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The map label for this gene is pgcA [H]

Identifier: 82752080

GI number: 82752080

Start: 2504564

End: 2506327

Strand: Direct

Name: pgcA [H]

Synonym: SAB2371

Alternate gene names: 82752080

Gene position: 2504564-2506327 (Clockwise)

Preceding gene: 82752072

Following gene: 82752081

Centisome position: 91.32

GC content: 34.64

Gene sequence:

>1764_bases
TTGTCTTGGGGCTGTGTTTTTTACTTTTGGGGCGTATTTCTTTATAATTCATTACATAAATGTAAGGGCTTTAGTTTTCA
TGTTTTATTAAGTCTAACTGAGATTTTGAAAGGATGTTTAGCAACAATGGATAAAGAATTATGGATAGAAAGAGCTAATG
ATAGTTTAGTTAAACATTTTTATGAGCAGCAATCTGGCATTGAACAGCGAGATGGTTTTGAAAGTAAATTAACGTTTGGT
ACTGCGGGTATACGCGGAAAATTCGGTCTTGGTGAAGGTCGACTTAATAAGTTTACTATTGAAAAATTGGCATTAGGTTT
AGCGCGTTATTTAAATGCCCAAACAAACAATCCAACGATAGTCATTCATTATGATATTAGACATCTTTCAACTGAATTCG
CCCAAATTATTGCTAATGTATTAGCAAACCATCAAATAACAGTTTATTTACCTGATACATATAAAACGACACCGGAATTA
TCGTTCGCGGTGCGCAATCTTAATACTGCTGCTGGCATTATGATTACAGCAAGTCATAATCCGAAAGACTATAACGGCAT
TAAAGTATATGGTTCTGATGGCGCGCAACTATCGACTGATGCATCTGAGCTTGCAAGTCGTTATATCGAAGAAGTTGGCG
ATCCATTACAGATTGATATACCTATTTCAAAACAAAATACATCTTATATCAAGCCTTTCCCGAAATCTGTAACTGATGAC
TATATGAAACACATTCAAAATATGATTGGCTATATTCCTAAATCTGATTTACAAGTTGTGTTCACTAGTTTGCATGGTAC
AAGTGTTCCGATTGTACCTGAGTTATTACAATCTTTGAATTTCAATCAATTTAATCTTGTAGAAGCACAATGTAAACCTG
ATCCGAATTTCAGCTCAGTTCAAAGTGCTAATCCTGAAGATCATCGCGCTTTTGATCAAGCAGTCGAACTTGCAAATAAA
AGTCATGCAGACTTATTAATATCAACTGACCCAGATGCAGATCGACTTGGTATTGCTGAATGTGATGCACACGGTCATAT
CACATATTTTAATGGCAACCAAATTGGTGCGTTGTTACTTAATTATCGTATTCAACAAACGTCTCAATTACGTCACCGAT
TAATGATTCAATCTATTGTAAGTAGTGAGTTAACAAAGTCATTAGCACGCTATAATAATGTTGAATACAAAGAGGTGCTG
ACGGGATTTAAATTTATTGCTCAGGAAATAAGGCAACTGGACGATCATCAAAATATGATTTTCGCCTTTGAAGAGAGTTA
CGGTTTTCTATCAGAGCCTTTTGTACGTGATAAAGATGCCGTACAAATTGTGCCACTCATTATAAAATACGCTTCTGAGT
TAAAATTATATGGCAAAACATTGAAAGATGCATTAGAACAGATTTATCAAACTGTTGGTAGACATGAGGATACATTATTC
TCACATACGCTAGAAGGATTAGAAGGGAAAAAGAAAATTAATGCAATAATGACCAAATTCCGTTCAAATCCACCGCAAGA
GATTCAAGGACTGAAAGTGAAAGCAATTGAAGATTATTTAACTAGCGAGGTTTATCAGTTGGATAAAGATACAACGTCGC
AGATTAATTCTCCTAAGTCAAATGTTATTCGCGTGTTATTTGACGAAGGATTTATCGCTTTACGTCCTTCTGGTACTGAA
CCTAAAATTAAATTATATGTGTCGTTAAAATGTCCGAATTTTGATGATGTAGCTCAAAAAATTAATGCGATGATTTTTAG
CTAA

Upstream 100 bases:

>100_bases
AATTTTTCACTTATTATCAATTATACATTATAAAAATTTATTGAACGCTCTACTCCATGCATTTTCATACACATCTATTA
TATAATACTTGTGAAAAGTA

Downstream 100 bases:

>100_bases
TTAAAAATTTTATACATCGAAATATTACATTTCATTTTATACTTATCAGCCCTTTTGAAACTAGAATCCTTATGTTTTCG
CGTTTTGAAGGGGCTAATTT

Product: phosphoglucomutase

Products: NA

Alternate protein names: PGM; Alpha-phosphoglucomutase; Glucose phosphomutase [H]

Number of amino acids: Translated: 587; Mature: 586

Protein sequence:

>587_residues
MSWGCVFYFWGVFLYNSLHKCKGFSFHVLLSLTEILKGCLATMDKELWIERANDSLVKHFYEQQSGIEQRDGFESKLTFG
TAGIRGKFGLGEGRLNKFTIEKLALGLARYLNAQTNNPTIVIHYDIRHLSTEFAQIIANVLANHQITVYLPDTYKTTPEL
SFAVRNLNTAAGIMITASHNPKDYNGIKVYGSDGAQLSTDASELASRYIEEVGDPLQIDIPISKQNTSYIKPFPKSVTDD
YMKHIQNMIGYIPKSDLQVVFTSLHGTSVPIVPELLQSLNFNQFNLVEAQCKPDPNFSSVQSANPEDHRAFDQAVELANK
SHADLLISTDPDADRLGIAECDAHGHITYFNGNQIGALLLNYRIQQTSQLRHRLMIQSIVSSELTKSLARYNNVEYKEVL
TGFKFIAQEIRQLDDHQNMIFAFEESYGFLSEPFVRDKDAVQIVPLIIKYASELKLYGKTLKDALEQIYQTVGRHEDTLF
SHTLEGLEGKKKINAIMTKFRSNPPQEIQGLKVKAIEDYLTSEVYQLDKDTTSQINSPKSNVIRVLFDEGFIALRPSGTE
PKIKLYVSLKCPNFDDVAQKINAMIFS

Sequences:

>Translated_587_residues
MSWGCVFYFWGVFLYNSLHKCKGFSFHVLLSLTEILKGCLATMDKELWIERANDSLVKHFYEQQSGIEQRDGFESKLTFG
TAGIRGKFGLGEGRLNKFTIEKLALGLARYLNAQTNNPTIVIHYDIRHLSTEFAQIIANVLANHQITVYLPDTYKTTPEL
SFAVRNLNTAAGIMITASHNPKDYNGIKVYGSDGAQLSTDASELASRYIEEVGDPLQIDIPISKQNTSYIKPFPKSVTDD
YMKHIQNMIGYIPKSDLQVVFTSLHGTSVPIVPELLQSLNFNQFNLVEAQCKPDPNFSSVQSANPEDHRAFDQAVELANK
SHADLLISTDPDADRLGIAECDAHGHITYFNGNQIGALLLNYRIQQTSQLRHRLMIQSIVSSELTKSLARYNNVEYKEVL
TGFKFIAQEIRQLDDHQNMIFAFEESYGFLSEPFVRDKDAVQIVPLIIKYASELKLYGKTLKDALEQIYQTVGRHEDTLF
SHTLEGLEGKKKINAIMTKFRSNPPQEIQGLKVKAIEDYLTSEVYQLDKDTTSQINSPKSNVIRVLFDEGFIALRPSGTE
PKIKLYVSLKCPNFDDVAQKINAMIFS
>Mature_586_residues
SWGCVFYFWGVFLYNSLHKCKGFSFHVLLSLTEILKGCLATMDKELWIERANDSLVKHFYEQQSGIEQRDGFESKLTFGT
AGIRGKFGLGEGRLNKFTIEKLALGLARYLNAQTNNPTIVIHYDIRHLSTEFAQIIANVLANHQITVYLPDTYKTTPELS
FAVRNLNTAAGIMITASHNPKDYNGIKVYGSDGAQLSTDASELASRYIEEVGDPLQIDIPISKQNTSYIKPFPKSVTDDY
MKHIQNMIGYIPKSDLQVVFTSLHGTSVPIVPELLQSLNFNQFNLVEAQCKPDPNFSSVQSANPEDHRAFDQAVELANKS
HADLLISTDPDADRLGIAECDAHGHITYFNGNQIGALLLNYRIQQTSQLRHRLMIQSIVSSELTKSLARYNNVEYKEVLT
GFKFIAQEIRQLDDHQNMIFAFEESYGFLSEPFVRDKDAVQIVPLIIKYASELKLYGKTLKDALEQIYQTVGRHEDTLFS
HTLEGLEGKKKINAIMTKFRSNPPQEIQGLKVKAIEDYLTSEVYQLDKDTTSQINSPKSNVIRVLFDEGFIALRPSGTEP
KIKLYVSLKCPNFDDVAQKINAMIFS

Specific function: Catalyzes the interconversion between glucose-6- phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in the S.aureus membrane, which is also use

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI63055049, Length=564, Percent_Identity=32.8014184397163, Blast_Score=247, Evalue=2e-65,
Organism=Homo sapiens, GI31377548, Length=542, Percent_Identity=31.9188191881919, Blast_Score=227, Evalue=2e-59,
Organism=Escherichia coli, GI1788361, Length=264, Percent_Identity=29.1666666666667, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71993870, Length=565, Percent_Identity=29.9115044247788, Blast_Score=202, Evalue=6e-52,
Organism=Caenorhabditis elegans, GI71993878, Length=320, Percent_Identity=31.25, Blast_Score=134, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6323934, Length=555, Percent_Identity=28.2882882882883, Blast_Score=172, Evalue=9e-44,
Organism=Drosophila melanogaster, GI20129809, Length=563, Percent_Identity=28.9520426287744, Blast_Score=216, Evalue=5e-56,
Organism=Drosophila melanogaster, GI24651977, Length=442, Percent_Identity=30.316742081448, Blast_Score=202, Evalue=6e-52,
Organism=Drosophila melanogaster, GI24653722, Length=430, Percent_Identity=30.9302325581395, Blast_Score=186, Evalue=5e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 66273; Mature: 66142

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSWGCVFYFWGVFLYNSLHKCKGFSFHVLLSLTEILKGCLATMDKELWIERANDSLVKHF
CCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHCCHHHHHHH
YEQQSGIEQRDGFESKLTFGTAGIRGKFGLGEGRLNKFTIEKLALGLARYLNAQTNNPTI
HHHHCCCCHHCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEE
VIHYDIRHLSTEFAQIIANVLANHQITVYLPDTYKTTPELSFAVRNLNTAAGIMITASHN
EEEECHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHCCCCCCCEEEEECCC
PKDYNGIKVYGSDGAQLSTDASELASRYIEEVGDPLQIDIPISKQNTSYIKPFPKSVTDD
CCCCCCEEEECCCCCEECCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHHHHH
YMKHIQNMIGYIPKSDLQVVFTSLHGTSVPIVPELLQSLNFNQFNLVEAQCKPDPNFSSV
HHHHHHHHHHCCCCCCHHEEEECCCCCCCCHHHHHHHHCCCCCEEEEEEECCCCCCCCCC
QSANPEDHRAFDQAVELANKSHADLLISTDPDADRLGIAECDAHGHITYFNGNQIGALLL
CCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCEEECCCCEEEEECCCCCEEHHH
NYRIQQTSQLRHRLMIQSIVSSELTKSLARYNNVEYKEVLTGFKFIAQEIRQLDDHQNMI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEE
FAFEESYGFLSEPFVRDKDAVQIVPLIIKYASELKLYGKTLKDALEQIYQTVGRHEDTLF
EEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
SHTLEGLEGKKKINAIMTKFRSNPPQEIQGLKVKAIEDYLTSEVYQLDKDTTSQINSPKS
HHHHHCCCHHHHHHHHHHHHCCCCCHHHCCCCHHHHHHHHHHHHHHCCCCHHHHCCCCHH
NVIRVLFDEGFIALRPSGTEPKIKLYVSLKCPNFDDVAQKINAMIFS
HEEEEEEECCEEEECCCCCCCEEEEEEEEECCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SWGCVFYFWGVFLYNSLHKCKGFSFHVLLSLTEILKGCLATMDKELWIERANDSLVKHF
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHCCHHHHHHH
YEQQSGIEQRDGFESKLTFGTAGIRGKFGLGEGRLNKFTIEKLALGLARYLNAQTNNPTI
HHHHCCCCHHCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEE
VIHYDIRHLSTEFAQIIANVLANHQITVYLPDTYKTTPELSFAVRNLNTAAGIMITASHN
EEEECHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHCCCCCCCEEEEECCC
PKDYNGIKVYGSDGAQLSTDASELASRYIEEVGDPLQIDIPISKQNTSYIKPFPKSVTDD
CCCCCCEEEECCCCCEECCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHHHHH
YMKHIQNMIGYIPKSDLQVVFTSLHGTSVPIVPELLQSLNFNQFNLVEAQCKPDPNFSSV
HHHHHHHHHHCCCCCCHHEEEECCCCCCCCHHHHHHHHCCCCCEEEEEEECCCCCCCCCC
QSANPEDHRAFDQAVELANKSHADLLISTDPDADRLGIAECDAHGHITYFNGNQIGALLL
CCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCEEECCCCEEEEECCCCCEEHHH
NYRIQQTSQLRHRLMIQSIVSSELTKSLARYNNVEYKEVLTGFKFIAQEIRQLDDHQNMI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEE
FAFEESYGFLSEPFVRDKDAVQIVPLIIKYASELKLYGKTLKDALEQIYQTVGRHEDTLF
EEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
SHTLEGLEGKKKINAIMTKFRSNPPQEIQGLKVKAIEDYLTSEVYQLDKDTTSQINSPKS
HHHHHCCCHHHHHHHHHHHHCCCCCHHHCCCCHHHHHHHHHHHHHHCCCCHHHHCCCCHH
NVIRVLFDEGFIALRPSGTEPKIKLYVSLKCPNFDDVAQKINAMIFS
HEEEEEEECCEEEECCCCCCCEEEEEEEEECCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA