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The map label for this gene is arcA [H]

Identifier: 83310434

GI number: 83310434

Start: 1452773

End: 1453309

Strand: Reverse

Name: arcA [H]

Synonym: amb1335

Alternate gene names: 83310434

Gene position: 1453309-1452773 (Counterclockwise)

Preceding gene: 83310437

Following gene: 83310433

Centisome position: 29.26

GC content: 67.6

Gene sequence:

>537_bases
GTGTCGACAAAAGCACACGTCTTGATCGTCGAGGATGAACCCGTTACCCGCGCAAAGCTTGCCGCGTATCTGACGGGGGA
AGGGTTCCAGGTCAGCGAAGCCGCTGACGCCAAGGACATGAAGGCCATCGTCTCCAAGACGGTGCCCGACGTGGTGCTGC
TCGACATCAACCTTCCCGATGAGAGCGGCCTGATCCTGGCCCGCGAGCTGCGCGCCAAGTCGTCGGTGGGCATCATCCTG
GTCACCGCCCGTCAGGACGAGACCGACCGCATCGTCGGCCTGGAGATCGGTGCCGACGACTACATCACCAAGCCGTTCAA
TCCCCGAGAACTGGCCGTGCGGGTGCGCAACCTGCAGCGCCGCGTCGCCCCCACCATGGCCGCCGAGCGCTCGGCCACCG
GCATCCATTCCTTCGCCGGCTGGCGCCTGGATTGCGACGCCCGCCAGCTGACCTCGCCCACCGGCGAACTGGTGCGCCTC
ACCCGCGGCGAGTTCGACGTGCTGGCCGCCTGGCCCGCAATGCCGGGCGGGCGCTGA

Upstream 100 bases:

>100_bases
GGCGCAACTTCACAATGGAATTACGGCAGTGATTGAATTGTGCGGCAATACCCTGTAAACGGGTGATGAATACTAGCCGG
GGCGTCGGCCGGAGAATGCA

Downstream 100 bases:

>100_bases
CCCGTGACCAGTTGCTCGATCTCACCCAGCATGACGGCGAGGCGGTCATCGACCGCACCATCGACGTGCTGGTCGGCCGC
CTGCGCCGCAAGATCGAGGC

Product: response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 178; Mature: 177

Protein sequence:

>178_residues
MSTKAHVLIVEDEPVTRAKLAAYLTGEGFQVSEAADAKDMKAIVSKTVPDVVLLDINLPDESGLILARELRAKSSVGIIL
VTARQDETDRIVGLEIGADDYITKPFNPRELAVRVRNLQRRVAPTMAAERSATGIHSFAGWRLDCDARQLTSPTGELVRL
TRGEFDVLAAWPAMPGGR

Sequences:

>Translated_178_residues
MSTKAHVLIVEDEPVTRAKLAAYLTGEGFQVSEAADAKDMKAIVSKTVPDVVLLDINLPDESGLILARELRAKSSVGIIL
VTARQDETDRIVGLEIGADDYITKPFNPRELAVRVRNLQRRVAPTMAAERSATGIHSFAGWRLDCDARQLTSPTGELVRL
TRGEFDVLAAWPAMPGGR
>Mature_177_residues
STKAHVLIVEDEPVTRAKLAAYLTGEGFQVSEAADAKDMKAIVSKTVPDVVLLDINLPDESGLILARELRAKSSVGIILV
TARQDETDRIVGLEIGADDYITKPFNPRELAVRVRNLQRRVAPTMAAERSATGIHSFAGWRLDCDARQLTSPTGELVRLT
RGEFDVLAAWPAMPGGR

Specific function: Member of the two-component regulatory system ArcB/ArcA. Represses a wide variety of aerobic enzymes under anaerobic conditions. It also may be involved in the osmoregulation of envelope proteins. When activated by ArcB, it negatively regulates the expres

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790863, Length=173, Percent_Identity=47.9768786127168, Blast_Score=172, Evalue=1e-44,
Organism=Escherichia coli, GI1787229, Length=172, Percent_Identity=49.4186046511628, Blast_Score=166, Evalue=6e-43,
Organism=Escherichia coli, GI1789809, Length=177, Percent_Identity=42.3728813559322, Blast_Score=129, Evalue=8e-32,
Organism=Escherichia coli, GI1788394, Length=170, Percent_Identity=38.2352941176471, Blast_Score=110, Evalue=7e-26,
Organism=Escherichia coli, GI1790860, Length=171, Percent_Identity=39.1812865497076, Blast_Score=100, Evalue=9e-23,
Organism=Escherichia coli, GI1786599, Length=126, Percent_Identity=42.0634920634921, Blast_Score=99, Evalue=1e-22,
Organism=Escherichia coli, GI1787375, Length=163, Percent_Identity=34.9693251533742, Blast_Score=98, Evalue=3e-22,
Organism=Escherichia coli, GI1786911, Length=164, Percent_Identity=38.4146341463415, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI1786784, Length=171, Percent_Identity=36.2573099415205, Blast_Score=80, Evalue=7e-17,
Organism=Escherichia coli, GI1790552, Length=116, Percent_Identity=38.7931034482759, Blast_Score=78, Evalue=3e-16,
Organism=Escherichia coli, GI2367329, Length=168, Percent_Identity=34.5238095238095, Blast_Score=78, Evalue=4e-16,
Organism=Escherichia coli, GI87082012, Length=162, Percent_Identity=29.0123456790123, Blast_Score=70, Evalue=7e-14,
Organism=Escherichia coli, GI145693140, Length=102, Percent_Identity=37.2549019607843, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1789402, Length=124, Percent_Identity=32.258064516129, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1788550, Length=117, Percent_Identity=31.6239316239316, Blast_Score=63, Evalue=1e-11,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 19378; Mature: 19247

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTKAHVLIVEDEPVTRAKLAAYLTGEGFQVSEAADAKDMKAIVSKTVPDVVLLDINLPD
CCCCEEEEEECCCCCCHHHEEEEECCCCEEECCCCCHHHHHHHHHCCCCCEEEEEEECCC
ESGLILARELRAKSSVGIILVTARQDETDRIVGLEIGADDYITKPFNPRELAVRVRNLQR
CCCEEEEEECCCCCCCCEEEEEECCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHH
RVAPTMAAERSATGIHSFAGWRLDCDARQLTSPTGELVRLTRGEFDVLAAWPAMPGGR
HHHHHHHHHCCCCCCHHCCCEEEECCHHHHCCCCCCEEEEECCCEEEEEECCCCCCCC
>Mature Secondary Structure 
STKAHVLIVEDEPVTRAKLAAYLTGEGFQVSEAADAKDMKAIVSKTVPDVVLLDINLPD
CCCEEEEEECCCCCCHHHEEEEECCCCEEECCCCCHHHHHHHHHCCCCCEEEEEEECCC
ESGLILARELRAKSSVGIILVTARQDETDRIVGLEIGADDYITKPFNPRELAVRVRNLQR
CCCEEEEEECCCCCCCCEEEEEECCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHH
RVAPTMAAERSATGIHSFAGWRLDCDARQLTSPTGELVRLTRGEFDVLAAWPAMPGGR
HHHHHHHHHCCCCCCHHCCCEEEECCHHHHCCCCCCEEEEECCCEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]