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The map label for this gene is yitJ [H]

Identifier: 83590039

GI number: 83590039

Start: 1223354

End: 1224274

Strand: Reverse

Name: yitJ [H]

Synonym: Moth_1191

Alternate gene names: 83590039

Gene position: 1224274-1223354 (Counterclockwise)

Preceding gene: 83590040

Following gene: 83590038

Centisome position: 46.57

GC content: 57.44

Gene sequence:

>921_bases
ATGGTTGAAAGCAAGATGGCGAAAATCCTCTCCCAGGGGCAATTTCTGGTCAGCGGTGAGATTGGACCGCCGAAGCACGC
CGATCCTACAGAGATCAAGAAGCACGCCGCTCTCCTCAAGGACTACGTTGATGCCATGAACCTGACGGACAACCAGACGG
CCATCGTCCGCCTGTCGAGTATCGCCGCTGGGGTCCACGTCCTCCAGGCCGGGGGCGAACCCATTATCCAGATGACGGTT
CGGGACCGCAACCGTATCGCCCTCCAGAGTGATCTCCTGGGTGCCTACAGCCTGGGGATGCGGAACGTCCTCTGCCTGTC
CGGCGACCATCAATCTTTTGGTAACCATCCGACGGCGAAAAACGTCCATGACGTGGATTCCCTCCAGCTGATCCGGATCG
TGAAGGACCTCCGGGATGAGAAAAAATTCGCCTGCGGTGAAGAGATTAAGGGCCAGGAACCCCGCTTCTTCATCGGCGCC
GCCGCCAACCCCTTTGCCGACCCCTTTGAGTTCCGGGTCATGCGCCTGGAGAAGAAGATCAATGCCGGCGCCGACTTTAT
TCAAACCCAGTGCATTTTTGATATGGAGCGTTTTGAACGCTTTATGGCCCTGGTCCGGGAGCGCGGCCTGCATAAAAGAG
CCAAAATTATTGCCGGCGTCATGCCCCTGAAATCCGCCCGGGCCGCCAAATATATGCAACAATCGGTGGCCGGGATGATT
GTCCCCGACGAAATCGTCAACCGCATGGAAAAAGCCTCCGACCCCAAGGCCGAAGGGGTGGCCATCTGTGTGGAACAGAT
TAAACACCTGCAGTCCATCGAGGGTGTAGCCGGCGTCCATATCATGGCCGTCATGTGGGAAGATATCATCCCCACCATCG
TCAAGGAAGCCGGCCTGTATCCCCGTCCCAAGGTAGAGTAG

Upstream 100 bases:

>100_bases
GGAAAACTGGATCTCCTCATGGAAATCCAGCCGCCCAAGGACTGGTCCAAATCCCGGGATGGCGGGCCGCGGAAAGTTGT
ACGAGAGGATGTGACAATCG

Downstream 100 bases:

>100_bases
TTAACGACCCCCGGGTTAACCCCGGGGATTTTTTTAAGGTTCTTATTCCCAGCCTGGCCGCATAAACTGATAGGAGGAAC
AGCTGCCAGGAGGTGGATTG

Product: methylenetetrahydrofolate reductase

Products: NA

Alternate protein names: Homocysteine S-methyltransferase; S-methylmethionine:homocysteine methyltransferase; 5,10-methylenetetrahydrofolate reductase [H]

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MVESKMAKILSQGQFLVSGEIGPPKHADPTEIKKHAALLKDYVDAMNLTDNQTAIVRLSSIAAGVHVLQAGGEPIIQMTV
RDRNRIALQSDLLGAYSLGMRNVLCLSGDHQSFGNHPTAKNVHDVDSLQLIRIVKDLRDEKKFACGEEIKGQEPRFFIGA
AANPFADPFEFRVMRLEKKINAGADFIQTQCIFDMERFERFMALVRERGLHKRAKIIAGVMPLKSARAAKYMQQSVAGMI
VPDEIVNRMEKASDPKAEGVAICVEQIKHLQSIEGVAGVHIMAVMWEDIIPTIVKEAGLYPRPKVE

Sequences:

>Translated_306_residues
MVESKMAKILSQGQFLVSGEIGPPKHADPTEIKKHAALLKDYVDAMNLTDNQTAIVRLSSIAAGVHVLQAGGEPIIQMTV
RDRNRIALQSDLLGAYSLGMRNVLCLSGDHQSFGNHPTAKNVHDVDSLQLIRIVKDLRDEKKFACGEEIKGQEPRFFIGA
AANPFADPFEFRVMRLEKKINAGADFIQTQCIFDMERFERFMALVRERGLHKRAKIIAGVMPLKSARAAKYMQQSVAGMI
VPDEIVNRMEKASDPKAEGVAICVEQIKHLQSIEGVAGVHIMAVMWEDIIPTIVKEAGLYPRPKVE
>Mature_306_residues
MVESKMAKILSQGQFLVSGEIGPPKHADPTEIKKHAALLKDYVDAMNLTDNQTAIVRLSSIAAGVHVLQAGGEPIIQMTV
RDRNRIALQSDLLGAYSLGMRNVLCLSGDHQSFGNHPTAKNVHDVDSLQLIRIVKDLRDEKKFACGEEIKGQEPRFFIGA
AANPFADPFEFRVMRLEKKINAGADFIQTQCIFDMERFERFMALVRERGLHKRAKIIAGVMPLKSARAAKYMQQSVAGMI
VPDEIVNRMEKASDPKAEGVAICVEQIKHLQSIEGVAGVHIMAVMWEDIIPTIVKEAGLYPRPKVE

Specific function: Methionine biosynthesis. [C]

COG id: COG0685

COG function: function code E; 5,10-methylenetetrahydrofolate reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Hcy-binding domain [H]

Homologues:

Organism=Homo sapiens, GI87240000, Length=320, Percent_Identity=24.375, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI25147441, Length=317, Percent_Identity=23.6593059936909, Blast_Score=81, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI25147436, Length=317, Percent_Identity=23.6593059936909, Blast_Score=81, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003171
- InterPro:   IPR003726 [H]

Pfam domain/function: PF02219 MTHFR; PF02574 S-methyl_trans [H]

EC number: =2.1.1.10; =1.5.1.20 [H]

Molecular weight: Translated: 33925; Mature: 33925

Theoretical pI: Translated: 8.34; Mature: 8.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVESKMAKILSQGQFLVSGEIGPPKHADPTEIKKHAALLKDYVDAMNLTDNQTAIVRLSS
CCHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHEEEHHH
IAAGVHVLQAGGEPIIQMTVRDRNRIALQSDLLGAYSLGMRNVLCLSGDHQSFGNHPTAK
HHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCEEEECCCCHHCCCCCCCC
NVHDVDSLQLIRIVKDLRDEKKFACGEEIKGQEPRFFIGAAANPFADPFEFRVMRLEKKI
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHH
NAGADFIQTQCIFDMERFERFMALVRERGLHKRAKIIAGVMPLKSARAAKYMQQSVAGMI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCC
VPDEIVNRMEKASDPKAEGVAICVEQIKHLQSIEGVAGVHIMAVMWEDIIPTIVKEAGLY
CCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCC
PRPKVE
CCCCCC
>Mature Secondary Structure
MVESKMAKILSQGQFLVSGEIGPPKHADPTEIKKHAALLKDYVDAMNLTDNQTAIVRLSS
CCHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHEEEHHH
IAAGVHVLQAGGEPIIQMTVRDRNRIALQSDLLGAYSLGMRNVLCLSGDHQSFGNHPTAK
HHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCEEEECCCCHHCCCCCCCC
NVHDVDSLQLIRIVKDLRDEKKFACGEEIKGQEPRFFIGAAANPFADPFEFRVMRLEKKI
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHH
NAGADFIQTQCIFDMERFERFMALVRERGLHKRAKIIAGVMPLKSARAAKYMQQSVAGMI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCC
VPDEIVNRMEKASDPKAEGVAICVEQIKHLQSIEGVAGVHIMAVMWEDIIPTIVKEAGLY
CCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCC
PRPKVE
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353932; 9384377 [H]