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The map label for this gene is der

Identifier: 83590169

GI number: 83590169

Start: 1367103

End: 1368419

Strand: Reverse

Name: der

Synonym: Moth_1322

Alternate gene names: 83590169

Gene position: 1368419-1367103 (Counterclockwise)

Preceding gene: 83590170

Following gene: 83590168

Centisome position: 52.06

GC content: 57.4

Gene sequence:

>1317_bases
TTGCCTAAACCAATAGTTGCCATCATCGGTCGACCTAATGTTGGCAAATCAACCCTTTTTAACCGTATCACCGGCGGGCG
GGTGGCCATCGTCGAGGATACTCCCGGGGTTACAAGGGACCGCCTGTACCGGGACGCCGAGTGGTGCGGTCGCCAGTTCA
CCTTGGTAGATACCGGAGGTATTGCCACCCACCAGGATGACCCCCTGGTGGCCAGGGTCAGGAGCCAGGCCGAACAGGCC
CTCAAGGAAGCTGACGTAATCATCTTCCTGGTAGACAGCCGGACGGGAATCACGGCTGATGATGAGGAGATAGCCGCTCT
TTTACGCCGTTCTGACCGGCCGGTGATCCTGGTAGCCAATAAAGTCGAAGACTTCAGTGACCCCACTGTGACCCATGAGT
TTTACCGGTTGGGATTGGGTGACCCTGTGCCCATCTCAGCAGCCCACGGTTTGAATACCGGCGACCTCCTGGACAGGGTG
GTGGAGCTTTTGCCGGCAGTACCCGCCGGCGAAGAAGGGGACGCCTTGAAGGTAGCCATAGTAGGGAGGCCGAACGTGGG
CAAGTCCTCCCTGGTAAATCGCCTGCTGGGAGAAGAACGGGTGATTGTCAGCGACCTGCCAGGAACTACCCGGGACGCCG
TTGATACATACATTCGCCGTGGCGAAAGGGAATACATCCTCATCGACACTGCCGGTATGAGACGTAAGAGCCGGATTACC
GTACCCACCGAGCGTTACAGTGTCCTGCGAGCCCTGAGGGCCGTGGAACGGGCCGATGTCGTCCTGGTGATCCTGGACGG
TACCGAGGGCGTGACGGAACAGGATAAAAAGATTGCCGGTTATGGGCACGAAAAGGGCAAGGCGACTATAATAGTAGTAA
ACAAGTGGGATCTGGTGCCCAAAGATGAACGGACCATGGACCATTACCGGGAAGCCGTCCGGCAGGAGCTCAGCTTTATG
GCCTACGCCCCGGTATTATTTATCTCCGCCCTGACAGGTCAACGGGTAGACCAGGTCCTGATGACCATCGACGCCGTTGG
CGAAGCGGCCAACCGGCGCGTTGCTACCGGAACATTGAATGCTGTCGTCCGGGAGGCGGTGCTGCTGACGCCGCCACCTT
CGGTGAAAGGGCAGGAGGTCAAGATCTATTACGCTACCCAGGTTAAGGTTAAGCCGCCGACCTTTGTCTTCTTTACTAAT
CGCCCCGAAGGCGTCCATTTCTCTTACCAGCGCTACCTGGAAAACCAGTTGCGACAGGCCTTCGGTTTTGAAGGTACACC
AATCCGTTTGATTTTCCGGCGCGGCAGGGAACGTTAA

Upstream 100 bases:

>100_bases
GCCAGCACGTTATTTTTCGTTCCCTGGTGGTGCCGCCTGAGTTGCGGATGGATATATCCCCACCAACAGGAGTAGATGGT
ATTTTGTGGAGGAATCCTTA

Downstream 100 bases:

>100_bases
AGCCGGTGAGGGAGGGGAAATTGATGTGGCTGCTGGCCCTGGTAGTGGCCTACCTGATTGGGTCCATTCCCACCGCCTAC
GTTGTAGGTCGTTATTTATA

Product: small GTP-binding protein domain-containing protein

Products: NA

Alternate protein names: GTP-binding protein EngA

Number of amino acids: Translated: 438; Mature: 437

Protein sequence:

>438_residues
MPKPIVAIIGRPNVGKSTLFNRITGGRVAIVEDTPGVTRDRLYRDAEWCGRQFTLVDTGGIATHQDDPLVARVRSQAEQA
LKEADVIIFLVDSRTGITADDEEIAALLRRSDRPVILVANKVEDFSDPTVTHEFYRLGLGDPVPISAAHGLNTGDLLDRV
VELLPAVPAGEEGDALKVAIVGRPNVGKSSLVNRLLGEERVIVSDLPGTTRDAVDTYIRRGEREYILIDTAGMRRKSRIT
VPTERYSVLRALRAVERADVVLVILDGTEGVTEQDKKIAGYGHEKGKATIIVVNKWDLVPKDERTMDHYREAVRQELSFM
AYAPVLFISALTGQRVDQVLMTIDAVGEAANRRVATGTLNAVVREAVLLTPPPSVKGQEVKIYYATQVKVKPPTFVFFTN
RPEGVHFSYQRYLENQLRQAFGFEGTPIRLIFRRGRER

Sequences:

>Translated_438_residues
MPKPIVAIIGRPNVGKSTLFNRITGGRVAIVEDTPGVTRDRLYRDAEWCGRQFTLVDTGGIATHQDDPLVARVRSQAEQA
LKEADVIIFLVDSRTGITADDEEIAALLRRSDRPVILVANKVEDFSDPTVTHEFYRLGLGDPVPISAAHGLNTGDLLDRV
VELLPAVPAGEEGDALKVAIVGRPNVGKSSLVNRLLGEERVIVSDLPGTTRDAVDTYIRRGEREYILIDTAGMRRKSRIT
VPTERYSVLRALRAVERADVVLVILDGTEGVTEQDKKIAGYGHEKGKATIIVVNKWDLVPKDERTMDHYREAVRQELSFM
AYAPVLFISALTGQRVDQVLMTIDAVGEAANRRVATGTLNAVVREAVLLTPPPSVKGQEVKIYYATQVKVKPPTFVFFTN
RPEGVHFSYQRYLENQLRQAFGFEGTPIRLIFRRGRER
>Mature_437_residues
PKPIVAIIGRPNVGKSTLFNRITGGRVAIVEDTPGVTRDRLYRDAEWCGRQFTLVDTGGIATHQDDPLVARVRSQAEQAL
KEADVIIFLVDSRTGITADDEEIAALLRRSDRPVILVANKVEDFSDPTVTHEFYRLGLGDPVPISAAHGLNTGDLLDRVV
ELLPAVPAGEEGDALKVAIVGRPNVGKSSLVNRLLGEERVIVSDLPGTTRDAVDTYIRRGEREYILIDTAGMRRKSRITV
PTERYSVLRALRAVERADVVLVILDGTEGVTEQDKKIAGYGHEKGKATIIVVNKWDLVPKDERTMDHYREAVRQELSFMA
YAPVLFISALTGQRVDQVLMTIDAVGEAANRRVATGTLNAVVREAVLLTPPPSVKGQEVKIYYATQVKVKPPTFVFFTNR
PEGVHFSYQRYLENQLRQAFGFEGTPIRLIFRRGRER

Specific function: GTPase that plays an essential role in the late steps of ribosome biogenesis

COG id: COG1160

COG function: function code R; Predicted GTPases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH-like domain

Homologues:

Organism=Homo sapiens, GI193082991, Length=203, Percent_Identity=29.5566502463054, Blast_Score=66, Evalue=8e-11,
Organism=Homo sapiens, GI193082988, Length=203, Percent_Identity=29.5566502463054, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI87082120, Length=461, Percent_Identity=40.997830802603, Blast_Score=341, Evalue=5e-95,
Organism=Escherichia coli, GI1788919, Length=166, Percent_Identity=32.5301204819277, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI2367268, Length=95, Percent_Identity=46.3157894736842, Blast_Score=79, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17507259, Length=110, Percent_Identity=35.4545454545455, Blast_Score=72, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6323665, Length=207, Percent_Identity=32.8502415458937, Blast_Score=94, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DER_MOOTA (Q2RIV4)

Other databases:

- EMBL:   CP000232
- RefSeq:   YP_430178.1
- ProteinModelPortal:   Q2RIV4
- SMR:   Q2RIV4
- STRING:   Q2RIV4
- GeneID:   3831032
- GenomeReviews:   CP000232_GR
- KEGG:   mta:Moth_1322
- NMPDR:   fig|264732.9.peg.1317
- eggNOG:   COG1160
- HOGENOM:   HBG592135
- OMA:   TRDRTYQ
- PhylomeDB:   Q2RIV4
- BioCyc:   MTHE264732:MOTH_1322-MONOMER
- GO:   GO:0005622
- HAMAP:   MF_00195
- InterPro:   IPR003593
- InterPro:   IPR016484
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:3.30.300.20
- PIRSF:   PIRSF006485
- PRINTS:   PR00326
- SMART:   SM00382
- TIGRFAMs:   TIGR03594
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF01926 MMR_HSR1

EC number: NA

Molecular weight: Translated: 48617; Mature: 48486

Theoretical pI: Translated: 8.80; Mature: 8.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKPIVAIIGRPNVGKSTLFNRITGGRVAIVEDTPGVTRDRLYRDAEWCGRQFTLVDTGG
CCCCEEEEECCCCCCHHHHHHHCCCCEEEEEECCCCCCHHHHHHCHHHHCCEEEEEECCC
IATHQDDPLVARVRSQAEQALKEADVIIFLVDSRTGITADDEEIAALLRRSDRPVILVAN
CCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCHHHHHHHHHCCCCCEEEEEC
KVEDFSDPTVTHEFYRLGLGDPVPISAAHGLNTGDLLDRVVELLPAVPAGEEGDALKVAI
CCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEE
VGRPNVGKSSLVNRLLGEERVIVSDLPGTTRDAVDTYIRRGEREYILIDTAGMRRKSRIT
EECCCCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCEEC
VPTERYSVLRALRAVERADVVLVILDGTEGVTEQDKKIAGYGHEKGKATIIVVNKWDLVP
CCHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCHHCCCCCCCCCEEEEEEECCCCCC
KDERTMDHYREAVRQELSFMAYAPVLFISALTGQRVDQVLMTIDAVGEAANRRVATGTLN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEHHHHH
AVVREAVLLTPPPSVKGQEVKIYYATQVKVKPPTFVFFTNRPEGVHFSYQRYLENQLRQA
HHHHHHEEECCCCCCCCCEEEEEEEEEEEECCCEEEEECCCCCCCCHHHHHHHHHHHHHH
FGFEGTPIRLIFRRGRER
HCCCCCCEEEEECCCCCC
>Mature Secondary Structure 
PKPIVAIIGRPNVGKSTLFNRITGGRVAIVEDTPGVTRDRLYRDAEWCGRQFTLVDTGG
CCCEEEEECCCCCCHHHHHHHCCCCEEEEEECCCCCCHHHHHHCHHHHCCEEEEEECCC
IATHQDDPLVARVRSQAEQALKEADVIIFLVDSRTGITADDEEIAALLRRSDRPVILVAN
CCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCHHHHHHHHHCCCCCEEEEEC
KVEDFSDPTVTHEFYRLGLGDPVPISAAHGLNTGDLLDRVVELLPAVPAGEEGDALKVAI
CCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEE
VGRPNVGKSSLVNRLLGEERVIVSDLPGTTRDAVDTYIRRGEREYILIDTAGMRRKSRIT
EECCCCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCEEC
VPTERYSVLRALRAVERADVVLVILDGTEGVTEQDKKIAGYGHEKGKATIIVVNKWDLVP
CCHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCHHCCCCCCCCCEEEEEEECCCCCC
KDERTMDHYREAVRQELSFMAYAPVLFISALTGQRVDQVLMTIDAVGEAANRRVATGTLN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEHHHHH
AVVREAVLLTPPPSVKGQEVKIYYATQVKVKPPTFVFFTNRPEGVHFSYQRYLENQLRQA
HHHHHHEEECCCCCCCCCEEEEEEEEEEEECCCEEEEECCCCCCCCHHHHHHHHHHHHHH
FGFEGTPIRLIFRRGRER
HCCCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA