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The map label for this gene is mvaA

Identifier: 82752127

GI number: 82752127

Start: 2553966

End: 2555246

Strand: Reverse

Name: mvaA

Synonym: SAB2419c

Alternate gene names: 82752127

Gene position: 2555246-2553966 (Counterclockwise)

Preceding gene: 82752129

Following gene: 82752124

Centisome position: 93.17

GC content: 38.72

Gene sequence:

>1281_bases
ATGCAAAGTTTAGATAAGAATTTCCGACATTTATCTCGTCAACAAAAGTTACAACAATTGGTAGATAAGCAATGGTTATC
AGAAGAGCAATTCAACATTTTATTGAATCATCCATTAATTGATGAGGAAGTAGCAAATAGTTTAATTGAAAATGTCATCG
CGCAAGGTGCATTACCCGTTGGATTATTACCGAATATCATTGTGGACGATAAGGCATATGTTGTACCTATGATGGTGGAA
GAGCCTTCAGTTGTCGCTGCAGCTAGTTATGGTGCAAAGCTAGTGAATCAGACTGGCGGATTTAAAACGGTATCTTCTGA
ACGTATTATGATAGGTCAAATCGTCTTTGATGGCGTTGACGATACTGAAAAATTATCAGCAGAAATTAAAGCTTTAGAAA
ATCAAATTCATAAAATTGCGGATGAGGCATATCCTTCTATTAAAGCGCGTGGTGGTGGTTACCAACGTATAGCTATTGAT
ACATTTCCTGAGCAACAGTTACTATCTTTAAAAGTATTTGTTGATACGAAAGATGCTATGGGCGCTAATATGCTTAATAC
GATTTTAGAGGCCATAACTGCATTTTTAAAAAATGAATTTCCGCAAAGCGACATTTTAATGAGTATTTTATCCAATCATG
CAACAGCGTCCGTTGTTAAAGTTCAAGGCGAAATTGACGTTAAAGATTTAGCAAGGGGTGAGAGAACTGGAGAAGAGGTT
GCCAAACGAATGGAACGTGCTTCTGTATTGGCACAAGTTGATATTCATCGTGCTGCAACACATAATAAAGGTGTTATGAA
TGGCATACATGCCGTTGTTTTAGCAACAGGAAATGATACGCGTGGTGCAGAAGCAAGTGCGCATGCATACGCAAGTAAAG
ATGGTCAATATCGTGGTATTGCAACATGGAGATACGATCAAGAACGTCAACGTTTAATTGGTACAATAGAAGTGCCTATG
ACATTGGCAATCGTTGGCGGTGGTACAAAAGTATTACCAATTGCTAAAGCTTCTTTAGAATTGCTAAATGTAGATTCAGC
ACAAGAATTAGGTCATGTAGTTGCTGCCGTTGGTTTAGCGCAAAACTTTGCAGCATGTCGCGCGCTCGTTTCCGAAGGTA
TCCAGCAAGGCCATATGAGCTTGCAATATAAATCTTTAGCTATTGTTGTAGGTGCAAAAGGTGATGAAATTGCGCAAGTA
GCTGAAGCATTGAAGCAAGAACCCCGTGCGAATACACAAGTAGCTGAACGCATTTTACAAGATTTAAGAAGCCAACAATA
A

Upstream 100 bases:

>100_bases
CAATTATTCAATTGAATTTTAGGACGAATAACGTTATTTTATGGTAAAAATAGTAGTGATTGAAATGTTAAAAATTATGT
GAAGTAAAAGGAGTATGTCC

Downstream 100 bases:

>100_bases
TCAAATGCGAATAGCGATTTTAAAGAAAAGTTTAAGTCAGTCCATCGTAGCGCTTAGATAAATTAATATGAACAAAAAAT
AAAAACTTCTATCACACGCA

Product: hydroxymethylglutaryl-CoA reductase

Products: NA

Alternate protein names: HMG-CoA reductase [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MQSLDKNFRHLSRQQKLQQLVDKQWLSEEQFNILLNHPLIDEEVANSLIENVIAQGALPVGLLPNIIVDDKAYVVPMMVE
EPSVVAAASYGAKLVNQTGGFKTVSSERIMIGQIVFDGVDDTEKLSAEIKALENQIHKIADEAYPSIKARGGGYQRIAID
TFPEQQLLSLKVFVDTKDAMGANMLNTILEAITAFLKNEFPQSDILMSILSNHATASVVKVQGEIDVKDLARGERTGEEV
AKRMERASVLAQVDIHRAATHNKGVMNGIHAVVLATGNDTRGAEASAHAYASKDGQYRGIATWRYDQERQRLIGTIEVPM
TLAIVGGGTKVLPIAKASLELLNVDSAQELGHVVAAVGLAQNFAACRALVSEGIQQGHMSLQYKSLAIVVGAKGDEIAQV
AEALKQEPRANTQVAERILQDLRSQQ

Sequences:

>Translated_426_residues
MQSLDKNFRHLSRQQKLQQLVDKQWLSEEQFNILLNHPLIDEEVANSLIENVIAQGALPVGLLPNIIVDDKAYVVPMMVE
EPSVVAAASYGAKLVNQTGGFKTVSSERIMIGQIVFDGVDDTEKLSAEIKALENQIHKIADEAYPSIKARGGGYQRIAID
TFPEQQLLSLKVFVDTKDAMGANMLNTILEAITAFLKNEFPQSDILMSILSNHATASVVKVQGEIDVKDLARGERTGEEV
AKRMERASVLAQVDIHRAATHNKGVMNGIHAVVLATGNDTRGAEASAHAYASKDGQYRGIATWRYDQERQRLIGTIEVPM
TLAIVGGGTKVLPIAKASLELLNVDSAQELGHVVAAVGLAQNFAACRALVSEGIQQGHMSLQYKSLAIVVGAKGDEIAQV
AEALKQEPRANTQVAERILQDLRSQQ
>Mature_426_residues
MQSLDKNFRHLSRQQKLQQLVDKQWLSEEQFNILLNHPLIDEEVANSLIENVIAQGALPVGLLPNIIVDDKAYVVPMMVE
EPSVVAAASYGAKLVNQTGGFKTVSSERIMIGQIVFDGVDDTEKLSAEIKALENQIHKIADEAYPSIKARGGGYQRIAID
TFPEQQLLSLKVFVDTKDAMGANMLNTILEAITAFLKNEFPQSDILMSILSNHATASVVKVQGEIDVKDLARGERTGEEV
AKRMERASVLAQVDIHRAATHNKGVMNGIHAVVLATGNDTRGAEASAHAYASKDGQYRGIATWRYDQERQRLIGTIEVPM
TLAIVGGGTKVLPIAKASLELLNVDSAQELGHVVAAVGLAQNFAACRALVSEGIQQGHMSLQYKSLAIVVGAKGDEIAQV
AEALKQEPRANTQVAERILQDLRSQQ

Specific function: P.mevalonii can use mevalonate as sole carbon source. With this enzyme mevalonate is deacetylated to HMG-CoA [H]

COG id: COG1257

COG function: function code I; Hydroxymethylglutaryl-CoA reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA reductase family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6323483, Length=423, Percent_Identity=25.7683215130024, Blast_Score=73, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6323565, Length=374, Percent_Identity=27.5401069518717, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002202
- InterPro:   IPR004553
- InterPro:   IPR023074
- InterPro:   IPR023076
- InterPro:   IPR009023
- InterPro:   IPR009029 [H]

Pfam domain/function: PF00368 HMG-CoA_red [H]

EC number: =1.1.1.88 [H]

Molecular weight: Translated: 46301; Mature: 46301

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS00066 HMG_COA_REDUCTASE_1 ; PS01192 HMG_COA_REDUCTASE_3 ; PS50065 HMG_COA_REDUCTASE_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSLDKNFRHLSRQQKLQQLVDKQWLSEEQFNILLNHPLIDEEVANSLIENVIAQGALPV
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCC
GLLPNIIVDDKAYVVPMMVEEPSVVAAASYGAKLVNQTGGFKTVSSERIMIGQIVFDGVD
CCCCCEEECCCCEEEEEEECCCCEEEEHHHHHHHHHCCCCCEEECCCCEEEEEEEECCCC
DTEKLSAEIKALENQIHKIADEAYPSIKARGGGYQRIAIDTFPEQQLLSLKVFVDTKDAM
CHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCEEEEEEECCCCHHHEEEEEEEECCHHC
GANMLNTILEAITAFLKNEFPQSDILMSILSNHATASVVKVQGEIDVKDLARGERTGEEV
CHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEECCCCHHHHHCCCCCHHHH
AKRMERASVLAQVDIHRAATHNKGVMNGIHAVVLATGNDTRGAEASAHAYASKDGQYRGI
HHHHHHHHHHHHHHHHHHHCCCCCHHCCEEEEEEEECCCCCCCCCHHHHHHCCCCCCCCE
ATWRYDQERQRLIGTIEVPMTLAIVGGGTKVLPIAKASLELLNVDSAQELGHVVAAVGLA
EEEECCHHHHHHHEEEECCEEEEEECCCCEEEEEHHHHHHHCCCCCHHHHHHHHHHHHHH
QNFAACRALVSEGIQQGHMSLQYKSLAIVVGAKGDEIAQVAEALKQEPRANTQVAERILQ
HHHHHHHHHHHHHHHHCCCEEEEEEEEEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHH
DLRSQQ
HHHCCC
>Mature Secondary Structure
MQSLDKNFRHLSRQQKLQQLVDKQWLSEEQFNILLNHPLIDEEVANSLIENVIAQGALPV
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCC
GLLPNIIVDDKAYVVPMMVEEPSVVAAASYGAKLVNQTGGFKTVSSERIMIGQIVFDGVD
CCCCCEEECCCCEEEEEEECCCCEEEEHHHHHHHHHCCCCCEEECCCCEEEEEEEECCCC
DTEKLSAEIKALENQIHKIADEAYPSIKARGGGYQRIAIDTFPEQQLLSLKVFVDTKDAM
CHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCEEEEEEECCCCHHHEEEEEEEECCHHC
GANMLNTILEAITAFLKNEFPQSDILMSILSNHATASVVKVQGEIDVKDLARGERTGEEV
CHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEECCCCHHHHHCCCCCHHHH
AKRMERASVLAQVDIHRAATHNKGVMNGIHAVVLATGNDTRGAEASAHAYASKDGQYRGI
HHHHHHHHHHHHHHHHHHHCCCCCHHCCEEEEEEEECCCCCCCCCHHHHHHCCCCCCCCE
ATWRYDQERQRLIGTIEVPMTLAIVGGGTKVLPIAKASLELLNVDSAQELGHVVAAVGLA
EEEECCHHHHHHHEEEECCEEEEEECCCCEEEEEHHHHHHHCCCCCHHHHHHHHHHHHHH
QNFAACRALVSEGIQQGHMSLQYKSLAIVVGAKGDEIAQVAEALKQEPRANTQVAERILQ
HHHHHHHHHHHHHHHHCCCEEEEEEEEEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHH
DLRSQQ
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2656635; 2477360; 2123872; 1634543; 10377386 [H]