Click here to switch to the map view.

The map label for this gene is guaB [H]

Identifier: 83589385

GI number: 83589385

Start: 541638

End: 542510

Strand: Reverse

Name: guaB [H]

Synonym: Moth_0521

Alternate gene names: 83589385

Gene position: 542510-541638 (Counterclockwise)

Preceding gene: 83589386

Following gene: 83589373

Centisome position: 20.64

GC content: 45.59

Gene sequence:

>873_bases
GTGCCCACGGTAAAAAGCCTTATAAGCGAGAAGCTTTATACAATTGACCCGTTAGCAAGCGTCGGTCGGGCGGCCGCTAT
TATGGAACGCTATGGTATAGGCAGCCTCCCGGTAGTAGAAGAGGGAAAACTGGTAGGCATTATCACTTCCAGGGATGTCA
GGAGGTTTCACCCAAACCGGCTGGTTGCCGATGCCATGACGAGAAAAGTGATCACCATATCACCAACAGCTTCCCTGACA
GAAGCACAAAAATTAATGGTCAAGAATAAGATTGAGCGTCTGGTAGTTACCTCGGAAAGCAACATTGTTGGTATAATTAC
CTACGCCCAGATCATGCTGGAATTGGGCAAATATACCGATAGCCTTACGGGTTTAAACAAAGCCGAAATCTTTTATGAAA
AAGCCCTGGAGTTATTAAGACGAGGCCAGGAGATAGCAATAATCTTTCTGGATTTGGATAACTTTGGGGGTATTAATAAA
GAATACGGCCATATTTATGGTGACAATGTCCTGCGCCAGGCCACTATAATCTTAAAAAATTTAATTAACATGAATGAGGA
TACCCTGTGCCGCTATGCCGGCGATGAATTTGCTATTGTTACCACCAGGTCCCTGGCTGCAGCAGAAAAATTAGCCCGGC
AAATTGTCACGGCCTTCGCCAACGAAAATTGGCCCGGTAAAATAAAGGTCACCATCTCTGCTGGCGTAGCCGGAGGCCGT
CGCTCAAAAATACGCGAATGTGGTAAAGACAGCAGCTATATCGTCAAAAACCTGGTCAATATGGCCAGCCTGGCTTCAAC
CAAAGCCAAAAGACTGAAAAAACCGGTAGTAGTAGTTGAGGCCGTTGAATTTAAAGAAACAGCATGCATGTAG

Upstream 100 bases:

>100_bases
CAGTAGTAATCGAAGAAAGTAACCGCATCGCCGACGATAAAATGGTGCTTAAGGCCCAGATAAATATTACCATCCAGGTC
AGCAGGACGGTGGATTTGTA

Downstream 100 bases:

>100_bases
CGCCTACCATGTCCATCCCTTCATGAAAAATGCGGCAGTTAGCCGGATTAGGCTAAAAATTCTATATTTAACCCGCGCGG
CAATCGGCTGCAATTCTTGC

Product: diguanylate cyclase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 290; Mature: 289

Protein sequence:

>290_residues
MPTVKSLISEKLYTIDPLASVGRAAAIMERYGIGSLPVVEEGKLVGIITSRDVRRFHPNRLVADAMTRKVITISPTASLT
EAQKLMVKNKIERLVVTSESNIVGIITYAQIMLELGKYTDSLTGLNKAEIFYEKALELLRRGQEIAIIFLDLDNFGGINK
EYGHIYGDNVLRQATIILKNLINMNEDTLCRYAGDEFAIVTTRSLAAAEKLARQIVTAFANENWPGKIKVTISAGVAGGR
RSKIRECGKDSSYIVKNLVNMASLASTKAKRLKKPVVVVEAVEFKETACM

Sequences:

>Translated_290_residues
MPTVKSLISEKLYTIDPLASVGRAAAIMERYGIGSLPVVEEGKLVGIITSRDVRRFHPNRLVADAMTRKVITISPTASLT
EAQKLMVKNKIERLVVTSESNIVGIITYAQIMLELGKYTDSLTGLNKAEIFYEKALELLRRGQEIAIIFLDLDNFGGINK
EYGHIYGDNVLRQATIILKNLINMNEDTLCRYAGDEFAIVTTRSLAAAEKLARQIVTAFANENWPGKIKVTISAGVAGGR
RSKIRECGKDSSYIVKNLVNMASLASTKAKRLKKPVVVVEAVEFKETACM
>Mature_289_residues
PTVKSLISEKLYTIDPLASVGRAAAIMERYGIGSLPVVEEGKLVGIITSRDVRRFHPNRLVADAMTRKVITISPTASLTE
AQKLMVKNKIERLVVTSESNIVGIITYAQIMLELGKYTDSLTGLNKAEIFYEKALELLRRGQEIAIIFLDLDNFGGINKE
YGHIYGDNVLRQATIILKNLINMNEDTLCRYAGDEFAIVTTRSLAAAEKLARQIVTAFANENWPGKIKVTISAGVAGGRR
SKIRECGKDSSYIVKNLVNMASLASTKAKRLKKPVVVVEAVEFKETACM

Specific function: IMP is the rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth [H]

COG id: COG0517

COG function: function code R; FOG: CBS domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Escherichia coli, GI1787541, Length=153, Percent_Identity=30.718954248366, Blast_Score=65, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6322012, Length=104, Percent_Identity=36.5384615384615, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6319352, Length=104, Percent_Identity=36.5384615384615, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 31955; Mature: 31824

Theoretical pI: Translated: 9.91; Mature: 9.91

Prosite motif: PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTVKSLISEKLYTIDPLASVGRAAAIMERYGIGSLPVVEEGKLVGIITSRDVRRFHPNR
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEECCCCEEEEEECCCHHHHCCCH
LVADAMTRKVITISPTASLTEAQKLMVKNKIERLVVTSESNIVGIITYAQIMLELGKYTD
HHHHHHHCEEEEECCCCHHHHHHHHHHHHHHHHEEEECCCCEEEHHHHHHHHHHHHHHHH
SLTGLNKAEIFYEKALELLRRGQEIAIIFLDLDNFGGINKEYGHIYGDNVLRQATIILKN
HHCCCCHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHH
LINMNEDTLCRYAGDEFAIVTTRSLAAAEKLARQIVTAFANENWPGKIKVTISAGVAGGR
HHCCCCCHHEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCH
RSKIRECGKDSSYIVKNLVNMASLASTKAKRLKKPVVVVEAVEFKETACM
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEHHHHHHCC
>Mature Secondary Structure 
PTVKSLISEKLYTIDPLASVGRAAAIMERYGIGSLPVVEEGKLVGIITSRDVRRFHPNR
CCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEECCCCEEEEEECCCHHHHCCCH
LVADAMTRKVITISPTASLTEAQKLMVKNKIERLVVTSESNIVGIITYAQIMLELGKYTD
HHHHHHHCEEEEECCCCHHHHHHHHHHHHHHHHEEEECCCCEEEHHHHHHHHHHHHHHHH
SLTGLNKAEIFYEKALELLRRGQEIAIIFLDLDNFGGINKEYGHIYGDNVLRQATIILKN
HHCCCCHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHH
LINMNEDTLCRYAGDEFAIVTTRSLAAAEKLARQIVTAFANENWPGKIKVTISAGVAGGR
HHCCCCCHHEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCH
RSKIRECGKDSSYIVKNLVNMASLASTKAKRLKKPVVVVEAVEFKETACM
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]