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The map label for this gene is fnr [H]

Identifier: 83312455

GI number: 83312455

Start: 3648572

End: 3649381

Strand: Reverse

Name: fnr [H]

Synonym: amb3356

Alternate gene names: 83312455

Gene position: 3649381-3648572 (Counterclockwise)

Preceding gene: 83312456

Following gene: 83312453

Centisome position: 73.47

GC content: 70.25

Gene sequence:

>810_bases
GTGTGGCCCGGCTGGCCGGGGGAAAGGCGTAGGGCGAGTCACATCGCCTATTCCTCCCCGGCCTTTCCGCGGGTTATCCT
TGCCGCCCTTCTCGGAAAAGCGGCCGGGTATCCCATGCGTGACCACGAGATCGAGGCGGCCTGGCGCGGGCTGGCCTCGT
GCGAGCAATGCTCTATCCGCGACCTGGTGCTGTTCGCCGACCTCAAGGGTGAGGATTTCGGCGTCATCCACCTGCCCATC
GAGGATATCCGCCTGCCGGCCGGGGCCGCCCTCTACCAGCCGGGGCAGGAGGCTGGGCACGCCTTTACCGTGCGCGAGGG
GCTGTTCAAGCTGGAACAGTATCTCCCCGACGGCAGCCACCGCATCGTCAGCCTGCTGGGCCAGGGCGACGTGGCCGGGC
TGGAGGCCACGGTGGCCGATGCCTACGAGCACGCGGCGGTCGCCCTGTCGCCCGCCAAGGTCTGCCGCATCCCCCGCGAG
GTGCTGACCCGCCTGTCGCCCAAGCTGCACCGCCAGCTAATGAAGAAGTGGCACGACGCCGTCCAGCGCTCCCACGAATG
CACCCGCGAATTGTCCACCGGCAGCGCCCGGCAGCGGGTGGCCCGGCTGTTCCGGCTGCTGGCCCCCGAGACCTCCCCCG
ATTGCCGCCTGTTCGGGCGGGAGGACCTGGGGGCGCTGCTGGGCATCACGCCCGAAACCGCCAGCCGGGTGGTGGCGGAA
TTCAAGCGCCTGGGCGTGGTCACCGAGATCGCGCCGAACCTGTTCCAGCGCGATCTCGCCGCCCTCGACGGCATCGCCGG
CGAGGGCTGA

Upstream 100 bases:

>100_bases
TGGGGACTGGCCGGGTTGTGTCCGGCGCCCGCTTTGGCGGTTTCCCTGCACCATCCGGTGGCGCTGGTCTTCGTGGCTGG
CTTCGTCGCCGGATTGCTGG

Downstream 100 bases:

>100_bases
CTCCGCTTACCGGTCGGGTCCGGCGAACAGGGTTTCCGTCTTGACCTGGCGGCCGGGTCCGGTGAGCTGGAAGCTGACCG
GCATGCTCTTGGACACCACC

Product: cAMP-binding protein - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 269; Mature: 269

Protein sequence:

>269_residues
MWPGWPGERRRASHIAYSSPAFPRVILAALLGKAAGYPMRDHEIEAAWRGLASCEQCSIRDLVLFADLKGEDFGVIHLPI
EDIRLPAGAALYQPGQEAGHAFTVREGLFKLEQYLPDGSHRIVSLLGQGDVAGLEATVADAYEHAAVALSPAKVCRIPRE
VLTRLSPKLHRQLMKKWHDAVQRSHECTRELSTGSARQRVARLFRLLAPETSPDCRLFGREDLGALLGITPETASRVVAE
FKRLGVVTEIAPNLFQRDLAALDGIAGEG

Sequences:

>Translated_269_residues
MWPGWPGERRRASHIAYSSPAFPRVILAALLGKAAGYPMRDHEIEAAWRGLASCEQCSIRDLVLFADLKGEDFGVIHLPI
EDIRLPAGAALYQPGQEAGHAFTVREGLFKLEQYLPDGSHRIVSLLGQGDVAGLEATVADAYEHAAVALSPAKVCRIPRE
VLTRLSPKLHRQLMKKWHDAVQRSHECTRELSTGSARQRVARLFRLLAPETSPDCRLFGREDLGALLGITPETASRVVAE
FKRLGVVTEIAPNLFQRDLAALDGIAGEG
>Mature_269_residues
MWPGWPGERRRASHIAYSSPAFPRVILAALLGKAAGYPMRDHEIEAAWRGLASCEQCSIRDLVLFADLKGEDFGVIHLPI
EDIRLPAGAALYQPGQEAGHAFTVREGLFKLEQYLPDGSHRIVSLLGQGDVAGLEATVADAYEHAAVALSPAKVCRIPRE
VLTRLSPKLHRQLMKKWHDAVQRSHECTRELSTGSARQRVARLFRLLAPETSPDCRLFGREDLGALLGITPETASRVVAE
FKRLGVVTEIAPNLFQRDLAALDGIAGEG

Specific function: It is involved in the activation of genes necessary for anaerobic respiration. It probably also activates genes involved in the production of virulence factors [H]

COG id: COG0664

COG function: function code T; cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH crp-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787595, Length=205, Percent_Identity=28.2926829268293, Blast_Score=73, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018490
- InterPro:   IPR000595
- InterPro:   IPR001808
- InterPro:   IPR012318
- InterPro:   IPR014710
- InterPro:   IPR018335
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00027 cNMP_binding; PF00325 Crp [H]

EC number: NA

Molecular weight: Translated: 29484; Mature: 29484

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: PS50042 CNMP_BINDING_3 ; PS51063 HTH_CRP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWPGWPGERRRASHIAYSSPAFPRVILAALLGKAAGYPMRDHEIEAAWRGLASCEQCSIR
CCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHH
DLVLFADLKGEDFGVIHLPIEDIRLPAGAALYQPGQEAGHAFTVREGLFKLEQYLPDGSH
HEEEEEECCCCCCCEEEECHHHHCCCCCHHHCCCCHHHCCCHHHHHHHHHHHHHCCCCHH
RIVSLLGQGDVAGLEATVADAYEHAAVALSPAKVCRIPREVLTRLSPKLHRQLMKKWHDA
HHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHCHHHHHHHCCHHHHHHHHHHHHHH
VQRSHECTRELSTGSARQRVARLFRLLAPETSPDCRLFGREDLGALLGITPETASRVVAE
HHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCEEECHHHHHHHHCCCHHHHHHHHHH
FKRLGVVTEIAPNLFQRDLAALDGIAGEG
HHHHCHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MWPGWPGERRRASHIAYSSPAFPRVILAALLGKAAGYPMRDHEIEAAWRGLASCEQCSIR
CCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHH
DLVLFADLKGEDFGVIHLPIEDIRLPAGAALYQPGQEAGHAFTVREGLFKLEQYLPDGSH
HEEEEEECCCCCCCEEEECHHHHCCCCCHHHCCCCHHHCCCHHHHHHHHHHHHHCCCCHH
RIVSLLGQGDVAGLEATVADAYEHAAVALSPAKVCRIPREVLTRLSPKLHRQLMKKWHDA
HHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHCHHHHHHHCCHHHHHHHHHHHHHH
VQRSHECTRELSTGSARQRVARLFRLLAPETSPDCRLFGREDLGALLGITPETASRVVAE
HHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCEEECHHHHHHHHCCCHHHHHHHHHH
FKRLGVVTEIAPNLFQRDLAALDGIAGEG
HHHHCHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11130862; 8998988 [H]