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The map label for this gene is lexA

Identifier: 83589968

GI number: 83589968

Start: 1148397

End: 1149014

Strand: Reverse

Name: lexA

Synonym: Moth_1120

Alternate gene names: 83589968

Gene position: 1149014-1148397 (Counterclockwise)

Preceding gene: 83589969

Following gene: 83589919

Centisome position: 43.71

GC content: 50.97

Gene sequence:

>618_bases
TTGCAACCTGATTTATCACCTCAACTGGCCATGGTCCTCAATTACATCCGGCACTTTATTGATATAAATGGCTACCCTCC
CTCCATCCGGGACATATGTAAGGCCACCGGCTTGCGTTCCAGTTCTACCGTCTATAATTACTTAAACAAGCTGGAAGAAA
AAGGTTATATCCGTCGCGACCCCTCACGCTCCCGGGCTATTGAAATCCTCACCCCCTATCCCGCCCTCACCAGAGCCAAG
AATATGGTCTCCGTACCCTTGCTGGGAAAAATAACCGCCGGCCAGCCCATCCTGGCCTTTGAAAATATCGAGGATGTTTT
CCCCCTACCTGCTGACCTGGCAGGAGCGGAAAACGCCTTTATGCTTCACGTCAGCGGGGATAGTATGATCGAGGCCGGTA
TCCTAGATGGCGACTACCTGATCGTCCGGCCCCAGGATACGGCTGAAAACGGCGATATTGTTGTTGCCCTTCTGGAGGAT
GAAGCGACTGTAAAGTACTTTTACCGCTATCCCGACCATATTGAACTGGTTCCGGCTAACAGCAGTATGCAGCCCCTTAT
CGTTCACAAAGTAACAATCCTTGGAAAGGTGGTAGGCCTCTACCGCCATTTCTCTTGA

Upstream 100 bases:

>100_bases
GGTAATAATCAGAGGTTTTTCCTTGATGCTTACAAACTGTTGTTTGCCGGTTTAAAGTATGGTAGTATGGATGGTGATTT
TAATCGGGAAGGGGATCTCC

Downstream 100 bases:

>100_bases
ATTAACCCCCTGTTTACCATCTCCTGGGCTGCCATAAGGAGGGCCACCCTGGTATAAGGGTAGGAGAGCCCCCCCTGTAA
AAATACTGCATAAGGCGGGC

Product: SOS-response transcriptional repressor, LexA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 205; Mature: 205

Protein sequence:

>205_residues
MQPDLSPQLAMVLNYIRHFIDINGYPPSIRDICKATGLRSSSTVYNYLNKLEEKGYIRRDPSRSRAIEILTPYPALTRAK
NMVSVPLLGKITAGQPILAFENIEDVFPLPADLAGAENAFMLHVSGDSMIEAGILDGDYLIVRPQDTAENGDIVVALLED
EATVKYFYRYPDHIELVPANSSMQPLIVHKVTILGKVVGLYRHFS

Sequences:

>Translated_205_residues
MQPDLSPQLAMVLNYIRHFIDINGYPPSIRDICKATGLRSSSTVYNYLNKLEEKGYIRRDPSRSRAIEILTPYPALTRAK
NMVSVPLLGKITAGQPILAFENIEDVFPLPADLAGAENAFMLHVSGDSMIEAGILDGDYLIVRPQDTAENGDIVVALLED
EATVKYFYRYPDHIELVPANSSMQPLIVHKVTILGKVVGLYRHFS
>Mature_205_residues
MQPDLSPQLAMVLNYIRHFIDINGYPPSIRDICKATGLRSSSTVYNYLNKLEEKGYIRRDPSRSRAIEILTPYPALTRAK
NMVSVPLLGKITAGQPILAFENIEDVFPLPADLAGAENAFMLHVSGDSMIEAGILDGDYLIVRPQDTAENGDIVVALLED
EATVKYFYRYPDHIELVPANSSMQPLIVHKVTILGKVVGLYRHFS

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family

Homologues:

Organism=Escherichia coli, GI1790476, Length=203, Percent_Identity=33.9901477832512, Blast_Score=113, Evalue=7e-27,
Organism=Escherichia coli, GI1787431, Length=126, Percent_Identity=35.7142857142857, Blast_Score=60, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LEXA_MOOTA (Q2RJF5)

Other databases:

- EMBL:   CP000232
- RefSeq:   YP_429977.1
- ProteinModelPortal:   Q2RJF5
- SMR:   Q2RJF5
- STRING:   Q2RJF5
- MEROPS:   S24.001
- GeneID:   3833252
- GenomeReviews:   CP000232_GR
- KEGG:   mta:Moth_1120
- NMPDR:   fig|264732.9.peg.1103
- eggNOG:   COG1974
- HOGENOM:   HBG679610
- OMA:   IAENPDF
- PhylomeDB:   Q2RJF5
- BioCyc:   MTHE264732:MOTH_1120-MONOMER
- GO:   GO:0006508
- GO:   GO:0006350
- HAMAP:   MF_00015
- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991
- Gene3D:   G3DSA:2.10.109.10
- Gene3D:   G3DSA:1.10.10.10
- PRINTS:   PR00726
- TIGRFAMs:   TIGR00498

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24; SSF51306 Pept_S24_S26_C

EC number: =3.4.21.88

Molecular weight: Translated: 22833; Mature: 22833

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: NA

Important sites: ACT_SITE 128-128 ACT_SITE 165-165

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPDLSPQLAMVLNYIRHFIDINGYPPSIRDICKATGLRSSSTVYNYLNKLEEKGYIRRD
CCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEECC
PSRSRAIEILTPYPALTRAKNMVSVPLLGKITAGQPILAFENIEDVFPLPADLAGAENAF
CCCCCEEEEEECCHHHHHHCCEEECCCEEEECCCCEEEEECCCHHHCCCCCCCCCCCCEE
MLHVSGDSMIEAGILDGDYLIVRPQDTAENGDIVVALLEDEATVKYFYRYPDHIELVPAN
EEEECCCCEEEEEEECCCEEEECCCCCCCCCCEEEEEECCCCEEEEEEECCCEEEEEECC
SSMQPLIVHKVTILGKVVGLYRHFS
CCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQPDLSPQLAMVLNYIRHFIDINGYPPSIRDICKATGLRSSSTVYNYLNKLEEKGYIRRD
CCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEECC
PSRSRAIEILTPYPALTRAKNMVSVPLLGKITAGQPILAFENIEDVFPLPADLAGAENAF
CCCCCEEEEEECCHHHHHHCCEEECCCEEEECCCCEEEEECCCHHHCCCCCCCCCCCCEE
MLHVSGDSMIEAGILDGDYLIVRPQDTAENGDIVVALLEDEATVKYFYRYPDHIELVPAN
EEEECCCCEEEEEEECCCEEEECCCCCCCCCCEEEEEECCCCEEEEEEECCCEEEEEECC
SSMQPLIVHKVTILGKVVGLYRHFS
CCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA