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The map label for this gene is moeA

Identifier: 82751861

GI number: 82751861

Start: 2279326

End: 2280585

Strand: Reverse

Name: moeA

Synonym: SAB2145c

Alternate gene names: 82751861

Gene position: 2280585-2279326 (Counterclockwise)

Preceding gene: 82751863

Following gene: 82751860

Centisome position: 83.16

GC content: 37.38

Gene sequence:

>1260_bases
ATGGTAGTAGAAAAAAGAAACCCAATCCCAGTTAAAGAAGCAATTCAACGTATCGTTAATCAGCAGAGTTCAATGCCGGC
AATTACGGTAGCACTTGAAAAAAGTCTAAATCATATCTTAGCAGAAGATATTGTAGCTACTTATGATATACCAAGGTTTG
ATAAATCACCTTATGATGGTTTTGCAATTCGCAGTGTTGATTCACAAGGGGCAAGTGGTCAGAATCGCATTGAGTTTAAA
GTGATTGATCATATTGGTGCAGGTTCAGTTTCTGATAAATTAGTTGGGGGTCACGAAGCGGTGCGTATTATGACTGGAGC
ACAAATACCTAATGGCGCAGATGCTGTTGTTATGTTTGAACAAACGATTGAACTAGAAGATACATTTACAATTCGTAAAC
CATTTTCAAAAAATGAAAATATATCTTTAAAAGGTGAAGAAACAACGACAGGCGATGTTGTTCTAAAAAAAGGACAAGTA
ATTAATCCAGGTGCTATTGCGGTCCTTGCAACATATGGCTATGCAGAGGTTAAAGTTATTAAGCAACCAAGCGTCGCTGT
TATTGCAACAGGAAGCGAATTATTAGATGTTAATGATGTATTAGAAGATGGAAAAATTCGTAACTCTAATGGTCCAATGA
TTCGTGCCTTAGCAGAAAAATTAGGTCTTGAAGTTGGTATTTACAAAACACAACAAGATGATTTAGATAGTGGTATACAA
GTCGTTAAAGAAGCTATGGAAAAACATGATATCGTTATTACAACGGGCGGAGTTTCTGTTGGAGATTTTGACTATTTACC
TGAGATTTATAAGGCTGTAAAGGCGGAAGTGTTATTTAATAAAGTAGCAATGCGTCCTGGTAGCGTAACAACGGTTGCAT
TTGCAGATGGAAAATATTTGTTTGGATTATCTGGAAATCCATCAGCTTGTTTTACAGGATTTGAACTATTTGTGAAACCA
GCTGTTAAACATATGTGTGGCGCACTAGAAGTCTTCCCGCAAATAATTAAAGCAACATTAATGGAAGATTTTACCAAGGC
AAACCCATTCACACGATTTATACGTGCTAAAGCAACGTTAACAAGTGCAGGAGCTACTGTAGTACCTTCAGGATTCAATA
AATCAGGTGCGGTTGTAGCGATTGCACATGCTAACTGTATGGTCATGTTACCAGGAGGGTCACGTGGTTTTAAAGCGGGT
CATACAGTAGATATTATATTGACTGAATCTGACGCTGCTGAAGAGGAACTTCTTTTATGA

Upstream 100 bases:

>100_bases
GCGTGGCCTTGTTGATTAATATGAGTAAACTCAGTCATTTTACCCCTCCTAGTGCATCTAGTATATCATGAAAAAATAAA
AGTTTTGGAGATGATTTTTA

Downstream 100 bases:

>100_bases
TTTTACAAATTGTAGGTTACAAAAAGTCTGGCAAGACAACATTGATGAGGCATATTGTCTCTTTCTTAAAGTCACATGGT
TATACAGTTGCTACTATTAA

Product: molybdopterin biosynthesis protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MVVEKRNPIPVKEAIQRIVNQQSSMPAITVALEKSLNHILAEDIVATYDIPRFDKSPYDGFAIRSVDSQGASGQNRIEFK
VIDHIGAGSVSDKLVGGHEAVRIMTGAQIPNGADAVVMFEQTIELEDTFTIRKPFSKNENISLKGEETTTGDVVLKKGQV
INPGAIAVLATYGYAEVKVIKQPSVAVIATGSELLDVNDVLEDGKIRNSNGPMIRALAEKLGLEVGIYKTQQDDLDSGIQ
VVKEAMEKHDIVITTGGVSVGDFDYLPEIYKAVKAEVLFNKVAMRPGSVTTVAFADGKYLFGLSGNPSACFTGFELFVKP
AVKHMCGALEVFPQIIKATLMEDFTKANPFTRFIRAKATLTSAGATVVPSGFNKSGAVVAIAHANCMVMLPGGSRGFKAG
HTVDIILTESDAAEEELLL

Sequences:

>Translated_419_residues
MVVEKRNPIPVKEAIQRIVNQQSSMPAITVALEKSLNHILAEDIVATYDIPRFDKSPYDGFAIRSVDSQGASGQNRIEFK
VIDHIGAGSVSDKLVGGHEAVRIMTGAQIPNGADAVVMFEQTIELEDTFTIRKPFSKNENISLKGEETTTGDVVLKKGQV
INPGAIAVLATYGYAEVKVIKQPSVAVIATGSELLDVNDVLEDGKIRNSNGPMIRALAEKLGLEVGIYKTQQDDLDSGIQ
VVKEAMEKHDIVITTGGVSVGDFDYLPEIYKAVKAEVLFNKVAMRPGSVTTVAFADGKYLFGLSGNPSACFTGFELFVKP
AVKHMCGALEVFPQIIKATLMEDFTKANPFTRFIRAKATLTSAGATVVPSGFNKSGAVVAIAHANCMVMLPGGSRGFKAG
HTVDIILTESDAAEEELLL
>Mature_419_residues
MVVEKRNPIPVKEAIQRIVNQQSSMPAITVALEKSLNHILAEDIVATYDIPRFDKSPYDGFAIRSVDSQGASGQNRIEFK
VIDHIGAGSVSDKLVGGHEAVRIMTGAQIPNGADAVVMFEQTIELEDTFTIRKPFSKNENISLKGEETTTGDVVLKKGQV
INPGAIAVLATYGYAEVKVIKQPSVAVIATGSELLDVNDVLEDGKIRNSNGPMIRALAEKLGLEVGIYKTQQDDLDSGIQ
VVKEAMEKHDIVITTGGVSVGDFDYLPEIYKAVKAEVLFNKVAMRPGSVTTVAFADGKYLFGLSGNPSACFTGFELFVKP
AVKHMCGALEVFPQIIKATLMEDFTKANPFTRFIRAKATLTSAGATVVPSGFNKSGAVVAIAHANCMVMLPGGSRGFKAG
HTVDIILTESDAAEEELLL

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=401, Percent_Identity=33.6658354114713, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI10880983, Length=401, Percent_Identity=33.6658354114713, Blast_Score=180, Evalue=3e-45,
Organism=Escherichia coli, GI1787049, Length=299, Percent_Identity=34.1137123745819, Blast_Score=155, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI25147659, Length=339, Percent_Identity=30.6784660766962, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17562606, Length=375, Percent_Identity=27.2, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI17136978, Length=398, Percent_Identity=29.3969849246231, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24638841, Length=398, Percent_Identity=29.3969849246231, Blast_Score=129, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 44904; Mature: 44904

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVEKRNPIPVKEAIQRIVNQQSSMPAITVALEKSLNHILAEDIVATYDIPRFDKSPYDG
CCCCCCCCCCHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
FAIRSVDSQGASGQNRIEFKVIDHIGAGSVSDKLVGGHEAVRIMTGAQIPNGADAVVMFE
EEEEECCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEE
QTIELEDTFTIRKPFSKNENISLKGEETTTGDVVLKKGQVINPGAIAVLATYGYAEVKVI
EEECCCCEEEEECCCCCCCCEEEECCCCCCCCEEEECCCEECCCCEEEEEECCCEEEEEE
KQPSVAVIATGSELLDVNDVLEDGKIRNSNGPMIRALAEKLGLEVGIYKTQQDDLDSGIQ
ECCCEEEEECCCHHCCHHHHHCCCEEECCCCCHHHHHHHHHCCEEEEEECCCCCHHHHHH
VVKEAMEKHDIVITTGGVSVGDFDYLPEIYKAVKAEVLFNKVAMRPGSVTTVAFADGKYL
HHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEE
FGLSGNPSACFTGFELFVKPAVKHMCGALEVFPQIIKATLMEDFTKANPFTRFIRAKATL
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHEE
TSAGATVVPSGFNKSGAVVAIAHANCMVMLPGGSRGFKAGHTVDIILTESDAAEEELLL
ECCCCEEECCCCCCCCCEEEEEECCEEEEECCCCCCCCCCCEEEEEEECCCCCCHHCCC
>Mature Secondary Structure
MVVEKRNPIPVKEAIQRIVNQQSSMPAITVALEKSLNHILAEDIVATYDIPRFDKSPYDG
CCCCCCCCCCHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
FAIRSVDSQGASGQNRIEFKVIDHIGAGSVSDKLVGGHEAVRIMTGAQIPNGADAVVMFE
EEEEECCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEE
QTIELEDTFTIRKPFSKNENISLKGEETTTGDVVLKKGQVINPGAIAVLATYGYAEVKVI
EEECCCCEEEEECCCCCCCCEEEECCCCCCCCEEEECCCEECCCCEEEEEECCCEEEEEE
KQPSVAVIATGSELLDVNDVLEDGKIRNSNGPMIRALAEKLGLEVGIYKTQQDDLDSGIQ
ECCCEEEEECCCHHCCHHHHHCCCEEECCCCCHHHHHHHHHCCEEEEEECCCCCHHHHHH
VVKEAMEKHDIVITTGGVSVGDFDYLPEIYKAVKAEVLFNKVAMRPGSVTTVAFADGKYL
HHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEE
FGLSGNPSACFTGFELFVKPAVKHMCGALEVFPQIIKATLMEDFTKANPFTRFIRAKATL
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHEE
TSAGATVVPSGFNKSGAVVAIAHANCMVMLPGGSRGFKAGHTVDIILTESDAAEEELLL
ECCCCEEECCCCCCCCCEEEEEECCEEEEECCCCCCCCCCCEEEEEEECCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA