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The map label for this gene is maeB [H]

Identifier: 83309819

GI number: 83309819

Start: 779375

End: 781663

Strand: Reverse

Name: maeB [H]

Synonym: amb0720

Alternate gene names: 83309819

Gene position: 781663-779375 (Counterclockwise)

Preceding gene: 83309821

Following gene: 83309818

Centisome position: 15.74

GC content: 66.71

Gene sequence:

>2289_bases
ATGAGCATGTCCGACGAGTTGCGCGACGCGGCGCTGGAATACCATCGCCTGCCCACCCCCGGTAAGATCAGCGTCACCCC
CACCAAGCCGCTGGCCACCCAGCGCGACCTGGCGCTGGCCTATTCCCCCGGTGTGGCCGCCGCCTGCGAGCTGATCGTCG
CCGACGAGGACAGCGCCGCCGATGTGACGGCGCGCGGCAATCTGGTGGCCGTGGTGACCAACGGCACCGCCGTGCTGGGC
CTCGGCCCCATCGGCCCCCTGGCCGCCAAGCCGGTGATGGAGGGCAAGGGCGTCCTGTTCAAGAAGTTCGCCGGCATCGA
CGTGTTCGACATGGAGCTGGCCGAGCTTGACCCGGACAAGCTGGTGAACATCATCGCCGCCATGGAGCCCACCTTCGGCG
CCATCAACCTTGAAGACATCAAGGCCCCCGAGTGTTTCGAGGTCGAGCGCAAGCTGCAGGAGCGGGTGAAGATCCCGGTC
ATGCACGACGACCAGCACGGCACCGCCATCGTGGTGGGCGCCGCCATGGTCAACGCGCTGCGCGTGGTGGGCAAGGACAT
CGCCGACGTCAAGCTGGTGGCCTCGGGCGCCGGCGCCGCCGCGCTGGCCTGCCTCAACCTGCTGGTCAAGCTGGGCGTCA
AGCGCGAGAACGTCTGGGTCACCGACATCAAGGGCGTGGTCTACGAGGGCCGCACCGAGCTGATGGACGAGTACAAGTCC
ATCTATGCCAAGAAGACCGACATGCGCACTCTGGCCGAGGTCATCGAGGGCGCCGACATCTTCCTGGGCCTGTCCGCGCC
CCGCGTGCTGACCGGCGAGATGGTCGACAAGATGGCGCAAAAGCCCATCGTCTTCGCCCTGGCCAATCCCACCCCGGAAA
TCCTGCCCGACGAGGTCAAGGCGGTGCGTCCCGACGCCATCATCGCCACCGGCCGCTCGGACTATCCCAACCAGGTCAAC
AACGTCCTGGTGTTCCCCTACATCTTCCGCGGCGCCCTGGACGTGGGCGCCACCGAGATCAACGACGCCATGAAGCTGGC
CTGCGTCTATGCGCTGGCCAATCTCGCCATGGCCGAATCCGATGAGCGGGTGCGCGCCGCCTATGGCACCGCGCCACTGA
CCTTCGGGCCGGAATACCTGATCCCCAAGCCGTTCGATTCCCGCTTGATCATCAAGATCGCCCCGGCGGTGGCCAAGGCG
GCCATGGAATCGGGCGTGGCGCGGCGCCCCATCATCGATTTCGACGTCTACATGGACCGGCTCAACCAGTTCGTGTTCCG
CTCTGGCCTGGTGATGAAGCCGGTGTTCGACCGCGCCCGCCAGGACATGCGCCGCGTGGTCTATTGCGAGGGCGAGGGCC
GCCGCGTGCTGCATGCCGCCCAGACCGTGGTGGACGAGGGGCTGGCCCGTCCCGTGCTGATCGGCCGCCGCGAAGTGGTG
GAAAAGCGCATTCAGGACCTGGACCTGCGCCTGCGCATCGACCAGGACTTCGACCTGTGCGATCCCGAGGACGATCCCCG
CTTCAACGAGTACTGGCGCCTTTACCACTCCATCATGGAGCGCCAGGGCGTCAGCCCGGAATACGCCCGCACCGTGGTCC
GCACCCGCAACACGGTGATCGGCACCCTGATGCTGAAGCGCAAGGAAGTGGACGCCATGATCTGCGGCACCATCGGCCGC
TATGACAAGCACCTGTCCCACATCCTCAACGTCATCGGCACGCGGGAAGGCGTCAAGGTCCCGGCCGCCATGAACCTGCT
GATCATGCCGATCGGCACCTTCTTCATCTGCGACACCTATGTGACGCCCGAGCCGACCCCCGAGCAGATCTGCGACATGA
CCTTGCTGGCCTCGGAAGAGGTGCGACGCTTCGGTATCGAGCCCAAGGTGGCCTTCCTGTCCCACGCCAATTTCGGCAAC
CGCCAGACCGCCTCGGCCCAGCGCCAGCGCGACGCCCTGGCCCTGCTGCGCGAAAAGGCCCCCTATCTGGAGGCCGAGGG
CGAGATGCACGGCGACGCGGCCCTGTCCGAGGAAATCCGCACCCGCATCTTCCCCAATTCCAAGCTGAAGGGCGCCGCCA
ACCTGCTGGTCATGCCGACGCTGGACGCCGCCAACATCTCGTTCAACCTGCTGAAGGTGGCGGGCGACGCCCTGTCGGTG
GGACCGATCCTGATGGGCATCGCCCAGCCCGCCCACGTGCTGACGCCCTCGGCCACGGTGCGCAACATCATCAACATCAC
CGCCCTGGCGGCGGTGGATGCCCAGATGCACGCCGGCCGGGGACGGTAG

Upstream 100 bases:

>100_bases
TCCGAAATTCATCCGATCAGAGGCTTTGCGCGGCGCCCCCAAGCGAGTATGGTATCGGCCCGGTCCAAGAAATAACATTA
CGCCAGAGGTTGCCGTTCCC

Downstream 100 bases:

>100_bases
TCAGCTTCCCACCAGGAACCTGTGCGATGATGGCCCCGGATGCTTTTGCCGAAGCATCCGGGGCCATTCTCTTTCGGACG
GAGAAGCATCATGCGGGCTT

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 762; Mature: 761

Protein sequence:

>762_residues
MSMSDELRDAALEYHRLPTPGKISVTPTKPLATQRDLALAYSPGVAAACELIVADEDSAADVTARGNLVAVVTNGTAVLG
LGPIGPLAAKPVMEGKGVLFKKFAGIDVFDMELAELDPDKLVNIIAAMEPTFGAINLEDIKAPECFEVERKLQERVKIPV
MHDDQHGTAIVVGAAMVNALRVVGKDIADVKLVASGAGAAALACLNLLVKLGVKRENVWVTDIKGVVYEGRTELMDEYKS
IYAKKTDMRTLAEVIEGADIFLGLSAPRVLTGEMVDKMAQKPIVFALANPTPEILPDEVKAVRPDAIIATGRSDYPNQVN
NVLVFPYIFRGALDVGATEINDAMKLACVYALANLAMAESDERVRAAYGTAPLTFGPEYLIPKPFDSRLIIKIAPAVAKA
AMESGVARRPIIDFDVYMDRLNQFVFRSGLVMKPVFDRARQDMRRVVYCEGEGRRVLHAAQTVVDEGLARPVLIGRREVV
EKRIQDLDLRLRIDQDFDLCDPEDDPRFNEYWRLYHSIMERQGVSPEYARTVVRTRNTVIGTLMLKRKEVDAMICGTIGR
YDKHLSHILNVIGTREGVKVPAAMNLLIMPIGTFFICDTYVTPEPTPEQICDMTLLASEEVRRFGIEPKVAFLSHANFGN
RQTASAQRQRDALALLREKAPYLEAEGEMHGDAALSEEIRTRIFPNSKLKGAANLLVMPTLDAANISFNLLKVAGDALSV
GPILMGIAQPAHVLTPSATVRNIINITALAAVDAQMHAGRGR

Sequences:

>Translated_762_residues
MSMSDELRDAALEYHRLPTPGKISVTPTKPLATQRDLALAYSPGVAAACELIVADEDSAADVTARGNLVAVVTNGTAVLG
LGPIGPLAAKPVMEGKGVLFKKFAGIDVFDMELAELDPDKLVNIIAAMEPTFGAINLEDIKAPECFEVERKLQERVKIPV
MHDDQHGTAIVVGAAMVNALRVVGKDIADVKLVASGAGAAALACLNLLVKLGVKRENVWVTDIKGVVYEGRTELMDEYKS
IYAKKTDMRTLAEVIEGADIFLGLSAPRVLTGEMVDKMAQKPIVFALANPTPEILPDEVKAVRPDAIIATGRSDYPNQVN
NVLVFPYIFRGALDVGATEINDAMKLACVYALANLAMAESDERVRAAYGTAPLTFGPEYLIPKPFDSRLIIKIAPAVAKA
AMESGVARRPIIDFDVYMDRLNQFVFRSGLVMKPVFDRARQDMRRVVYCEGEGRRVLHAAQTVVDEGLARPVLIGRREVV
EKRIQDLDLRLRIDQDFDLCDPEDDPRFNEYWRLYHSIMERQGVSPEYARTVVRTRNTVIGTLMLKRKEVDAMICGTIGR
YDKHLSHILNVIGTREGVKVPAAMNLLIMPIGTFFICDTYVTPEPTPEQICDMTLLASEEVRRFGIEPKVAFLSHANFGN
RQTASAQRQRDALALLREKAPYLEAEGEMHGDAALSEEIRTRIFPNSKLKGAANLLVMPTLDAANISFNLLKVAGDALSV
GPILMGIAQPAHVLTPSATVRNIINITALAAVDAQMHAGRGR
>Mature_761_residues
SMSDELRDAALEYHRLPTPGKISVTPTKPLATQRDLALAYSPGVAAACELIVADEDSAADVTARGNLVAVVTNGTAVLGL
GPIGPLAAKPVMEGKGVLFKKFAGIDVFDMELAELDPDKLVNIIAAMEPTFGAINLEDIKAPECFEVERKLQERVKIPVM
HDDQHGTAIVVGAAMVNALRVVGKDIADVKLVASGAGAAALACLNLLVKLGVKRENVWVTDIKGVVYEGRTELMDEYKSI
YAKKTDMRTLAEVIEGADIFLGLSAPRVLTGEMVDKMAQKPIVFALANPTPEILPDEVKAVRPDAIIATGRSDYPNQVNN
VLVFPYIFRGALDVGATEINDAMKLACVYALANLAMAESDERVRAAYGTAPLTFGPEYLIPKPFDSRLIIKIAPAVAKAA
MESGVARRPIIDFDVYMDRLNQFVFRSGLVMKPVFDRARQDMRRVVYCEGEGRRVLHAAQTVVDEGLARPVLIGRREVVE
KRIQDLDLRLRIDQDFDLCDPEDDPRFNEYWRLYHSIMERQGVSPEYARTVVRTRNTVIGTLMLKRKEVDAMICGTIGRY
DKHLSHILNVIGTREGVKVPAAMNLLIMPIGTFFICDTYVTPEPTPEQICDMTLLASEEVRRFGIEPKVAFLSHANFGNR
QTASAQRQRDALALLREKAPYLEAEGEMHGDAALSEEIRTRIFPNSKLKGAANLLVMPTLDAANISFNLLKVAGDALSVG
PILMGIAQPAHVLTPSATVRNIINITALAAVDAQMHAGRGR

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=396, Percent_Identity=25.7575757575758, Blast_Score=91, Evalue=6e-18,
Organism=Homo sapiens, GI62420882, Length=389, Percent_Identity=25.706940874036, Blast_Score=83, Evalue=9e-16,
Organism=Homo sapiens, GI62420880, Length=389, Percent_Identity=25.706940874036, Blast_Score=83, Evalue=9e-16,
Organism=Homo sapiens, GI239049447, Length=389, Percent_Identity=25.706940874036, Blast_Score=83, Evalue=9e-16,
Organism=Homo sapiens, GI4505145, Length=397, Percent_Identity=25.4408060453401, Blast_Score=77, Evalue=8e-14,
Organism=Homo sapiens, GI270265879, Length=368, Percent_Identity=25.5434782608696, Blast_Score=74, Evalue=7e-13,
Organism=Escherichia coli, GI1788806, Length=757, Percent_Identity=62.4834874504623, Blast_Score=963, Evalue=0.0,
Organism=Escherichia coli, GI1788635, Length=343, Percent_Identity=27.1137026239067, Blast_Score=139, Evalue=7e-34,
Organism=Escherichia coli, GI1788800, Length=319, Percent_Identity=29.7805642633229, Blast_Score=129, Evalue=6e-31,
Organism=Escherichia coli, GI87081919, Length=452, Percent_Identity=23.6725663716814, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322823, Length=323, Percent_Identity=28.1733746130031, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI281362672, Length=404, Percent_Identity=26.7326732673267, Blast_Score=89, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21356279, Length=404, Percent_Identity=26.7326732673267, Blast_Score=89, Evalue=1e-17,
Organism=Drosophila melanogaster, GI281362674, Length=404, Percent_Identity=26.7326732673267, Blast_Score=89, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24646388, Length=396, Percent_Identity=26.5151515151515, Blast_Score=74, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24646386, Length=396, Percent_Identity=26.5151515151515, Blast_Score=74, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 83272; Mature: 83141

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMSDELRDAALEYHRLPTPGKISVTPTKPLATQRDLALAYSPGVAAACELIVADEDSAA
CCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCEEEEECCCHHHEEEEEEECCCCCC
DVTARGNLVAVVTNGTAVLGLGPIGPLAAKPVMEGKGVLFKKFAGIDVFDMELAELDPDK
CEEECCCEEEEEECCEEEEEECCCCCHHCCCCCCCCCEEEEHHCCCCEEECHHHHCCHHH
LVNIIAAMEPTFGAINLEDIKAPECFEVERKLQERVKIPVMHDDQHGTAIVVGAAMVNAL
HHHHHHHCCCCCCCEEHHHCCCCCHHHHHHHHHHHCCCCEEECCCCCCEEEEHHHHHHHH
RVVGKDIADVKLVASGAGAAALACLNLLVKLGVKRENVWVTDIKGVVYEGRTELMDEYKS
HHHCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCEEEEECCCEEECCHHHHHHHHHH
IYAKKTDMRTLAEVIEGADIFLGLSAPRVLTGEMVDKMAQKPIVFALANPTPEILPDEVK
HHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCHHH
AVRPDAIIATGRSDYPNQVNNVLVFPYIFRGALDVGATEINDAMKLACVYALANLAMAES
HCCCCEEEECCCCCCCCHHCCEEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCC
DERVRAAYGTAPLTFGPEYLIPKPFDSRLIIKIAPAVAKAAMESGVARRPIIDFDVYMDR
CCHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHCCCCCCCEEHHHHHHHH
LNQFVFRSGLVMKPVFDRARQDMRRVVYCEGEGRRVLHAAQTVVDEGLARPVLIGRREVV
HHHHHHHCCCEEHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHCCCCCHHHCHHHHH
EKRIQDLDLRLRIDQDFDLCDPEDDPRFNEYWRLYHSIMERQGVSPEYARTVVRTRNTVI
HHHHHCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHH
GTLMLKRKEVDAMICGTIGRYDKHLSHILNVIGTREGVKVPAAMNLLIMPIGTFFICDTY
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCEEECCCEEEEECC
VTPEPTPEQICDMTLLASEEVRRFGIEPKVAFLSHANFGNRQTASAQRQRDALALLREKA
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCC
PYLEAEGEMHGDAALSEEIRTRIFPNSKLKGAANLLVMPTLDAANISFNLLKVAGDALSV
CCEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCEEEEEECCCCCHHH
GPILMGIAQPAHVLTPSATVRNIINITALAAVDAQMHAGRGR
HHHHHHHCCCCCEECCCHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SMSDELRDAALEYHRLPTPGKISVTPTKPLATQRDLALAYSPGVAAACELIVADEDSAA
CCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCEEEEECCCHHHEEEEEEECCCCCC
DVTARGNLVAVVTNGTAVLGLGPIGPLAAKPVMEGKGVLFKKFAGIDVFDMELAELDPDK
CEEECCCEEEEEECCEEEEEECCCCCHHCCCCCCCCCEEEEHHCCCCEEECHHHHCCHHH
LVNIIAAMEPTFGAINLEDIKAPECFEVERKLQERVKIPVMHDDQHGTAIVVGAAMVNAL
HHHHHHHCCCCCCCEEHHHCCCCCHHHHHHHHHHHCCCCEEECCCCCCEEEEHHHHHHHH
RVVGKDIADVKLVASGAGAAALACLNLLVKLGVKRENVWVTDIKGVVYEGRTELMDEYKS
HHHCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCEEEEECCCEEECCHHHHHHHHHH
IYAKKTDMRTLAEVIEGADIFLGLSAPRVLTGEMVDKMAQKPIVFALANPTPEILPDEVK
HHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCHHH
AVRPDAIIATGRSDYPNQVNNVLVFPYIFRGALDVGATEINDAMKLACVYALANLAMAES
HCCCCEEEECCCCCCCCHHCCEEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCC
DERVRAAYGTAPLTFGPEYLIPKPFDSRLIIKIAPAVAKAAMESGVARRPIIDFDVYMDR
CCHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHCCCCCCCEEHHHHHHHH
LNQFVFRSGLVMKPVFDRARQDMRRVVYCEGEGRRVLHAAQTVVDEGLARPVLIGRREVV
HHHHHHHCCCEEHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHCCCCCHHHCHHHHH
EKRIQDLDLRLRIDQDFDLCDPEDDPRFNEYWRLYHSIMERQGVSPEYARTVVRTRNTVI
HHHHHCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHH
GTLMLKRKEVDAMICGTIGRYDKHLSHILNVIGTREGVKVPAAMNLLIMPIGTFFICDTY
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCEEECCCEEEEECC
VTPEPTPEQICDMTLLASEEVRRFGIEPKVAFLSHANFGNRQTASAQRQRDALALLREKA
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCC
PYLEAEGEMHGDAALSEEIRTRIFPNSKLKGAANLLVMPTLDAANISFNLLKVAGDALSV
CCEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCEEEEEECCCCCHHH
GPILMGIAQPAHVLTPSATVRNIINITALAAVDAQMHAGRGR
HHHHHHHCCCCCEECCCHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 36376 [H]