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The map label for this gene is dmsA [H]

Identifier: 83590236

GI number: 83590236

Start: 1436384

End: 1438957

Strand: Reverse

Name: dmsA [H]

Synonym: Moth_1389

Alternate gene names: 83590236

Gene position: 1438957-1436384 (Counterclockwise)

Preceding gene: 83590237

Following gene: 83590235

Centisome position: 54.74

GC content: 57.34

Gene sequence:

>2574_bases
ATGAGTAATCTCATCGAAAAAGCCATGGAATACAAAATGACCCGCAGGGCTTTCCTGAAATCGACGGCCGTTGCCTCGGC
AGCCCTTACCCTGTCGGGTTGCACCAACGGGCTCACCCGAGTCTCCAAGGCACAGGCGGCCAAACTGGCGAGTAAGGAGG
GGCAGTGGCTTACCGCCGCCTGCTGGCATAACTGCGGCGGCCGCTGCCTGAATAAAGCCTATGTAGTTGACGGGGTGGTA
GTGCGGCAAAAGACCGACGATACCCATCCCGACACCCCTGATTACCCCCAGCAGCGGGGCTGCGCCCGGGGTCGTTCCCA
GCGCAAGCAGGCCTTTGGCGTCGACCGGTTGAAGTATCCCATGAAGCGTAAGCACTGGGAACCTGGCGGCGGCAATAAGG
AACTCCGGGGCCGGGACGAATGGGTGCGTATTTCCTGGGAAGAGGCCCTGGACATTGTAGCCAGCGAGATAAAACGGATC
AAGGAGAAATACGGTAACAGGGCTATTTTTGTCGGCGGCGGCAATGAAATTAGTAATATCCTGGCCCTCTACGGCGGCTA
TGTATCCCACTGGGGTACTACCTCGTGGGGTTCCTGGCGTTACGCCGGTGACATCATCGGTCTGGCGGATGGTTATTATA
AATTCAGCCACAACGACCGCTTTGATTTGCGGAATTCGCAGCTCATTGTCCTCTGGGGAGCCAACCCGGCTTGGAGCAGC
CTGGGCAACCCTACCTATAATTACCTGCAGGCCAAAAAGGCCGGAGCTAAATTCATTTTTATCGACCCTATCTACACCGA
AGCAGCCAGGGTCCTGGGAGGGGAGTGGATCCCCATCCGGCCGGCCACCGACCACGCCATGCTCCTGGGTATGGCCTATA
CCCTGATTAAAGAAGACGACCCGGTCACCAACCCGTTAATCGACTGGGATTTTCTTAACCGCTGTACCATTGGTTTCGAT
GCCGACCACATGCCGGCAGGGGCGGACCCCAAAGAGAATTTTAAAGATTATGTCCTGGGGACCTATGACGGTGTACCCAA
GACGCCGGAGTGGGCGGCGGAGATCTGCGGCGTAGACCCCGAGAAGATTCGCAGCCTGGCGCGGGAAATCGCCACTACTA
AAAGGGTCGCCCTTCTTACCGGCTGGGCGCCAGCCAGGGTCCATAATAGTGATTCTTGGCCGCAGATGTTCATGACCCTG
GGTTGTATGACGGGCCACATCGGCCAGCCGGGCCGAATGACGGGCGTCAGCTGCCATCAGAGCGCCAGTAACGGCGGGCC
GCCCCTAGTTGTCCCCGGCAGCAACGGTTTGCCCAGCATTAAAAACCCGGTTGCCGACAGCATCAATGACAGCGAGATTT
GGGATGCAATTCTCAAAGGTAAATACACCGCCGGTTATAACGATATCCGGGAGATCAATATCCAGATGATTTACCACGGC
GGCGGCGCCACCCTGCAGACCCGGGACGGGATGACCAAAGGTATTGAGGCCCATCGCAAGGTGGAGTTTGTCGTTTCCCA
TTCCCAGTTTTTAACAACAAACTCCAGATATGCTGACGTCGTTCTCCCGGTGACTACTGAGTGGGAACGGGAAGGAGGAC
TCCTTACCGGCAACCGGGAGATCTTGATCTATTACACCCGGATAACCGAACCCCTTTATGAAGCCCGGGACGATCAGTGG
ATCGCCATTGAGTTGGCCAAGAGGCTGGGCCTTGACCCCCGGCAGGCTTACCCAATATCCCCCAAACAGCAACTCTTCAA
CCAGCTGGCCGGGGCAAAGGTAATGAAGGAGGACGGTTCCGGCTTTGAGAAGCTTTTGACCATTACGGCAGCGGACATCG
CCGCCTGGGGCGTCCAGGGCGCGCCCCAGCAGGGCCGGATAACTTTGCAGGAATTCCAGGAGAAAGGTATTTACCAGGTA
CCTCGGAAACCCGGGGACAAGCTGGGCTTTATCGCCCTGAAGGACTTCCGGGAGGACCCCCAGGGTCACCCCTTAAAGAC
GGCGACCGGCAAACTGGAGATTTATTCCCAGGCCCTGGCCAAGATGGTGAAGGATAAGGGCTGGACGCAAATCAGGCCCA
TACCAACTTACAACCCTCCCCGGGAGGGTTATGAGGACACCTTTGCCGATTGGGCCAAAAAGGTGAAAGGGGATTATCCC
CTGCAGCTAATTACGCCCCATTATCTCCGGCGGTCCCACTCCGTTTTTGACAATATTCCCTGGTTGCGAGAGGCCTTTCT
CAACCACGCTTGGATGAATCCAGTCGATGCCGTGGGGCGGGGGATTAAAGAGGGAGACACCATCCTGATCACCAGCCGCC
ACGGCAAGACCCTGCGCCCGGTACATCTGTCGGAGCGGATAATGCCAGGCGTTGTCGCCTGCCCCCACGGCGCCTGGGTG
GAGATGGACGAAAAGACGGGTATCGATAAAGCCGGTGCCGATAATATCCTCTGCGGCGCCATCCCTACGGGCCAGGGTAT
CTCAGGCTGGAACTCGTGTAATGTTCAGGTCGAAAAATGGACTGGGGCGCCCTTGCCGCCTGATGACAAGTGGCCCCTGC
GCATCGTTTTTTAG

Upstream 100 bases:

>100_bases
CTACCTGGACCGGCAGGCCATTGCAGAAATTTTGCAGGCGATTGCCTGAGAGGGCGTAACAAGGTAAGCTTCGAGGGACT
TTACCGGAGGTGAGGGAAAC

Downstream 100 bases:

>100_bases
GGAGGCGGGATTATGGCTCAACTGGGGTTTTACTACGACATGACTGCCTGCATCGGCTGTAAGACCTGCCAGGTAGCCTG
TAAAGATAAAAATAACCTGG

Product: trimethylamine-N-oxide reductase (cytochrome c)

Products: Reduced form of N-Oxide compounds [C]

Alternate protein names: DMSO reductase [H]

Number of amino acids: Translated: 857; Mature: 856

Protein sequence:

>857_residues
MSNLIEKAMEYKMTRRAFLKSTAVASAALTLSGCTNGLTRVSKAQAAKLASKEGQWLTAACWHNCGGRCLNKAYVVDGVV
VRQKTDDTHPDTPDYPQQRGCARGRSQRKQAFGVDRLKYPMKRKHWEPGGGNKELRGRDEWVRISWEEALDIVASEIKRI
KEKYGNRAIFVGGGNEISNILALYGGYVSHWGTTSWGSWRYAGDIIGLADGYYKFSHNDRFDLRNSQLIVLWGANPAWSS
LGNPTYNYLQAKKAGAKFIFIDPIYTEAARVLGGEWIPIRPATDHAMLLGMAYTLIKEDDPVTNPLIDWDFLNRCTIGFD
ADHMPAGADPKENFKDYVLGTYDGVPKTPEWAAEICGVDPEKIRSLAREIATTKRVALLTGWAPARVHNSDSWPQMFMTL
GCMTGHIGQPGRMTGVSCHQSASNGGPPLVVPGSNGLPSIKNPVADSINDSEIWDAILKGKYTAGYNDIREINIQMIYHG
GGATLQTRDGMTKGIEAHRKVEFVVSHSQFLTTNSRYADVVLPVTTEWEREGGLLTGNREILIYYTRITEPLYEARDDQW
IAIELAKRLGLDPRQAYPISPKQQLFNQLAGAKVMKEDGSGFEKLLTITAADIAAWGVQGAPQQGRITLQEFQEKGIYQV
PRKPGDKLGFIALKDFREDPQGHPLKTATGKLEIYSQALAKMVKDKGWTQIRPIPTYNPPREGYEDTFADWAKKVKGDYP
LQLITPHYLRRSHSVFDNIPWLREAFLNHAWMNPVDAVGRGIKEGDTILITSRHGKTLRPVHLSERIMPGVVACPHGAWV
EMDEKTGIDKAGADNILCGAIPTGQGISGWNSCNVQVEKWTGAPLPPDDKWPLRIVF

Sequences:

>Translated_857_residues
MSNLIEKAMEYKMTRRAFLKSTAVASAALTLSGCTNGLTRVSKAQAAKLASKEGQWLTAACWHNCGGRCLNKAYVVDGVV
VRQKTDDTHPDTPDYPQQRGCARGRSQRKQAFGVDRLKYPMKRKHWEPGGGNKELRGRDEWVRISWEEALDIVASEIKRI
KEKYGNRAIFVGGGNEISNILALYGGYVSHWGTTSWGSWRYAGDIIGLADGYYKFSHNDRFDLRNSQLIVLWGANPAWSS
LGNPTYNYLQAKKAGAKFIFIDPIYTEAARVLGGEWIPIRPATDHAMLLGMAYTLIKEDDPVTNPLIDWDFLNRCTIGFD
ADHMPAGADPKENFKDYVLGTYDGVPKTPEWAAEICGVDPEKIRSLAREIATTKRVALLTGWAPARVHNSDSWPQMFMTL
GCMTGHIGQPGRMTGVSCHQSASNGGPPLVVPGSNGLPSIKNPVADSINDSEIWDAILKGKYTAGYNDIREINIQMIYHG
GGATLQTRDGMTKGIEAHRKVEFVVSHSQFLTTNSRYADVVLPVTTEWEREGGLLTGNREILIYYTRITEPLYEARDDQW
IAIELAKRLGLDPRQAYPISPKQQLFNQLAGAKVMKEDGSGFEKLLTITAADIAAWGVQGAPQQGRITLQEFQEKGIYQV
PRKPGDKLGFIALKDFREDPQGHPLKTATGKLEIYSQALAKMVKDKGWTQIRPIPTYNPPREGYEDTFADWAKKVKGDYP
LQLITPHYLRRSHSVFDNIPWLREAFLNHAWMNPVDAVGRGIKEGDTILITSRHGKTLRPVHLSERIMPGVVACPHGAWV
EMDEKTGIDKAGADNILCGAIPTGQGISGWNSCNVQVEKWTGAPLPPDDKWPLRIVF
>Mature_856_residues
SNLIEKAMEYKMTRRAFLKSTAVASAALTLSGCTNGLTRVSKAQAAKLASKEGQWLTAACWHNCGGRCLNKAYVVDGVVV
RQKTDDTHPDTPDYPQQRGCARGRSQRKQAFGVDRLKYPMKRKHWEPGGGNKELRGRDEWVRISWEEALDIVASEIKRIK
EKYGNRAIFVGGGNEISNILALYGGYVSHWGTTSWGSWRYAGDIIGLADGYYKFSHNDRFDLRNSQLIVLWGANPAWSSL
GNPTYNYLQAKKAGAKFIFIDPIYTEAARVLGGEWIPIRPATDHAMLLGMAYTLIKEDDPVTNPLIDWDFLNRCTIGFDA
DHMPAGADPKENFKDYVLGTYDGVPKTPEWAAEICGVDPEKIRSLAREIATTKRVALLTGWAPARVHNSDSWPQMFMTLG
CMTGHIGQPGRMTGVSCHQSASNGGPPLVVPGSNGLPSIKNPVADSINDSEIWDAILKGKYTAGYNDIREINIQMIYHGG
GATLQTRDGMTKGIEAHRKVEFVVSHSQFLTTNSRYADVVLPVTTEWEREGGLLTGNREILIYYTRITEPLYEARDDQWI
AIELAKRLGLDPRQAYPISPKQQLFNQLAGAKVMKEDGSGFEKLLTITAADIAAWGVQGAPQQGRITLQEFQEKGIYQVP
RKPGDKLGFIALKDFREDPQGHPLKTATGKLEIYSQALAKMVKDKGWTQIRPIPTYNPPREGYEDTFADWAKKVKGDYPL
QLITPHYLRRSHSVFDNIPWLREAFLNHAWMNPVDAVGRGIKEGDTILITSRHGKTLRPVHLSERIMPGVVACPHGAWVE
MDEKTGIDKAGADNILCGAIPTGQGISGWNSCNVQVEKWTGAPLPPDDKWPLRIVF

Specific function: Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. Allows E.coli to grow anaerobically on Me(2)SO as respiratory oxidant [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI87081797, Length=879, Percent_Identity=32.650739476678, Blast_Score=404, Evalue=1e-113,
Organism=Escherichia coli, GI1787870, Length=849, Percent_Identity=32.6266195524146, Blast_Score=387, Evalue=1e-108,
Organism=Escherichia coli, GI171474008, Length=868, Percent_Identity=32.0276497695853, Blast_Score=380, Evalue=1e-106,
Organism=Escherichia coli, GI145693196, Length=779, Percent_Identity=32.4775353016688, Blast_Score=295, Evalue=1e-80,
Organism=Escherichia coli, GI87081994, Length=879, Percent_Identity=28.6689419795222, Blast_Score=252, Evalue=8e-68,
Organism=Escherichia coli, GI1787231, Length=789, Percent_Identity=28.0101394169835, Blast_Score=228, Evalue=2e-60,
Organism=Escherichia coli, GI3868721, Length=640, Percent_Identity=26.71875, Blast_Score=117, Evalue=3e-27,
Organism=Escherichia coli, GI1787477, Length=287, Percent_Identity=27.5261324041812, Blast_Score=79, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011888
- InterPro:   IPR009010
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655
- InterPro:   IPR006311 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: 1.8.99.- [C]

Molecular weight: Translated: 95323; Mature: 95191

Theoretical pI: Translated: 8.67; Mature: 8.67

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNLIEKAMEYKMTRRAFLKSTAVASAALTLSGCTNGLTRVSKAQAAKLASKEGQWLTAA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHCCCCCEEEHH
CWHNCGGRCLNKAYVVDGVVVRQKTDDTHPDTPDYPQQRGCARGRSQRKQAFGVDRLKYP
HHHCCCHHHHCCEEEECCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHCC
MKRKHWEPGGGNKELRGRDEWVRISWEEALDIVASEIKRIKEKYGNRAIFVGGGNEISNI
HHHCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHHHH
LALYGGYVSHWGTTSWGSWRYAGDIIGLADGYYKFSHNDRFDLRNSQLIVLWGANPAWSS
HHHHCCHHHHCCCCCCCCEEECCCEEECCCCEEEECCCCCCCCCCCEEEEEECCCCCHHH
LGNPTYNYLQAKKAGAKFIFIDPIYTEAARVLGGEWIPIRPATDHAMLLGMAYTLIKEDD
CCCCHHHHHHHHHCCCEEEEECCHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHCCCC
PVTNPLIDWDFLNRCTIGFDADHMPAGADPKENFKDYVLGTYDGVPKTPEWAAEICGVDP
CCCCCCCCHHHHCCEEECCCCCCCCCCCCHHHCHHHCEEECCCCCCCCHHHHHHHHCCCH
EKIRSLAREIATTKRVALLTGWAPARVHNSDSWPQMFMTLGCMTGHIGQPGRMTGVSCHQ
HHHHHHHHHHHHHHEEEEEECCCCCEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCC
SASNGGPPLVVPGSNGLPSIKNPVADSINDSEIWDAILKGKYTAGYNDIREINIQMIYHG
CCCCCCCEEEEECCCCCCCCCCHHHCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEC
GGATLQTRDGMTKGIEAHRKVEFVVSHSQFLTTNSRYADVVLPVTTEWEREGGLLTGNRE
CCCEEEECCCCHHHHHHHHEEEEEEECCCEEECCCCEEEEEEEECCCHHHCCCEEECCCE
ILIYYTRITEPLYEARDDQWIAIELAKRLGLDPRQAYPISPKQQLFNQLAGAKVMKEDGS
EEEEEEHHCCHHHHCCCCCEEEEEHHHHHCCCCCCCCCCCHHHHHHHHHHCCEEECCCCC
GFEKLLTITAADIAAWGVQGAPQQGRITLQEFQEKGIYQVPRKPGDKLGFIALKDFREDP
CHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHCCCEECCCCCCCCEEEEEEECHHCCC
QGHPLKTATGKLEIYSQALAKMVKDKGWTQIRPIPTYNPPREGYEDTFADWAKKVKGDYP
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHCCCCC
LQLITPHYLRRSHSVFDNIPWLREAFLNHAWMNPVDAVGRGIKEGDTILITSRHGKTLRP
EEECCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHCCCCCCCCEEEEECCCCCEECC
VHLSERIMPGVVACPHGAWVEMDEKTGIDKAGADNILCGAIPTGQGISGWNSCNVQVEKW
CCHHHHHCCCEEECCCCCEEEEHHHCCCCCCCCCCEEEECCCCCCCCCCCCCCCEEEEEC
TGAPLPPDDKWPLRIVF
CCCCCCCCCCCCEEEEC
>Mature Secondary Structure 
SNLIEKAMEYKMTRRAFLKSTAVASAALTLSGCTNGLTRVSKAQAAKLASKEGQWLTAA
CHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHCCCCCEEEHH
CWHNCGGRCLNKAYVVDGVVVRQKTDDTHPDTPDYPQQRGCARGRSQRKQAFGVDRLKYP
HHHCCCHHHHCCEEEECCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHCC
MKRKHWEPGGGNKELRGRDEWVRISWEEALDIVASEIKRIKEKYGNRAIFVGGGNEISNI
HHHCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHHHH
LALYGGYVSHWGTTSWGSWRYAGDIIGLADGYYKFSHNDRFDLRNSQLIVLWGANPAWSS
HHHHCCHHHHCCCCCCCCEEECCCEEECCCCEEEECCCCCCCCCCCEEEEEECCCCCHHH
LGNPTYNYLQAKKAGAKFIFIDPIYTEAARVLGGEWIPIRPATDHAMLLGMAYTLIKEDD
CCCCHHHHHHHHHCCCEEEEECCHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHCCCC
PVTNPLIDWDFLNRCTIGFDADHMPAGADPKENFKDYVLGTYDGVPKTPEWAAEICGVDP
CCCCCCCCHHHHCCEEECCCCCCCCCCCCHHHCHHHCEEECCCCCCCCHHHHHHHHCCCH
EKIRSLAREIATTKRVALLTGWAPARVHNSDSWPQMFMTLGCMTGHIGQPGRMTGVSCHQ
HHHHHHHHHHHHHHEEEEEECCCCCEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCC
SASNGGPPLVVPGSNGLPSIKNPVADSINDSEIWDAILKGKYTAGYNDIREINIQMIYHG
CCCCCCCEEEEECCCCCCCCCCHHHCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEC
GGATLQTRDGMTKGIEAHRKVEFVVSHSQFLTTNSRYADVVLPVTTEWEREGGLLTGNRE
CCCEEEECCCCHHHHHHHHEEEEEEECCCEEECCCCEEEEEEEECCCHHHCCCEEECCCE
ILIYYTRITEPLYEARDDQWIAIELAKRLGLDPRQAYPISPKQQLFNQLAGAKVMKEDGS
EEEEEEHHCCHHHHCCCCCEEEEEHHHHHCCCCCCCCCCCHHHHHHHHHHCCEEECCCCC
GFEKLLTITAADIAAWGVQGAPQQGRITLQEFQEKGIYQVPRKPGDKLGFIALKDFREDP
CHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHCCCEECCCCCCCCEEEEEEECHHCCC
QGHPLKTATGKLEIYSQALAKMVKDKGWTQIRPIPTYNPPREGYEDTFADWAKKVKGDYP
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHCCCCC
LQLITPHYLRRSHSVFDNIPWLREAFLNHAWMNPVDAVGRGIKEGDTILITSRHGKTLRP
EEECCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHCCCCCCCCEEEEECCCCCEECC
VHLSERIMPGVVACPHGAWVEMDEKTGIDKAGADNILCGAIPTGQGISGWNSCNVQVEKW
CCHHHHHCCCEEECCCCCEEEEHHHCCCCCCCCCCEEEECCCCCCCCCCCCCCCEEEEEC
TGAPLPPDDKWPLRIVF
CCCCCCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: May Bind 4Fe-4S Cluster. [C]

Metal ions: Fe; Mo [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-Oxide; Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

Specific reaction: Reduces Various N-Oxide And Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3062312; 8905232; 9278503; 2170332; 8125918; 10801884 [H]