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The map label for this gene is folK [H]

Identifier: 83311398

GI number: 83311398

Start: 2502514

End: 2503014

Strand: Reverse

Name: folK [H]

Synonym: amb2299

Alternate gene names: 83311398

Gene position: 2503014-2502514 (Counterclockwise)

Preceding gene: 83311399

Following gene: 83311397

Centisome position: 50.39

GC content: 64.27

Gene sequence:

>501_bases
ATGACACTGGTTCATCTCGGCCTCGGCACCAACCTGGGCGACCGGCCCGCCAATCTGCGCGCCGCCATTGACGCCCTTGG
AACTGTCGGAGCGATCGCCGCCTATTCCCAGGTGTGGGAGACGGCGCCGCTTTACGTCATCGACCAGCCGGCCTTTCTCA
ACATGGCCGTGGCGCTGGAGACCGGCCTTGCCCCGCTGGAACTTCTGGCCCACCTCAAGGCCATGGAGGACGAGCTTGGC
CGGGTCGCCTCGGTGCGCTATGGGCCGCGCCTGATTGATCTCGACATCCTTCTTTATGCCGATATGGTGATGGCGAGTGA
AATACTCACCCTGCCTCACGCCCGGCTGCACGAACGGCACTTCGCCCTCGCCCCTCTGGCCGAGATTGCCGGGGAGGTGC
GTCACCCTACCTTGGGAGTCAGTATCTTAGCCTTGCTGCAGGGACTCCCCGGCCCCGGCGATATCCACCGACTCGGCCCC
CTGACGTCTATGACCTTGTAG

Upstream 100 bases:

>100_bases
GCGCCTGCAGCGGCTGAAAAAGCGCAAGCTGCACCTCAAGGACGAGATCACGCGGCTGGAAAACATCCTGATCCCCGACA
TCATCGCCTGATATTTCGCC

Downstream 100 bases:

>100_bases
CCGACAGGCCAAGCAACCACATCCATATGGCATAAGCCAAGGGTGTTTAGGATTGCCGATGAGAGGCTTGTTTCAAATTT
GCGAACCGATCCGGGACGCG

Product: 7,8-dihydro-6-hydroxymethylpterin- pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 166; Mature: 165

Protein sequence:

>166_residues
MTLVHLGLGTNLGDRPANLRAAIDALGTVGAIAAYSQVWETAPLYVIDQPAFLNMAVALETGLAPLELLAHLKAMEDELG
RVASVRYGPRLIDLDILLYADMVMASEILTLPHARLHERHFALAPLAEIAGEVRHPTLGVSILALLQGLPGPGDIHRLGP
LTSMTL

Sequences:

>Translated_166_residues
MTLVHLGLGTNLGDRPANLRAAIDALGTVGAIAAYSQVWETAPLYVIDQPAFLNMAVALETGLAPLELLAHLKAMEDELG
RVASVRYGPRLIDLDILLYADMVMASEILTLPHARLHERHFALAPLAEIAGEVRHPTLGVSILALLQGLPGPGDIHRLGP
LTSMTL
>Mature_165_residues
TLVHLGLGTNLGDRPANLRAAIDALGTVGAIAAYSQVWETAPLYVIDQPAFLNMAVALETGLAPLELLAHLKAMEDELGR
VASVRYGPRLIDLDILLYADMVMASEILTLPHARLHERHFALAPLAEIAGEVRHPTLGVSILALLQGLPGPGDIHRLGPL
TSMTL

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=139, Percent_Identity=44.6043165467626, Blast_Score=107, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6324073, Length=153, Percent_Identity=36.6013071895425, Blast_Score=91, Evalue=9e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 17720; Mature: 17589

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLVHLGLGTNLGDRPANLRAAIDALGTVGAIAAYSQVWETAPLYVIDQPAFLNMAVALE
CEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHH
TGLAPLELLAHLKAMEDELGRVASVRYGPRLIDLDILLYADMVMASEILTLPHARLHERH
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHCCHHHHHHHH
FALAPLAEIAGEVRHPTLGVSILALLQGLPGPGDIHRLGPLTSMTL
HHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHCCCCHHCCC
>Mature Secondary Structure 
TLVHLGLGTNLGDRPANLRAAIDALGTVGAIAAYSQVWETAPLYVIDQPAFLNMAVALE
EEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHH
TGLAPLELLAHLKAMEDELGRVASVRYGPRLIDLDILLYADMVMASEILTLPHARLHERH
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHCCHHHHHHHH
FALAPLAEIAGEVRHPTLGVSILALLQGLPGPGDIHRLGPLTSMTL
HHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377; 2123867 [H]