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The map label for this gene is ilvC

Identifier: 83590197

GI number: 83590197

Start: 1396374

End: 1397366

Strand: Reverse

Name: ilvC

Synonym: Moth_1350

Alternate gene names: 83590197

Gene position: 1397366-1396374 (Counterclockwise)

Preceding gene: 83590198

Following gene: 83590196

Centisome position: 53.16

GC content: 55.69

Gene sequence:

>993_bases
GTGGCAGTTGTATACTATGACCAGGACGCAGATCTAAACGTCCTGAAGGGCAAAAAAATCGCCGTGATGGGTTATGGCAG
CCAGGGACACTCCCAGGCTCAAAATTTAAAGGATAGCGGCTTGGACGTAGTGGTTGGCCTGCGCCCGGAGAGTAAATCCA
GGGCCGCAGCCCAGGCTGCCGGCCTGGAGGTAAAGACGGTAGCCGAAGCAGCCGCAGAGGCTGATATAATCCAGATCCTC
CTCCCGGATGAAACCCAGGCCAGGGTTTATCGGGAAGAGATCGCCCCTTACCTGACGGGCGGCAAGGTCCTGATGTTCTC
CCATGGCTTTAACATTCATTTCAACCAGATTGTACCTCCGGCCGATGTCGATGTAATCATGGTTGCCCCCAAGGGTCCCG
GGCACCTGGTACGCCGTACCTATGTTGAAGGCCAGGGGGTTCCGGCCTTGATTGCCATTTACCAGGATGCCAGCGGTAAG
GCCAAAGAAATCGGCCTGGCCTATGCCAAGGGCATCGGTGCCACCCGCGCGGGGGTAATCGAGACCACCTTCAAAGAAGA
GACGGAAACCGACCTCTTCGGAGAGCAGGCCGTCCTTTGCGGGGGGACAACTGCCCTGGTTAAAGCCGGTTTCGAAACCC
TGGTCGAGGCCGGTTATCAGCCGGAGATTGCCTACTTTGAGTGCCTCCACGAACTGAAGCTTATTGTCGACTTGATGTAT
GAGGGCGGCATTAAGTACATGCGCTACTCCATCAGCGACACGGCCGAGTATGGTGATGTCACCAGGGGACCCCGGCTGAT
CGATGACCATGTCAAGTCAACTATGAAATCTATTTTAAAGGAGATCCAGGACGGTGTCTTTGCCAGGGAATGGATCTTGG
AAAACCAGGCCGGGCGCCCCAGCTTCAACGCTTTCCGGAAGAAGGAACGTGAACACCTCATCGAACAGGTCGGCGACCAG
CTCCGGGAAATGATGTCCTGGTTGAAGAAATAG

Upstream 100 bases:

>100_bases
TTTATAGGCAGGAATTTCCGCAACGGGTGCGAATATCATACATTTAATACAATATACAGGAGGTGAATTCCTGGCCGGCT
TTTTTAGGGTCAGGAGCAAA

Downstream 100 bases:

>100_bases
AATTCCGGAAGCCATAGAAGAATGGCCCCGGGGCTTCTCCAGGGCCATTCTTGGATTTTAACAGTTGGGAGGTTAAAAGG
GAAATTTAGGTAATAACAAG

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 330; Mature: 329

Protein sequence:

>330_residues
MAVVYYDQDADLNVLKGKKIAVMGYGSQGHSQAQNLKDSGLDVVVGLRPESKSRAAAQAAGLEVKTVAEAAAEADIIQIL
LPDETQARVYREEIAPYLTGGKVLMFSHGFNIHFNQIVPPADVDVIMVAPKGPGHLVRRTYVEGQGVPALIAIYQDASGK
AKEIGLAYAKGIGATRAGVIETTFKEETETDLFGEQAVLCGGTTALVKAGFETLVEAGYQPEIAYFECLHELKLIVDLMY
EGGIKYMRYSISDTAEYGDVTRGPRLIDDHVKSTMKSILKEIQDGVFAREWILENQAGRPSFNAFRKKEREHLIEQVGDQ
LREMMSWLKK

Sequences:

>Translated_330_residues
MAVVYYDQDADLNVLKGKKIAVMGYGSQGHSQAQNLKDSGLDVVVGLRPESKSRAAAQAAGLEVKTVAEAAAEADIIQIL
LPDETQARVYREEIAPYLTGGKVLMFSHGFNIHFNQIVPPADVDVIMVAPKGPGHLVRRTYVEGQGVPALIAIYQDASGK
AKEIGLAYAKGIGATRAGVIETTFKEETETDLFGEQAVLCGGTTALVKAGFETLVEAGYQPEIAYFECLHELKLIVDLMY
EGGIKYMRYSISDTAEYGDVTRGPRLIDDHVKSTMKSILKEIQDGVFAREWILENQAGRPSFNAFRKKEREHLIEQVGDQ
LREMMSWLKK
>Mature_329_residues
AVVYYDQDADLNVLKGKKIAVMGYGSQGHSQAQNLKDSGLDVVVGLRPESKSRAAAQAAGLEVKTVAEAAAEADIIQILL
PDETQARVYREEIAPYLTGGKVLMFSHGFNIHFNQIVPPADVDVIMVAPKGPGHLVRRTYVEGQGVPALIAIYQDASGKA
KEIGLAYAKGIGATRAGVIETTFKEETETDLFGEQAVLCGGTTALVKAGFETLVEAGYQPEIAYFECLHELKLIVDLMYE
GGIKYMRYSISDTAEYGDVTRGPRLIDDHVKSTMKSILKEIQDGVFAREWILENQAGRPSFNAFRKKEREHLIEQVGDQL
REMMSWLKK

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=286, Percent_Identity=36.013986013986, Blast_Score=147, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6323387, Length=325, Percent_Identity=33.5384615384615, Blast_Score=149, Evalue=7e-37,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_MOOTA (Q2RIS6)

Other databases:

- EMBL:   CP000232
- RefSeq:   YP_430206.1
- HSSP:   P05793
- ProteinModelPortal:   Q2RIS6
- SMR:   Q2RIS6
- STRING:   Q2RIS6
- GeneID:   3831908
- GenomeReviews:   CP000232_GR
- KEGG:   mta:Moth_1350
- NMPDR:   fig|264732.9.peg.1346
- eggNOG:   COG0059
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- PhylomeDB:   Q2RIS6
- ProtClustDB:   PRK05479
- BioCyc:   MTHE264732:MOTH_1350-MONOMER
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 36273; Mature: 36142

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: NA

Important sites: ACT_SITE 108-108

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVVYYDQDADLNVLKGKKIAVMGYGSQGHSQAQNLKDSGLDVVVGLRPESKSRAAAQAA
CEEEEECCCCCCEEECCCEEEEEECCCCCHHHHHHHCCCCCEEEEECCCCCHHHHHHHHH
GLEVKTVAEAAAEADIIQILLPDETQARVYREEIAPYLTGGKVLMFSHGFNIHFNQIVPP
CCCHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCEECCCEEEEEECCCCEEECCCCCC
ADVDVIMVAPKGPGHLVRRTYVEGQGVPALIAIYQDASGKAKEIGLAYAKGIGATRAGVI
CCCCEEEECCCCCCHHHHEEEECCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCE
ETTFKEETETDLFGEQAVLCGGTTALVKAGFETLVEAGYQPEIAYFECLHELKLIVDLMY
EHHHHCCHHHHHCCCCEEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
EGGIKYMRYSISDTAEYGDVTRGPRLIDDHVKSTMKSILKEIQDGVFAREWILENQAGRP
HCCCEEEEEECCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCC
SFNAFRKKEREHLIEQVGDQLREMMSWLKK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AVVYYDQDADLNVLKGKKIAVMGYGSQGHSQAQNLKDSGLDVVVGLRPESKSRAAAQAA
EEEEECCCCCCEEECCCEEEEEECCCCCHHHHHHHCCCCCEEEEECCCCCHHHHHHHHH
GLEVKTVAEAAAEADIIQILLPDETQARVYREEIAPYLTGGKVLMFSHGFNIHFNQIVPP
CCCHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCEECCCEEEEEECCCCEEECCCCCC
ADVDVIMVAPKGPGHLVRRTYVEGQGVPALIAIYQDASGKAKEIGLAYAKGIGATRAGVI
CCCCEEEECCCCCCHHHHEEEECCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCE
ETTFKEETETDLFGEQAVLCGGTTALVKAGFETLVEAGYQPEIAYFECLHELKLIVDLMY
EHHHHCCHHHHHCCCCEEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
EGGIKYMRYSISDTAEYGDVTRGPRLIDDHVKSTMKSILKEIQDGVFAREWILENQAGRP
HCCCEEEEEECCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCC
SFNAFRKKEREHLIEQVGDQLREMMSWLKK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA