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The map label for this gene is purC [H]

Identifier: 83590881

GI number: 83590881

Start: 2142794

End: 2143528

Strand: Reverse

Name: purC [H]

Synonym: Moth_2051

Alternate gene names: 83590881

Gene position: 2143528-2142794 (Counterclockwise)

Preceding gene: 83590882

Following gene: 83590880

Centisome position: 81.54

GC content: 58.37

Gene sequence:

>735_bases
ATGCCTGTTAAAGGCGAACTACTGTATGAAGGTAAAGCCAAACGGGTTTACCGGACGGACGACCCCGACCATTACCTGGT
GGAATTCAAGGACGAGGCCACCGCTTTTGACGGCTTGAAAAAGGGCACCATAGCCCGCAAAGGGGAGATTAACACCCGGC
TATCGGCCCTGTTCTTTCAAATGCTGGCCGGCCGGGGTATCCCCACCCACTTTATCGAGCAGACCGGCCCCCGGGAGATG
CTGGTCCGAGCGGTAGACATTATCCCGGTGGAAGTGGTCGCCCGCAACATTGCCGCCGGCAGCCTGGCTAAACGCCTGGG
CCTGGCTGAGGGCGAGCCCCTCAAACGACCGGTCCTGGAGTTTTACTACAAATCCGACGAGCTCCACGACCCAATGATTA
ACAACTACCACATCGCCGCCCTGGAACTGGCCGCCGGCGACCAGGTAGAAGCAATGGAAGGTTACGCGTGGAAGGTAAAC
GAATTGCTGACGGAATTTTTAAAACCGGCCAACTTGGTCCTGGTGGACTTTAAGCTGGAGTTTGGCCTGCACCACGGCCA
GGTCCTTTTGGCGGACGAGATCTCCCCCGACACCTGCCGCTTCTGGGACAGCACCAGCGGAGAAAAGCTGGACAAGGACC
GCTTCCGCCGCGACCTGGGCGGGGTAGAAGACGCCTACGAGGAAGTTCTGCGCCGGGTGGAGAGATTGTGCCTGAACCTT
GAAAGTGTAGGCTGA

Upstream 100 bases:

>100_bases
CGAGAACCAACCGGAGGGCGGAGACTTACCCTCCCGCCTCCAGGAAGCCGACCAATAATTTCCTTATTTGGTATAGATTA
TTTCAAAGGAGAGGGATGAC

Downstream 100 bases:

>100_bases
GGCAAGGGGCTGGCAGATACAGGCGGAGGGTAGAACCTATTTTCAAAGGAGCGTCATCTATGTTACTGGCCAAGATTCAC
GTTACCTTAAAGCCAGGTGT

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 244; Mature: 243

Protein sequence:

>244_residues
MPVKGELLYEGKAKRVYRTDDPDHYLVEFKDEATAFDGLKKGTIARKGEINTRLSALFFQMLAGRGIPTHFIEQTGPREM
LVRAVDIIPVEVVARNIAAGSLAKRLGLAEGEPLKRPVLEFYYKSDELHDPMINNYHIAALELAAGDQVEAMEGYAWKVN
ELLTEFLKPANLVLVDFKLEFGLHHGQVLLADEISPDTCRFWDSTSGEKLDKDRFRRDLGGVEDAYEEVLRRVERLCLNL
ESVG

Sequences:

>Translated_244_residues
MPVKGELLYEGKAKRVYRTDDPDHYLVEFKDEATAFDGLKKGTIARKGEINTRLSALFFQMLAGRGIPTHFIEQTGPREM
LVRAVDIIPVEVVARNIAAGSLAKRLGLAEGEPLKRPVLEFYYKSDELHDPMINNYHIAALELAAGDQVEAMEGYAWKVN
ELLTEFLKPANLVLVDFKLEFGLHHGQVLLADEISPDTCRFWDSTSGEKLDKDRFRRDLGGVEDAYEEVLRRVERLCLNL
ESVG
>Mature_243_residues
PVKGELLYEGKAKRVYRTDDPDHYLVEFKDEATAFDGLKKGTIARKGEINTRLSALFFQMLAGRGIPTHFIEQTGPREML
VRAVDIIPVEVVARNIAAGSLAKRLGLAEGEPLKRPVLEFYYKSDELHDPMINNYHIAALELAAGDQVEAMEGYAWKVNE
LLTEFLKPANLVLVDFKLEFGLHHGQVLLADEISPDTCRFWDSTSGEKLDKDRFRRDLGGVEDAYEEVLRRVERLCLNLE
SVG

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Homo sapiens, GI119220557, Length=250, Percent_Identity=32.4, Blast_Score=118, Evalue=4e-27,
Organism=Homo sapiens, GI5453539, Length=250, Percent_Identity=32.4, Blast_Score=118, Evalue=4e-27,
Organism=Homo sapiens, GI119220559, Length=257, Percent_Identity=31.1284046692607, Blast_Score=110, Evalue=1e-24,
Organism=Escherichia coli, GI1788820, Length=226, Percent_Identity=44.2477876106195, Blast_Score=206, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17531275, Length=225, Percent_Identity=32, Blast_Score=103, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6319326, Length=255, Percent_Identity=26.6666666666667, Blast_Score=66, Evalue=6e-12,
Organism=Drosophila melanogaster, GI18860083, Length=237, Percent_Identity=31.2236286919831, Blast_Score=116, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24583917, Length=254, Percent_Identity=33.4645669291339, Blast_Score=112, Evalue=3e-25,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 27565; Mature: 27434

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS01057 SAICAR_SYNTHETASE_1 ; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVKGELLYEGKAKRVYRTDDPDHYLVEFKDEATAFDGLKKGTIARKGEINTRLSALFFQ
CCCCCCEEECCCCCEEEECCCCCEEEEEECCHHHHHHCHHCCCCCCCCCCHHHHHHHHHH
MLAGRGIPTHFIEQTGPREMLVRAVDIIPVEVVARNIAAGSLAKRLGLAEGEPLKRPVLE
HHHCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
FYYKSDELHDPMINNYHIAALELAAGDQVEAMEGYAWKVNELLTEFLKPANLVLVDFKLE
HHHCCCCCCCCCCCCEEEEEEEECCCCCHHHHCCCEEEHHHHHHHHCCCCCEEEEEEEEE
FGLHHGQVLLADEISPDTCRFWDSTSGEKLDKDRFRRDLGGVEDAYEEVLRRVERLCLNL
ECCCCCEEEEECCCCCCCEECCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
ESVG
HCCC
>Mature Secondary Structure 
PVKGELLYEGKAKRVYRTDDPDHYLVEFKDEATAFDGLKKGTIARKGEINTRLSALFFQ
CCCCCEEECCCCCEEEECCCCCEEEEEECCHHHHHHCHHCCCCCCCCCCHHHHHHHHHH
MLAGRGIPTHFIEQTGPREMLVRAVDIIPVEVVARNIAAGSLAKRLGLAEGEPLKRPVLE
HHHCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
FYYKSDELHDPMINNYHIAALELAAGDQVEAMEGYAWKVNELLTEFLKPANLVLVDFKLE
HHHCCCCCCCCCCCCEEEEEEEECCCCCHHHHCCCEEEHHHHHHHHCCCCCEEEEEEEEE
FGLHHGQVLLADEISPDTCRFWDSTSGEKLDKDRFRRDLGGVEDAYEEVLRRVERLCLNL
ECCCCCEEEEECCCCCCCEECCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
ESVG
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA