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The map label for this gene is moeA [H]

Identifier: 83312896

GI number: 83312896

Start: 4193523

End: 4194758

Strand: Reverse

Name: moeA [H]

Synonym: amb3797

Alternate gene names: 83312896

Gene position: 4194758-4193523 (Counterclockwise)

Preceding gene: 83312897

Following gene: 83312895

Centisome position: 84.45

GC content: 72.01

Gene sequence:

>1236_bases
GTGAGCGACCGTTTCGCCGTCTCCGCGGACATGATGACGGTTGCCGAGGCCCTGGCCCGGCTGGAAGAGCGCCTTGCCCC
CGCCGTCGGTGTCGAGGATATCCGTCTGCACGACGGCCTGGGCCGCATCCTGGCCGACGACGTGGTCTCGGCGGTCAATG
TGCCGCCCCACGACAATTCGGCGGTGGATGGCTGGGCCTTTCGCCGCGCCGACCTGCCCGCCGACGGCATCCTGCCGGTG
GTGGGGCGCGTCGCCGCCGGCCATCCCCTGGACGGGCCGCTGCCTGCGGGCGGCGCGGTGCGCATCTTTACCGGCGCGCC
CATGCCGGACGGGGCCGACACGGTGGCCATGCAGGAGGACTGTAAGGACCTGGACGGCCGGGTGGCGCTGCCCGTCAGGC
TGGCGGAGGGCGACAATGCCCGGCAGGCCGGCGAGGACATCTCGAAGGGCTCGGTGGTGCTGCGCGCCGGCACCCGGCTG
CGGCCGCAGGAACTGGGCGTGGCGGCGGCCACCGGCCGGTCGTCCCTCAAGGTTTACCGGCCGCTGCGGGCCGCCGTGTT
CTCTACCGGCGACGAAATCCGCGATCCCGGCGCCGACCTGCCGCCCGGCTGCATCTACGACACCAACCGCTTTACCGCCA
CGGGCCTGCTGCGCGCCCTGGGGGCCGAGGTCACCGATCTCGGCATCCTTCCCGACCGCTTCGAGACCATCCGGGATGCC
CTGGCCGAAGCGGCTGTGTCGCACCAGCTGATCCTGACCTCGGGCGGGGTGTCGGTGGGCGACGAGGACCATGTGAAGCC
CGCCGTGCTGGCCCAGGGTTCGCTGGATTTCTGGCGTCTGGCCATCAAGCCCGGCCGCCCCGTGGCCCTGGGGGAGGTGG
CGGGAACGCCCTTCGTCGGCCTGCCGGGCAATCCGGTGGCGGTGATGGTCACCTTCATGCTGATCGCCCGGCCCATGGTG
CTGCGCCTGATGGGGGCCGCCCAGACCGCCTTGCCCCGCTACCCGGTGGAGGCCGGCTTCGCCTTCAAGCACAAGCCGGG
GCGCCGCGAATATCTGCGCGCCCGCCTCGCCCACATGGACGGCCGGCTGGTGGCGGCCAAGTTCCCCTCCGACGGCTCGG
GCGTGCTGACCTCCATGACCTGGTCGGACGGGCTGGTGGACATCCCCGAGGACCGGGGCGACATCGCGCCCGGCGAGATG
GTGGACTTCCTCTCCTATGCGGACATGATGCGATGA

Upstream 100 bases:

>100_bases
CGCCGGCCTGCCCGCTGCCCCAGCTCAACGTCGACGATACCGAGGCCATCGGCCGTCTGATCGCCGAAAGGGTTGGGCTG
GTCGTAGAAAGGGTTGGGCT

Downstream 100 bases:

>100_bases
AGGTGCTGTACTTCGCCTGGCTGAAGGCCAAGACCGGAGTGGGGGAGGAGGACGTCGCCCCGCCCGCCGAGGTGGCCACC
GTCGGGCAATTGGTGGCGTT

Product: molybdopterin biosynthesis protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 411; Mature: 410

Protein sequence:

>411_residues
MSDRFAVSADMMTVAEALARLEERLAPAVGVEDIRLHDGLGRILADDVVSAVNVPPHDNSAVDGWAFRRADLPADGILPV
VGRVAAGHPLDGPLPAGGAVRIFTGAPMPDGADTVAMQEDCKDLDGRVALPVRLAEGDNARQAGEDISKGSVVLRAGTRL
RPQELGVAAATGRSSLKVYRPLRAAVFSTGDEIRDPGADLPPGCIYDTNRFTATGLLRALGAEVTDLGILPDRFETIRDA
LAEAAVSHQLILTSGGVSVGDEDHVKPAVLAQGSLDFWRLAIKPGRPVALGEVAGTPFVGLPGNPVAVMVTFMLIARPMV
LRLMGAAQTALPRYPVEAGFAFKHKPGRREYLRARLAHMDGRLVAAKFPSDGSGVLTSMTWSDGLVDIPEDRGDIAPGEM
VDFLSYADMMR

Sequences:

