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The map label for this gene is pth

Identifier: 83313446

GI number: 83313446

Start: 4752438

End: 4753142

Strand: Reverse

Name: pth

Synonym: amb4347

Alternate gene names: 83313446

Gene position: 4753142-4752438 (Counterclockwise)

Preceding gene: 83313447

Following gene: 83313445

Centisome position: 95.69

GC content: 67.8

Gene sequence:

>705_bases
ATGCTCCTGGTGGTCGGACTGGGCAATCCCGGCTCCGACTACGCCAGGAATCGGCACAATATCGGCTTTATGGCGGCGGA
CGTTCTCGTCCGCCGCTATTCCTTTGGGCCCTGGCGCTCCAAGTTCCAGGGCGAAGTGGCCGAAGGGATCATCGGGGGCG
AGAAGGTCATCGCCTTGAAGCCCCAGACCTACATGAACCTGTCGGGCCAGTCGGTGGCGGCGGCCGCGCGCTTTCTCAAG
GTGCCGGTGGACGACATCATCGTGCTGCATGACGAGCTGGACGTGGCGCCGGGCCGCCTCAAGGTCAAGCGCGGCGGCGG
CGCGGGCGGCCATAACGGGCTGAAGAGCATCGATTCCCATCTGGGACAGAATTACCGCCGGGTCCGTCTGGGCATCGGCC
ATCCCGGCGACCGCGATCTGGTGTCGGGCTACGTGCTGCACGACTTCGCCAAGGCGGACGAGGCCTGGCTGGTGCCGGTG
CTCGACGCCGTGGCCGATACCTTTCCCATGCTGGTGTCGGGCGACGATGCCGGCTTCGCGACCCGGGTGGCGCACCTCAC
CGCGCCGCCCAAGCCGAAAAAGGACAGACCGGCCGCCGAAGCGGCGCCGGCCCCCGCTCCGGCCCAAGTTTCCGCTCCGC
CGTCGGGCGGCAGCCTCGCCGAGGCGCTGAAGGCGGCCATGACCAAGATCATCAGGAAGGACTGA

Upstream 100 bases:

>100_bases
TGCCAAGCCCTACCACGTGGCGTCGGGCGCTACCGTGGCCTCCATCGCGGCCCCCACCGTGGCCCGTGCCGAGACCACCG
AGACCGAGGCTGCCGGCTAA

Downstream 100 bases:

>100_bases
GTCCATGGGTTTCAATTGCGGTATCGTCGGCCTGCCCAACGTGGGCAAGAGCACCCTGTTCAACGCCCTGACCTCGACGG
CGGCGGCGCAGGCGGCCAAC

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MLLVVGLGNPGSDYARNRHNIGFMAADVLVRRYSFGPWRSKFQGEVAEGIIGGEKVIALKPQTYMNLSGQSVAAAARFLK
VPVDDIIVLHDELDVAPGRLKVKRGGGAGGHNGLKSIDSHLGQNYRRVRLGIGHPGDRDLVSGYVLHDFAKADEAWLVPV
LDAVADTFPMLVSGDDAGFATRVAHLTAPPKPKKDRPAAEAAPAPAPAQVSAPPSGGSLAEALKAAMTKIIRKD

Sequences:

>Translated_234_residues
MLLVVGLGNPGSDYARNRHNIGFMAADVLVRRYSFGPWRSKFQGEVAEGIIGGEKVIALKPQTYMNLSGQSVAAAARFLK
VPVDDIIVLHDELDVAPGRLKVKRGGGAGGHNGLKSIDSHLGQNYRRVRLGIGHPGDRDLVSGYVLHDFAKADEAWLVPV
LDAVADTFPMLVSGDDAGFATRVAHLTAPPKPKKDRPAAEAAPAPAPAQVSAPPSGGSLAEALKAAMTKIIRKD
>Mature_234_residues
MLLVVGLGNPGSDYARNRHNIGFMAADVLVRRYSFGPWRSKFQGEVAEGIIGGEKVIALKPQTYMNLSGQSVAAAARFLK
VPVDDIIVLHDELDVAPGRLKVKRGGGAGGHNGLKSIDSHLGQNYRRVRLGIGHPGDRDLVSGYVLHDFAKADEAWLVPV
LDAVADTFPMLVSGDDAGFATRVAHLTAPPKPKKDRPAAEAAPAPAPAQVSAPPSGGSLAEALKAAMTKIIRKD

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=170, Percent_Identity=35.2941176470588, Blast_Score=98, Evalue=8e-21,
Organism=Escherichia coli, GI1787455, Length=148, Percent_Identity=52.7027027027027, Blast_Score=125, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_MAGSA (Q2VZ24)

Other databases:

- EMBL:   AP007255
- RefSeq:   YP_423710.1
- ProteinModelPortal:   Q2VZ24
- SMR:   Q2VZ24
- STRING:   Q2VZ24
- GeneID:   3805811
- GenomeReviews:   AP007255_GR
- KEGG:   mag:amb4347
- NMPDR:   fig|342108.5.peg.3905
- eggNOG:   COG0193
- HOGENOM:   HBG610927
- OMA:   HIRERSQ
- PhylomeDB:   Q2VZ24
- ProtClustDB:   PRK05426
- BioCyc:   MMAG342108:AMB4347-MONOMER
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 24725; Mature: 24725

Theoretical pI: Translated: 9.98; Mature: 9.98

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLVVGLGNPGSDYARNRHNIGFMAADVLVRRYSFGPWRSKFQGEVAEGIIGGEKVIALK
CEEEEECCCCCHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHCCHHHHCCCCCCEEEEEC
PQTYMNLSGQSVAAAARFLKVPVDDIIVLHDELDVAPGRLKVKRGGGAGGHNGLKSIDSH
CCHHCCCCCCHHHHHHHHHHCCHHHEEEEECCCCCCCCEEEEEECCCCCCCHHHHHHHHH
LGQNYRRVRLGIGHPGDRDLVSGYVLHDFAKADEAWLVPVLDAVADTFPMLVSGDDAGFA
HCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCEEEECCCCCHH
TRVAHLTAPPKPKKDRPAAEAAPAPAPAQVSAPPSGGSLAEALKAAMTKIIRKD
HHEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLLVVGLGNPGSDYARNRHNIGFMAADVLVRRYSFGPWRSKFQGEVAEGIIGGEKVIALK
CEEEEECCCCCHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHCCHHHHCCCCCCEEEEEC
PQTYMNLSGQSVAAAARFLKVPVDDIIVLHDELDVAPGRLKVKRGGGAGGHNGLKSIDSH
CCHHCCCCCCHHHHHHHHHHCCHHHEEEEECCCCCCCCEEEEEECCCCCCCHHHHHHHHH
LGQNYRRVRLGIGHPGDRDLVSGYVLHDFAKADEAWLVPVLDAVADTFPMLVSGDDAGFA
HCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCEEEECCCCCHH
TRVAHLTAPPKPKKDRPAAEAAPAPAPAQVSAPPSGGSLAEALKAAMTKIIRKD
HHEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA