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The map label for this gene is csd [H]

Identifier: 83311978

GI number: 83311978

Start: 3079743

End: 3080945

Strand: Reverse

Name: csd [H]

Synonym: amb2879

Alternate gene names: 83311978

Gene position: 3080945-3079743 (Counterclockwise)

Preceding gene: 83311979

Following gene: 83311977

Centisome position: 62.03

GC content: 71.4

Gene sequence:

>1203_bases
ATGAGCCAATCCATGCGCGAGGCCTTTCCCGCCCTGTCGCGTCCGGGATTCCATTACCTGGACAACGCCGCCATGGCCCA
GCTTCCCGGACTGGTCTCCGAGGCCGTCGCCAGCTTCAATCGCGTCGCCCGTTCCAACGTCCGGCGGGGCCTGCACGAAT
CGGCGCAACGCGCCGATGCGGCCTATGACGGCGCCCGTGAAGCCGTGGGCCGCTTCCTCAACGCACCGGCCGAGGAGGTT
GTGTTCACCGGCGGCTGCACCCTGGCGCTGAACCTGGCGGCCTGGGGGCTGGGGCGAACTTTGGGGCCGGGCGACGAGGT
GGTGGTCAGCCGCCTGGAGCATCATTCCGCCTGCCTGCCCTGGATGGCCCTGGCCAAGGAGCGGGGATTCACGCTGCGCT
GGTTGCCGGTCACGCCCGAGGGACGGCTGGATCTCGGCGATCCGGGCGCGGTGATCTCGTCCCGCTGCAAGGTGGTGGCG
GTGACCCACGCCTCCAATGTCACCGGCGCCATCAGCGATCTGCCCCGGCTGGCCGAGGCGGCCCATGCGGTGGGGGCCAG
ACTGGTGGTGGACGGTGCCCAGATGGTGCCTCACGGTCGGGTCGATCCCCGCGCCCTGGGCGCCGATCTCTATGCCTTCG
CCGGGCACAAGGCCTATGGCCCCACCGGCGTCGGGGTGCTGTGGGGGCGGGCCGAGGTGCTGGACGGCATGGCGCCGCTG
GTGATGGGCGGCGGCATGGTCGGCGCGGTGGACGATGACGGCTTCACCTGGGGAGAGGTGCCCCACCGTTTCGAGGCGGG
CACCCCGCCGGTGGCCCAGGCGGTCGGTCTGGCCGCCGCATTGGACTGGATGAGCGGCCTCGACTGGCAGGCGGTGCATC
AGCAGGAATCGGCGCTGACCTGGCACCTGCTGGATGGGCTGCGCGCCATGGAGGGTGTGCGGATCGTCGGGCCGCTGGGC
CTGGAGGCCCGCGTGCCGGTGGTGTCGTTCACGGTGGACGGTTGTCATCCCCACGATCTGGCCCATCTGCTGGCCGAGCG
CGGCGTGGCGGTGCGTGGTGGCGCCCATTGCGCCCGGCCGCTGATGAGCGTCCTGGGGCTGGAGGAGGGGACCGTCCGGG
CCTCGCTGGCGCCCTATTCCGACCGATCGGACGTGGAGGCGCTGCTGCAAGGGCTGGCCGAGGCGGTCAAGGTGCTGCGA
TGA

Upstream 100 bases:

>100_bases
CCCAGCATGCCGAGGCGGTGATCGAGGTGCCCATGGCCGATGACGGCATTCTGATCGATGTGGACACGCCCGAAAGCTTG
CGGGCGTTGGGAGGAGAGGG

Downstream 100 bases:

>100_bases
GCGACGATCTCTACGGCCAGGGCCTCAAGGATCTGGCGGGGCGGGAGCCGGCGGCGGTTGCCGGTCCCGATGCCAGCGCC
AGCCTCGACAACCCCTTGTG

Product: selenocysteine lyase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 400; Mature: 399

Protein sequence:

>400_residues
MSQSMREAFPALSRPGFHYLDNAAMAQLPGLVSEAVASFNRVARSNVRRGLHESAQRADAAYDGAREAVGRFLNAPAEEV
VFTGGCTLALNLAAWGLGRTLGPGDEVVVSRLEHHSACLPWMALAKERGFTLRWLPVTPEGRLDLGDPGAVISSRCKVVA
VTHASNVTGAISDLPRLAEAAHAVGARLVVDGAQMVPHGRVDPRALGADLYAFAGHKAYGPTGVGVLWGRAEVLDGMAPL
VMGGGMVGAVDDDGFTWGEVPHRFEAGTPPVAQAVGLAAALDWMSGLDWQAVHQQESALTWHLLDGLRAMEGVRIVGPLG
LEARVPVVSFTVDGCHPHDLAHLLAERGVAVRGGAHCARPLMSVLGLEEGTVRASLAPYSDRSDVEALLQGLAEAVKVLR

Sequences:

>Translated_400_residues
MSQSMREAFPALSRPGFHYLDNAAMAQLPGLVSEAVASFNRVARSNVRRGLHESAQRADAAYDGAREAVGRFLNAPAEEV
VFTGGCTLALNLAAWGLGRTLGPGDEVVVSRLEHHSACLPWMALAKERGFTLRWLPVTPEGRLDLGDPGAVISSRCKVVA
VTHASNVTGAISDLPRLAEAAHAVGARLVVDGAQMVPHGRVDPRALGADLYAFAGHKAYGPTGVGVLWGRAEVLDGMAPL
VMGGGMVGAVDDDGFTWGEVPHRFEAGTPPVAQAVGLAAALDWMSGLDWQAVHQQESALTWHLLDGLRAMEGVRIVGPLG
LEARVPVVSFTVDGCHPHDLAHLLAERGVAVRGGAHCARPLMSVLGLEEGTVRASLAPYSDRSDVEALLQGLAEAVKVLR
>Mature_399_residues
SQSMREAFPALSRPGFHYLDNAAMAQLPGLVSEAVASFNRVARSNVRRGLHESAQRADAAYDGAREAVGRFLNAPAEEVV
FTGGCTLALNLAAWGLGRTLGPGDEVVVSRLEHHSACLPWMALAKERGFTLRWLPVTPEGRLDLGDPGAVISSRCKVVAV
THASNVTGAISDLPRLAEAAHAVGARLVVDGAQMVPHGRVDPRALGADLYAFAGHKAYGPTGVGVLWGRAEVLDGMAPLV
MGGGMVGAVDDDGFTWGEVPHRFEAGTPPVAQAVGLAAALDWMSGLDWQAVHQQESALTWHLLDGLRAMEGVRIVGPLGL
EARVPVVSFTVDGCHPHDLAHLLAERGVAVRGGAHCARPLMSVLGLEEGTVRASLAPYSDRSDVEALLQGLAEAVKVLR

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=399, Percent_Identity=24.0601503759398, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI156713448, Length=225, Percent_Identity=24, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1789175, Length=398, Percent_Identity=40.7035175879397, Blast_Score=276, Evalue=1e-75,
Organism=Escherichia coli, GI1787970, Length=404, Percent_Identity=37.6237623762376, Blast_Score=261, Evalue=6e-71,
Organism=Escherichia coli, GI48994898, Length=401, Percent_Identity=25.1870324189526, Blast_Score=105, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI193211090, Length=333, Percent_Identity=28.2282282282282, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI25143064, Length=213, Percent_Identity=25.3521126760563, Blast_Score=86, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6319831, Length=417, Percent_Identity=24.4604316546763, Blast_Score=100, Evalue=3e-22,
Organism=Drosophila melanogaster, GI20129463, Length=346, Percent_Identity=26.5895953757225, Blast_Score=102, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 42094; Mature: 41962

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQSMREAFPALSRPGFHYLDNAAMAQLPGLVSEAVASFNRVARSNVRRGLHESAQRADA
CCCHHHHHHHHHCCCCCHHHCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYDGAREAVGRFLNAPAEEVVFTGGCTLALNLAAWGLGRTLGPGDEVVVSRLEHHSACLP
HHHHHHHHHHHHHCCCHHHEEEECCCCEEEEHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
WMALAKERGFTLRWLPVTPEGRLDLGDPGAVISSRCKVVAVTHASNVTGAISDLPRLAEA
HHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHCCCEEEEEEECCCCCHHHHHHHHHHHH
AHAVGARLVVDGAQMVPHGRVDPRALGADLYAFAGHKAYGPTGVGVLWGRAEVLDGMAPL
HHHHCCEEEECCHHHCCCCCCCHHHHCCHHHHHCCCCCCCCCCCHHHHCHHHHHCCHHHH
VMGGGMVGAVDDDGFTWGEVPHRFEAGTPPVAQAVGLAAALDWMSGLDWQAVHQQESALT
HHCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
WHLLDGLRAMEGVRIVGPLGLEARVPVVSFTVDGCHPHDLAHLLAERGVAVRGGAHCARP
HHHHHHHHHHCCEEEECCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCEEECCHHHHHH
LMSVLGLEEGTVRASLAPYSDRSDVEALLQGLAEAVKVLR
HHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
SQSMREAFPALSRPGFHYLDNAAMAQLPGLVSEAVASFNRVARSNVRRGLHESAQRADA
CCHHHHHHHHHCCCCCHHHCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYDGAREAVGRFLNAPAEEVVFTGGCTLALNLAAWGLGRTLGPGDEVVVSRLEHHSACLP
HHHHHHHHHHHHHCCCHHHEEEECCCCEEEEHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
WMALAKERGFTLRWLPVTPEGRLDLGDPGAVISSRCKVVAVTHASNVTGAISDLPRLAEA
HHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHCCCEEEEEEECCCCCHHHHHHHHHHHH
AHAVGARLVVDGAQMVPHGRVDPRALGADLYAFAGHKAYGPTGVGVLWGRAEVLDGMAPL
HHHHCCEEEECCHHHCCCCCCCHHHHCCHHHHHCCCCCCCCCCCHHHHCHHHHHCCHHHH
VMGGGMVGAVDDDGFTWGEVPHRFEAGTPPVAQAVGLAAALDWMSGLDWQAVHQQESALT
HHCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
WHLLDGLRAMEGVRIVGPLGLEARVPVVSFTVDGCHPHDLAHLLAERGVAVRGGAHCARP
HHHHHHHHHHCCEEEECCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCEEECCHHHHHH
LMSVLGLEEGTVRASLAPYSDRSDVEALLQGLAEAVKVLR
HHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA