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The map label for this gene is menA [H]

Identifier: 83312174

GI number: 83312174

Start: 3324814

End: 3325644

Strand: Reverse

Name: menA [H]

Synonym: amb3075

Alternate gene names: 83312174

Gene position: 3325644-3324814 (Counterclockwise)

Preceding gene: 83312175

Following gene: 83312173

Centisome position: 66.95

GC content: 72.2

Gene sequence:

>831_bases
ATGAAGCTGGAGTCCGGCCAGCCCGAAAAGCCGTCCCTGGTCATCCCCGGCCCCGATGCCAGCCGCGCCGACCAGCCGGA
CGGCTGGCGGCTGTGGTGGCTGGCCATCCGGCCCAAGACCCTGACCATTTCCGTGGCCCCGGTGCTGGCGGGCGGCGCCC
TGGCCTTCGCCGATGCCGGACAGTTGGACCCGCGTCCCCTGGCCGCCGCGCTGCTGGGCGCCCTGGCCATTCAGGCGGGG
ACCAATCTCTACAACGATGTGGGCGATGCCCTGCGCGGCGGCGACCAGCCCCTGCGTCAGGGGCCGCCGCGCGTCACCGC
GCTGGGCTGGGCCACCCCCGAGCGGGTCAAGCGCGCCGCCCTGGTCTGCTTCGCCCTGGCCGCCCTGGTGGGGCTTTATC
TCGCCTGGCTGGGCGGCTGGCCGGTGGTCGCCCTGGGCCTCGCCTCGCTGCTGGCCGGCTGGGCCTATTCCAGCGGTCCC
CGGCCCATCGCCTATACTCCCTCCGGCGAGCTCTTCGTCATCGCCTTCTTCGGCATCGGCGCGGTGGGGGGGACGTATTA
CCTTCAGACACTGTCATTGACCGGTCAGTCGATCATGGTCGGCGCCGCCATGGGGGCGGTGGCCGCGGCGGTGCTGCTGG
CCAATAATTACCGCGACATGGAGCCCGACCGTCTGGCCGGGCGCCGCACCCTGGCCATTCGGGTCGGCATCGAGGCCTCC
AGGCGGTCTACGGCATGCTGCTGCTGTCGCCCATCGCGCTTTTGGCCTCGCCCCTGGGGCCGAAGGGCGGCTGGCTGTGC
CTGGGGGCCTTGCCCTTCGCCCTGTGGCTGA

Upstream 100 bases:

>100_bases
AGATGGCCGGTCTGATGGCGGATGCGGGATTCCAGCGCGTCGTCTGGCGCAATCTGTCGGCGGGCATCGCCTGCCTGCAT
TCCGGCGTGAAGCCCGCGTC

Downstream 100 bases:

>100_bases
TCCTGCGCTTTGCCACCCAGGCCCGGGGTCCGGCCTTCAACGCCATCCTGGCCTCGACCGCCCGCTTCCAGTTGCTGCTG
GCGGGGCTGCTTGGGGTCGG

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MKLESGQPEKPSLVIPGPDASRADQPDGWRLWWLAIRPKTLTISVAPVLAGGALAFADAGQLDPRPLAAALLGALAIQAG
TNLYNDVGDALRGGDQPLRQGPPRVTALGWATPERVKRAALVCFALAALVGLYLAWLGGWPVVALGLASLLAGWAYSSGP
RPIAYTPSGELFVIAFFGIGAVGGTYYLQTLSLTGQSIMVGAAMGAVAAAVLLANNYRDMEPDRLAGRRTLAIRVGIEAS
RRSTACCCCRPSRFWPRPWGRRAAGCAWGPCPSPCG

Sequences:

>Translated_276_residues
MKLESGQPEKPSLVIPGPDASRADQPDGWRLWWLAIRPKTLTISVAPVLAGGALAFADAGQLDPRPLAAALLGALAIQAG
TNLYNDVGDALRGGDQPLRQGPPRVTALGWATPERVKRAALVCFALAALVGLYLAWLGGWPVVALGLASLLAGWAYSSGP
RPIAYTPSGELFVIAFFGIGAVGGTYYLQTLSLTGQSIMVGAAMGAVAAAVLLANNYRDMEPDRLAGRRTLAIRVGIEAS
RRSTACCCCRPSRFWPRPWGRRAAGCAWGPCPSPCG
>Mature_276_residues
MKLESGQPEKPSLVIPGPDASRADQPDGWRLWWLAIRPKTLTISVAPVLAGGALAFADAGQLDPRPLAAALLGALAIQAG
TNLYNDVGDALRGGDQPLRQGPPRVTALGWATPERVKRAALVCFALAALVGLYLAWLGGWPVVALGLASLLAGWAYSSGP
RPIAYTPSGELFVIAFFGIGAVGGTYYLQTLSLTGQSIMVGAAMGAVAAAVLLANNYRDMEPDRLAGRRTLAIRVGIEAS
RRSTACCCCRPSRFWPRPWGRRAAGCAWGPCPSPCG

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Homo sapiens, GI7019551, Length=225, Percent_Identity=31.1111111111111, Blast_Score=85, Evalue=7e-17,
Organism=Escherichia coli, GI1790365, Length=221, Percent_Identity=38.0090497737557, Blast_Score=129, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 28920; Mature: 28920

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLESGQPEKPSLVIPGPDASRADQPDGWRLWWLAIRPKTLTISVAPVLAGGALAFADAG
CCCCCCCCCCCEEEECCCCCCCCCCCCCEEEEEEEECCEEEEEEEHHHHCCCEEEECCCC
QLDPRPLAAALLGALAIQAGTNLYNDVGDALRGGDQPLRQGPPRVTALGWATPERVKRAA
CCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHCCCCCEEEECCCCHHHHHHHH
LVCFALAALVGLYLAWLGGWPVVALGLASLLAGWAYSSGPRPIAYTPSGELFVIAFFGIG
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEECCCCCEEEEEEECCC
AVGGTYYLQTLSLTGQSIMVGAAMGAVAAAVLLANNYRDMEPDRLAGRRTLAIRVGIEAS
CCCHHHEEEEHECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCEEEEEEECCCCC
RRSTACCCCRPSRFWPRPWGRRAAGCAWGPCPSPCG
CCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKLESGQPEKPSLVIPGPDASRADQPDGWRLWWLAIRPKTLTISVAPVLAGGALAFADAG
CCCCCCCCCCCEEEECCCCCCCCCCCCCEEEEEEEECCEEEEEEEHHHHCCCEEEECCCC
QLDPRPLAAALLGALAIQAGTNLYNDVGDALRGGDQPLRQGPPRVTALGWATPERVKRAA
CCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHCCCCCEEEECCCCHHHHHHHH
LVCFALAALVGLYLAWLGGWPVVALGLASLLAGWAYSSGPRPIAYTPSGELFVIAFFGIG
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEECCCCCEEEEEEECCC
AVGGTYYLQTLSLTGQSIMVGAAMGAVAAAVLLANNYRDMEPDRLAGRRTLAIRVGIEAS
CCCHHHEEEEHECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCEEEEEEECCCCC
RRSTACCCCRPSRFWPRPWGRRAAGCAWGPCPSPCG
CCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9573170; 8346018; 9278503 [H]