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The map label for this gene is yhcA [H]

Identifier: 82751947

GI number: 82751947

Start: 2359392

End: 2361323

Strand: Reverse

Name: yhcA [H]

Synonym: SAB2231c

Alternate gene names: 82751947

Gene position: 2361323-2359392 (Counterclockwise)

Preceding gene: 82751948

Following gene: 82751945

Centisome position: 86.1

GC content: 33.8

Gene sequence:

>1932_bases
ATGACTACGACCTTCATTATTAGCTACATTGTTTTAGCGCTCATTATTGTTGGGGTTATCAATTTATTATTAATAAGATC
AAGAAGAAAAGCAAAACGCCAACAAAAGGAACAACATTTTGCGACACGTCAATCAAATCAATCTAAATTTAAAGCAAGTG
ATTTAGACAGAACAACTGATCAATCGTCACAACATACGGCGCGTGAAGAGGCACGTATTGACAATAAAGACAATCAGAAT
CAAGTTAGTCTAACTGATCATGCGAAAGGGTCTGAACAAGATCAAGGATTATTCAATGATAATAAGGATGATGAAGCATT
TGCTGCTAAAAATCCTGAATCAGAAGAATATAAAGTAAATGAGAAAATTAAAAAAGAACATAAAAACTATATTTTTGGTG
AAGGTGTTTCACGCGGTAAAATATTAGCGGCATTATTATTCGGTATGTTTATTGCGATTTTAAACCAAACATTATTAAAT
GTTGCTTTGCCAAAAATTAATACGGAATTTAATATTTCTGCGTCAACAGGGCAATGGTTGATGACGGGATTCATGTTAGT
AAACGGTATTTTAATACCAATTACGGCGTATCTATTTAATAAATATTCATATCGAAAATTATTTTTAGTTGCGTTAGTAC
TCTTTACAATTGGTTCATTAATATGTGCGATTTCAATGAATTTCCCAATCATGATGGTTGGACGTGTATTACAAGCCATT
GGTGCAGGTGTACTAATGCCATTAGGTTCAATTGTTATTATTACAATTTATCCACCTGAAAAACGTGGTGCTGCCATGGG
TACAATGGGTATCGCAATGATTTTAGCACCTGCAATTGGTCCAACATTATCAGGTTATATTGTACAAAATTACCATTGGA
ATGTGATGTTTTACGGTATGTTCATTATCGGAATTATTGCAATCTTAGTTGGTTTTGTATGGTTTAAGTTATATCAATAT
ACAACAAACCCTAAAGCTGATATCCCAGGTATCATTTTTAGTACAATTGGTTTTGGTGCTTTGTTATACGGCTTTTCAGA
AGCGGGGAACAAAGGCTGGGGTTCTGTTGAGATAGAAACAATGTTTGCGATTGGTATTATCTTTATTATTCTATTTGTAA
TAAGAGAATTAAGAATGAAAGCACCAATGCTGAATTTAGAAGTATTGAAATTTCCAACATTTACACTAACAACAGTAATT
AATATGGTTGTAATGTTGAGCTTGTATGGTGGTATGATTTTATTACCAATTTACTTACAAAATTTACGTGGTTTCTCAGC
ATTAGATTCCGGATTGTTATTATTACCTGGTTCTCTAATTATGGGTCTACTAGGACCATTTGCTGGTAAGTTGTTAGACA
CGATTGGTTTAAAACCTTTAGCCATTTTTGGTATTGCTGTCATGACTTATGCAACATGGGAATTAACTAAATTGAATATG
GATACGCCATATATGACAATCATGGGCATCTATGTACTACGTTCATTTGGTATGGCATTTATTATGATGCCAATGGTAAC
AGCAGCTATTAATGCGTTGCCGGGACGACTAGCCTCCCATGGTAATGCCTTCTTAAATACGATGCGTCAACTAGCTGGTT
CTATAGGAACAGCAATCTTGGTTACTGTAATGACAACGCAAACTACACAACATTTATCAGCTTTTGGGGAAGAGTTAGAT
AAAACGAATCCTGTTGTACAAGATCATATGCGTGAATTAGCATCGCAATATGGTGGTCAAGAAGGCGCAATGAAAGTGTT
ATTACAGTTTGTAAATAAACTAGCAACAGTTGAAGGGATTAATGATGCATTTATAGTTGCAACGATATTTAGCATCATTG
CTTTAATTTTATGCTTATTTTTACAAAGTAACAAAAAAGCAAAAGCTACGGCTCAAAAGATAGATGCAGATAATAGTATC
AATCATGAATAA

Upstream 100 bases:

>100_bases
TATACCTGTTAAAATTACGTTAGATTCAGAACCGTCTAAACAAGTTGTTCCTGGAATGAACGCTGAAGTAAAAATTCATA
AAAATTAAGGGGGTCATTAA

Downstream 100 bases:

>100_bases
ATAAAATAAATTAATTGAAGTGTGACTAATCAAAAATTATGTTGTGGGGACATGATTTTTAAAGTATCGGTGCCAATATA
TGGTTATCGATACTTTTTTT

Product: multidrug ABC transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 643; Mature: 642

Protein sequence:

>643_residues
MTTTFIISYIVLALIIVGVINLLLIRSRRKAKRQQKEQHFATRQSNQSKFKASDLDRTTDQSSQHTAREEARIDNKDNQN
QVSLTDHAKGSEQDQGLFNDNKDDEAFAAKNPESEEYKVNEKIKKEHKNYIFGEGVSRGKILAALLFGMFIAILNQTLLN
VALPKINTEFNISASTGQWLMTGFMLVNGILIPITAYLFNKYSYRKLFLVALVLFTIGSLICAISMNFPIMMVGRVLQAI
GAGVLMPLGSIVIITIYPPEKRGAAMGTMGIAMILAPAIGPTLSGYIVQNYHWNVMFYGMFIIGIIAILVGFVWFKLYQY
TTNPKADIPGIIFSTIGFGALLYGFSEAGNKGWGSVEIETMFAIGIIFIILFVIRELRMKAPMLNLEVLKFPTFTLTTVI
NMVVMLSLYGGMILLPIYLQNLRGFSALDSGLLLLPGSLIMGLLGPFAGKLLDTIGLKPLAIFGIAVMTYATWELTKLNM
DTPYMTIMGIYVLRSFGMAFIMMPMVTAAINALPGRLASHGNAFLNTMRQLAGSIGTAILVTVMTTQTTQHLSAFGEELD
KTNPVVQDHMRELASQYGGQEGAMKVLLQFVNKLATVEGINDAFIVATIFSIIALILCLFLQSNKKAKATAQKIDADNSI
NHE

Sequences:

>Translated_643_residues
MTTTFIISYIVLALIIVGVINLLLIRSRRKAKRQQKEQHFATRQSNQSKFKASDLDRTTDQSSQHTAREEARIDNKDNQN
QVSLTDHAKGSEQDQGLFNDNKDDEAFAAKNPESEEYKVNEKIKKEHKNYIFGEGVSRGKILAALLFGMFIAILNQTLLN
VALPKINTEFNISASTGQWLMTGFMLVNGILIPITAYLFNKYSYRKLFLVALVLFTIGSLICAISMNFPIMMVGRVLQAI
GAGVLMPLGSIVIITIYPPEKRGAAMGTMGIAMILAPAIGPTLSGYIVQNYHWNVMFYGMFIIGIIAILVGFVWFKLYQY
TTNPKADIPGIIFSTIGFGALLYGFSEAGNKGWGSVEIETMFAIGIIFIILFVIRELRMKAPMLNLEVLKFPTFTLTTVI
NMVVMLSLYGGMILLPIYLQNLRGFSALDSGLLLLPGSLIMGLLGPFAGKLLDTIGLKPLAIFGIAVMTYATWELTKLNM
DTPYMTIMGIYVLRSFGMAFIMMPMVTAAINALPGRLASHGNAFLNTMRQLAGSIGTAILVTVMTTQTTQHLSAFGEELD
KTNPVVQDHMRELASQYGGQEGAMKVLLQFVNKLATVEGINDAFIVATIFSIIALILCLFLQSNKKAKATAQKIDADNSI
NHE
>Mature_642_residues
TTTFIISYIVLALIIVGVINLLLIRSRRKAKRQQKEQHFATRQSNQSKFKASDLDRTTDQSSQHTAREEARIDNKDNQNQ
VSLTDHAKGSEQDQGLFNDNKDDEAFAAKNPESEEYKVNEKIKKEHKNYIFGEGVSRGKILAALLFGMFIAILNQTLLNV
ALPKINTEFNISASTGQWLMTGFMLVNGILIPITAYLFNKYSYRKLFLVALVLFTIGSLICAISMNFPIMMVGRVLQAIG
AGVLMPLGSIVIITIYPPEKRGAAMGTMGIAMILAPAIGPTLSGYIVQNYHWNVMFYGMFIIGIIAILVGFVWFKLYQYT
TNPKADIPGIIFSTIGFGALLYGFSEAGNKGWGSVEIETMFAIGIIFIILFVIRELRMKAPMLNLEVLKFPTFTLTTVIN
MVVMLSLYGGMILLPIYLQNLRGFSALDSGLLLLPGSLIMGLLGPFAGKLLDTIGLKPLAIFGIAVMTYATWELTKLNMD
TPYMTIMGIYVLRSFGMAFIMMPMVTAAINALPGRLASHGNAFLNTMRQLAGSIGTAILVTVMTTQTTQHLSAFGEELDK
TNPVVQDHMRELASQYGGQEGAMKVLLQFVNKLATVEGINDAFIVATIFSIIALILCLFLQSNKKAKATAQKIDADNSIN
HE

Specific function: Translocase That Confers Resistance To Substances Of High Hydrophobicity. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1789042, Length=476, Percent_Identity=28.3613445378151, Blast_Score=189, Evalue=5e-49,
Organism=Escherichia coli, GI1788710, Length=490, Percent_Identity=28.1632653061224, Blast_Score=185, Evalue=7e-48,
Organism=Escherichia coli, GI87081983, Length=413, Percent_Identity=27.6029055690073, Blast_Score=151, Evalue=1e-37,
Organism=Escherichia coli, GI1790195, Length=438, Percent_Identity=28.310502283105, Blast_Score=127, Evalue=3e-30,
Organism=Escherichia coli, GI1788392, Length=417, Percent_Identity=25.6594724220624, Blast_Score=101, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6322958, Length=544, Percent_Identity=21.875, Blast_Score=88, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6323735, Length=320, Percent_Identity=25, Blast_Score=77, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6325455, Length=233, Percent_Identity=26.1802575107296, Blast_Score=74, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6323520, Length=386, Percent_Identity=26.9430051813472, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6321663, Length=129, Percent_Identity=28.6821705426357, Blast_Score=64, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 70874; Mature: 70743

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTFIISYIVLALIIVGVINLLLIRSRRKAKRQQKEQHFATRQSNQSKFKASDLDRTTD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCC
QSSQHTAREEARIDNKDNQNQVSLTDHAKGSEQDQGLFNDNKDDEAFAAKNPESEEYKVN
CCHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
EKIKKEHKNYIFGEGVSRGKILAALLFGMFIAILNQTLLNVALPKINTEFNISASTGQWL
HHHHHHHCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHH
MTGFMLVNGILIPITAYLFNKYSYRKLFLVALVLFTIGSLICAISMNFPIMMVGRVLQAI
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
GAGVLMPLGSIVIITIYPPEKRGAAMGTMGIAMILAPAIGPTLSGYIVQNYHWNVMFYGM
CCHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECEECHHHHHHH
FIIGIIAILVGFVWFKLYQYTTNPKADIPGIIFSTIGFGALLYGFSEAGNKGWGSVEIET
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHH
MFAIGIIFIILFVIRELRMKAPMLNLEVLKFPTFTLTTVINMVVMLSLYGGMILLPIYLQ
HHHHHHHHHHHHHHHHHHHHCCCCCEEEHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHH
NLRGFSALDSGLLLLPGSLIMGLLGPFAGKLLDTIGLKPLAIFGIAVMTYATWELTKLNM
HCCCHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEEEEECC
DTPYMTIMGIYVLRSFGMAFIMMPMVTAAINALPGRLASHGNAFLNTMRQLAGSIGTAIL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHH
VTVMTTQTTQHLSAFGEELDKTNPVVQDHMRELASQYGGQEGAMKVLLQFVNKLATVEGI
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC
NDAFIVATIFSIIALILCLFLQSNKKAKATAQKIDADNSINHE
CHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TTTFIISYIVLALIIVGVINLLLIRSRRKAKRQQKEQHFATRQSNQSKFKASDLDRTTD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCC
QSSQHTAREEARIDNKDNQNQVSLTDHAKGSEQDQGLFNDNKDDEAFAAKNPESEEYKVN
CCHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
EKIKKEHKNYIFGEGVSRGKILAALLFGMFIAILNQTLLNVALPKINTEFNISASTGQWL
HHHHHHHCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHH
MTGFMLVNGILIPITAYLFNKYSYRKLFLVALVLFTIGSLICAISMNFPIMMVGRVLQAI
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
GAGVLMPLGSIVIITIYPPEKRGAAMGTMGIAMILAPAIGPTLSGYIVQNYHWNVMFYGM
CCHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECEECHHHHHHH
FIIGIIAILVGFVWFKLYQYTTNPKADIPGIIFSTIGFGALLYGFSEAGNKGWGSVEIET
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHH
MFAIGIIFIILFVIRELRMKAPMLNLEVLKFPTFTLTTVINMVVMLSLYGGMILLPIYLQ
HHHHHHHHHHHHHHHHHHHHCCCCCEEEHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHH
NLRGFSALDSGLLLLPGSLIMGLLGPFAGKLLDTIGLKPLAIFGIAVMTYATWELTKLNM
HCCCHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEEEEECC
DTPYMTIMGIYVLRSFGMAFIMMPMVTAAINALPGRLASHGNAFLNTMRQLAGSIGTAIL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHH
VTVMTTQTTQHLSAFGEELDKTNPVVQDHMRELASQYGGQEGAMKVLLQFVNKLATVEGI
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC
NDAFIVATIFSIIALILCLFLQSNKKAKATAQKIDADNSINHE
CHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 8969498 [H]