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The map label for this gene is mutM

Identifier: 83590674

GI number: 83590674

Start: 1896719

End: 1897543

Strand: Reverse

Name: mutM

Synonym: Moth_1840

Alternate gene names: 83590674

Gene position: 1897543-1896719 (Counterclockwise)

Preceding gene: 83590675

Following gene: 83590673

Centisome position: 72.18

GC content: 63.64

Gene sequence:

>825_bases
ATGCCCGAACTACCCGAAGTAGAAACCATTAAACGGACACTGACTCCCTGCTTACGGGAGCAAAAAATCGCCAGGGTGGA
GGTCTACCACCCTGGCGTTATTGCTGCCCCCGACCCGGAGACCTTCAGCCGGTTACTGGCCGGCAGGATTATTACCGGCC
TGGACCGGCGGGGCAAGTACCTACTGGTGCATCTTTCAGGAGAATACTGTTTGGTGGTTCACCTGCGCATGACCGGGCGC
CTGGTTTTTACTGAAGGGGCAGCCCCCCTGGCTCCCCATACCCACGTCGTTTTTAGCCTGGCTGGGGGACCTTCTTTACG
CTTTGTAGACACCCGCCGCTTCGGCCGTCTCTACCTGGCCGCGAAGGCGGAGGTAGAAACGCTGCCCGGCTTGCGGGACC
TGGGGCCGGAGCCCCTGGACCCGGCCTTTGACGCCCTGGCCCTGGCGGCTATTCTAGCCGGCCGGCGCAGGCCAATTAAA
CAGGTCCTCCTGGACCAGCGCCTGGTGGCCGGGATCGGCAATATCTATGCCGATGAGATGCTTTTTGCCGCCGGCATCGA
CCCCCGGCGCCCGGCGGCCTCCCTGAATCATGAGGAGGTGGCTCGCCTGCGCGGGGCTATGCAAAGGGTCCTGGAGCAGG
GGATTGCCAACCGTGGCACCTCAATCAGGGATTATGTTGACGGCAGCGGCCGCCAGGGGAGCAACCAGGAGCACCTCCAG
GTTTATGGCCGGACAGGCCGACCATGCCCCCGCTGCGGGCAACCCCTGGAGAGGGTGCGCCTCGGCGGCCGCAGCACCCA
TTTTTGCCCCCGCTGCCAGGTATAA

Upstream 100 bases:

>100_bases
ACCATGGAGCATACCCTGGAACTCCAGGTCCCCCTCCAGGTAGATTTAAAGGCCGGGCCCAACTGGTATGACCTGGAGCC
GTATAAGGAGTAAAAGGAAA

Downstream 100 bases:

>100_bases
CCCCTGGCAGTTGACCGGCGCCCGGGGAGACCTGCCCTGCTCCTGGTACAAGAAAAAGGGCAGGGGCCGTGGCCAGAACA
TGACAGGCACGAATCCCACC

Product: formamidopyrimidine-DNA glycosylase / DNA-(apurinic or apyrimidinic site) lyase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM

Number of amino acids: Translated: 274; Mature: 273

Protein sequence:

>274_residues
MPELPEVETIKRTLTPCLREQKIARVEVYHPGVIAAPDPETFSRLLAGRIITGLDRRGKYLLVHLSGEYCLVVHLRMTGR
LVFTEGAAPLAPHTHVVFSLAGGPSLRFVDTRRFGRLYLAAKAEVETLPGLRDLGPEPLDPAFDALALAAILAGRRRPIK
QVLLDQRLVAGIGNIYADEMLFAAGIDPRRPAASLNHEEVARLRGAMQRVLEQGIANRGTSIRDYVDGSGRQGSNQEHLQ
VYGRTGRPCPRCGQPLERVRLGGRSTHFCPRCQV

Sequences:

>Translated_274_residues
MPELPEVETIKRTLTPCLREQKIARVEVYHPGVIAAPDPETFSRLLAGRIITGLDRRGKYLLVHLSGEYCLVVHLRMTGR
LVFTEGAAPLAPHTHVVFSLAGGPSLRFVDTRRFGRLYLAAKAEVETLPGLRDLGPEPLDPAFDALALAAILAGRRRPIK
QVLLDQRLVAGIGNIYADEMLFAAGIDPRRPAASLNHEEVARLRGAMQRVLEQGIANRGTSIRDYVDGSGRQGSNQEHLQ
VYGRTGRPCPRCGQPLERVRLGGRSTHFCPRCQV
>Mature_273_residues
PELPEVETIKRTLTPCLREQKIARVEVYHPGVIAAPDPETFSRLLAGRIITGLDRRGKYLLVHLSGEYCLVVHLRMTGRL
VFTEGAAPLAPHTHVVFSLAGGPSLRFVDTRRFGRLYLAAKAEVETLPGLRDLGPEPLDPAFDALALAAILAGRRRPIKQ
VLLDQRLVAGIGNIYADEMLFAAGIDPRRPAASLNHEEVARLRGAMQRVLEQGIANRGTSIRDYVDGSGRQGSNQEHLQV
YGRTGRPCPRCGQPLERVRLGGRSTHFCPRCQV

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger

Homologues:

Organism=Escherichia coli, GI1790066, Length=273, Percent_Identity=39.9267399267399, Blast_Score=174, Evalue=4e-45,
Organism=Escherichia coli, GI1786932, Length=276, Percent_Identity=26.4492753623188, Blast_Score=94, Evalue=7e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FPG_MOOTA (Q2RHE9)

Other databases:

- EMBL:   CP000232
- RefSeq:   YP_430683.1
- HSSP:   P42371
- STRING:   Q2RHE9
- GeneID:   3831700
- GenomeReviews:   CP000232_GR
- KEGG:   mta:Moth_1840
- NMPDR:   fig|264732.9.peg.1845
- eggNOG:   COG0266
- HOGENOM:   HBG690070
- OMA:   RSTFYCA
- PhylomeDB:   Q2RHE9
- ProtClustDB:   CLSK843193
- BioCyc:   MTHE264732:MOTH_1840-MONOMER
- HAMAP:   MF_00103
- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663
- SMART:   SM00898
- TIGRFAMs:   TIGR00577

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS; SSF81624 Form_DNAglyc_cat; SSF46946 Ribosomal_H2TH

EC number: =3.2.2.23; =4.2.99.18

Molecular weight: Translated: 30189; Mature: 30058

Theoretical pI: Translated: 9.89; Mature: 9.89

Prosite motif: PS51068 FPG_CAT; PS01242 ZF_FPG_1; PS51066 ZF_FPG_2

Important sites: ACT_SITE 2-2 ACT_SITE 3-3 ACT_SITE 59-59 ACT_SITE 264-264 BINDING 93-93 BINDING 112-112 BINDING 155-155

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETIKRTLTPCLREQKIARVEVYHPGVIAAPDPETFSRLLAGRIITGLDRRGKY
CCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCEEECCCHHHHHHHHHHHHHHCCCCCCCE
LLVHLSGEYCLVVHLRMTGRLVFTEGAAPLAPHTHVVFSLAGGPSLRFVDTRRFGRLYLA
EEEEECCCEEEEEEEEECCEEEEECCCCCCCCCCEEEEEECCCCCEEEEECCCCCEEEEE
AKAEVETLPGLRDLGPEPLDPAFDALALAAILAGRRRPIKQVLLDQRLVAGIGNIYADEM
ECCCHHHCCCHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
LFAAGIDPRRPAASLNHEEVARLRGAMQRVLEQGIANRGTSIRDYVDGSGRQGSNQEHLQ
HHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCEE
VYGRTGRPCPRCGQPLERVRLGGRSTHFCPRCQV
EECCCCCCCCHHCCHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
PELPEVETIKRTLTPCLREQKIARVEVYHPGVIAAPDPETFSRLLAGRIITGLDRRGKY
CCCCHHHHHHHHHHHHHHHCCCCEEEEECCCEEECCCHHHHHHHHHHHHHHCCCCCCCE
LLVHLSGEYCLVVHLRMTGRLVFTEGAAPLAPHTHVVFSLAGGPSLRFVDTRRFGRLYLA
EEEEECCCEEEEEEEEECCEEEEECCCCCCCCCCEEEEEECCCCCEEEEECCCCCEEEEE
AKAEVETLPGLRDLGPEPLDPAFDALALAAILAGRRRPIKQVLLDQRLVAGIGNIYADEM
ECCCHHHCCCHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
LFAAGIDPRRPAASLNHEEVARLRGAMQRVLEQGIANRGTSIRDYVDGSGRQGSNQEHLQ
HHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCEE
VYGRTGRPCPRCGQPLERVRLGGRSTHFCPRCQV
EECCCCCCCCHHCCHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA