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The map label for this gene is hutU

Identifier: 82751924

GI number: 82751924

Start: 2338288

End: 2339949

Strand: Reverse

Name: hutU

Synonym: SAB2208c

Alternate gene names: 82751924

Gene position: 2339949-2338288 (Counterclockwise)

Preceding gene: 82751926

Following gene: 82751923

Centisome position: 85.32

GC content: 39.35

Gene sequence:

>1662_bases
ATGAGAAAAATTCAAGCAAAAAAAGGTTTGAGTATTGAGTGTAAAGGTTGGGAACAAGAAGCAGTACTTAGAATGTTATA
CAACAATTTAGACCCAGAAGTTGCTGAAAGACCAGAAGATTTAGTTGTTTATGGTGGTATTGGAAAAGCAGCTCGTAATT
GGGAAGCTTTTGAAGCAATAGAGAAAACGTTACGAGAATTAGAATCAGATGAGACAATGTTAGTACAATCAGGAAAGCCA
GTTGCTGTATTTAAAACACATGAAGAAGCGCCACGTGTATTAATTTCAAATTCAGTATTAGTACCTGAATGGGCAAACTG
GGATCATTTTAATGAATTAGATAAAAAAGGTTTAATCATGTATGGACAGATGACAGCCGGTAGTTGGATATATATTGGTT
CTCAAGGTATTGTGCAAGGTACTTATGAGACATTTGCCGAGCTAGGTAATCAACACTTTAATGGAGATTTAGCAGGCACT
GTTACACTGACAGCAGGTTTAGGTGGTATGGGTGGTGCGCAACCGTTAGCAATTACTATGAATCATGGGGTAGTAATTTG
CGTGGATGTTGATGAAACACGTGTTGATAAGCGGATTGATACGAAATACTGTGATGTTAAAACAGCTGATTTAGATGAAG
CATTAAAATTAGCAGAAGAGGCGAAAGAACGTGGAGAAGGATTATCAATCGGGTTAGTTGGAAATGCTGTAGACATCCAT
CAAGCGATTCTAGAAAAAGGATTTAAAATTGACATTATTACTGACCAAACAAGTGCACATGATCCGCTAAATGGATATGT
GCCACAAGGATACTCTGTAGAAGAAGCGAAAGTATTGCGTGAAAAAGATCCGAAAAAATATGTTGAACTGTCACAAGCTT
CAATGGCAAAGCATGTTGAATTAATGCTTGAATTCCAAAAACGTGGCGCTGTAGCATTTGATTATGGTAACAATATTCGA
CAAGTAGCCTTCAATAACGGAGTGAAAAATGCTTTTGACTTCCCAGGTTTTGTACCAGCTTACATTAGACCATTATTCTG
TGAAGGTAAAGGGCCATTCCGCTTTGCTGCGTTGAGTGGTGATCCAAAAGATATCGAGCGTGCGGATGAAGAAATGCGCA
AACTTTTCCCAGAAAATGAAAAGTTATTAAGATGGCTTGATTTAGCTGAAGAAAAAATTTCATATCAAGGACTACCATCA
CGTATTGCTTGGTTAGGCTATGGAGAAAGAGCGAAAATGGGCTTAGCTTTAAATCGTCTTGTACGTGACGGTGAAATTTC
AGCACCAATTGTTATTGGACGAGACCATTTAGATGCTGGTTCAGTTGCTAGTCCTAACCGTGAAACAGAAAGTATGAAAG
ATGGTAGTGACGCGGTTGGTGATTGGGCTGTATTGAATGCACTAATTAACACAGCTGCAGGTGGTTCATGGATTTCATTC
CATCACGGTGGCGGTGTTGGCATGGGATATTCACTTCATGCGGGTATGGTTGTTGTAGCAGATGGATCAGAGCGTGCTGA
AAGAAGATTGGGACGCGTATTGACTACTGATCCAGGTATGGGTGTTGCCCGACATGTTGATGCTGGCTATGACATCGCTA
TTCAAACAGCTAAAGAAAAAGGTATTCATATTCCAATGATTGATAAAGCAGGTGATAAGTAA

Upstream 100 bases:

>100_bases
TTGGCTATATTTTAACATACTATAATGAATATTGAAGATAATAATGTAAGCGTTTTAAATTCAGTAGAATTAACTTCTAA
AAAGAACAGGAGCGAATTTT

Downstream 100 bases:

>100_bases
TGAATGATTTAATAATTAATCATATAGCAGAATTAATTTTACCGAGATCAACAGATAAACCTTTGAAGGGTAAGGAATTA
GATGAATTAAATGTTGTGAA

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase [H]

Number of amino acids: Translated: 553; Mature: 553

Protein sequence:

>553_residues
MRKIQAKKGLSIECKGWEQEAVLRMLYNNLDPEVAERPEDLVVYGGIGKAARNWEAFEAIEKTLRELESDETMLVQSGKP
VAVFKTHEEAPRVLISNSVLVPEWANWDHFNELDKKGLIMYGQMTAGSWIYIGSQGIVQGTYETFAELGNQHFNGDLAGT
VTLTAGLGGMGGAQPLAITMNHGVVICVDVDETRVDKRIDTKYCDVKTADLDEALKLAEEAKERGEGLSIGLVGNAVDIH
QAILEKGFKIDIITDQTSAHDPLNGYVPQGYSVEEAKVLREKDPKKYVELSQASMAKHVELMLEFQKRGAVAFDYGNNIR
QVAFNNGVKNAFDFPGFVPAYIRPLFCEGKGPFRFAALSGDPKDIERADEEMRKLFPENEKLLRWLDLAEEKISYQGLPS
RIAWLGYGERAKMGLALNRLVRDGEISAPIVIGRDHLDAGSVASPNRETESMKDGSDAVGDWAVLNALINTAAGGSWISF
HHGGGVGMGYSLHAGMVVVADGSERAERRLGRVLTTDPGMGVARHVDAGYDIAIQTAKEKGIHIPMIDKAGDK

Sequences:

>Translated_553_residues
MRKIQAKKGLSIECKGWEQEAVLRMLYNNLDPEVAERPEDLVVYGGIGKAARNWEAFEAIEKTLRELESDETMLVQSGKP
VAVFKTHEEAPRVLISNSVLVPEWANWDHFNELDKKGLIMYGQMTAGSWIYIGSQGIVQGTYETFAELGNQHFNGDLAGT
VTLTAGLGGMGGAQPLAITMNHGVVICVDVDETRVDKRIDTKYCDVKTADLDEALKLAEEAKERGEGLSIGLVGNAVDIH
QAILEKGFKIDIITDQTSAHDPLNGYVPQGYSVEEAKVLREKDPKKYVELSQASMAKHVELMLEFQKRGAVAFDYGNNIR
QVAFNNGVKNAFDFPGFVPAYIRPLFCEGKGPFRFAALSGDPKDIERADEEMRKLFPENEKLLRWLDLAEEKISYQGLPS
RIAWLGYGERAKMGLALNRLVRDGEISAPIVIGRDHLDAGSVASPNRETESMKDGSDAVGDWAVLNALINTAAGGSWISF
HHGGGVGMGYSLHAGMVVVADGSERAERRLGRVLTTDPGMGVARHVDAGYDIAIQTAKEKGIHIPMIDKAGDK
>Mature_553_residues
MRKIQAKKGLSIECKGWEQEAVLRMLYNNLDPEVAERPEDLVVYGGIGKAARNWEAFEAIEKTLRELESDETMLVQSGKP
VAVFKTHEEAPRVLISNSVLVPEWANWDHFNELDKKGLIMYGQMTAGSWIYIGSQGIVQGTYETFAELGNQHFNGDLAGT
VTLTAGLGGMGGAQPLAITMNHGVVICVDVDETRVDKRIDTKYCDVKTADLDEALKLAEEAKERGEGLSIGLVGNAVDIH
QAILEKGFKIDIITDQTSAHDPLNGYVPQGYSVEEAKVLREKDPKKYVELSQASMAKHVELMLEFQKRGAVAFDYGNNIR
QVAFNNGVKNAFDFPGFVPAYIRPLFCEGKGPFRFAALSGDPKDIERADEEMRKLFPENEKLLRWLDLAEEKISYQGLPS
RIAWLGYGERAKMGLALNRLVRDGEISAPIVIGRDHLDAGSVASPNRETESMKDGSDAVGDWAVLNALINTAAGGSWISF
HHGGGVGMGYSLHAGMVVVADGSERAERRLGRVLTTDPGMGVARHVDAGYDIAIQTAKEKGIHIPMIDKAGDK

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family [H]

Homologues:

Organism=Homo sapiens, GI21389467, Length=559, Percent_Identity=33.4525939177102, Blast_Score=307, Evalue=2e-83,
Organism=Homo sapiens, GI260306182, Length=619, Percent_Identity=30.8562197092084, Blast_Score=284, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI71997891, Length=550, Percent_Identity=33.4545454545455, Blast_Score=313, Evalue=2e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000193 [H]

Pfam domain/function: PF01175 Urocanase [H]

EC number: =4.2.1.49 [H]

Molecular weight: Translated: 60590; Mature: 60590

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS01233 UROCANASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKIQAKKGLSIECKGWEQEAVLRMLYNNLDPEVAERPEDLVVYGGIGKAARNWEAFEAI
CCCCCCCCCCEEEECCCCHHHHHHHHHHCCCCHHHCCCCCEEEECCCCCHHCCHHHHHHH
EKTLRELESDETMLVQSGKPVAVFKTHEEAPRVLISNSVLVPEWANWDHFNELDKKGLIM
HHHHHHHCCCCEEEEECCCCEEEEECCCCCCEEEEECCEECCCCCCCCHHHHHCCCCEEE
YGQMTAGSWIYIGSQGIVQGTYETFAELGNQHFNGDLAGTVTLTAGLGGMGGAQPLAITM
EEEECCCCEEEECCCCCEECHHHHHHHHCCCCCCCCEEEEEEEEECCCCCCCCCCEEEEE
NHGVVICVDVDETRVDKRIDTKYCDVKTADLDEALKLAEEAKERGEGLSIGLVGNAVDIH
CCCEEEEEECCHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHHHCCCEEEEEECCHHHHH
QAILEKGFKIDIITDQTSAHDPLNGYVPQGYSVEEAKVLREKDPKKYVELSQASMAKHVE
HHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LMLEFQKRGAVAFDYGNNIRQVAFNNGVKNAFDFPGFVPAYIRPLFCEGKGPFRFAALSG
HHHHHHHCCCEEEECCCCEEEEEECCCCCCCCCCCCCCHHHHCEEEECCCCCEEEEEECC
DPKDIERADEEMRKLFPENEKLLRWLDLAEEKISYQGLPSRIAWLGYGERAKMGLALNRL
CHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHH
VRDGEISAPIVIGRDHLDAGSVASPNRETESMKDGSDAVGDWAVLNALINTAAGGSWISF
HCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEE
HHGGGVGMGYSLHAGMVVVADGSERAERRLGRVLTTDPGMGVARHVDAGYDIAIQTAKEK
ECCCCCCCCEEECCCEEEEECCHHHHHHHHCCEEECCCCCCEEEECCCCCEEEEEEHHHC
GIHIPMIDKAGDK
CCEEEECCCCCCC
>Mature Secondary Structure
MRKIQAKKGLSIECKGWEQEAVLRMLYNNLDPEVAERPEDLVVYGGIGKAARNWEAFEAI
CCCCCCCCCCEEEECCCCHHHHHHHHHHCCCCHHHCCCCCEEEECCCCCHHCCHHHHHHH
EKTLRELESDETMLVQSGKPVAVFKTHEEAPRVLISNSVLVPEWANWDHFNELDKKGLIM
HHHHHHHCCCCEEEEECCCCEEEEECCCCCCEEEEECCEECCCCCCCCHHHHHCCCCEEE
YGQMTAGSWIYIGSQGIVQGTYETFAELGNQHFNGDLAGTVTLTAGLGGMGGAQPLAITM
EEEECCCCEEEECCCCCEECHHHHHHHHCCCCCCCCEEEEEEEEECCCCCCCCCCEEEEE
NHGVVICVDVDETRVDKRIDTKYCDVKTADLDEALKLAEEAKERGEGLSIGLVGNAVDIH
CCCEEEEEECCHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHHHCCCEEEEEECCHHHHH
QAILEKGFKIDIITDQTSAHDPLNGYVPQGYSVEEAKVLREKDPKKYVELSQASMAKHVE
HHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LMLEFQKRGAVAFDYGNNIRQVAFNNGVKNAFDFPGFVPAYIRPLFCEGKGPFRFAALSG
HHHHHHHCCCEEEECCCCEEEEEECCCCCCCCCCCCCCHHHHCEEEECCCCCEEEEEECC
DPKDIERADEEMRKLFPENEKLLRWLDLAEEKISYQGLPSRIAWLGYGERAKMGLALNRL
CHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHH
VRDGEISAPIVIGRDHLDAGSVASPNRETESMKDGSDAVGDWAVLNALINTAAGGSWISF
HCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEE
HHGGGVGMGYSLHAGMVVVADGSERAERRLGRVLTTDPGMGVARHVDAGYDIAIQTAKEK
ECCCCCCCCEEECCCEEEEECCHHHHHHHHCCEEECCCCCCEEEECCCCCEEEEEEHHHC
GIHIPMIDKAGDK
CCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA