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The map label for this gene is trxA [H]

Identifier: 83313385

GI number: 83313385

Start: 4692373

End: 4692729

Strand: Reverse

Name: trxA [H]

Synonym: amb4286

Alternate gene names: 83313385

Gene position: 4692729-4692373 (Counterclockwise)

Preceding gene: 83313387

Following gene: 83313384

Centisome position: 94.48

GC content: 61.9

Gene sequence:

>357_bases
GTGTTCCCCGTCCGCCGTTGGAATTCGACAAGGAACCTGCCTATGAAGATTGTGACCGATTCCTCGTTCGAGGCCGAGGT
GCTCAAGGCCCCCGGCCCGGTTCTGGTGGATTTCTGGGCCGAGTGGTGCGGCCCTTGCCGCCAGATCGCCCCGGCGCTCG
AGGAACTCTCCAAGGACAGGGCCGACAAGATCACCATCGCCAAGATCAACATCGACGAGAATCCCGGCACCCCCGGCAAG
TACGGCGTGCGCGGCATTCCCACCCTGATGATCTTCAAGAACGGCCAGGTCGCCGCCACCAAGATCGGCGCGCTGCCCAA
GAGCAAGCTTTACGAATGGGTGGATTCCAGCCTGTAA

Upstream 100 bases:

>100_bases
GACCCTGACGCCCGGCCTGCTTGACGCTGACGCGGGGGCTTTCTACAGTGATCGCTCCCAAGGGGTGTTCGCCCCGATAG
GGTGACGGGCGGGAAGACGT

Downstream 100 bases:

>100_bases
CGGCTGGAATTCGTTTCGCATTCCGATGTCGGGCCCCGCTTTGGCGGGGCTCGACGCGCTTCTCGTGTCCGTGCGGGGTG
CCATGGCCGTCTTCGACGAA

Product: Thiol-disulfide isomerase and thioredoxins

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 118; Mature: 118

Protein sequence:

>118_residues
MFPVRRWNSTRNLPMKIVTDSSFEAEVLKAPGPVLVDFWAEWCGPCRQIAPALEELSKDRADKITIAKINIDENPGTPGK
YGVRGIPTLMIFKNGQVAATKIGALPKSKLYEWVDSSL

Sequences:

>Translated_118_residues
MFPVRRWNSTRNLPMKIVTDSSFEAEVLKAPGPVLVDFWAEWCGPCRQIAPALEELSKDRADKITIAKINIDENPGTPGK
YGVRGIPTLMIFKNGQVAATKIGALPKSKLYEWVDSSL
>Mature_118_residues
MFPVRRWNSTRNLPMKIVTDSSFEAEVLKAPGPVLVDFWAEWCGPCRQIAPALEELSKDRADKITIAKINIDENPGTPGK
YGVRGIPTLMIFKNGQVAATKIGALPKSKLYEWVDSSL

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=92, Percent_Identity=33.695652173913, Blast_Score=74, Evalue=3e-14,
Organism=Homo sapiens, GI21361657, Length=88, Percent_Identity=37.5, Blast_Score=68, Evalue=2e-12,
Organism=Homo sapiens, GI20070125, Length=88, Percent_Identity=37.5, Blast_Score=64, Evalue=3e-11,
Organism=Homo sapiens, GI5031973, Length=109, Percent_Identity=29.3577981651376, Blast_Score=62, Evalue=8e-11,
Organism=Escherichia coli, GI87082331, Length=101, Percent_Identity=62.3762376237624, Blast_Score=146, Evalue=4e-37,
Organism=Escherichia coli, GI1788936, Length=107, Percent_Identity=41.1214953271028, Blast_Score=99, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI212646193, Length=96, Percent_Identity=37.5, Blast_Score=82, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI71998175, Length=94, Percent_Identity=40.4255319148936, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17509965, Length=90, Percent_Identity=33.3333333333333, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI115532380, Length=90, Percent_Identity=36.6666666666667, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115532378, Length=90, Percent_Identity=36.6666666666667, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17544108, Length=90, Percent_Identity=36.6666666666667, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17554386, Length=101, Percent_Identity=34.6534653465347, Blast_Score=65, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6323072, Length=75, Percent_Identity=41.3333333333333, Blast_Score=67, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6321648, Length=88, Percent_Identity=32.9545454545455, Blast_Score=63, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24639826, Length=78, Percent_Identity=38.4615384615385, Blast_Score=78, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28573567, Length=102, Percent_Identity=31.3725490196078, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17648013, Length=76, Percent_Identity=38.1578947368421, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24583090, Length=76, Percent_Identity=38.1578947368421, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24664269, Length=81, Percent_Identity=39.5061728395062, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24639068, Length=102, Percent_Identity=29.4117647058824, Blast_Score=65, Evalue=8e-12,
Organism=Drosophila melanogaster, GI21358065, Length=108, Percent_Identity=30.5555555555556, Blast_Score=64, Evalue=1e-11,
Organism=Drosophila melanogaster, GI19921434, Length=75, Percent_Identity=37.3333333333333, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 13102; Mature: 13102

Theoretical pI: Translated: 9.23; Mature: 9.23

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFPVRRWNSTRNLPMKIVTDSSFEAEVLKAPGPVLVDFWAEWCGPCRQIAPALEELSKDR
CCCCCCCCCCCCCCEEEEECCCCCCCEECCCCCEEHHHHHHHCCHHHHHHHHHHHHHCCC
ADKITIAKINIDENPGTPGKYGVRGIPTLMIFKNGQVAATKIGALPKSKLYEWVDSSL
CCEEEEEEEEECCCCCCCCCCCCCCCCEEEEEECCCEEEEECCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MFPVRRWNSTRNLPMKIVTDSSFEAEVLKAPGPVLVDFWAEWCGPCRQIAPALEELSKDR
CCCCCCCCCCCCCCEEEEECCCCCCCEECCCCCEEHHHHHHHCCHHHHHHHHHHHHHCCC
ADKITIAKINIDENPGTPGKYGVRGIPTLMIFKNGQVAATKIGALPKSKLYEWVDSSL
CCEEEEEEEEECCCCCCCCCCCCCCCCEEEEEECCCEEEEECCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3129411 [H]