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The map label for this gene is cph1 [H]

Identifier: 83311743

GI number: 83311743

Start: 2832035

End: 2834626

Strand: Reverse

Name: cph1 [H]

Synonym: amb2644

Alternate gene names: 83311743

Gene position: 2834626-2832035 (Counterclockwise)

Preceding gene: 83311744

Following gene: 83311742

Centisome position: 57.07

GC content: 64.24

Gene sequence:

>2592_bases
GTGGATTTCAGGTCTCTGCGTATCAGAATTCTCTCTCTTTTCCTTCTGTCCTTCCTGGGGGCGGGCGCCGTGGTGGCTTT
GGCGCTTGCCGGATCGCTGCAACGGGACGTTGAAACTCTGCTGGCCCGGCAGCAGGTGACCTTCGTCAGCGGATTGGCCG
AGGAACTGGATCAGAAGATCAAGCTGCAGATCGAGGCCATGGAGCGGGTGGCGCCGCTGGTGCTCCGCGTCGATCGCGGC
GACGGCGGTGCGCTCAAGGCTTTCATCGAGGACCGGACCGGCATCAAGGGATTTTTCGCCGGCGGCTTGCTGGTTCTCGG
CGCGGATGGCCGGGTTCTGGCCGAAACGCCCAACCTGGGCCGGCTCGGCAAAGGCATGGCGGACGAGATCGGGGTCGGTT
CGGTTCTGGCCTCCGGTCGCTCGCTGGTCAGCGAGCCCTATTTCGATCATGCGCTCAACCAGCCGGCGGTCGCCATGGCG
GTGCCCATCCGCCGGGGCGAGGCCGTGGTCGGAGCGTTGGTGGGGATCGCCACCCTGACCCAAAGCAATCTTCTCGGCCG
GCTGGTCGAGCAGAAGGTCGGTGAAAGCGGCGGCCTGTACATGGTGTCGCCGAAATCCGGCCTGATCGTCGTTTCCACCA
ATAAGGAACGCATATTCACCCCCGTCCCTCGCCGTGGGCAGAACCATATGCTTGACCGTTACATGGACGGTTTCGAGGGC
TCGGGGGTGACCGTCAGCTCGGCCGGGCTGGAGGAACTGACGTCGGCCCGGCGTATCGCTTCCACCGGCTGGGTGCTGGT
GGCGCGGCTGCCCACCGCCGAGGCCTTCGAGCCGGTGGCCGATATCAAGACCCGCCTGTTCGCCGCCCTGGCCGGACTGG
GGCTGACTTCCCTGGGGCTGCTGTGGCTGGTGCTTCGCTCGGCGCTGTCGCCGCTGCACCGGGCCACCGGGCGAATTCAG
GCCATGGTCGACGGCAATGCCCCGTTCGAGGCGGTGGAGATTTCGCGCGGCGACGAGGTCGGGCGGATGATCGGCGCCTT
CAATGCCCTGCAGGCCAAGGTTGCCGCCGCCGACGTGGCGCTGCGGGAGCGCGAGGGGCTCTATCATGCGCTGTTCCGCG
GCTGCAAGGCGGTGGAACTGCTGATCGATCCCGCCGAGGACGGCCGCATCATCGACGCCAATCGCGCCGCCGAGGCTTAT
TACGGTTGGTCCCATGACCAACTCCTGTCCATGCGGATTTCCGAGATCAATATCCTGGACAGGGCCGCCATCATCGCCGA
AATGCACAAGGCCGAGCTTGAAGAGCGGGATCATTTCGATTTCCGCCACCGCCTGGCGTCCGGGGAAGTCCGCGACGTGG
AGGTATGGTCGGGGCCGGTCCAGGTCACCGGCCGGCAATTGCTCTATTCCATCGTTCACGATGTGACCGCCAGACGCGCC
GCGGAGCGTGAGGTCCGCTCGCTCCTGGCCTTCCGGCGAGCGGTTCTGGACGGTGCGGGGTCCTCCATCGTCGCTACCGC
AGTCGACGGCACCATTCTGCTGTTCAATCCGACTGCCGAACGCTGGCTTGGCTACGGCGCGGAAGAGGTGGTCGGACGGA
TGACCCCGGCGGCTTTCCATGATTCCGAAGAAGTTAGCCAGCGTGTAGCCCGTCTGAGCCAGGAACTGGGCCGAGAAGTC
GAGCCCGGATTCGAGTGCTTCATCGCCAAGGTTCTGGACAGCGGCAAGCCCGACAGCGGTGAGTGGACCTATGTGCGCAA
GGATGGCAGTCGGTTCCGCGTTCTGTTGACCGTTACCGCGCTCTATGACGAAGAGGGCGTGCTTTCGGGCTTTCTAGGTG
TTGCCCAGGATATTAGTGCTCGCCTTTCGATAGAAAAAGAGCTGAAGCGTTCCAATGCCGAGCTGGAAAATTTCGCCTAT
GTCGCGTCCCACGACCTTCGTCAGCCGCTGCGTATGATCAGTTCCTACATCGCCCTGCTGCAGCGGCGTTTGGGCGACGC
TCTCGATCAGGACTGCCAGGACTTCATCGGCTTTGCCGTGGGCGGTGCCCAGCGCATGGATCACATGATCACGGATCTGC
TGCAATACTCCCGTCTCGGGCGGAGCGGCACTCCGCCGGCGGCCGTGAATCTGGCTGAGGTGGTCAAGCTGGCCCAGGCC
AATCTTGGCGCGCTGATCGAGGAAACCGGCGCGGCCGTTACCGTGGCCGAGGGATTGCCCACGGTGCGGGGCAATGAGGT
GGAACTGGAACGGCTGTTCCAGAACCTGATCTCCAACGCGGTGAAGTTTCAGGCCCAAGGCCGGCTTCCGCTCGTGGAGA
TTACGTGGAGAGCCACGGCGGATGAATGGATCATCTCGGTCCGGGACAACGGTATCGGCATCGACGAGGCCGGGCGGCAG
AAGCTGTTTCAGATCTTCCAGCGGCTGGTGAGACTGGATCAGTACCCGGGAAGCGGTATCGGGCTGGCATCCTGCCGCAA
GATTGCCGAGCACCACGGCGGCCGTATCTGGGTGGAATCCCAGCCGGGCGAGGGGTCGACGTTCCAGGTTGCACTGCCCG
TGTCGGGACCGGACGAGTCGCACGCCGGATAA

Upstream 100 bases:

>100_bases
AGTTGGAAAGCTGAAAAGGACGGGACTGGCCAGCAACAGGACTTGAGAGTGATTACCATTTCCCCTTACCCTGTTCGATG
AACCAGGGGAGAGAGAAGAC

Downstream 100 bases:

>100_bases
CGCGCTTGGGCGCCCAGGTGGCGCGTAGGTGCAATAATTCGTCTTCAAGGCATGGTTGCAATCCGTATGCACCCAGGCTA
GGGTGAGGGATCGAACGTCG

Product: Signal transduction histidine kinase

Products: NA

Alternate protein names: Bacteriophytochrome cph1; Light-regulated histidine kinase 1 [H]

Number of amino acids: Translated: 863; Mature: 863

Protein sequence:

>863_residues
MDFRSLRIRILSLFLLSFLGAGAVVALALAGSLQRDVETLLARQQVTFVSGLAEELDQKIKLQIEAMERVAPLVLRVDRG
DGGALKAFIEDRTGIKGFFAGGLLVLGADGRVLAETPNLGRLGKGMADEIGVGSVLASGRSLVSEPYFDHALNQPAVAMA
VPIRRGEAVVGALVGIATLTQSNLLGRLVEQKVGESGGLYMVSPKSGLIVVSTNKERIFTPVPRRGQNHMLDRYMDGFEG
SGVTVSSAGLEELTSARRIASTGWVLVARLPTAEAFEPVADIKTRLFAALAGLGLTSLGLLWLVLRSALSPLHRATGRIQ
AMVDGNAPFEAVEISRGDEVGRMIGAFNALQAKVAAADVALREREGLYHALFRGCKAVELLIDPAEDGRIIDANRAAEAY
YGWSHDQLLSMRISEINILDRAAIIAEMHKAELEERDHFDFRHRLASGEVRDVEVWSGPVQVTGRQLLYSIVHDVTARRA
AEREVRSLLAFRRAVLDGAGSSIVATAVDGTILLFNPTAERWLGYGAEEVVGRMTPAAFHDSEEVSQRVARLSQELGREV
EPGFECFIAKVLDSGKPDSGEWTYVRKDGSRFRVLLTVTALYDEEGVLSGFLGVAQDISARLSIEKELKRSNAELENFAY
VASHDLRQPLRMISSYIALLQRRLGDALDQDCQDFIGFAVGGAQRMDHMITDLLQYSRLGRSGTPPAAVNLAEVVKLAQA
NLGALIEETGAAVTVAEGLPTVRGNEVELERLFQNLISNAVKFQAQGRLPLVEITWRATADEWIISVRDNGIGIDEAGRQ
KLFQIFQRLVRLDQYPGSGIGLASCRKIAEHHGGRIWVESQPGEGSTFQVALPVSGPDESHAG

Sequences:

>Translated_863_residues
MDFRSLRIRILSLFLLSFLGAGAVVALALAGSLQRDVETLLARQQVTFVSGLAEELDQKIKLQIEAMERVAPLVLRVDRG
DGGALKAFIEDRTGIKGFFAGGLLVLGADGRVLAETPNLGRLGKGMADEIGVGSVLASGRSLVSEPYFDHALNQPAVAMA
VPIRRGEAVVGALVGIATLTQSNLLGRLVEQKVGESGGLYMVSPKSGLIVVSTNKERIFTPVPRRGQNHMLDRYMDGFEG
SGVTVSSAGLEELTSARRIASTGWVLVARLPTAEAFEPVADIKTRLFAALAGLGLTSLGLLWLVLRSALSPLHRATGRIQ
AMVDGNAPFEAVEISRGDEVGRMIGAFNALQAKVAAADVALREREGLYHALFRGCKAVELLIDPAEDGRIIDANRAAEAY
YGWSHDQLLSMRISEINILDRAAIIAEMHKAELEERDHFDFRHRLASGEVRDVEVWSGPVQVTGRQLLYSIVHDVTARRA
AEREVRSLLAFRRAVLDGAGSSIVATAVDGTILLFNPTAERWLGYGAEEVVGRMTPAAFHDSEEVSQRVARLSQELGREV
EPGFECFIAKVLDSGKPDSGEWTYVRKDGSRFRVLLTVTALYDEEGVLSGFLGVAQDISARLSIEKELKRSNAELENFAY
VASHDLRQPLRMISSYIALLQRRLGDALDQDCQDFIGFAVGGAQRMDHMITDLLQYSRLGRSGTPPAAVNLAEVVKLAQA
NLGALIEETGAAVTVAEGLPTVRGNEVELERLFQNLISNAVKFQAQGRLPLVEITWRATADEWIISVRDNGIGIDEAGRQ
KLFQIFQRLVRLDQYPGSGIGLASCRKIAEHHGGRIWVESQPGEGSTFQVALPVSGPDESHAG
>Mature_863_residues
MDFRSLRIRILSLFLLSFLGAGAVVALALAGSLQRDVETLLARQQVTFVSGLAEELDQKIKLQIEAMERVAPLVLRVDRG
DGGALKAFIEDRTGIKGFFAGGLLVLGADGRVLAETPNLGRLGKGMADEIGVGSVLASGRSLVSEPYFDHALNQPAVAMA
VPIRRGEAVVGALVGIATLTQSNLLGRLVEQKVGESGGLYMVSPKSGLIVVSTNKERIFTPVPRRGQNHMLDRYMDGFEG
SGVTVSSAGLEELTSARRIASTGWVLVARLPTAEAFEPVADIKTRLFAALAGLGLTSLGLLWLVLRSALSPLHRATGRIQ
AMVDGNAPFEAVEISRGDEVGRMIGAFNALQAKVAAADVALREREGLYHALFRGCKAVELLIDPAEDGRIIDANRAAEAY
YGWSHDQLLSMRISEINILDRAAIIAEMHKAELEERDHFDFRHRLASGEVRDVEVWSGPVQVTGRQLLYSIVHDVTARRA
AEREVRSLLAFRRAVLDGAGSSIVATAVDGTILLFNPTAERWLGYGAEEVVGRMTPAAFHDSEEVSQRVARLSQELGREV
EPGFECFIAKVLDSGKPDSGEWTYVRKDGSRFRVLLTVTALYDEEGVLSGFLGVAQDISARLSIEKELKRSNAELENFAY
VASHDLRQPLRMISSYIALLQRRLGDALDQDCQDFIGFAVGGAQRMDHMITDLLQYSRLGRSGTPPAAVNLAEVVKLAQA
NLGALIEETGAAVTVAEGLPTVRGNEVELERLFQNLISNAVKFQAQGRLPLVEITWRATADEWIISVRDNGIGIDEAGRQ
KLFQIFQRLVRLDQYPGSGIGLASCRKIAEHHGGRIWVESQPGEGSTFQVALPVSGPDESHAG

Specific function: Regulatory photoreceptor which exists in two forms that are reversibly interconvertible by light:the R form that absorbs maximally in the red region of the spectrum and the FR form that absorbs maximally in the far-red region. Has also a slight blue shift

COG id: COG4251

COG function: function code T; Bacteriophytochrome (light-regulated signal transduction histidine kinase)

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788549, Length=395, Percent_Identity=25.5696202531646, Blast_Score=111, Evalue=2e-25,
Organism=Escherichia coli, GI87081881, Length=126, Percent_Identity=36.5079365079365, Blast_Score=94, Evalue=4e-20,
Organism=Escherichia coli, GI145693157, Length=264, Percent_Identity=28.4090909090909, Blast_Score=89, Evalue=8e-19,
Organism=Escherichia coli, GI1788713, Length=410, Percent_Identity=21.4634146341463, Blast_Score=86, Evalue=1e-17,
Organism=Escherichia coli, GI48994928, Length=278, Percent_Identity=28.4172661870504, Blast_Score=85, Evalue=2e-17,
Organism=Escherichia coli, GI1789149, Length=226, Percent_Identity=30.0884955752212, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1786600, Length=248, Percent_Identity=25.8064516129032, Blast_Score=70, Evalue=5e-13,
Organism=Escherichia coli, GI1790346, Length=222, Percent_Identity=28.3783783783784, Blast_Score=70, Evalue=8e-13,
Organism=Escherichia coli, GI87081816, Length=125, Percent_Identity=32.8, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1786912, Length=271, Percent_Identity=28.0442804428044, Blast_Score=67, Evalue=5e-12,
Organism=Escherichia coli, GI1790436, Length=251, Percent_Identity=26.2948207171315, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003018
- InterPro:   IPR000014
- InterPro:   IPR013654
- InterPro:   IPR016132
- InterPro:   IPR001294
- InterPro:   IPR013515
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF01590 GAF; PF02518 HATPase_c; PF00512 HisKA; PF08446 PAS_2; PF00360 Phytochrome [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 93575; Mature: 93575

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS50885 HAMP ; PS50112 PAS ; PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFRSLRIRILSLFLLSFLGAGAVVALALAGSLQRDVETLLARQQVTFVSGLAEELDQKI
CCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLQIEAMERVAPLVLRVDRGDGGALKAFIEDRTGIKGFFAGGLLVLGADGRVLAETPNLG
HHHHHHHHHHCEEEEEEECCCCCEEHHHHHCCCCCCCEECCCEEEECCCCEEEECCCCCC
RLGKGMADEIGVGSVLASGRSLVSEPYFDHALNQPAVAMAVPIRRGEAVVGALVGIATLT
CCCCCCHHHCCHHHHHHCCHHHHCCCCHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHH
QSNLLGRLVEQKVGESGGLYMVSPKSGLIVVSTNKERIFTPVPRRGQNHMLDRYMDGFEG
HHHHHHHHHHHHCCCCCCEEEECCCCCEEEEECCCCEEECCCCCCCCHHHHHHHHCCCCC
SGVTVSSAGLEELTSARRIASTGWVLVARLPTAEAFEPVADIKTRLFAALAGLGLTSLGL
CCEEEECCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHH
LWLVLRSALSPLHRATGRIQAMVDGNAPFEAVEISRGDEVGRMIGAFNALQAKVAAADVA
HHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
LREREGLYHALFRGCKAVELLIDPAEDGRIIDANRAAEAYYGWSHDQLLSMRISEINILD
HHHHCCHHHHHHCCCCEEEEEECCCCCCEEEECCCCHHHHCCCCHHHHHHHHHHHHHHHH
RAAIIAEMHKAELEERDHFDFRHRLASGEVRDVEVWSGPVQVTGRQLLYSIVHDVTARRA
HHHHHHHHHHHHHHHCCCHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHH
AEREVRSLLAFRRAVLDGAGSSIVATAVDGTILLFNPTAERWLGYGAEEVVGRMTPAAFH
HHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEEECCCHHHHHCCCHHHHHHHCCCHHCC
DSEEVSQRVARLSQELGREVEPGFECFIAKVLDSGKPDSGEWTYVRKDGSRFRVLLTVTA
CHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCEEEEEEEEEE
LYDEEGVLSGFLGVAQDISARLSIEKELKRSNAELENFAYVASHDLRQPLRMISSYIALL
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
QRRLGDALDQDCQDFIGFAVGGAQRMDHMITDLLQYSRLGRSGTPPAAVNLAEVVKLAQA
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
NLGALIEETGAAVTVAEGLPTVRGNEVELERLFQNLISNAVKFQAQGRLPLVEITWRATA
HHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHEEHCCCCCCEEEEEEECCC
DEWIISVRDNGIGIDEAGRQKLFQIFQRLVRLDQYPGSGIGLASCRKIAEHHGGRIWVES
CCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCEEEEEC
QPGEGSTFQVALPVSGPDESHAG
CCCCCCEEEEEEECCCCCCCCCC
>Mature Secondary Structure
MDFRSLRIRILSLFLLSFLGAGAVVALALAGSLQRDVETLLARQQVTFVSGLAEELDQKI
CCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLQIEAMERVAPLVLRVDRGDGGALKAFIEDRTGIKGFFAGGLLVLGADGRVLAETPNLG
HHHHHHHHHHCEEEEEEECCCCCEEHHHHHCCCCCCCEECCCEEEECCCCEEEECCCCCC
RLGKGMADEIGVGSVLASGRSLVSEPYFDHALNQPAVAMAVPIRRGEAVVGALVGIATLT
CCCCCCHHHCCHHHHHHCCHHHHCCCCHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHH
QSNLLGRLVEQKVGESGGLYMVSPKSGLIVVSTNKERIFTPVPRRGQNHMLDRYMDGFEG
HHHHHHHHHHHHCCCCCCEEEECCCCCEEEEECCCCEEECCCCCCCCHHHHHHHHCCCCC
SGVTVSSAGLEELTSARRIASTGWVLVARLPTAEAFEPVADIKTRLFAALAGLGLTSLGL
CCEEEECCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHH
LWLVLRSALSPLHRATGRIQAMVDGNAPFEAVEISRGDEVGRMIGAFNALQAKVAAADVA
HHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
LREREGLYHALFRGCKAVELLIDPAEDGRIIDANRAAEAYYGWSHDQLLSMRISEINILD
HHHHCCHHHHHHCCCCEEEEEECCCCCCEEEECCCCHHHHCCCCHHHHHHHHHHHHHHHH
RAAIIAEMHKAELEERDHFDFRHRLASGEVRDVEVWSGPVQVTGRQLLYSIVHDVTARRA
HHHHHHHHHHHHHHHCCCHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHH
AEREVRSLLAFRRAVLDGAGSSIVATAVDGTILLFNPTAERWLGYGAEEVVGRMTPAAFH
HHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEEECCCHHHHHCCCHHHHHHHCCCHHCC
DSEEVSQRVARLSQELGREVEPGFECFIAKVLDSGKPDSGEWTYVRKDGSRFRVLLTVTA
CHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCEEEEEEEEEE
LYDEEGVLSGFLGVAQDISARLSIEKELKRSNAELENFAYVASHDLRQPLRMISSYIALL
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
QRRLGDALDQDCQDFIGFAVGGAQRMDHMITDLLQYSRLGRSGTPPAAVNLAEVVKLAQA
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
NLGALIEETGAAVTVAEGLPTVRGNEVELERLFQNLISNAVKFQAQGRLPLVEITWRATA
HHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHEEHCCCCCCEEEEEEECCC
DEWIISVRDNGIGIDEAGRQKLFQIFQRLVRLDQYPGSGIGLASCRKIAEHHGGRIWVES
CCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCEEEEEC
QPGEGSTFQVALPVSGPDESHAG
CCCCCCEEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231; 9109482; 9278513; 10828948 [H]