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The map label for this gene is thrS

Identifier: 83590594

GI number: 83590594

Start: 1812365

End: 1814266

Strand: Reverse

Name: thrS

Synonym: Moth_1759

Alternate gene names: 83590594

Gene position: 1814266-1812365 (Counterclockwise)

Preceding gene: 83590595

Following gene: 83590593

Centisome position: 69.02

GC content: 60.09

Gene sequence:

>1902_bases
ATGCGCATAACTCTACCTGACGGTACAGTAAAGGAGTATGCCCCCGGCACCACAGCCCTGCAGGTTGCCAGGGATATTTC
CCCCAGGTTGGCCCGGGAGGCCCTGGCGGCGCGGGTCAATGGAGAGGTCTGGGATCTGACCCGTCCCCTGCCGGAGGAGT
GCCAGCTGGAACTCCTGACCTTTGCCGACGAAGGCGGGCGTCTCGCCTACCGCCACACGGCGGCCCACGTTCTGGCCCAG
GCTGTCAAGCACCTTTTCCCGGGTACTGAACTGGGCATCGGGCCGGCTATAACCGACGGGTTTTATTACGACTTTGACAG
TGAGCATAAATTCACCCCTGAAGACCTGACGGCCCTTGAGGCTGAGATGCAGAGGATTATCAAGGCCGACCTGCCCCTGG
AACGGCGGGAGGTGAGCCGGGAGGAAGCCCTGGAGCTATTCCGGCGGCTGGGCGAGCCTTATAAGGTTGAGCTTATTAAC
GACCTGCCGGAGGGGGTGCCCATCAGCACCTACCGCCAGGGTGACTTCATCGACCTTTGCGCCGGCCCCCACCTCCCCAG
CACCGGTTACCTGAAGGCTGTAAAGCTTACCAGCCTGGCCGGGGCCTACTGGCGTGGCAGCGAAAGAAATCCCATGCTCC
AACGCATTTACGGTACCGCCTTCCCTAAAGCAAAAGACCTGGAGGAGTACCTGCACCGTCTGGAAGAGGCCCGCAAGAGG
GACCACCGCCGCCTGGGAGCCCAGCTGGGGATCTTCAGCCTCCATGAGGAAGGTCCAGGCTTTCCTTTCTTCCATCACAA
GGGTATGATTATCCGTAACGAACTGGAACAGTTCTGGCGGGAGGAGCACCGCCGTGCCGGCTACCTGGAGATTCGCACCC
CGGTTATTTTAAGCCGTACCCTCTGGGAGCAGTCGGGTCACTGGGACCACTACCGGGAGAATATGTACTTCACCAAAATT
GACGGGGCTGACTATGCCATCAAGCCCATGAACTGTCCCGGCGCCATCCTGGTTTATAAAACCGAGCAGCACAGCTACCG
CGACCTGCCCCTGCGCCTGGCAGAGCTGGGGCTGGTCCATCGCCACGAGAAATCGGGTGTCCTTCACGGCCTGATGCGGG
TACGGGCCTTCACCCAGGACGATTCCCACATCTTTATGCTGCCCTCCCAGATTGCCAGCGAGATCCAGGGAGTTATCGAC
CTGGTGGACCGTTTCTACAATCTTTTCGGCTTCAAGTACCACGTAGAGCTTTCCACCCGGCCGGACAATGCCATGGGCTC
GGAGGAAATATGGGAAACGGCTACCAGCGCCCTGCGCCAGGCCCTGGAGGCCAAGGGCATGCCTTACGCCGTCAATGAAG
GCGATGGCGCCTTCTACGGCCCCAAGATTGATTTCCATCTGGAGGATTCCCTGGGCCGTACCTGGCAGTGCGGCACCATC
CAGCTGGACTTCCTCATGCCCGAAAAGTTCGATCTGACCTACATCGGTGAAGACGGCCAAAAGCATCGGCCGGTTATGAT
CCACCGGGTGGTCTTCGGTAGCATTGAGCGCTTTATCGGCATCCTCATTGAACACTACGGCGGTTCCTTCCCGGTCTGGC
TGGCGCCGGTACAGGTGCGGGTGCTACCCATTACCGACCGCCACAACGATTACGCCTTTAAAGTCAGGGCGGAACTGATC
CGGGCCGGCATCCGGGCGGAGGTGAACGACCGCAACGACAAAATCGGCTACAAGATCCGGGCCGCCCAGATGGAGCATAT
ACCCTATATGCTGGTAGTGGGGGATAAGGAAGCGGCCGAAGGCACCGTGGCCGTGCGGGAACGGCAGGCCGGGGATACCG
GCAGGGTACCCCTGGCAGAGTTTATTGCCAGGGTCACCAGGGAGATAAGCAGGCGGGAATAA

Upstream 100 bases:

>100_bases
CAGAGGGGGGAGCATATCCCCTGAAGAAGGGTGGAACCACGGGCACAACTCCCGTCCCTTTACGGGGCGGGGGTTATTTT
TTTCCACAGGAGGTTTTTAT

Downstream 100 bases:

>100_bases
TTTTCTTCTATGGATATTGACGCCTGATATGCCCTGTGATATACTTTCCCAGGAAGTAGAAGCCATCCGCTTCTCACCTT
ACGGCCCCAGGCTGGTAAGG

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS [H]

Number of amino acids: Translated: 633; Mature: 633

Protein sequence:

>633_residues
MRITLPDGTVKEYAPGTTALQVARDISPRLAREALAARVNGEVWDLTRPLPEECQLELLTFADEGGRLAYRHTAAHVLAQ
AVKHLFPGTELGIGPAITDGFYYDFDSEHKFTPEDLTALEAEMQRIIKADLPLERREVSREEALELFRRLGEPYKVELIN
DLPEGVPISTYRQGDFIDLCAGPHLPSTGYLKAVKLTSLAGAYWRGSERNPMLQRIYGTAFPKAKDLEEYLHRLEEARKR
DHRRLGAQLGIFSLHEEGPGFPFFHHKGMIIRNELEQFWREEHRRAGYLEIRTPVILSRTLWEQSGHWDHYRENMYFTKI
DGADYAIKPMNCPGAILVYKTEQHSYRDLPLRLAELGLVHRHEKSGVLHGLMRVRAFTQDDSHIFMLPSQIASEIQGVID
LVDRFYNLFGFKYHVELSTRPDNAMGSEEIWETATSALRQALEAKGMPYAVNEGDGAFYGPKIDFHLEDSLGRTWQCGTI
QLDFLMPEKFDLTYIGEDGQKHRPVMIHRVVFGSIERFIGILIEHYGGSFPVWLAPVQVRVLPITDRHNDYAFKVRAELI
RAGIRAEVNDRNDKIGYKIRAAQMEHIPYMLVVGDKEAAEGTVAVRERQAGDTGRVPLAEFIARVTREISRRE

Sequences:

>Translated_633_residues
MRITLPDGTVKEYAPGTTALQVARDISPRLAREALAARVNGEVWDLTRPLPEECQLELLTFADEGGRLAYRHTAAHVLAQ
AVKHLFPGTELGIGPAITDGFYYDFDSEHKFTPEDLTALEAEMQRIIKADLPLERREVSREEALELFRRLGEPYKVELIN
DLPEGVPISTYRQGDFIDLCAGPHLPSTGYLKAVKLTSLAGAYWRGSERNPMLQRIYGTAFPKAKDLEEYLHRLEEARKR
DHRRLGAQLGIFSLHEEGPGFPFFHHKGMIIRNELEQFWREEHRRAGYLEIRTPVILSRTLWEQSGHWDHYRENMYFTKI
DGADYAIKPMNCPGAILVYKTEQHSYRDLPLRLAELGLVHRHEKSGVLHGLMRVRAFTQDDSHIFMLPSQIASEIQGVID
LVDRFYNLFGFKYHVELSTRPDNAMGSEEIWETATSALRQALEAKGMPYAVNEGDGAFYGPKIDFHLEDSLGRTWQCGTI
QLDFLMPEKFDLTYIGEDGQKHRPVMIHRVVFGSIERFIGILIEHYGGSFPVWLAPVQVRVLPITDRHNDYAFKVRAELI
RAGIRAEVNDRNDKIGYKIRAAQMEHIPYMLVVGDKEAAEGTVAVRERQAGDTGRVPLAEFIARVTREISRRE
>Mature_633_residues
MRITLPDGTVKEYAPGTTALQVARDISPRLAREALAARVNGEVWDLTRPLPEECQLELLTFADEGGRLAYRHTAAHVLAQ
AVKHLFPGTELGIGPAITDGFYYDFDSEHKFTPEDLTALEAEMQRIIKADLPLERREVSREEALELFRRLGEPYKVELIN
DLPEGVPISTYRQGDFIDLCAGPHLPSTGYLKAVKLTSLAGAYWRGSERNPMLQRIYGTAFPKAKDLEEYLHRLEEARKR
DHRRLGAQLGIFSLHEEGPGFPFFHHKGMIIRNELEQFWREEHRRAGYLEIRTPVILSRTLWEQSGHWDHYRENMYFTKI
DGADYAIKPMNCPGAILVYKTEQHSYRDLPLRLAELGLVHRHEKSGVLHGLMRVRAFTQDDSHIFMLPSQIASEIQGVID
LVDRFYNLFGFKYHVELSTRPDNAMGSEEIWETATSALRQALEAKGMPYAVNEGDGAFYGPKIDFHLEDSLGRTWQCGTI
QLDFLMPEKFDLTYIGEDGQKHRPVMIHRVVFGSIERFIGILIEHYGGSFPVWLAPVQVRVLPITDRHNDYAFKVRAELI
RAGIRAEVNDRNDKIGYKIRAAQMEHIPYMLVVGDKEAAEGTVAVRERQAGDTGRVPLAEFIARVTREISRRE

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI38202255, Length=631, Percent_Identity=43.4231378763867, Blast_Score=538, Evalue=1e-153,
Organism=Homo sapiens, GI38570111, Length=629, Percent_Identity=42.6073131955485, Blast_Score=534, Evalue=1e-151,
Organism=Homo sapiens, GI20070344, Length=647, Percent_Identity=41.2673879443586, Blast_Score=479, Evalue=1e-135,
Organism=Homo sapiens, GI27886570, Length=191, Percent_Identity=29.8429319371728, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI27886582, Length=191, Percent_Identity=29.8429319371728, Blast_Score=81, Evalue=3e-15,
Organism=Escherichia coli, GI1788013, Length=632, Percent_Identity=46.9936708860759, Blast_Score=619, Evalue=1e-178,
Organism=Caenorhabditis elegans, GI71984184, Length=631, Percent_Identity=41.9968304278922, Blast_Score=537, Evalue=1e-153,
Organism=Caenorhabditis elegans, GI71984192, Length=631, Percent_Identity=41.9968304278922, Blast_Score=536, Evalue=1e-153,
Organism=Saccharomyces cerevisiae, GI6322112, Length=650, Percent_Identity=40.3076923076923, Blast_Score=501, Evalue=1e-142,
Organism=Saccharomyces cerevisiae, GI6322654, Length=384, Percent_Identity=39.5833333333333, Blast_Score=298, Evalue=2e-81,
Organism=Drosophila melanogaster, GI24583842, Length=630, Percent_Identity=43.4920634920635, Blast_Score=550, Evalue=1e-156,
Organism=Drosophila melanogaster, GI28574141, Length=630, Percent_Identity=43.4920634920635, Blast_Score=550, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24583839, Length=630, Percent_Identity=43.4920634920635, Blast_Score=549, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24664387, Length=241, Percent_Identity=29.045643153527, Blast_Score=78, Evalue=2e-14,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD [H]

EC number: =6.1.1.3 [H]

Molecular weight: Translated: 72344; Mature: 72344

Theoretical pI: Translated: 6.48; Mature: 6.48

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRITLPDGTVKEYAPGTTALQVARDISPRLAREALAARVNGEVWDLTRPLPEECQLELLT
CEEECCCCCHHHCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCEEECCCCCCHHHCEEEEE
FADEGGRLAYRHTAAHVLAQAVKHLFPGTELGIGPAITDGFYYDFDSEHKFTPEDLTALE
EECCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHH
AEMQRIIKADLPLERREVSREEALELFRRLGEPYKVELINDLPEGVPISTYRQGDFIDLC
HHHHHHHHHCCCHHHHHCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEECCCCEEEEC
AGPHLPSTGYLKAVKLTSLAGAYWRGSERNPMLQRIYGTAFPKAKDLEEYLHRLEEARKR
CCCCCCCCCCEEEEEHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
DHRRLGAQLGIFSLHEEGPGFPFFHHKGMIIRNELEQFWREEHRRAGYLEIRTPVILSRT
HHHHHHHHCCEEEECCCCCCCCCCCCCCEEEHHHHHHHHHHHHCCCCEEEECCHHHHHHH
LWEQSGHWDHYRENMYFTKIDGADYAIKPMNCPGAILVYKTEQHSYRDLPLRLAELGLVH
HHHCCCCCCHHHCCEEEEEECCCCEEEECCCCCCEEEEEECCCCCCCCCCHHHHHHHHHH
RHEKSGVLHGLMRVRAFTQDDSHIFMLPSQIASEIQGVIDLVDRFYNLFGFKYHVELSTR
HCHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECC
PDNAMGSEEIWETATSALRQALEAKGMPYAVNEGDGAFYGPKIDFHLEDSLGRTWQCGTI
CCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEECCEEEEEECCCCCCEEECCEE
QLDFLMPEKFDLTYIGEDGQKHRPVMIHRVVFGSIERFIGILIEHYGGSFPVWLAPVQVR
EEEEECCCCCCEEEECCCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEECEEEE
VLPITDRHNDYAFKVRAELIRAGIRAEVNDRNDKIGYKIRAAQMEHIPYMLVVGDKEAAE
EEEEECCCCCEEEHHHHHHHHHCCCEECCCCCCCCCEEEEEEHHCCCCEEEEECCCCCCC
GTVAVRERQAGDTGRVPLAEFIARVTREISRRE
CEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRITLPDGTVKEYAPGTTALQVARDISPRLAREALAARVNGEVWDLTRPLPEECQLELLT
CEEECCCCCHHHCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCEEECCCCCCHHHCEEEEE
FADEGGRLAYRHTAAHVLAQAVKHLFPGTELGIGPAITDGFYYDFDSEHKFTPEDLTALE
EECCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHH
AEMQRIIKADLPLERREVSREEALELFRRLGEPYKVELINDLPEGVPISTYRQGDFIDLC
HHHHHHHHHCCCHHHHHCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEECCCCEEEEC
AGPHLPSTGYLKAVKLTSLAGAYWRGSERNPMLQRIYGTAFPKAKDLEEYLHRLEEARKR
CCCCCCCCCCEEEEEHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
DHRRLGAQLGIFSLHEEGPGFPFFHHKGMIIRNELEQFWREEHRRAGYLEIRTPVILSRT
HHHHHHHHCCEEEECCCCCCCCCCCCCCEEEHHHHHHHHHHHHCCCCEEEECCHHHHHHH
LWEQSGHWDHYRENMYFTKIDGADYAIKPMNCPGAILVYKTEQHSYRDLPLRLAELGLVH
HHHCCCCCCHHHCCEEEEEECCCCEEEECCCCCCEEEEEECCCCCCCCCCHHHHHHHHHH
RHEKSGVLHGLMRVRAFTQDDSHIFMLPSQIASEIQGVIDLVDRFYNLFGFKYHVELSTR
HCHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECC
PDNAMGSEEIWETATSALRQALEAKGMPYAVNEGDGAFYGPKIDFHLEDSLGRTWQCGTI
CCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEECCEEEEEECCCCCCEEECCEE
QLDFLMPEKFDLTYIGEDGQKHRPVMIHRVVFGSIERFIGILIEHYGGSFPVWLAPVQVR
EEEEECCCCCCEEEECCCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEECEEEE
VLPITDRHNDYAFKVRAELIRAGIRAEVNDRNDKIGYKIRAAQMEHIPYMLVVGDKEAAE
EEEEECCCCCEEEHHHHHHHHHCCCEECCCCCCCCCEEEEEEHHCCCCEEEEECCCCCCC
GTVAVRERQAGDTGRVPLAEFIARVTREISRRE
CEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA