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The map label for this gene is degU [H]

Identifier: 83310970

GI number: 83310970

Start: 2011005

End: 2011646

Strand: Reverse

Name: degU [H]

Synonym: amb1871

Alternate gene names: 83310970

Gene position: 2011646-2011005 (Counterclockwise)

Preceding gene: 83310972

Following gene: 83310969

Centisome position: 40.5

GC content: 67.76

Gene sequence:

>642_bases
ATGAGAATCATCATCGCCGACGACCATCCGCTCTATCTGGAGGCGGTGCTGGGCCAGTTGGAGAAGGCGTTCCCTGCGGG
AAGCTTCCATACCGCCCGCAATCTGGCCGACACGCTGGCCCTGCTCGAGCGGGAAAGCGTGGATCTGGTCATGCTCGATT
ATTCCATGCCGGGCATGAACGGGGTGGAGGGGATTCCCACCGCCATCGCCGCCGCCAGGGGCACGCCCGTGGCGATCATG
TCCGGGGTGGCCGACGACGACGCCGTGCGCGCCTGCATCGCGGCGGGGGCCAGGGGCTTCCTGCCCAAGACCCTGGAAAG
CAGGGTATTCATCCAGGCCGTGGGCCTCGTGGGCGCGGGCGGCACCTATGTGCCCGCCGAGTTCGCCGCCCTGCCGTCCA
AACCCGCCGCTCCCGCCACTCCCACCCTGGACCCGTCGCTCTTCACCTCGCGCGAGATGGAAGTCCTGGCCCTGATCGTC
GCCGGCGCCTCCAACAAGGAGATCGCCCGGCAATTGGACCTTCAGGAGGTCACCATCAAGCTCCACCTCACCCGCATCTT
TCAGAAGCTGGGGGTGAAGAACCGTTCCCACGCCGCCGTCACGGCGGTGCGCGGCGGCCTGGTGGCGGACGCGGTCCAGT
AG

Upstream 100 bases:

>100_bases
CTAATGGTGGCAGCTCTACCGGCATCGGTACAGCGCCCGATAGACTTCCGTCTAGTGGCGGGGTAGAACCTTCCAGTTGT
TTTTCCAGGGGTGCGCCAAG

Downstream 100 bases:

>100_bases
CCATCCCCCATACCCTTGGCGGCGCCCGCTAGACCTCCGCCGCCCGCCGGAATACGTCTGCCGGAATGCGCCCGGCCCGG
GCTCGCGCCATGCTTCCTCC

Product: response regulator

Products: NA

Alternate protein names: Protease production enhancer protein [H]

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MRIIIADDHPLYLEAVLGQLEKAFPAGSFHTARNLADTLALLERESVDLVMLDYSMPGMNGVEGIPTAIAAARGTPVAIM
SGVADDDAVRACIAAGARGFLPKTLESRVFIQAVGLVGAGGTYVPAEFAALPSKPAAPATPTLDPSLFTSREMEVLALIV
AGASNKEIARQLDLQEVTIKLHLTRIFQKLGVKNRSHAAVTAVRGGLVADAVQ

Sequences:

>Translated_213_residues
MRIIIADDHPLYLEAVLGQLEKAFPAGSFHTARNLADTLALLERESVDLVMLDYSMPGMNGVEGIPTAIAAARGTPVAIM
SGVADDDAVRACIAAGARGFLPKTLESRVFIQAVGLVGAGGTYVPAEFAALPSKPAAPATPTLDPSLFTSREMEVLALIV
AGASNKEIARQLDLQEVTIKLHLTRIFQKLGVKNRSHAAVTAVRGGLVADAVQ
>Mature_213_residues
MRIIIADDHPLYLEAVLGQLEKAFPAGSFHTARNLADTLALLERESVDLVMLDYSMPGMNGVEGIPTAIAAARGTPVAIM
SGVADDDAVRACIAAGARGFLPKTLESRVFIQAVGLVGAGGTYVPAEFAALPSKPAAPATPTLDPSLFTSREMEVLALIV
AGASNKEIARQLDLQEVTIKLHLTRIFQKLGVKNRSHAAVTAVRGGLVADAVQ

Specific function: Regulating factor for the production of extracellular proteases. The N-terminal region acts as an inhibitor, whereas the C-terminal region carries enhancing activity [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788521, Length=202, Percent_Identity=32.1782178217822, Blast_Score=84, Evalue=5e-18,
Organism=Escherichia coli, GI1786747, Length=191, Percent_Identity=27.2251308900524, Blast_Score=78, Evalue=4e-16,
Organism=Escherichia coli, GI1789937, Length=200, Percent_Identity=25, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1787473, Length=200, Percent_Identity=31, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788222, Length=210, Percent_Identity=26.1904761904762, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1790102, Length=200, Percent_Identity=32, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1788712, Length=196, Percent_Identity=26.0204081632653, Blast_Score=62, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 22324; Mature: 22324

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIIIADDHPLYLEAVLGQLEKAFPAGSFHTARNLADTLALLERESVDLVMLDYSMPGMN
CEEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCC
GVEGIPTAIAAARGTPVAIMSGVADDDAVRACIAAGARGFLPKTLESRVFIQAVGLVGAG
CCCCCHHHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHEEEHHHCEECCC
GTYVPAEFAALPSKPAAPATPTLDPSLFTSREMEVLALIVAGASNKEIARQLDLQEVTIK
CCCCCHHHHCCCCCCCCCCCCCCCCHHHCCCCCEEEEEEEECCCCHHHHHHHCHHHHHHH
LHLTRIFQKLGVKNRSHAAVTAVRGGLVADAVQ
HHHHHHHHHHCCCCCCCHHHHHHHCCHHHHCCC
>Mature Secondary Structure
MRIIIADDHPLYLEAVLGQLEKAFPAGSFHTARNLADTLALLERESVDLVMLDYSMPGMN
CEEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCC
GVEGIPTAIAAARGTPVAIMSGVADDDAVRACIAAGARGFLPKTLESRVFIQAVGLVGAG
CCCCCHHHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHEEEHHHCEECCC
GTYVPAEFAALPSKPAAPATPTLDPSLFTSREMEVLALIVAGASNKEIARQLDLQEVTIK
CCCCCHHHHCCCCCCCCCCCCCCCCHHHCCCCCEEEEEEEECCCCHHHHHHHCHHHHHHH
LHLTRIFQKLGVKNRSHAAVTAVRGGLVADAVQ
HHHHHHHHHHCCCCCCCHHHHHHHCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3136143; 3141378; 3141377; 9384377 [H]