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The map label for this gene is hemN [H]

Identifier: 83311797

GI number: 83311797

Start: 2890404

End: 2891759

Strand: Reverse

Name: hemN [H]

Synonym: amb2698

Alternate gene names: 83311797

Gene position: 2891759-2890404 (Counterclockwise)

Preceding gene: 83311798

Following gene: 83311796

Centisome position: 58.22

GC content: 66.37

Gene sequence:

>1356_bases
ATGCGCCCCGATCTTGCGGCCAAGTATGACCTTCGCGTTCCCCGCTACACCTCCTATCCCACCGCGCCCCATTTCCATCC
GGGCGTGACGGGCGAGACCTATCGGGGCTGGCTGGGGGCGATCGACCCCAAGCTGGAGCTGTCGCTTTACCTCCACATCG
CCTTTTGCGCCGAGATGTGCTGGTTCTGCGGCTGCCACACCAAGATCACCAAGCGCTACGCCCCCGTCGCCGCCTATATG
GACGCCCTGTGGCGCGAGGTGGAACTGGTGGCCGAGGCGCTGCCCACCCGCATGACGGCGCGGCATGTCCATTTCGGCGG
CGGCTCGCCCACCATCCTGTCGTCCGAGGATTTCGTCCGCACCATCGACCTGCTGAAGAGCCACTTCATCCTGAAGCCCG
ATGCCGAGGTGGCGGTGGAGCTGGACCCGCGCACCGCCGACGAAGCCTATGTCAAGGCCATGGCCGGGGCGGGGGTGACC
CGCGCCTCCATCGGCGTGCAGGACCTGGACGATAAGGTGCAGCAGGCCATCAACCGCATCCAGCCTTACGAGGTCACCGA
GCGGGTGGTGGAGTGGCTGGGCAAGTATGGCGTGCCCGAGGTCAATATCGACCTGATCTACGGCCTGCCGCATCAGACCC
TCGATGGTCTGCTGGCCACCATCGACAAGGCGGTGAGGGGCTTCAGGCCCCGCCGGGTGGCGCTGTTCGGCTATGCCCAT
GTGCCGTGGATGAAGAAGCATCAGCGCCTGATCCCCGAAGAGACCCTGCCCGATACCGAGACCCGCTGGCAGCAGTATGA
GCAGGGCTGCCGGCTGCTGACAGAGACCCTGGGCTATGTCCAGATCGGCCTCGATCACTTCGCCGCCCCCGACGACGCCA
TGGCCATCGCGCTGCGGGAAAAGCGGCTGCACCGCAACTTCCAGGGCTACACCACCGATTCCGCCACCACCCTGATCGGC
TTTGGGGCGTCGGGCATCGGCTCGCTGCCCCAGGGCTATGTGGTCAATGACGGCGAAGTGCACGCCTACCAGCGCTCCAT
CGCCGAGGGCAAGCTGGCCATTTCGCGGGGCGTCGCCATTACCGCCGACGATATTCTGCGGCGCGAGATCATCGAGCGGC
TGATGTGCGATCTGGAGATCGATCTGGACGTGGTCGCCGGCCGTCACGGTTCCGACGGTTCGCATTTCGCCGCCGAGCTG
GCCTCGCTGGCTCCCCTGCAGGCCGATGGGCTGGTGGAGGTCCAGGGCCACCGCATCCATGTCACCGACGAGGGCCGCAC
CCTGGTCCGCGCCGTCTGCGCCGCCTTCGACCGCTACCTCAAGGCGGGCGAACAGCGACATTCGAAGGCGGTCTGA

Upstream 100 bases:

>100_bases
CAGCCATTTAGGGCTGGCCGAATACCCACACGCCGCCCGGTGTTGCCAATGGCGGGGCGCTGGGAGTAGGGTTCCAGCCG
AATTTTCCGGGATACCTCAG

Downstream 100 bases:

>100_bases
GCATCATGACCATGGCCTGGTATGACTACTTCATGGGCTTCGCCAAGCACGCCGCCAGCAAGTCCAAGGACCCCAGCACC
CAGGTGGGCGCCGTGGCGGT

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MRPDLAAKYDLRVPRYTSYPTAPHFHPGVTGETYRGWLGAIDPKLELSLYLHIAFCAEMCWFCGCHTKITKRYAPVAAYM
DALWREVELVAEALPTRMTARHVHFGGGSPTILSSEDFVRTIDLLKSHFILKPDAEVAVELDPRTADEAYVKAMAGAGVT
RASIGVQDLDDKVQQAINRIQPYEVTERVVEWLGKYGVPEVNIDLIYGLPHQTLDGLLATIDKAVRGFRPRRVALFGYAH
VPWMKKHQRLIPEETLPDTETRWQQYEQGCRLLTETLGYVQIGLDHFAAPDDAMAIALREKRLHRNFQGYTTDSATTLIG
FGASGIGSLPQGYVVNDGEVHAYQRSIAEGKLAISRGVAITADDILRREIIERLMCDLEIDLDVVAGRHGSDGSHFAAEL
ASLAPLQADGLVEVQGHRIHVTDEGRTLVRAVCAAFDRYLKAGEQRHSKAV

Sequences:

>Translated_451_residues
MRPDLAAKYDLRVPRYTSYPTAPHFHPGVTGETYRGWLGAIDPKLELSLYLHIAFCAEMCWFCGCHTKITKRYAPVAAYM
DALWREVELVAEALPTRMTARHVHFGGGSPTILSSEDFVRTIDLLKSHFILKPDAEVAVELDPRTADEAYVKAMAGAGVT
RASIGVQDLDDKVQQAINRIQPYEVTERVVEWLGKYGVPEVNIDLIYGLPHQTLDGLLATIDKAVRGFRPRRVALFGYAH
VPWMKKHQRLIPEETLPDTETRWQQYEQGCRLLTETLGYVQIGLDHFAAPDDAMAIALREKRLHRNFQGYTTDSATTLIG
FGASGIGSLPQGYVVNDGEVHAYQRSIAEGKLAISRGVAITADDILRREIIERLMCDLEIDLDVVAGRHGSDGSHFAAEL
ASLAPLQADGLVEVQGHRIHVTDEGRTLVRAVCAAFDRYLKAGEQRHSKAV
>Mature_451_residues
MRPDLAAKYDLRVPRYTSYPTAPHFHPGVTGETYRGWLGAIDPKLELSLYLHIAFCAEMCWFCGCHTKITKRYAPVAAYM
DALWREVELVAEALPTRMTARHVHFGGGSPTILSSEDFVRTIDLLKSHFILKPDAEVAVELDPRTADEAYVKAMAGAGVT
RASIGVQDLDDKVQQAINRIQPYEVTERVVEWLGKYGVPEVNIDLIYGLPHQTLDGLLATIDKAVRGFRPRRVALFGYAH
VPWMKKHQRLIPEETLPDTETRWQQYEQGCRLLTETLGYVQIGLDHFAAPDDAMAIALREKRLHRNFQGYTTDSATTLIG
FGASGIGSLPQGYVVNDGEVHAYQRSIAEGKLAISRGVAITADDILRREIIERLMCDLEIDLDVVAGRHGSDGSHFAAEL
ASLAPLQADGLVEVQGHRIHVTDEGRTLVRAVCAAFDRYLKAGEQRHSKAV

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=176, Percent_Identity=27.2727272727273, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI87082341, Length=454, Percent_Identity=39.2070484581498, Blast_Score=316, Evalue=2e-87,
Organism=Escherichia coli, GI1789325, Length=297, Percent_Identity=27.9461279461279, Blast_Score=103, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 50169; Mature: 50169

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPDLAAKYDLRVPRYTSYPTAPHFHPGVTGETYRGWLGAIDPKLELSLYLHIAFCAEMC
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCEEEHHHHHHHHHHHHH
WFCGCHTKITKRYAPVAAYMDALWREVELVAEALPTRMTARHVHFGGGSPTILSSEDFVR
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCEEEECCCCCCEECCHHHHH
TIDLLKSHFILKPDAEVAVELDPRTADEAYVKAMAGAGVTRASIGVQDLDDKVQQAINRI
HHHHHHHCEEECCCCCEEEEECCCCCHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHC
QPYEVTERVVEWLGKYGVPEVNIDLIYGLPHQTLDGLLATIDKAVRGFRPRRVALFGYAH
CCHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEEC
VPWMKKHQRLIPEETLPDTETRWQQYEQGCRLLTETLGYVQIGLDHFAAPDDAMAIALRE
CCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEECHHHHCCCCHHHHHHHHH
KRLHRNFQGYTTDSATTLIGFGASGIGSLPQGYVVNDGEVHAYQRSIAEGKLAISRGVAI
HHHHCCCCCEECCCCEEEEEECCCCCCCCCCCEEECCCCHHHHHHHHHHCCEEHHCCCEE
TADDILRREIIERLMCDLEIDLDVVAGRHGSDGSHFAAELASLAPLQADGLVEVQGHRIH
CHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCEEEECCCEEE
VTDEGRTLVRAVCAAFDRYLKAGEQRHSKAV
EECCCHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRPDLAAKYDLRVPRYTSYPTAPHFHPGVTGETYRGWLGAIDPKLELSLYLHIAFCAEMC
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCEEEHHHHHHHHHHHHH
WFCGCHTKITKRYAPVAAYMDALWREVELVAEALPTRMTARHVHFGGGSPTILSSEDFVR
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCEEEECCCCCCEECCHHHHH
TIDLLKSHFILKPDAEVAVELDPRTADEAYVKAMAGAGVTRASIGVQDLDDKVQQAINRI
HHHHHHHCEEECCCCCEEEEECCCCCHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHC
QPYEVTERVVEWLGKYGVPEVNIDLIYGLPHQTLDGLLATIDKAVRGFRPRRVALFGYAH
CCHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEEC
VPWMKKHQRLIPEETLPDTETRWQQYEQGCRLLTETLGYVQIGLDHFAAPDDAMAIALRE
CCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEECHHHHCCCCHHHHHHHHH
KRLHRNFQGYTTDSATTLIGFGASGIGSLPQGYVVNDGEVHAYQRSIAEGKLAISRGVAI
HHHHCCCCCEECCCCEEEEEECCCCCCCCCCCEEECCCCHHHHHHHHHHCCEEHHCCCEE
TADDILRREIIERLMCDLEIDLDVVAGRHGSDGSHFAAELASLAPLQADGLVEVQGHRIH
CHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCEEEECCCEEE
VTDEGRTLVRAVCAAFDRYLKAGEQRHSKAV
EECCCHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11157943; 12597275 [H]