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The map label for this gene is ykpB [H]

Identifier: 83311085

GI number: 83311085

Start: 2145907

End: 2146827

Strand: Reverse

Name: ykpB [H]

Synonym: amb1986

Alternate gene names: 83311085

Gene position: 2146827-2145907 (Counterclockwise)

Preceding gene: 83311086

Following gene: 83311081

Centisome position: 43.22

GC content: 69.49

Gene sequence:

>921_bases
ATGCGGGTCCTGGTTCTGGGTGCGGGAGCGACGGGGGGATATTTCGGCGGACGGCTGGCGGAGGCCGGGGTGGACGTCAC
CTTCCTGGTGCGTCCCAAGCGTGCCGCCTTACTGGCCGAGAAGGGATTGCGCATCGAAAGCCCCCACGGAGATTCCACCC
GCCCGGTCAAGACGGTCACCGCCGAAACCCTGTCGGGGCATTGGGACGCCGTCCTGCTGTCGTGCAAGGCTTATGACCTG
GAAGAGTCCATCAAGGCCATCGCGCCGGCGGTGGGGCCGGACAGCATGGTCGTGCCCATCTTGAACGGCCTTGCCCATTA
CGGCCCGCTGGACGCGGCCTTTGGGGCGGGGCGGGTGATCGGCGGGTTGTGCCACATCTTCTCGACCCTGGGCGCCGATG
GCGAGATCCGGCATATGAACACTATCCACCGCATCACCTTCGGCGAGCGGTCGGGCGGCACCTCGGCGCGGACCGAGGCG
CTGGCCCAGGCCTTCGCCGGGGCTAATTGCGAGACGCGCCATTCGTCCGAGATCATGCAGGAAGCCTGGGAGAAGTATGT
GCTTCTCACCCCCATGGCCGCCATGACCTGCCTGATGCGGGCCAGTATCGGCACCATCATGGCCACCGGGGAGGGCGAGG
CGCTGATGCGCGAGACCTTCGAGGAATGCGCCGCCGTGGCGTCACGGGCCGGGCACGGGCCGCGCCCCGAGGCCCGGGAC
CTGGCCCTGGGCTTCCTGACCCAGAAGGGCTCGGCCATGACGGCGTCCATGCTGCGCGACCTGGAGGGCGGCGGCCCCAC
CGAGGGCGAGCACATCGTCGGCGACATGCTGCGCCGCGCCGGGGCGGCCGGAGTGGCGGCCCCCATGCTGCGGGTGGCCC
TGACCCATCTGCGGGCCTACGAGATCAGGCGGAAGGGATAG

Upstream 100 bases:

>100_bases
AGAGTTACGTGAAATCCAAAGGCTTGTCCGACTGCTAGACCCTTGCTCCGCTTGGCGCGCTCGGCTAGCCTCGCCCCACT
GGTCATACCGGAGGCGAGCG

Downstream 100 bases:

>100_bases
GGATCGGGGGCGCCCCCCTCCCGCACCAAATCTCAGCAGTCAGCGTACCAGCGCTTGAAGAAGGTATCATCGCCTTCTTC
GCGCAGCCCCATGGTGGGGG

Product: 2-dehydropantoate 2-reductase

Products: Nicotinamide adenine dinucleotide phosphate; (R)-Pantoate [C]

Alternate protein names: NA

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MRVLVLGAGATGGYFGGRLAEAGVDVTFLVRPKRAALLAEKGLRIESPHGDSTRPVKTVTAETLSGHWDAVLLSCKAYDL
EESIKAIAPAVGPDSMVVPILNGLAHYGPLDAAFGAGRVIGGLCHIFSTLGADGEIRHMNTIHRITFGERSGGTSARTEA
LAQAFAGANCETRHSSEIMQEAWEKYVLLTPMAAMTCLMRASIGTIMATGEGEALMRETFEECAAVASRAGHGPRPEARD
LALGFLTQKGSAMTASMLRDLEGGGPTEGEHIVGDMLRRAGAAGVAAPMLRVALTHLRAYEIRRKG

Sequences:

>Translated_306_residues
MRVLVLGAGATGGYFGGRLAEAGVDVTFLVRPKRAALLAEKGLRIESPHGDSTRPVKTVTAETLSGHWDAVLLSCKAYDL
EESIKAIAPAVGPDSMVVPILNGLAHYGPLDAAFGAGRVIGGLCHIFSTLGADGEIRHMNTIHRITFGERSGGTSARTEA
LAQAFAGANCETRHSSEIMQEAWEKYVLLTPMAAMTCLMRASIGTIMATGEGEALMRETFEECAAVASRAGHGPRPEARD
LALGFLTQKGSAMTASMLRDLEGGGPTEGEHIVGDMLRRAGAAGVAAPMLRVALTHLRAYEIRRKG
>Mature_306_residues
MRVLVLGAGATGGYFGGRLAEAGVDVTFLVRPKRAALLAEKGLRIESPHGDSTRPVKTVTAETLSGHWDAVLLSCKAYDL
EESIKAIAPAVGPDSMVVPILNGLAHYGPLDAAFGAGRVIGGLCHIFSTLGADGEIRHMNTIHRITFGERSGGTSARTEA
LAQAFAGANCETRHSSEIMQEAWEKYVLLTPMAAMTCLMRASIGTIMATGEGEALMRETFEECAAVASRAGHGPRPEARD
LALGFLTQKGSAMTASMLRDLEGGGPTEGEHIVGDMLRRAGAAGVAAPMLRVALTHLRAYEIRRKG

Specific function: Catalyzes The NADPH-Dependent Reduction Of Ketopantoate Into Pantoic Acid. [C]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: 1.1.1.169 [C]

Molecular weight: Translated: 32224; Mature: 32224

Theoretical pI: Translated: 7.31; Mature: 7.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLVLGAGATGGYFGGRLAEAGVDVTFLVRPKRAALLAEKGLRIESPHGDSTRPVKTVT
CEEEEEECCCCCCCCCCHHHHCCCCEEEEECCHHHHHHHHCCCEEECCCCCCCCCHHHHH
AETLSGHWDAVLLSCKAYDLEESIKAIAPAVGPDSMVVPILNGLAHYGPLDAAFGAGRVI
HHHHCCCCCEEEEEHHHHCHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHH
GGLCHIFSTLGADGEIRHMNTIHRITFGERSGGTSARTEALAQAFAGANCETRHSSEIMQ
HHHHHHHHHHCCCCCEEHHHHHHHEECCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHH
EAWEKYVLLTPMAAMTCLMRASIGTIMATGEGEALMRETFEECAAVASRAGHGPRPEARD
HHHHHEEEECHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHH
LALGFLTQKGSAMTASMLRDLEGGGPTEGEHIVGDMLRRAGAAGVAAPMLRVALTHLRAY
HHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
EIRRKG
HHHCCC
>Mature Secondary Structure
MRVLVLGAGATGGYFGGRLAEAGVDVTFLVRPKRAALLAEKGLRIESPHGDSTRPVKTVT
CEEEEEECCCCCCCCCCHHHHCCCCEEEEECCHHHHHHHHCCCEEECCCCCCCCCHHHHH
AETLSGHWDAVLLSCKAYDLEESIKAIAPAVGPDSMVVPILNGLAHYGPLDAAFGAGRVI
HHHHCCCCCEEEEEHHHHCHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHH
GGLCHIFSTLGADGEIRHMNTIHRITFGERSGGTSARTEALAQAFAGANCETRHSSEIMQ
HHHHHHHHHHCCCCCEEHHHHHHHEECCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHH
EAWEKYVLLTPMAAMTCLMRASIGTIMATGEGEALMRETFEECAAVASRAGHGPRPEARD
HHHHHEEEECHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHH
LALGFLTQKGSAMTASMLRDLEGGGPTEGEHIVGDMLRRAGAAGVAAPMLRVALTHLRAY
HHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
EIRRKG
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 4.0 {NADPH}} [C]

Substrates: 2-Dehydropantoate; H+; Nicotinamide adenine dinucleotide phosphate - reduced [C]

Specific reaction: 2-Dehydropantoate + H+ + Nicotinamide adenine dinucleotide phosphate - reduced --> Nicotinamide adenine dinucleotide phosphate + (R)-Pantoate [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]