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The map label for this gene is dxr [H]

Identifier: 83311591

GI number: 83311591

Start: 2670079

End: 2671242

Strand: Reverse

Name: dxr [H]

Synonym: amb2492

Alternate gene names: 83311591

Gene position: 2671242-2670079 (Counterclockwise)

Preceding gene: 83311592

Following gene: 83311590

Centisome position: 53.78

GC content: 67.61

Gene sequence:

>1164_bases
ATGAGCGGTCGGCGCGGCGTCACCATCCTGGGCTCGACGGGGTCCATCGGCTGCAACACGGTGGATCTGGTCGAACGGAA
TCCCGATCTTTATCGCGTCGAGGCTCTGGTCGCCAACTCGCGGGTCGACATTCTGGCCGAACAGGCGCGGAAGCTGCAGG
CCAAGCTGGCCGTAGTGGCCGATGAGAGCGCCTATGGCGCCCTGAAGTCCGCCCTGGCCGGTACCGGCATCGAGGTCGCC
GCCGGCGCCCAGGCCGTGGTTGCCGCTGCCGAACGGCCCGCCGACTGGGTCATGGCCGCCATTGTCGGCGCCGCCGGCCT
GGCCCCCACTTTGGCCGCAGTACGCCGCGGCGCCGTGGTGGGGTTGGCCAACAAGGAATGTCTGGTCTGCGCCGGTCAGC
TGATGATGGCGGAGGTGGAAAAGCACGGCGCCACCCTGCTGCCGGTGGATTCCGAGCACTCCGCCATCTTCCAGGTCTTC
GAGGCCGACCAGCACGATAAGATCGACAAGATCATCCTGACCGCTTCGGGCGGTCCGTTCCGAACCAAGACCCGCGAATT
CATGGCCGACGTGACACCCGAGCAGGCGGTGGCCCATCCCAACTGGTCCATGGGCGCCAAGATCTCGGTGGATTCCGCCT
CCATGTTCAACAAGGGGCTTGAACTGATCGAGGCCCACCACCTGTTCGACATGCCCGAGGACAAGATCGACATCGTCGTT
CATCCCCAATCGGTGATCCATTCGCTGGTGGCCTATGTGGACGGCTCGGTGCTGGCCCAGTTGGGCTCTCCCGACATGCG
CACGCCCATCGCCTACGCGCTCGGCTGGCCTAACCGCATGGAGGCGCCTGTGCCGAAGCTGGACCTGGCGGCCATCGCCA
CCTTGACCTTCGAGGCGCCGGACCCCGTGCGCTTCCCCTCGCTGCGCCTGGCGCGCGAGGCCCTGAGGGCGGGCGGTTCC
GCCGCCGCGGTGATGAACGCCGCCAACGAGGTGGCCGTGGCGGCCTTCCTTGGGCGGCGCATCGGCTTCCTTGATATCGC
CTCCCTGGTGGAGCGGACCGTGGCGGGGGTGAGCCACTGCGAGCTGACCTGCATCGACGACGTTCTGGCCCAGGATGCCG
AGGCGCGCCGCTTCGTCTCGGCCCTCATCGACGGTGGCCGCTAG

Upstream 100 bases:

>100_bases
CTGGATCGCGTCGACGGCCTGTTGACCGCCGCCCTGGCGGTGGCGGCACTATCTCTGGCGACCGGCAAGACGGTCCTGGA
CTGGCAATGAAGGAAATACC

Downstream 100 bases:

>100_bases
GTCATGGATCTCGCCAGCCTGCTCAACAGCGTCCTGCACGGCGTCTGGTACTACGTGGTCATCTTCCTGGTCATCCTGAC
CGTGGTGGTGTTCGTCCATG

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 387; Mature: 386

Protein sequence:

>387_residues
MSGRRGVTILGSTGSIGCNTVDLVERNPDLYRVEALVANSRVDILAEQARKLQAKLAVVADESAYGALKSALAGTGIEVA
AGAQAVVAAAERPADWVMAAIVGAAGLAPTLAAVRRGAVVGLANKECLVCAGQLMMAEVEKHGATLLPVDSEHSAIFQVF
EADQHDKIDKIILTASGGPFRTKTREFMADVTPEQAVAHPNWSMGAKISVDSASMFNKGLELIEAHHLFDMPEDKIDIVV
HPQSVIHSLVAYVDGSVLAQLGSPDMRTPIAYALGWPNRMEAPVPKLDLAAIATLTFEAPDPVRFPSLRLAREALRAGGS
AAAVMNAANEVAVAAFLGRRIGFLDIASLVERTVAGVSHCELTCIDDVLAQDAEARRFVSALIDGGR

Sequences:

>Translated_387_residues
MSGRRGVTILGSTGSIGCNTVDLVERNPDLYRVEALVANSRVDILAEQARKLQAKLAVVADESAYGALKSALAGTGIEVA
AGAQAVVAAAERPADWVMAAIVGAAGLAPTLAAVRRGAVVGLANKECLVCAGQLMMAEVEKHGATLLPVDSEHSAIFQVF
EADQHDKIDKIILTASGGPFRTKTREFMADVTPEQAVAHPNWSMGAKISVDSASMFNKGLELIEAHHLFDMPEDKIDIVV
HPQSVIHSLVAYVDGSVLAQLGSPDMRTPIAYALGWPNRMEAPVPKLDLAAIATLTFEAPDPVRFPSLRLAREALRAGGS
AAAVMNAANEVAVAAFLGRRIGFLDIASLVERTVAGVSHCELTCIDDVLAQDAEARRFVSALIDGGR
>Mature_386_residues
SGRRGVTILGSTGSIGCNTVDLVERNPDLYRVEALVANSRVDILAEQARKLQAKLAVVADESAYGALKSALAGTGIEVAA
GAQAVVAAAERPADWVMAAIVGAAGLAPTLAAVRRGAVVGLANKECLVCAGQLMMAEVEKHGATLLPVDSEHSAIFQVFE
ADQHDKIDKIILTASGGPFRTKTREFMADVTPEQAVAHPNWSMGAKISVDSASMFNKGLELIEAHHLFDMPEDKIDIVVH
PQSVIHSLVAYVDGSVLAQLGSPDMRTPIAYALGWPNRMEAPVPKLDLAAIATLTFEAPDPVRFPSLRLAREALRAGGSA
AAVMNAANEVAVAAFLGRRIGFLDIASLVERTVAGVSHCELTCIDDVLAQDAEARRFVSALIDGGR

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=385, Percent_Identity=51.6883116883117, Blast_Score=357, Evalue=1e-100,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 40729; Mature: 40598

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGRRGVTILGSTGSIGCNTVDLVERNPDLYRVEALVANSRVDILAEQARKLQAKLAVVA
CCCCCCEEEEECCCCCCCCEEEHHHCCCCCEEEHHHHHCCHHHHHHHHHHHHHHHEEEEE
DESAYGALKSALAGTGIEVAAGAQAVVAAAERPADWVMAAIVGAAGLAPTLAAVRRGAVV
CCHHHHHHHHHHHCCCCEECCCCHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHCCCEE
GLANKECLVCAGQLMMAEVEKHGATLLPVDSEHSAIFQVFEADQHDKIDKIILTASGGPF
EECCCCHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHCCCCCCCCEEEEEECCCCC
RTKTREFMADVTPEQAVAHPNWSMGAKISVDSASMFNKGLELIEAHHLFDMPEDKIDIVV
CHHHHHHHHCCCHHHHCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
HPQSVIHSLVAYVDGSVLAQLGSPDMRTPIAYALGWPNRMEAPVPKLDLAAIATLTFEAP
CCHHHHHHHHHHHCCHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCHHHHEEEEEEECCC
DPVRFPSLRLAREALRAGGSAAAVMNAANEVAVAAFLGRRIGFLDIASLVERTVAGVSHC
CCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCC
ELTCIDDVLAQDAEARRFVSALIDGGR
EEEEHHHHHHCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SGRRGVTILGSTGSIGCNTVDLVERNPDLYRVEALVANSRVDILAEQARKLQAKLAVVA
CCCCCEEEEECCCCCCCCEEEHHHCCCCCEEEHHHHHCCHHHHHHHHHHHHHHHEEEEE
DESAYGALKSALAGTGIEVAAGAQAVVAAAERPADWVMAAIVGAAGLAPTLAAVRRGAVV
CCHHHHHHHHHHHCCCCEECCCCHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHCCCEE
GLANKECLVCAGQLMMAEVEKHGATLLPVDSEHSAIFQVFEADQHDKIDKIILTASGGPF
EECCCCHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHCCCCCCCCEEEEEECCCCC
RTKTREFMADVTPEQAVAHPNWSMGAKISVDSASMFNKGLELIEAHHLFDMPEDKIDIVV
CHHHHHHHHCCCHHHHCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
HPQSVIHSLVAYVDGSVLAQLGSPDMRTPIAYALGWPNRMEAPVPKLDLAAIATLTFEAP
CCHHHHHHHHHHHCCHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCHHHHEEEEEEECCC
DPVRFPSLRLAREALRAGGSAAAVMNAANEVAVAAFLGRRIGFLDIASLVERTVAGVSHC
CCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCC
ELTCIDDVLAQDAEARRFVSALIDGGR
EEEEHHHHHHCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA