Click here to switch to the map view.

The map label for this gene is pleC [H]

Identifier: 83311645

GI number: 83311645

Start: 2728814

End: 2731357

Strand: Reverse

Name: pleC [H]

Synonym: amb2546

Alternate gene names: 83311645

Gene position: 2731357-2728814 (Counterclockwise)

Preceding gene: 83311648

Following gene: 83311641

Centisome position: 54.99

GC content: 64.66

Gene sequence:

>2544_bases
ATGAGTAAGAGCCAGGGCGCAGGACGGATCGGAAGACATGGCCTGATGGTGAGGCTGGTATTCCTGTGCGCGGCCGTCTG
TATGGTCCTCTGGGCGTTGATCGAGATCATTCATCGCCGAAATCTGGCAAATGTGGTCGACCAGATTTTGGTCGAGCGGT
TGGAACACAAAGTCGGGCGCGACGCCATGCGTATGGATGACGTCCTGGCATCCCACCAGGCGCTGGCTGATCTGGCCGGG
CGGCTGCAGGGTATTCGCGCGGCAGGAGAGCCCATCTGGTTTCCCACCGGGGAGGAGTTGAAGGCCTATCCCCCGATCGA
CTTTCTCGCCATTCTTGGCGCCGGGGGGATCGAGGGGGAAGGCGAGGCGAGACGTGGTCGCCCCTTTTCGCCGGAACTGG
CTCCCGCGCTGGCGCTTCTGCCGGCGGGGCAGGTTCAGCGCATCGCCATTTCCCAAACCGAAGGCCTGTTGATTTCGGCG
GCTCCCCTGGCGGGGGGCGGTGGTCGCCGGCTGGTCGTGGTGTCGGTCATCGATGACGATTTTCTGCGGATTACCATGGG
CCGGTTTATGGATCGCGGATTCGCCTTCCTGGCCAGTGAGCCGGCCGGCGACCGGGTTCTGGCCCTGGCCGGTTCCGCGG
ATCACACCGGGCAAGCTCGTTCCATGGCGGTCTGGGGCGAGGTCTTTCACCTCGGAACCGGACGGGTCCTGGGGGCTGGA
GATGGCTTTTCCGGGCTGACATTCACCACGGCCTTGCCGCGCAGCCGGCAGGGCGTGATGAGTGAGCCATTGATCTCCAT
GGAGCGCACCAGCCGAACCATCATGGGGGCCGGATTAAGCGCGCTGTTTTTCGCCGCTCTTGTTTACCTGGCCTGGAGAA
TTCGCCAGGCGGCCCTGCGGGTGGCGGCCATGACGCATCGGATTTCCAGTGCCGAGAGCACGGACCTCGGCCCCGACGAG
CTGGCTCACCTGGAAATCGAGGTGGAGACCCTGGTCTCCGAGGTTCAGCGCTCGCGTCAGGCCCTGAAGGACGAGGAGGA
GGCGCGCATCCATCTGCTGACGGAGCAGGCGGCCCTGGCTGCCGAGAACGAGCGACTGCATCTGCTTCATTCGGTGACCG
AGGTCATGGGCGTCGGCGTCATTCGCATGACCGATGGCGGACCCCAGGCCGAAAATTCGGTCATGCGGGACTTCGCTGCG
GTGGCGGGAGGGCTTGGCCCCTTTCTCCAGGCTCGGACCAGCGGAAGTGATCTGGTCCGCATCGCTCAGGGGGAGGGCGA
GCGGGTTTTCGAGACCATGTTGGCCCGCAGTGTCGATACCGGGTTGATCCTGGTGGAAGACGCCACCAGCCGGCGCCAGG
CCGAAGAAGCCATCGCCATCTTTGCCCAGTTCCCGTCGCAAGATCCCAATCCGGTGTTGCGGGTGACCCGTGCCGGTGTG
GTGACCCACGCCAATCAGGCGGCGTCGCGGTTGCTGGAATTCTGGGGCATTGACCTGGGCGGTATGCTGCCCGAGGCCTG
GAAGACGCATATTGTCGACGCCTTGGAAGGCGGAGTGCAGTCCGAGGCCGAAATAACCGTGCGGGACCGCATCCTGTCGC
TGGTCTTCGTGCCGCTGCCCGGCGTCGGCGTGGTCAACGTCTATGGCAGCGACATCACCGGCCGTATCGCCGCCGAGCGC
CTGCTGCACATGGTCAACGAGAGTCTGGAGCGCCGGGTGCACCAGCGCACCGAGGCCCTCAAGGCCGAAATCGCCGAGCA
TATCCGCGCCGAGCGGGAGCTGGTCGCCGCCAAGGAACAGGCCGACCTGGCCAACCGCGCCAAGACGGAATTCCTGGCCA
ATGTCAGCCATGAGCTGCGCACGCCCCTCAATGCCGTCATCGGCTTTTCCGAAGTGATGGCCGCCGAAATGTTCGGCCCC
CTGGGGTCTGCCCGCTACGTCGGTTACGTCAACGATATCCTGGCCTCGGGTCGCCATCTTCTGGCGGTGATCAATGACAT
TCTCGATATCGCCAAGATCGAGGCGGGGCAGATGGAATTCGACATGGAACTGGTCCAGCCCGCCGAGGTGGTGGCGGCGG
CGATTCGCATCGTCGAAAGCCGTGCCGATGCCGGTGGATTGGTTCTTGGCAGCCACATCGCCGAGGATGTTCCGGCCCTC
AAGGCCGACCGTCGGAGATTGCTGCAGATTTTGGTCAACCTGCTGTCCAACTCCGTCAAGTTCACCCCCGAGGGCGGCAG
CGTCGAAGTGACGGTGGAAGTTCTGGGCGACATGGTTGGGTTCACGGTCTCGGACACGGGCATCGGCATGAGTGACGACG
AAGTGGTCGTCGCCATGCTGCCGTTCCGGCAGGTGGACGGCAGCCTGTCGCGCCGTTACGACGGCACCGGCCTTGGCCTG
CCCCTGGTGCGGGCCTTCGTGGAACTTCACGGTGGCCATTTGGATATCGTCAGCCGCAAGGGGGAAGGCACCCAGGTCAC
CGTGCGGTTGCCGCAGGAGCCCCGTTCCGGTCAGGCCGCCGCCCTGCAGAGTGCCGGCGAGTAG

Upstream 100 bases:

>100_bases
GGGTGAATATTATTCTAAAGGTCCTTGTTGTTAGCGCTTCCTATGCATAAGTTTAGTTATTACCCCTTTGTACGTTGTCT
TCGGGGGGGCAAGGACGGCA

Downstream 100 bases:

>100_bases
CCGAGGTCAGCTGTAGCGCTCTTCCTTCCACGGGTCACCCTCGCCGTGATAGCCGCGCAATTCCCAGTAACCCGGGGTGT
CGCGGTCGGAAAAGGTAATG

Product: Signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 847; Mature: 846

Protein sequence:

>847_residues
MSKSQGAGRIGRHGLMVRLVFLCAAVCMVLWALIEIIHRRNLANVVDQILVERLEHKVGRDAMRMDDVLASHQALADLAG
RLQGIRAAGEPIWFPTGEELKAYPPIDFLAILGAGGIEGEGEARRGRPFSPELAPALALLPAGQVQRIAISQTEGLLISA
APLAGGGGRRLVVVSVIDDDFLRITMGRFMDRGFAFLASEPAGDRVLALAGSADHTGQARSMAVWGEVFHLGTGRVLGAG
DGFSGLTFTTALPRSRQGVMSEPLISMERTSRTIMGAGLSALFFAALVYLAWRIRQAALRVAAMTHRISSAESTDLGPDE
LAHLEIEVETLVSEVQRSRQALKDEEEARIHLLTEQAALAAENERLHLLHSVTEVMGVGVIRMTDGGPQAENSVMRDFAA
VAGGLGPFLQARTSGSDLVRIAQGEGERVFETMLARSVDTGLILVEDATSRRQAEEAIAIFAQFPSQDPNPVLRVTRAGV
VTHANQAASRLLEFWGIDLGGMLPEAWKTHIVDALEGGVQSEAEITVRDRILSLVFVPLPGVGVVNVYGSDITGRIAAER
LLHMVNESLERRVHQRTEALKAEIAEHIRAERELVAAKEQADLANRAKTEFLANVSHELRTPLNAVIGFSEVMAAEMFGP
LGSARYVGYVNDILASGRHLLAVINDILDIAKIEAGQMEFDMELVQPAEVVAAAIRIVESRADAGGLVLGSHIAEDVPAL
KADRRRLLQILVNLLSNSVKFTPEGGSVEVTVEVLGDMVGFTVSDTGIGMSDDEVVVAMLPFRQVDGSLSRRYDGTGLGL
PLVRAFVELHGGHLDIVSRKGEGTQVTVRLPQEPRSGQAAALQSAGE

Sequences:

>Translated_847_residues
MSKSQGAGRIGRHGLMVRLVFLCAAVCMVLWALIEIIHRRNLANVVDQILVERLEHKVGRDAMRMDDVLASHQALADLAG
RLQGIRAAGEPIWFPTGEELKAYPPIDFLAILGAGGIEGEGEARRGRPFSPELAPALALLPAGQVQRIAISQTEGLLISA
APLAGGGGRRLVVVSVIDDDFLRITMGRFMDRGFAFLASEPAGDRVLALAGSADHTGQARSMAVWGEVFHLGTGRVLGAG
DGFSGLTFTTALPRSRQGVMSEPLISMERTSRTIMGAGLSALFFAALVYLAWRIRQAALRVAAMTHRISSAESTDLGPDE
LAHLEIEVETLVSEVQRSRQALKDEEEARIHLLTEQAALAAENERLHLLHSVTEVMGVGVIRMTDGGPQAENSVMRDFAA
VAGGLGPFLQARTSGSDLVRIAQGEGERVFETMLARSVDTGLILVEDATSRRQAEEAIAIFAQFPSQDPNPVLRVTRAGV
VTHANQAASRLLEFWGIDLGGMLPEAWKTHIVDALEGGVQSEAEITVRDRILSLVFVPLPGVGVVNVYGSDITGRIAAER
LLHMVNESLERRVHQRTEALKAEIAEHIRAERELVAAKEQADLANRAKTEFLANVSHELRTPLNAVIGFSEVMAAEMFGP
LGSARYVGYVNDILASGRHLLAVINDILDIAKIEAGQMEFDMELVQPAEVVAAAIRIVESRADAGGLVLGSHIAEDVPAL
KADRRRLLQILVNLLSNSVKFTPEGGSVEVTVEVLGDMVGFTVSDTGIGMSDDEVVVAMLPFRQVDGSLSRRYDGTGLGL
PLVRAFVELHGGHLDIVSRKGEGTQVTVRLPQEPRSGQAAALQSAGE
>Mature_846_residues
SKSQGAGRIGRHGLMVRLVFLCAAVCMVLWALIEIIHRRNLANVVDQILVERLEHKVGRDAMRMDDVLASHQALADLAGR
LQGIRAAGEPIWFPTGEELKAYPPIDFLAILGAGGIEGEGEARRGRPFSPELAPALALLPAGQVQRIAISQTEGLLISAA
PLAGGGGRRLVVVSVIDDDFLRITMGRFMDRGFAFLASEPAGDRVLALAGSADHTGQARSMAVWGEVFHLGTGRVLGAGD
GFSGLTFTTALPRSRQGVMSEPLISMERTSRTIMGAGLSALFFAALVYLAWRIRQAALRVAAMTHRISSAESTDLGPDEL
AHLEIEVETLVSEVQRSRQALKDEEEARIHLLTEQAALAAENERLHLLHSVTEVMGVGVIRMTDGGPQAENSVMRDFAAV
AGGLGPFLQARTSGSDLVRIAQGEGERVFETMLARSVDTGLILVEDATSRRQAEEAIAIFAQFPSQDPNPVLRVTRAGVV
THANQAASRLLEFWGIDLGGMLPEAWKTHIVDALEGGVQSEAEITVRDRILSLVFVPLPGVGVVNVYGSDITGRIAAERL
LHMVNESLERRVHQRTEALKAEIAEHIRAERELVAAKEQADLANRAKTEFLANVSHELRTPLNAVIGFSEVMAAEMFGPL
GSARYVGYVNDILASGRHLLAVINDILDIAKIEAGQMEFDMELVQPAEVVAAAIRIVESRADAGGLVLGSHIAEDVPALK
ADRRRLLQILVNLLSNSVKFTPEGGSVEVTVEVLGDMVGFTVSDTGIGMSDDEVVVAMLPFRQVDGSLSRRYDGTGLGLP
LVRAFVELHGGHLDIVSRKGEGTQVTVRLPQEPRSGQAAALQSAGE

Specific function: Member of the two-component regulatory system involved in the regulation of polar organelle development. PleC functions as a membrane-associated protein kinase that transfers phosphate to the response regulator pleD, leading to its activation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI145693157, Length=253, Percent_Identity=36.7588932806324, Blast_Score=143, Evalue=4e-35,
Organism=Escherichia coli, GI1789149, Length=265, Percent_Identity=35.0943396226415, Blast_Score=142, Evalue=1e-34,
Organism=Escherichia coli, GI87081816, Length=289, Percent_Identity=32.8719723183391, Blast_Score=121, Evalue=2e-28,
Organism=Escherichia coli, GI48994928, Length=232, Percent_Identity=34.051724137931, Blast_Score=113, Evalue=6e-26,
Organism=Escherichia coli, GI1788713, Length=270, Percent_Identity=31.1111111111111, Blast_Score=107, Evalue=3e-24,
Organism=Escherichia coli, GI1786600, Length=228, Percent_Identity=30.2631578947368, Blast_Score=94, Evalue=4e-20,
Organism=Escherichia coli, GI1788393, Length=231, Percent_Identity=29.4372294372294, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1786912, Length=246, Percent_Identity=28.0487804878049, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI1790436, Length=219, Percent_Identity=27.3972602739726, Blast_Score=89, Evalue=2e-18,
Organism=Escherichia coli, GI1786783, Length=228, Percent_Identity=25.8771929824561, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI87082128, Length=229, Percent_Identity=27.9475982532751, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI1788549, Length=231, Percent_Identity=23.8095238095238, Blast_Score=72, Evalue=2e-13,
Organism=Escherichia coli, GI1790861, Length=223, Percent_Identity=27.8026905829596, Blast_Score=63, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 90945; Mature: 90813

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKSQGAGRIGRHGLMVRLVFLCAAVCMVLWALIEIIHRRNLANVVDQILVERLEHKVGR
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCH
DAMRMDDVLASHQALADLAGRLQGIRAAGEPIWFPTGEELKAYPPIDFLAILGAGGIEGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCC
GEARRGRPFSPELAPALALLPAGQVQRIAISQTEGLLISAAPLAGGGGRRLVVVSVIDDD
CCCCCCCCCCCHHHHHHHHCCCCCEEEEEEECCCCEEEEECCCCCCCCCEEEEEEEECCC
FLRITMGRFMDRGFAFLASEPAGDRVLALAGSADHTGQARSMAVWGEVFHLGTGRVLGAG
HHHHHHHHHHHCCCEEEECCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCEEECC
DGFSGLTFTTALPRSRQGVMSEPLISMERTSRTIMGAGLSALFFAALVYLAWRIRQAALR
CCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
VAAMTHRISSAESTDLGPDELAHLEIEVETLVSEVQRSRQALKDEEEARIHLLTEQAALA
HHHHHHHHCCCCCCCCCHHHHEEEEEHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHH
AENERLHLLHSVTEVMGVGVIRMTDGGPQAENSVMRDFAAVAGGLGPFLQARTSGSDLVR
CCCCHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHCCCCCCEEE
IAQGEGERVFETMLARSVDTGLILVEDATSRRQAEEAIAIFAQFPSQDPNPVLRVTRAGV
EECCCCHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCCHHHEEECCCH
VTHANQAASRLLEFWGIDLGGMLPEAWKTHIVDALEGGVQSEAEITVRDRILSLVFVPLP
HHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHEECCC
GVGVVNVYGSDITGRIAAERLLHMVNESLERRVHQRTEALKAEIAEHIRAERELVAAKEQ
CCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADLANRAKTEFLANVSHELRTPLNAVIGFSEVMAAEMFGPLGSARYVGYVNDILASGRHL
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHH
LAVINDILDIAKIEAGQMEFDMELVQPAEVVAAAIRIVESRADAGGLVLGSHIAEDVPAL
HHHHHHHHHHHHCCCCCCCHHHHHHCHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHH
KADRRRLLQILVNLLSNSVKFTPEGGSVEVTVEVLGDMVGFTVSDTGIGMSDDEVVVAML
HHHHHHHHHHHHHHHCCCEEECCCCCCEEEEHHHHHHHHCCEEECCCCCCCCCCEEEEEE
PFRQVDGSLSRRYDGTGLGLPLVRAFVELHGGHLDIVSRKGEGTQVTVRLPQEPRSGQAA
CHHHHCCHHHHCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCEEEEECCCCCCCCCHH
ALQSAGE
HHHCCCC
>Mature Secondary Structure 
SKSQGAGRIGRHGLMVRLVFLCAAVCMVLWALIEIIHRRNLANVVDQILVERLEHKVGR
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCH
DAMRMDDVLASHQALADLAGRLQGIRAAGEPIWFPTGEELKAYPPIDFLAILGAGGIEGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCC
GEARRGRPFSPELAPALALLPAGQVQRIAISQTEGLLISAAPLAGGGGRRLVVVSVIDDD
CCCCCCCCCCCHHHHHHHHCCCCCEEEEEEECCCCEEEEECCCCCCCCCEEEEEEEECCC
FLRITMGRFMDRGFAFLASEPAGDRVLALAGSADHTGQARSMAVWGEVFHLGTGRVLGAG
HHHHHHHHHHHCCCEEEECCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCEEECC
DGFSGLTFTTALPRSRQGVMSEPLISMERTSRTIMGAGLSALFFAALVYLAWRIRQAALR
CCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
VAAMTHRISSAESTDLGPDELAHLEIEVETLVSEVQRSRQALKDEEEARIHLLTEQAALA
HHHHHHHHCCCCCCCCCHHHHEEEEEHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHH
AENERLHLLHSVTEVMGVGVIRMTDGGPQAENSVMRDFAAVAGGLGPFLQARTSGSDLVR
CCCCHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHCCCCCCEEE
IAQGEGERVFETMLARSVDTGLILVEDATSRRQAEEAIAIFAQFPSQDPNPVLRVTRAGV
EECCCCHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCCHHHEEECCCH
VTHANQAASRLLEFWGIDLGGMLPEAWKTHIVDALEGGVQSEAEITVRDRILSLVFVPLP
HHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHEECCC
GVGVVNVYGSDITGRIAAERLLHMVNESLERRVHQRTEALKAEIAEHIRAERELVAAKEQ
CCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADLANRAKTEFLANVSHELRTPLNAVIGFSEVMAAEMFGPLGSARYVGYVNDILASGRHL
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHH
LAVINDILDIAKIEAGQMEFDMELVQPAEVVAAAIRIVESRADAGGLVLGSHIAEDVPAL
HHHHHHHHHHHHCCCCCCCHHHHHHCHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHH
KADRRRLLQILVNLLSNSVKFTPEGGSVEVTVEVLGDMVGFTVSDTGIGMSDDEVVVAML
HHHHHHHHHHHHHHHCCCEEECCCCCCEEEEHHHHHHHHCCEEECCCCCCCCCCEEEEEE
PFRQVDGSLSRRYDGTGLGLPLVRAFVELHGGHLDIVSRKGEGTQVTVRLPQEPRSGQAA
CHHHHCCHHHHCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCEEEEECCCCCCCCCHH
ALQSAGE
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8421698; 11259647 [H]