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The map label for this gene is lpxB

Identifier: 83311583

GI number: 83311583

Start: 2661632

End: 2662804

Strand: Reverse

Name: lpxB

Synonym: amb2484

Alternate gene names: 83311583

Gene position: 2662804-2661632 (Counterclockwise)

Preceding gene: 83311584

Following gene: 83311582

Centisome position: 53.61

GC content: 65.39

Gene sequence:

>1173_bases
ATGCTGATTTACCTCATCGCCGGTGAGCCTTCGGGCGATCTGCTGGGCGGGCGGCTGATGGCGGCCCTGAAAGAGCGCCT
CGGTGAGGGCGTGAGTTTCGCCGGTATCGGCGGGGAGAGCATGCGGGCCGAAGGGCTGACATCCCTGTTCCCCATGACCG
AATTGTCGGTGATGGGACTGGTGGAGGTGCTGCCGCGCATCCCCAAGATCCTGCGCCGCGTCAAACAGACCATTTCTGAC
ATCGAAACAAAACGCCCGGATGCCCTGGTGACCATTGATTCCTGGGGGTTCAACGGCCGCATTCAGGCGGGCTTGAAGGC
GCGGGGCGTGCCCGTGCCGCGCATCCATTACGTGGCTCCCATGGTGTGGGCCTGGAAATCGGGACGGACCAAGACCCTGG
CCCGGGTGCTGGATCTGCTGCTGACCCTGCTGCCCAACGAGCCCGAGTGGTTCGAGAAGGAGGGGCTCAAGACCCTGCAT
GTGGGCCATCCGGTGATCGAAGGGGCGGCCTCCCGGGGGGATGGCGCAGCTTTCCGTGTTCGGCACGGCTTTGCCCCTGA
CCGGAAACTGCTGTGCGTGTTGCCCGGCAGCCGCCATTCCGAGACGGCCAAGCTTTTGGCGCCGTTCGGGGAAACCATTG
CCTTGCTGGCCCGGCGCTTTCCAGACCTGGCGGTGGTGGTTCCCACCGTGGAGACCGTTGCCGACGAGGTATCGCAAGCG
GTCAAATCCTGGGCTCTGCCGTCCATGGTCGTGCGCGGGCCGGAAAAGTACGACGCCTTCGCCGCCTGCGATGCCGCTTT
GGCAGCGTCCGGCACCGTGGCGCTGGAACTGGCCATGGCGCGGCTGCCGGCGGTGATCACCTATAAGGTCTCGCCCGTGT
CGGCCTTCATCGCCACCCGTTTCCTGGGCCTCAGCCTCAAATTCGTCACTCTTGTCAACATTCTGGTTGACGAGGCGGTG
ATGCCGGAATTGCTGCAGGACGATTGCCGCCCCGATAAGCTGGCGGCGGCGGTCGAGCACCTGCTGACCGATGAGGCGGC
AAGGGCACTGCAGGCCGCAGGCGCCCGCCGTGCCCTGGAAAAGCTGGGGCTGGGCGGCGAAAGCCCGGGCAAGCGGGCCG
CCGATGCGGTGATCGACTTCATCCGGCAAGGCAAGGAGCAACGAAATGGCTGA

Upstream 100 bases:

>100_bases
GCGGCATCGCCATCGAGGCGGGGGGCGCGCTTGTGGTGGATGCCAAGGCGTTGGGCGCAGAGGCCGACCGCCTGGGCCTG
TTCGTCACCGGCATCACGCC

Downstream 100 bases:

>100_bases
CTGGCGCTTTCTCCACACCATGATCCGGGTGGGTAACCTGGATCGCTCCATCCACTTCTACACCAGCCTGCTGGGCATGA
AGCTGCTGCGGCGCACGGAC

Product: Lipid A disaccharide synthetase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MLIYLIAGEPSGDLLGGRLMAALKERLGEGVSFAGIGGESMRAEGLTSLFPMTELSVMGLVEVLPRIPKILRRVKQTISD
IETKRPDALVTIDSWGFNGRIQAGLKARGVPVPRIHYVAPMVWAWKSGRTKTLARVLDLLLTLLPNEPEWFEKEGLKTLH
VGHPVIEGAASRGDGAAFRVRHGFAPDRKLLCVLPGSRHSETAKLLAPFGETIALLARRFPDLAVVVPTVETVADEVSQA
VKSWALPSMVVRGPEKYDAFAACDAALAASGTVALELAMARLPAVITYKVSPVSAFIATRFLGLSLKFVTLVNILVDEAV
MPELLQDDCRPDKLAAAVEHLLTDEAARALQAAGARRALEKLGLGGESPGKRAADAVIDFIRQGKEQRNG

Sequences:

>Translated_390_residues
MLIYLIAGEPSGDLLGGRLMAALKERLGEGVSFAGIGGESMRAEGLTSLFPMTELSVMGLVEVLPRIPKILRRVKQTISD
IETKRPDALVTIDSWGFNGRIQAGLKARGVPVPRIHYVAPMVWAWKSGRTKTLARVLDLLLTLLPNEPEWFEKEGLKTLH
VGHPVIEGAASRGDGAAFRVRHGFAPDRKLLCVLPGSRHSETAKLLAPFGETIALLARRFPDLAVVVPTVETVADEVSQA
VKSWALPSMVVRGPEKYDAFAACDAALAASGTVALELAMARLPAVITYKVSPVSAFIATRFLGLSLKFVTLVNILVDEAV
MPELLQDDCRPDKLAAAVEHLLTDEAARALQAAGARRALEKLGLGGESPGKRAADAVIDFIRQGKEQRNG
>Mature_390_residues
MLIYLIAGEPSGDLLGGRLMAALKERLGEGVSFAGIGGESMRAEGLTSLFPMTELSVMGLVEVLPRIPKILRRVKQTISD
IETKRPDALVTIDSWGFNGRIQAGLKARGVPVPRIHYVAPMVWAWKSGRTKTLARVLDLLLTLLPNEPEWFEKEGLKTLH
VGHPVIEGAASRGDGAAFRVRHGFAPDRKLLCVLPGSRHSETAKLLAPFGETIALLARRFPDLAVVVPTVETVADEVSQA
VKSWALPSMVVRGPEKYDAFAACDAALAASGTVALELAMARLPAVITYKVSPVSAFIATRFLGLSLKFVTLVNILVDEAV
MPELLQDDCRPDKLAAAVEHLLTDEAARALQAAGARRALEKLGLGGESPGKRAADAVIDFIRQGKEQRNG

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family

Homologues:

Organism=Escherichia coli, GI1786379, Length=335, Percent_Identity=37.0149253731343, Blast_Score=206, Evalue=2e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXB_MAGSA (Q2W4D7)

Other databases:

- EMBL:   AP007255
- RefSeq:   YP_421847.1
- ProteinModelPortal:   Q2W4D7
- STRING:   Q2W4D7
- GeneID:   3804689
- GenomeReviews:   AP007255_GR
- KEGG:   mag:amb2484
- NMPDR:   fig|342108.5.peg.2185
- eggNOG:   COG0763
- HOGENOM:   HBG584837
- OMA:   DFTHRVA
- PhylomeDB:   Q2W4D7
- ProtClustDB:   CLSK745081
- BioCyc:   MMAG342108:AMB2484-MONOMER
- HAMAP:   MF_00392
- InterPro:   IPR003835
- TIGRFAMs:   TIGR00215

Pfam domain/function: PF02684 LpxB

EC number: =2.4.1.182

Molecular weight: Translated: 41913; Mature: 41913

Theoretical pI: Translated: 9.14; Mature: 9.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIYLIAGEPSGDLLGGRLMAALKERLGEGVSFAGIGGESMRAEGLTSLFPMTELSVMGL
CEEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCHHHHCCHHHHCCHHHHHHHHH
VEVLPRIPKILRRVKQTISDIETKRPDALVTIDSWGFNGRIQAGLKARGVPVPRIHYVAP
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEECCCEECCCCCCHHHHHHH
MVWAWKSGRTKTLARVLDLLLTLLPNEPEWFEKEGLKTLHVGHPVIEGAASRGDGAAFRV
HHHHCCCCCHHHHHHHHHHHHHHCCCCCCHHHHCCCCEEECCCHHHHCCCCCCCCCEEEE
RHGFAPDRKLLCVLPGSRHSETAKLLAPFGETIALLARRFPDLAVVVPTVETVADEVSQA
ECCCCCCCEEEEECCCCCCCHHHHHHHCCHHHHHHHHHHCCCCEEEECCHHHHHHHHHHH
VKSWALPSMVVRGPEKYDAFAACDAALAASGTVALELAMARLPAVITYKVSPVSAFIATR
HHHHCCCHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCEEEEEECCHHHHHHHHH
FLGLSLKFVTLVNILVDEAVMPELLQDDCRPDKLAAAVEHLLTDEAARALQAAGARRALE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLGLGGESPGKRAADAVIDFIRQGKEQRNG
HHCCCCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLIYLIAGEPSGDLLGGRLMAALKERLGEGVSFAGIGGESMRAEGLTSLFPMTELSVMGL
CEEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCHHHHCCHHHHCCHHHHHHHHH
VEVLPRIPKILRRVKQTISDIETKRPDALVTIDSWGFNGRIQAGLKARGVPVPRIHYVAP
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEECCCEECCCCCCHHHHHHH
MVWAWKSGRTKTLARVLDLLLTLLPNEPEWFEKEGLKTLHVGHPVIEGAASRGDGAAFRV
HHHHCCCCCHHHHHHHHHHHHHHCCCCCCHHHHCCCCEEECCCHHHHCCCCCCCCCEEEE
RHGFAPDRKLLCVLPGSRHSETAKLLAPFGETIALLARRFPDLAVVVPTVETVADEVSQA
ECCCCCCCEEEEECCCCCCCHHHHHHHCCHHHHHHHHHHCCCCEEEECCHHHHHHHHHHH
VKSWALPSMVVRGPEKYDAFAACDAALAASGTVALELAMARLPAVITYKVSPVSAFIATR
HHHHCCCHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCEEEEEECCHHHHHHHHH
FLGLSLKFVTLVNILVDEAVMPELLQDDCRPDKLAAAVEHLLTDEAARALQAAGARRALE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLGLGGESPGKRAADAVIDFIRQGKEQRNG
HHCCCCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA