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The map label for this gene is livH [H]

Identifier: 83310576

GI number: 83310576

Start: 1613949

End: 1615805

Strand: Reverse

Name: livH [H]

Synonym: amb1477

Alternate gene names: 83310576

Gene position: 1615805-1613949 (Counterclockwise)

Preceding gene: 83310577

Following gene: 83310575

Centisome position: 32.53

GC content: 67.31

Gene sequence:

>1857_bases
GTGAGCTTCTTCTTCATTCAATTCCTCAATGGGCTTGCCTCGGCGTCGTCCCTGTTCCTGGTGGCCTCGGGCCTGTCCAT
CATCTTCGGCGTCAGCCGCATCGTGAACTTCGCCCACGGCTCGTTCTACATGCTGGGCGCCTATATGGCCTTCACCCTGG
TGCAGAAGCTCAGCGGTGGCACCGTCTTCGGCTTCTGGGGCGCCATCGTGCTGGCGGCGGCGGCCGTCGCCCTGGTGGGC
GCCGTGGTGGAGATGGTCCTGCTGCGCCGCATCTACCAGGCGCCGGAACTGCTGCAATTGCTGGCCACCTTCGGGCTGGT
GCTGATCGTCCAGGATCTGGTGCTGGTGCTGTGGGGGCCGGAGGACCTGCTGGGGCCGCGCGCCCCCGGTCTCAAGGGCG
CCATCGACATCTTCGGCCAGTCCTTTCCCCAATACGATTTCGTGCTGATCATCCTGGGGCCGGTGGTTCTCGGGCTGCTG
TGGCTGTTGTTCCACCGCACCCGCTGGGGCACCCTGATCCGCGCCGCCACACAGGACCGCGAGATGGTCGCGGCGCTGGG
AGTCAATCAGGCCTGGCTGTTCACCTCGGTCTTCACCCTGGGCGCCTTCCTGGCCGGTCTGGGCGGGGCGGTGCAGTTGC
CGCGCGAGGCCGTCAACCACGTCATGGACCTGCAGATCATCACCGAGGCCTTCGTCATCGTGGTGATCGGCGGACTGGGC
AGCGTGCTGGGCGCCTTCCTGGCGGCGGTGATCATCGGCGAGTTGAACGCCTTCGGCATCCTGATCTTCCCGCAACTGAC
CCTGGTGCTGACCTTCCTGGTGATGGCGGTGATCCTGGTGGTCCGGCCCTGGGGCCTGCTGGGCAAGCCCGAGATGGTCA
TGCGCGGCGGCGGCGGAGTGGAGCGCCCCATCCGGCCGTTGACCCAGCGGGGCCGCAACGTCGCCTTCGCCGGTCTGGTG
GTGCTGCTGGCCCTGCCCATGGTGGGGGGCAGCTACGGGCTTTCGGTGGCGTCCGAAGTGCTGATCTTCGCCCTGTTCGC
CGCCTCGCTGCACTTCATGATGGGAACCGGCGGCATGGTGTCGTTCGGCCACGCCGCCTATTTCGGCCTGGGCAGCTATG
GCGCCGCCCTGATGGTCAAGTATTTCGGCATTCCCATGCTGGCCGCCCTGGTCACCGGCCCGCTGCTGGCCGCCGCCGCC
GCATTGGTGTTCGGCTGGTTCTGCGTCCGGCTGGCCGGCGCCTATCTCGCCATGCTGACCCTGGCCTTCGCCCAGATCGC
CTATGCGGTGGTGTTCCAGTGGTCCAGCTTCACCGGCGGCGACAACGGCCTGATCGGCATCTGGCCCGCGCCTTGGGCGG
CCAATCCGGTGGCCTTCTATTACCTGACCCTGGCCCTGTGCGGCGGCGGCATCCTGGCGGTGCGCCGCATCACCTTCGCC
CCCTTCGGCTATACGCTGCGAGCCTGCCGCGACTCCGCATTGCGGGCCGATTCCATCGGCATCAATCTGTCGTCCCACCG
CTGGGCGGGATTTGCCCTGGCCGGGTTCTTCGCCGGCATCGCCGGGTCGCTCTACGCCTTCCTCAAGGGCAGCGTGTTCC
CCGACACCATCTCCATCGCCACCTCGGTGGACGGGCTGGTGATGGTGCTGCTGGGCGGTGTCCAGACCCTGACCGGTCCC
GTGGTCGGCGCCCTGGTCTACAAGACCCTGCACGTGACCATCAGCAGCTATACCGACCAGTGGCGGACGGCCTTGGGCGT
GATCATCATCGTGCTGGTGGTGGCCTTCCCCCAGGGCATCTCCGGCTTCGTCCAGGGCCGACTGACACGCTCCGAGCCCA
AGGAGGACGCGGCATGA

Upstream 100 bases:

>100_bases
CAAGGCGCGTCCCAAGAACTGAGCCTGACGCCGGGCGGCGGGTGACAAGGCCCGCCGCCCCCTTTCCTCCCCCGACCTCC
GGCCGACAGGAGAGCGCCCA

Downstream 100 bases:

>100_bases
GCCAGAACCAGACCCTGTCCGTCCGCGGACTGTCCAAGAATTATGGCGGTGTCGCCGCCGTGACCAACGTGGATTTCGAT
CTGGCGCCGGGCGAGATCCT

Product: branched chain amino acid ABC transporter

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 618; Mature: 617

Protein sequence:

>618_residues
MSFFFIQFLNGLASASSLFLVASGLSIIFGVSRIVNFAHGSFYMLGAYMAFTLVQKLSGGTVFGFWGAIVLAAAAVALVG
AVVEMVLLRRIYQAPELLQLLATFGLVLIVQDLVLVLWGPEDLLGPRAPGLKGAIDIFGQSFPQYDFVLIILGPVVLGLL
WLLFHRTRWGTLIRAATQDREMVAALGVNQAWLFTSVFTLGAFLAGLGGAVQLPREAVNHVMDLQIITEAFVIVVIGGLG
SVLGAFLAAVIIGELNAFGILIFPQLTLVLTFLVMAVILVVRPWGLLGKPEMVMRGGGGVERPIRPLTQRGRNVAFAGLV
VLLALPMVGGSYGLSVASEVLIFALFAASLHFMMGTGGMVSFGHAAYFGLGSYGAALMVKYFGIPMLAALVTGPLLAAAA
ALVFGWFCVRLAGAYLAMLTLAFAQIAYAVVFQWSSFTGGDNGLIGIWPAPWAANPVAFYYLTLALCGGGILAVRRITFA
PFGYTLRACRDSALRADSIGINLSSHRWAGFALAGFFAGIAGSLYAFLKGSVFPDTISIATSVDGLVMVLLGGVQTLTGP
VVGALVYKTLHVTISSYTDQWRTALGVIIIVLVVAFPQGISGFVQGRLTRSEPKEDAA

Sequences:

>Translated_618_residues
MSFFFIQFLNGLASASSLFLVASGLSIIFGVSRIVNFAHGSFYMLGAYMAFTLVQKLSGGTVFGFWGAIVLAAAAVALVG
AVVEMVLLRRIYQAPELLQLLATFGLVLIVQDLVLVLWGPEDLLGPRAPGLKGAIDIFGQSFPQYDFVLIILGPVVLGLL
WLLFHRTRWGTLIRAATQDREMVAALGVNQAWLFTSVFTLGAFLAGLGGAVQLPREAVNHVMDLQIITEAFVIVVIGGLG
SVLGAFLAAVIIGELNAFGILIFPQLTLVLTFLVMAVILVVRPWGLLGKPEMVMRGGGGVERPIRPLTQRGRNVAFAGLV
VLLALPMVGGSYGLSVASEVLIFALFAASLHFMMGTGGMVSFGHAAYFGLGSYGAALMVKYFGIPMLAALVTGPLLAAAA
ALVFGWFCVRLAGAYLAMLTLAFAQIAYAVVFQWSSFTGGDNGLIGIWPAPWAANPVAFYYLTLALCGGGILAVRRITFA
PFGYTLRACRDSALRADSIGINLSSHRWAGFALAGFFAGIAGSLYAFLKGSVFPDTISIATSVDGLVMVLLGGVQTLTGP
VVGALVYKTLHVTISSYTDQWRTALGVIIIVLVVAFPQGISGFVQGRLTRSEPKEDAA
>Mature_617_residues
SFFFIQFLNGLASASSLFLVASGLSIIFGVSRIVNFAHGSFYMLGAYMAFTLVQKLSGGTVFGFWGAIVLAAAAVALVGA
VVEMVLLRRIYQAPELLQLLATFGLVLIVQDLVLVLWGPEDLLGPRAPGLKGAIDIFGQSFPQYDFVLIILGPVVLGLLW
LLFHRTRWGTLIRAATQDREMVAALGVNQAWLFTSVFTLGAFLAGLGGAVQLPREAVNHVMDLQIITEAFVIVVIGGLGS
VLGAFLAAVIIGELNAFGILIFPQLTLVLTFLVMAVILVVRPWGLLGKPEMVMRGGGGVERPIRPLTQRGRNVAFAGLVV
LLALPMVGGSYGLSVASEVLIFALFAASLHFMMGTGGMVSFGHAAYFGLGSYGAALMVKYFGIPMLAALVTGPLLAAAAA
LVFGWFCVRLAGAYLAMLTLAFAQIAYAVVFQWSSFTGGDNGLIGIWPAPWAANPVAFYYLTLALCGGGILAVRRITFAP
FGYTLRACRDSALRADSIGINLSSHRWAGFALAGFFAGIAGSLYAFLKGSVFPDTISIATSVDGLVMVLLGGVQTLTGPV
VGALVYKTLHVTISSYTDQWRTALGVIIIVLVVAFPQGISGFVQGRLTRSEPKEDAA

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=313, Percent_Identity=26.517571884984, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI1789865, Length=295, Percent_Identity=24.7457627118644, Blast_Score=92, Evalue=8e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 65343; Mature: 65211

Theoretical pI: Translated: 9.48; Mature: 9.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SFFFIQFLNGLASASSLFLVASGLSIIFGVSRIVNFAHGSFYMLGAYMAFTLVQKLSGG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCC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HHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]