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The map label for this gene is hisIE

Identifier: 82752251

GI number: 82752251

Start: 2704640

End: 2705272

Strand: Reverse

Name: hisIE

Synonym: SAB2548c

Alternate gene names: 82752251

Gene position: 2705272-2704640 (Counterclockwise)

Preceding gene: 82752252

Following gene: 82752250

Centisome position: 98.64

GC content: 34.76

Gene sequence:

>633_bases
ATGACCAATTACAAAATTGATTTTAGCAAAGGTTTAGTGCCAGCAATTTTACAAGATAATCAAACAAAGCAAGTATTGAT
GTTGGGTTATATGAACCAAGAAGCTTTTGATAAAACGATAGAAGATGGTGTGGTATGTTTCTATTCGCGGTCGAAACAAC
GGCTATGGACAAAAGGCGAAACATCTGGTCATACCCAACGTGTTAAAGATATTTATGTAGATTGCGACAATGACACTATT
TTAATTGATGTCATACCAAATGGACCAACATGTCATACAGGCAGTCAAAGTTGTTTTACCACAGAAGTTCCATTTTCAGT
GCAAACATTAGCGCAGACAGTTCAAGATAGTGCCCAATCCAATAATGAAAAGTCATATACAAAATATTTATTAACAGAAG
GTATAGAAAAGATTACAAAAAAATATGGTGAAGAAGCTTTTGAAGTCGTAATTGAAGCAATTAAAGGTGACAAAAAAGCA
TTTGTAAGTGAAGTAGCAGATGAACTTTATCATTTATTTGTCTTGATGCATGCGCTAGGCGTCGATTTTTCAGAAATTGA
GGCAGAATTAGCACGTAGACATCATAAGCGCAATAACTTTAAAGGCGAACGACAAAATATCGAACAGTGGTAA

Upstream 100 bases:

>100_bases
CGGATGTTTCTGCAGGTTTAGCTGCAAGTATATTACATGATCGAGAAACGACGGTTCAATCTATTAAAGAAGTGATACGG
CAAGGGGGTATAGCAGTAAG

Downstream 100 bases:

>100_bases
AGCAAGTATGGACTGAGATATAAGGAAAAGGCTCATGGCATATACACTTACAAATATTGTGGAAAACGTGACATTTTCAA
TTTTAAAATACGAACCAACA

Product: bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH [H]

Number of amino acids: Translated: 210; Mature: 209

Protein sequence:

>210_residues
MTNYKIDFSKGLVPAILQDNQTKQVLMLGYMNQEAFDKTIEDGVVCFYSRSKQRLWTKGETSGHTQRVKDIYVDCDNDTI
LIDVIPNGPTCHTGSQSCFTTEVPFSVQTLAQTVQDSAQSNNEKSYTKYLLTEGIEKITKKYGEEAFEVVIEAIKGDKKA
FVSEVADELYHLFVLMHALGVDFSEIEAELARRHHKRNNFKGERQNIEQW

Sequences:

>Translated_210_residues
MTNYKIDFSKGLVPAILQDNQTKQVLMLGYMNQEAFDKTIEDGVVCFYSRSKQRLWTKGETSGHTQRVKDIYVDCDNDTI
LIDVIPNGPTCHTGSQSCFTTEVPFSVQTLAQTVQDSAQSNNEKSYTKYLLTEGIEKITKKYGEEAFEVVIEAIKGDKKA
FVSEVADELYHLFVLMHALGVDFSEIEAELARRHHKRNNFKGERQNIEQW
>Mature_209_residues
TNYKIDFSKGLVPAILQDNQTKQVLMLGYMNQEAFDKTIEDGVVCFYSRSKQRLWTKGETSGHTQRVKDIYVDCDNDTIL
IDVIPNGPTCHTGSQSCFTTEVPFSVQTLAQTVQDSAQSNNEKSYTKYLLTEGIEKITKKYGEEAFEVVIEAIKGDKKAF
VSEVADELYHLFVLMHALGVDFSEIEAELARRHHKRNNFKGERQNIEQW

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=194, Percent_Identity=44.3298969072165, Blast_Score=169, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6319819, Length=200, Percent_Identity=33, Blast_Score=79, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH [H]

EC number: =3.5.4.19; =3.6.1.31 [H]

Molecular weight: Translated: 23986; Mature: 23855

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNYKIDFSKGLVPAILQDNQTKQVLMLGYMNQEAFDKTIEDGVVCFYSRSKQRLWTKGE
CCCCEEECCCCCHHHHHCCCCCCEEEEEECCCHHHHHHHHHCCEEEEEECCCHHHCCCCC
TSGHTQRVKDIYVDCDNDTILIDVIPNGPTCHTGSQSCFTTEVPFSVQTLAQTVQDSAQS
CCCHHHHHHEEEEECCCCEEEEEECCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHC
NNEKSYTKYLLTEGIEKITKKYGEEAFEVVIEAIKGDKKAFVSEVADELYHLFVLMHALG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHC
VDFSEIEAELARRHHKRNNFKGERQNIEQW
CCHHHHHHHHHHHHHHHCCCCCCHHCCCCC
>Mature Secondary Structure 
TNYKIDFSKGLVPAILQDNQTKQVLMLGYMNQEAFDKTIEDGVVCFYSRSKQRLWTKGE
CCCEEECCCCCHHHHHCCCCCCEEEEEECCCHHHHHHHHHCCEEEEEECCCHHHCCCCC
TSGHTQRVKDIYVDCDNDTILIDVIPNGPTCHTGSQSCFTTEVPFSVQTLAQTVQDSAQS
CCCHHHHHHEEEEECCCCEEEEEECCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHC
NNEKSYTKYLLTEGIEKITKKYGEEAFEVVIEAIKGDKKAFVSEVADELYHLFVLMHALG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHC
VDFSEIEAELARRHHKRNNFKGERQNIEQW
CCHHHHHHHHHHHHHHHCCCCCCHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA