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The map label for this gene is uvrB [H]

Identifier: 83312902

GI number: 83312902

Start: 4199974

End: 4202025

Strand: Reverse

Name: uvrB [H]

Synonym: amb3803

Alternate gene names: 83312902

Gene position: 4202025-4199974 (Counterclockwise)

Preceding gene: 83312903

Following gene: 83312901

Centisome position: 84.6

GC content: 65.94

Gene sequence:

>2052_bases
GTGGAGTTCAAGATCGTCTCCGACTATCAGCCGGCCGGCGACCAGCCCCAGGCCATCGCCGAACTGTCGGCCGGGGTGGA
CGCGGACGAGCGCGACCAGGTGCTGCTGGGCGTCACCGGCTCGGGCAAGACCTTCACCATGGCCCATGTCATCGCCAGGA
CCAGGCGTCCGGCCCTGGTCCTGGCCCCCAACAAGACCCTGGCCGCCCAGCTTTACGCCGAGATGAAGGGCTTCTTCCCC
GATAACGCGGTGGAGTATTTCGTCTCCTACTACGACTACTACCAGCCCGAAGCCTATATCCCGCGCACCGATACCTATAT
CGAGAAGGATTCGGCGGTGAACGAGCAGATCGACCGCATGCGCCATGCGGCGACGCGGGCCTTGCTCGAACGGCGCGACG
TGATCCTGGTGGCCTCGGTGTCGTGCATCTACGGCATCGGCTCGGTGGAATCCTATGCCCGCATGACCGTCGCCTTGAAG
GTGGGCGAAAGCATCGACCGCTCGGACCTCCTGAAGCGTCTGGTGGAACTGCAATACACCAGGAACGACGCCGCCTTCGA
GCGCGGCACCTTCCGCGTCAGGGGCGACGCGGTGGAGATCTTTCCCGTCCACTACGAGGACCGCGCCTGGCGCCTGTCGC
TGTTCGGCGACGAGATCGAGGCCATCAACGAGTTCGACCCGCTGACCGGCGAGAAGACCTGTTCGCTGTCCGAGGTGACC
GTCTACCCGTCCAGCCACTACGTCACGCCGCGCCCCACCATCACCCAGGCCATCAAGGGCATCAAGGCGGAGCTGAAGGA
GACGCTGGAGCGCTTCCACGCCGAGGGCAAGCTGCTGGAGGCCCAGCGCCTGGAACAGCGCACCAATTTCGATCTGGAAA
TGCTGGAGACCACCGGTCACTGCAAGTCCATCGAGAACTATTCCCGCTATCTCACCGGCCGGCGCCCCGGCGACCCGCCG
CCCACCCTGTTCGAGTACCTGCCCGAAGATGCCCTGCTGATCGTCGATGAAAGCCATGTCACCGTGCCGCAGATCGGCGG
CATGTACCGCGGCGACTTCAACCGCAAGAGCGTGCTGGCCGAGTTCGGCTTCCGCCTGCCGTCGTGCATCGACAACCGGC
CGCTGAAGTTCGAGGAATGGGAGCTGATGCGGCCCCAGACGGTCTATGTCTCGGCCACCCCCGGCCCGTGGGAGATGGAG
CGCACCGGCGGCGTGTTCACCGAACAGGTGATCCGCCCCACCGGCCTGATCGACCCGGTCTGCATCGTCCGGCCCGTGGA
GCATCAGGTGGACGACCTGCTGGGCGAGGTGCGGCAGATGGCGCGGCTGGGTAACCGCACCCTGGTCACCACGCTGACCA
AGCGCATGGCCGAGGACCTGACCGAGTACATGCACGACAACGGCGTGCGGGTGCGCTACCTGCATTCCGACATCGACACC
CTGGAGCGCATCGAGATCATCCGCGACCTGCGCCTCGGCGCCTTCGACGTGCTGATCGGCATCAACCTGCTGCGCGAAGG
CCTGGATATTCCCGAATGCGCCCTGGTGGCCATCCTCGACGCCGACAAGGAAGGATTCCTGCGCTCCAAGACCTCGCTGA
TCCAGACCATCGGCCGCGCCGCGCGCAATATCGACGGACGGGTCATCCTGTACGCCGACAAGATGACCGCCTCCCTGGAC
TACGCCCTGGCCGAGACCAACCGGCGGCGCGAGAAGCAGCAGGCCTACAACGCCCTTCACGGCATCACCCCGGAAGGCAT
CCGCAAGGCGGTCTCCGACGTCATGGACAGCGTCTACGAGGCCGATTACGTCACGGTGGGCACCGGCGATTCCGGGCTGG
CCCACGGGGTCGGGCACAATCTGGCCTCGGTCAAGGCCGATATCGAAAAGCGCATGAAGGCCGCCGCCGCCGATCTGGAG
TTCGAGGAGGCGGCAAGGCTGCGCGACGAATTGCGCCGCCTGGAGGCGCTGGACCTGGGCATCGAGGTCAATCTGGGGAC
CAAGGGGCGGCCGCGCTCCACCGGCAAGCCCAGGGGGCGTCGGCGCGGTTGA

Upstream 100 bases:

>100_bases
AAAAGGGGCTCCGTTCGGCTCGTGGAGGCTCTATACTGCCGCCATGAGCCGTCCACTGCCCTTCGACTTCATGGAACGCC
CGCCCCTGCCCGAGGGGGAT

Downstream 100 bases:

>100_bases
TTCGGTAACTACCCATCGGTCATGGGGACGAGCGCTTTCTACTCTGTTAGAGTAATGCCCAAGGATGGGGCCGGGGCTCG
CGCCGGCCGGGAAGGAGCAT

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 683; Mature: 683

Protein sequence:

>683_residues
MEFKIVSDYQPAGDQPQAIAELSAGVDADERDQVLLGVTGSGKTFTMAHVIARTRRPALVLAPNKTLAAQLYAEMKGFFP
DNAVEYFVSYYDYYQPEAYIPRTDTYIEKDSAVNEQIDRMRHAATRALLERRDVILVASVSCIYGIGSVESYARMTVALK
VGESIDRSDLLKRLVELQYTRNDAAFERGTFRVRGDAVEIFPVHYEDRAWRLSLFGDEIEAINEFDPLTGEKTCSLSEVT
VYPSSHYVTPRPTITQAIKGIKAELKETLERFHAEGKLLEAQRLEQRTNFDLEMLETTGHCKSIENYSRYLTGRRPGDPP
PTLFEYLPEDALLIVDESHVTVPQIGGMYRGDFNRKSVLAEFGFRLPSCIDNRPLKFEEWELMRPQTVYVSATPGPWEME
RTGGVFTEQVIRPTGLIDPVCIVRPVEHQVDDLLGEVRQMARLGNRTLVTTLTKRMAEDLTEYMHDNGVRVRYLHSDIDT
LERIEIIRDLRLGAFDVLIGINLLREGLDIPECALVAILDADKEGFLRSKTSLIQTIGRAARNIDGRVILYADKMTASLD
YALAETNRRREKQQAYNALHGITPEGIRKAVSDVMDSVYEADYVTVGTGDSGLAHGVGHNLASVKADIEKRMKAAAADLE
FEEAARLRDELRRLEALDLGIEVNLGTKGRPRSTGKPRGRRRG

Sequences:

>Translated_683_residues
MEFKIVSDYQPAGDQPQAIAELSAGVDADERDQVLLGVTGSGKTFTMAHVIARTRRPALVLAPNKTLAAQLYAEMKGFFP
DNAVEYFVSYYDYYQPEAYIPRTDTYIEKDSAVNEQIDRMRHAATRALLERRDVILVASVSCIYGIGSVESYARMTVALK
VGESIDRSDLLKRLVELQYTRNDAAFERGTFRVRGDAVEIFPVHYEDRAWRLSLFGDEIEAINEFDPLTGEKTCSLSEVT
VYPSSHYVTPRPTITQAIKGIKAELKETLERFHAEGKLLEAQRLEQRTNFDLEMLETTGHCKSIENYSRYLTGRRPGDPP
PTLFEYLPEDALLIVDESHVTVPQIGGMYRGDFNRKSVLAEFGFRLPSCIDNRPLKFEEWELMRPQTVYVSATPGPWEME
RTGGVFTEQVIRPTGLIDPVCIVRPVEHQVDDLLGEVRQMARLGNRTLVTTLTKRMAEDLTEYMHDNGVRVRYLHSDIDT
LERIEIIRDLRLGAFDVLIGINLLREGLDIPECALVAILDADKEGFLRSKTSLIQTIGRAARNIDGRVILYADKMTASLD
YALAETNRRREKQQAYNALHGITPEGIRKAVSDVMDSVYEADYVTVGTGDSGLAHGVGHNLASVKADIEKRMKAAAADLE
FEEAARLRDELRRLEALDLGIEVNLGTKGRPRSTGKPRGRRRG
>Mature_683_residues
MEFKIVSDYQPAGDQPQAIAELSAGVDADERDQVLLGVTGSGKTFTMAHVIARTRRPALVLAPNKTLAAQLYAEMKGFFP
DNAVEYFVSYYDYYQPEAYIPRTDTYIEKDSAVNEQIDRMRHAATRALLERRDVILVASVSCIYGIGSVESYARMTVALK
VGESIDRSDLLKRLVELQYTRNDAAFERGTFRVRGDAVEIFPVHYEDRAWRLSLFGDEIEAINEFDPLTGEKTCSLSEVT
VYPSSHYVTPRPTITQAIKGIKAELKETLERFHAEGKLLEAQRLEQRTNFDLEMLETTGHCKSIENYSRYLTGRRPGDPP
PTLFEYLPEDALLIVDESHVTVPQIGGMYRGDFNRKSVLAEFGFRLPSCIDNRPLKFEEWELMRPQTVYVSATPGPWEME
RTGGVFTEQVIRPTGLIDPVCIVRPVEHQVDDLLGEVRQMARLGNRTLVTTLTKRMAEDLTEYMHDNGVRVRYLHSDIDT
LERIEIIRDLRLGAFDVLIGINLLREGLDIPECALVAILDADKEGFLRSKTSLIQTIGRAARNIDGRVILYADKMTASLD
YALAETNRRREKQQAYNALHGITPEGIRKAVSDVMDSVYEADYVTVGTGDSGLAHGVGHNLASVKADIEKRMKAAAADLE
FEEAARLRDELRRLEALDLGIEVNLGTKGRPRSTGKPRGRRRG

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=672, Percent_Identity=59.9702380952381, Blast_Score=812, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 76863; Mature: 76863

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFKIVSDYQPAGDQPQAIAELSAGVDADERDQVLLGVTGSGKTFTMAHVIARTRRPALV
CCEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEECCCCCEEHHHHHHHHCCCCEEE
LAPNKTLAAQLYAEMKGFFPDNAVEYFVSYYDYYQPEAYIPRTDTYIEKDSAVNEQIDRM
ECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHH
RHAATRALLERRDVILVASVSCIYGIGSVESYARMTVALKVGESIDRSDLLKRLVELQYT
HHHHHHHHHHHCCEEEEEEHHHHHCCCCHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHC
RNDAAFERGTFRVRGDAVEIFPVHYEDRAWRLSLFGDEIEAINEFDPLTGEKTCSLSEVT
CCCHHHHCCCEEEECCEEEEEEEEECCCEEEEEECCCHHHHHHCCCCCCCCCCCCCEEEE
VYPSSHYVTPRPTITQAIKGIKAELKETLERFHAEGKLLEAQRLEQRTNFDLEMLETTGH
ECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEECCCCC
CKSIENYSRYLTGRRPGDPPPTLFEYLPEDALLIVDESHVTVPQIGGMYRGDFNRKSVLA
HHHHHHHHHHHCCCCCCCCCCHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHH
EFGFRLPSCIDNRPLKFEEWELMRPQTVYVSATPGPWEMERTGGVFTEQVIRPTGLIDPV
HHCCCCCHHHCCCCCCCCHHHCCCCEEEEEEECCCCCCCHHCCCHHHHHHHCCCCCCCCH
CIVRPVEHQVDDLLGEVRQMARLGNRTLVTTLTKRMAEDLTEYMHDNGVRVRYLHSDIDT
HHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHH
LERIEIIRDLRLGAFDVLIGINLLREGLDIPECALVAILDADKEGFLRSKTSLIQTIGRA
HHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHH
ARNIDGRVILYADKMTASLDYALAETNRRREKQQAYNALHGITPEGIRKAVSDVMDSVYE
HHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
ADYVTVGTGDSGLAHGVGHNLASVKADIEKRMKAAAADLEFEEAARLRDELRRLEALDLG
CCEEEECCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
IEVNLGTKGRPRSTGKPRGRRRG
EEEECCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MEFKIVSDYQPAGDQPQAIAELSAGVDADERDQVLLGVTGSGKTFTMAHVIARTRRPALV
CCEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEECCCCCEEHHHHHHHHCCCCEEE
LAPNKTLAAQLYAEMKGFFPDNAVEYFVSYYDYYQPEAYIPRTDTYIEKDSAVNEQIDRM
ECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHH
RHAATRALLERRDVILVASVSCIYGIGSVESYARMTVALKVGESIDRSDLLKRLVELQYT
HHHHHHHHHHHCCEEEEEEHHHHHCCCCHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHC
RNDAAFERGTFRVRGDAVEIFPVHYEDRAWRLSLFGDEIEAINEFDPLTGEKTCSLSEVT
CCCHHHHCCCEEEECCEEEEEEEEECCCEEEEEECCCHHHHHHCCCCCCCCCCCCCEEEE
VYPSSHYVTPRPTITQAIKGIKAELKETLERFHAEGKLLEAQRLEQRTNFDLEMLETTGH
ECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEECCCCC
CKSIENYSRYLTGRRPGDPPPTLFEYLPEDALLIVDESHVTVPQIGGMYRGDFNRKSVLA
HHHHHHHHHHHCCCCCCCCCCHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHH
EFGFRLPSCIDNRPLKFEEWELMRPQTVYVSATPGPWEMERTGGVFTEQVIRPTGLIDPV
HHCCCCCHHHCCCCCCCCHHHCCCCEEEEEEECCCCCCCHHCCCHHHHHHHCCCCCCCCH
CIVRPVEHQVDDLLGEVRQMARLGNRTLVTTLTKRMAEDLTEYMHDNGVRVRYLHSDIDT
HHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHH
LERIEIIRDLRLGAFDVLIGINLLREGLDIPECALVAILDADKEGFLRSKTSLIQTIGRA
HHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHH
ARNIDGRVILYADKMTASLDYALAETNRRREKQQAYNALHGITPEGIRKAVSDVMDSVYE
HHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
ADYVTVGTGDSGLAHGVGHNLASVKADIEKRMKAAAADLEFEEAARLRDELRRLEALDLG
CCEEEECCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
IEVNLGTKGRPRSTGKPRGRRRG
EEEECCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]