAAKILEGAGYDGFDADAGSYDAWYWAHPPVYQKHGCYL
HHCCCCCCCHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCC
PLTQRLKEVVKVPVIVAGRLEIPELAEEALVKGQADMIAIGRGLLTDPYWVNKVMTGRSK
HHHHHHHHHHHCCEEEECCCCCHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHCCCCC
NIRPCIGCHDGCLGRGFLGRPLSCTVNPACGREEEYAIDRAPEAKQVMVIGGGVAGMEAA
CCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHH
RVAALRGHRVSLYEKSDRLGGHVVEAAVPDFKADDGRLLEWYKTELGELQVEIHLNQEVT
HHHHHCCCEEEEEECCCCCCCEEEECCCCCCCCCCCCHHHHHHHCCCEEEEEEEECCCCC
PEFVEEKNPDVVVVATGSTPAIPDIPGVNKDKVTTVSDLLLGKKQAGDRVVIIGGGLAGC
HHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCHHH
ETALWLAQQGKDVTIIEILDDLMRAGIPVPYMNRMMLLDLLKMNGVKWLTETSVLEVTDD
HHHHHHHHCCCCEEHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEEECCEEEEEECC
GVTLIGKTYQRSPLPADTVILAVGFAADQRLYNALRDKIPNLYLIGDSREPRNILAAIWE
CEEEEECCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHC
GYEVGRGI
CHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: FAD. [C]

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: transDidehydroacyl-CoA; NADP+ [C]

Specific reaction: transDidehydroacyl-CoA + NADP+ =trans-transtetradehydroacyl-CoA + NADPH [C]

General reaction: Redox reaction [C]

Inhibitor: Iodoacetic acid; N-Ethyl maleimide [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8357835 [H]