>Translated_411_residues
MSDRFAVSADMMTVAEALARLEERLAPAVGVEDIRLHDGLGRILADDVVSAVNVPPHDNSAVDGWAFRRADLPADGILPV
VGRVAAGHPLDGPLPAGGAVRIFTGAPMPDGADTVAMQEDCKDLDGRVALPVRLAEGDNARQAGEDISKGSVVLRAGTRL
RPQELGVAAATGRSSLKVYRPLRAAVFSTGDEIRDPGADLPPGCIYDTNRFTATGLLRALGAEVTDLGILPDRFETIRDA
LAEAAVSHQLILTSGGVSVGDEDHVKPAVLAQGSLDFWRLAIKPGRPVALGEVAGTPFVGLPGNPVAVMVTFMLIARPMV
LRLMGAAQTALPRYPVEAGFAFKHKPGRREYLRARLAHMDGRLVAAKFPSDGSGVLTSMTWSDGLVDIPEDRGDIAPGEM
VDFLSYADMMR
>Mature_410_residues
SDRFAVSADMMTVAEALARLEERLAPAVGVEDIRLHDGLGRILADDVVSAVNVPPHDNSAVDGWAFRRADLPADGILPVV
GRVAAGHPLDGPLPAGGAVRIFTGAPMPDGADTVAMQEDCKDLDGRVALPVRLAEGDNARQAGEDISKGSVVLRAGTRLR
PQELGVAAATGRSSLKVYRPLRAAVFSTGDEIRDPGADLPPGCIYDTNRFTATGLLRALGAEVTDLGILPDRFETIRDAL
AEAAVSHQLILTSGGVSVGDEDHVKPAVLAQGSLDFWRLAIKPGRPVALGEVAGTPFVGLPGNPVAVMVTFMLIARPMVL
RLMGAAQTALPRYPVEAGFAFKHKPGRREYLRARLAHMDGRLVAAKFPSDGSGVLTSMTWSDGLVDIPEDRGDIAPGEMV
DFLSYADMMR

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=400, Percent_Identity=33.5, Blast_Score=179, Evalue=6e-45,
Organism=Homo sapiens, GI66932975, Length=400, Percent_Identity=33.5, Blast_Score=178, Evalue=7e-45,
Organism=Escherichia coli, GI1787049, Length=389, Percent_Identity=41.1311053984576, Blast_Score=290, Evalue=9e-80,
Organism=Caenorhabditis elegans, GI25147659, Length=346, Percent_Identity=30.9248554913295, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17562606, Length=332, Percent_Identity=26.5060240963855, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI17136978, Length=393, Percent_Identity=32.5699745547074, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24638841, Length=393, Percent_Identity=32.5699745547074, Blast_Score=142, Evalue=4e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 43444; Mature: 43313

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDRFAVSADMMTVAEALARLEERLAPAVGVEDIRLHDGLGRILADDVVSAVNVPPHDNS
CCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHCCCCCCCCC
AVDGWAFRRADLPADGILPVVGRVAAGHPLDGPLPAGGAVRIFTGAPMPDGADTVAMQED
CCCCCEEEECCCCCCCCHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHH
CKDLDGRVALPVRLAEGDNARQAGEDISKGSVVLRAGTRLRPQELGVAAATGRSSLKVYR
HHCCCCEEEEEEEECCCCCHHHHCCCCCCCCEEEECCCCCCHHHCCEEEECCCCCHHHHH
PLRAAVFSTGDEIRDPGADLPPGCIYDTNRFTATGLLRALGAEVTDLGILPDRFETIRDA
HHHHHHHCCCHHHCCCCCCCCCCCEEECCCHHHHHHHHHHCCCHHHCCCCHHHHHHHHHH
LAEAAVSHQLILTSGGVSVGDEDHVKPAVLAQGSLDFWRLAIKPGRPVALGEVAGTPFVG
HHHHHHHCEEEEEECCCCCCCCCCCCCCEEECCCCCEEEEEECCCCCEEEHHCCCCCEEC
LPGNPVAVMVTFMLIARPMVLRLMGAAQTALPRYPVEAGFAFKHKPGRREYLRARLAHMD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCHHHHHHHHHHHCC
GRLVAAKFPSDGSGVLTSMTWSDGLVDIPEDRGDIAPGEMVDFLSYADMMR
CEEEEEECCCCCCCEEEEEECCCCCEECCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SDRFAVSADMMTVAEALARLEERLAPAVGVEDIRLHDGLGRILADDVVSAVNVPPHDNS
CCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHCCCCCCCCC
AVDGWAFRRADLPADGILPVVGRVAAGHPLDGPLPAGGAVRIFTGAPMPDGADTVAMQED
CCCCCEEEECCCCCCCCHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHH
CKDLDGRVALPVRLAEGDNARQAGEDISKGSVVLRAGTRLRPQELGVAAATGRSSLKVYR
HHCCCCEEEEEEEECCCCCHHHHCCCCCCCCEEEECCCCCCHHHCCEEEECCCCCHHHHH
PLRAAVFSTGDEIRDPGADLPPGCIYDTNRFTATGLLRALGAEVTDLGILPDRFETIRDA
HHHHHHHCCCHHHCCCCCCCCCCCEEECCCHHHHHHHHHHCCCHHHCCCCHHHHHHHHHH
LAEAAVSHQLILTSGGVSVGDEDHVKPAVLAQGSLDFWRLAIKPGRPVALGEVAGTPFVG
HHHHHHHCEEEEEECCCCCCCCCCCCCCEEECCCCCEEEEEECCCCCEEEHHCCCCCEEC
LPGNPVAVMVTFMLIARPMVLRLMGAAQTALPRYPVEAGFAFKHKPGRREYLRARLAHMD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCHHHHHHHHHHHCC
GRLVAAKFPSDGSGVLTSMTWSDGLVDIPEDRGDIAPGEMVDFLSYADMMR
CEEEEEECCCCCCCEEEEEECCCCCEECCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]